Why do Nondepolarizing muscle relaxants cause Fade with TOF monitoring?

[@lbowlesrn]

i NEEDED someone to break this down for me simply and with moving pictures, THANK YOU SO MUCH!!! I ACTUALLY UNDERSTAND THIS NOW!!!

[@WooPoo2007]

Thanks for the breakdown and thorough explanation. It truly helped. And while I'm no longer in the Army, hearing "let me orient you" made me crack a smile.

[@xDomglmao]

Guy deserves an award for teaching. Would you be so kind to explain the pattern visible after using depol agents?

[@mariotorres2993]

This video really helps a lot to visualize the depletion of Ach. But @ 7:27 the doctor says that Ach has to stay away from pseudo cholinesterase. He should have said that Ach should stay away from True Cholinesterase which is the one that metabolizes Ach.

[@AhsanKhan1998]

He says "acetylcholinesterase" Edit: now that I hear it again, it does sound like he says "pseudo"

[@kirkgiles4136]

An awesome video that was even better when view in sequence w/ the video explaining twitch.

[@adeelkazmi9691]

Wow…simply amazing or amazingly simple u made it

[@Devilishsuki]

Thank you very helpful. Currently studying for the ICU part 1 examination in Australia :)

[@xDomglmao]

so...did you pass :D?

[@Devilishsuki]

xDomglmao yes! Thanks for asking! Though this topic did not come up for me, it was the subject of one of my practice vivas

[@xDomglmao]

@@Devilishsuki Glad to hear that! :D Grats!

[@jephh]

Sukey I almost stopped watching this video 20 seconds in but because of your comment I watched the whole thing. It is good.

[@emilymoore7897]

Great video, I'm a nurse in the Army Reserves attending Anesthesia school in Pennsylvania! Thanks so much

[@manuelloera5995]

Love the explanation, thank you sir!

[@MohamedKandilMD]

That was really helpful Dr. Bentley thank you very much but why do we also see fading pattern in phase II of depolarizing blockers?

[@xDomglmao]

same question here!

[@sandysara8423]

Very helpful, thank you very much 🙏

[@sonjaherzog5722]

So helpful! Thank you so much!

[@leetabgolden]

Thanks for this great brief!

[@drnykterstein_]

This video was a godsend! But I dont understand the same thing for the phase 2 of Depolarizing blockers.

[@MambaCool20]

Thank you Sir 🙏🏾

[@priyalhingrajiya229]

Thank you so much , so much understanding and enjoyable video 👍🏻👍🏻

[@dennerdovandojr.8878]

Great video. Thanks!

[@zipfish123]

Great video. I want to draw a parallel to succinylcholine: Is phase 2 block caused by desensitization of the presynaptic nicotinic receptors (rather than direct antagonism as seen with non-depolarizing agents)? I'm having a hard time understanding why this would only occur at high doses.

[@seanbernard6000]

Makes me wish I went to USAGPAN

[@radhika1218]

Thank you 🙏

[@abeltsehay8533]

very helpful, thank you!!

[@pankhuridhawan4393]

Thankyou so much

[@Jagadeesh_Gade39]

So helpful. Tq

[@drmohobaidullah9228]

thank you so much it really helped

[@broganthomas2259]

Thank you !!

[@soulmatesr64]

Very useful

[@tubakhalid9001]

Magical✨

[@paryjameel868]

Thank u I’m pary from iraq

[@mastakeaton]

awesome!

[@alexanderbrigantty3068]

best video ever

[@ElenaRox1994]

why is he wearing army clothes teaching medicine? extremely helpful and clear though! Wonderful simple diagrams~ easy to understand! Thank you!! :)

[@chrisopaas4987]

+ElenaRox1994 Because the army also deal with medicine. Actually the wars up trough the years has improved the surgical knowledge and skills that no hospital could ever experience. The military medical branch is a very important branch of the military.

[@ElenaRox1994]

Jorge Arizpe wow i see.. thank you!

[@ryanbrunner5622]

what does the presynaptic nicotinic receptor do? you explain the blocker is competing there but what does it NORMALLY do... I feel like thats essential in understanding this, and you dont explain it. for that reason.. thumbs down you just say positive feedback mechanism.. what are you talking about specifically? -First Year medical student

[@martinyowa]

+Ryan Brunner....... presynaptic it has acetylcholine a neuron transmitter which attach to post synaptic. the below one in the diagram to open a channel called na/k channel which lead to influx of sodium from out side to inside n efflux of potassium from inside to outside which lead to depolarization

[@ane28829]

PREsynaptic receptors move the next set Ach filled vesicles to the “front line” (the edge of nicotinic nerve for preparation) and when another action potential comes and stimulates Ca2+ influx (which destabilizes the proteins that hold the vesicles in place) the “front line” is ready for release into the synaptic cleft. I know this is 4yrs old but I thought this reply may be helpful for others in the future -SRNA

[@ane28829]

Ryan Brunner the other response is true for POSTsynaptic nicotinic muscle receptors NOT PRE-. When Ach is released not all diffuses time the motor end plate, a fraction bind to PRE (Pos Feedback Mech).

[@xDomglmao]

@@ane28829 Thank you very much!

[@pesmobile-progamer1327]

@@ane28829 i think u also need to open a youtube channel U explain superbly

[@khebhh]

Takes a decade to get to the point. Could have been concise and to the point. Anyway thanks for making the basic clear.

[@sunilbishnoi1364]

You take so much time to explain a single point but ok

[@brwnbaldie]

Thank you!