Local Anesthetics and Neuromuscular Blockers | Anesthesiology

[@MedicosisPerfectionalis]

🧠 CNS Pharmacology Course: www.medicosisperfectionalis.com/

[@Gbtorint]

Not to make you feel praised but sir ‘You are the best Teacher I’ve ever met’. I can’t believe I enjoy lecture videos just like the way I enjoy movies. Very simple way of learning, I laugh most times at your use of pun and funny comments😂. Thanks for making the world of learning a better place.

[@MedicosisPerfectionalis]

Thank you 🙏

[@rimshaabdullah8373]

After getting your video I realize the difference between superficial study and intellectual study thank you medicose for your effort you are the best

[@MedicosisPerfectionalis]

Thank you 😊

[@allielilia3794]

the price for 3rd level subscription is extremely high:( I understand it if was a one-time payment but every month:(( you're doing amazing work with this channel but were just jobless med students

[@I_love_BTS_2025]

Medicosis, you're a saviour❤ for lost medical students 😊

[@Tarunrunner]

Really

[@hadeelabbas917]

الفيديوهات الدراسية الأمتع، الأسلوب المميز، بتقدر تخلينا نضحك و احنا مندرس، شكرا جزيلا :")

[@MedicosisPerfectionalis]

My pleasure 😇

[@sucdicabdi3407]

My anesthesiology exam is tomorrow , perfect time to watch 😍 thanks medicosis

[@MedicosisPerfectionalis]

My pleasure 😇

[@luyombojonathan6688]

Beautiful presentation,I'm grateful 🥲 !! Cheers

[@MedicosisPerfectionalis]

Thank you so much 😊

[@aurora3107]

19:40 Neuromuscular Blockers

[@zane6577]

You're the real mvp

[@anastaziachiwile4826]

You explain very well,.makes it easy to understand and remember, thankyou😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@BFpro156]

God bless this channel. its been so helpful

[@MedicosisPerfectionalis]

Happy to hear that!

[@audraalvarado3190]

Love the way you explain 😆 awesome teaching!

[@MedicosisPerfectionalis]

Thank you 😊

[@LagoCamair]

Thank you so much! Have finals tomorrow and this was perfect.

[@MedicosisPerfectionalis]

You got this!

[@rumeysaeed1]

I finished my exams. One step closer to becoming a doc. And I thank you for these wonderful videos, medicosis. 😊

[@pomi6320]

hopefully you did well on your exam! good luck

[@rumeysaeed1]

@@pomi6320 thank you! 😊

[@MedicosisPerfectionalis]

You’re very welcome 😊 Congratulations!

[@sleepingdarth7217]

You did well in your exams ,as em myself appeared in fcps anesthesia exam .

[@ThatsWhy-]

Good luck my little sister 👏👏👏

[@fizasiddiqui6432]

Love your work. Thank you ❤

[@MedicosisPerfectionalis]

My pleasure!

[@paulinahambata3271]

Thank you Medicosis for giving me comedy in a tutorial 😂❤️

[@MedicosisPerfectionalis]

You’re very welcome ☺️

[@M.Sweatha]

Really Helpful video sir 👍

[@MedicosisPerfectionalis]

Thank you 😊

[@jorgeramirez8291]

It took me hours to understand pka in books, thanks for so much, sorry for so little

[@MedicosisPerfectionalis]

Thank you 🙏

[@ragnarockae]

While using succinylcholine as muscle relaxant respiratory paralysis occurs. This paralysis is not antagonised by acetylcholinesterase inhibitor. By giving ache inhibitors like pyridostigmine, Ach increases and increases the duration of paralysis.

[@The-advicer]

Commenting for the algorithm recomindation

[@MedicosisPerfectionalis]

Thank you for watching!

[@mahnoor7726]

Omg you’re the best 👏👏❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you 😊

[@Tomatoffel]

Come on as a dentist asking people questions while they have all my tools in their mouth is the best thing about the job xD

[@MedicosisPerfectionalis]

Haha 😂

[@saffron7423]

very simple way of remembering which drug is of amide grp and which is of ester group - esters have 1 i and amides have 2

[@sambhavi007]

You are soooo gooood... Thank u .

[@MedicosisPerfectionalis]

My pleasure 😇

[@studymbbswithme611]

You are amazing ❤

[@MedicosisPerfectionalis]

Thank you so much! Would you please help me by sharing?

[@studymbbswithme611]

Off course👍...I would love to..

[@moniasweri99]

😂😂😂😂❤❤ u made it so easy and funny

[@MedicosisPerfectionalis]

Thank you!

[@samasharajapakse]

thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@pomi6320]

Hello sir i have sort of a private question, did you finish studying medicine in Egypt and what medicine universities do you think are decent? Love your videos keep up the great work.

[@MedicosisPerfectionalis]

Most of my medical education was in Egypt. Most universities-that teach medicine-are terrible all over the world. I teach medical students in USA, Canada, Hong Kong, Australia, Japan, UAE,...etc., and the medical education they receive is not great. The secret sauce is you. If you really want to learn, you will find many ways to it (good textbooks, atlases, teachers, videos, audios, courses, lectures, apps,...etc whether online or offline). For instance, there was a brand new Gray’s Anatomy Textbook in my university’s library. I was the only one reading it. Even Anatomy professors and assistant professors were shy to approach it. Your medical education is your responsibility. Be diligent and persistent and you have no idea how good you can be. Good luck 🍀

[@pomi6320]

@@MedicosisPerfectionalis thank you sir, I really have a strong passion for medicine even since I was a child and I'm fascinated by the wonders of the human body. Hopefully I will be able to enter med school after I finish my high school ALevels. You and other youtubers such as ninja nerd lectures and aramdo hasudangun and chubbyemu really made studying medicine from random books i find at the library extremely fascinating, thank you for everything you did and how much you helped many students around the world, I will forever be your student. Wish you the best of luck.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@takyc7883]

why were we taught that B fibres were the first to be affected by a local anesthetic because they are myelinated? (and nodes of ranvier makes them more susceptible than unmyelinated)

[@إِبتَسمہي]

How can I get explanations and summaries as Pdf ?

[@garrettludescher9588]

I work in the ED and the doc i scribe for always says to buffer lido with bicarb. Now i know why!

[@MedicosisPerfectionalis]

Thank you so much for watching!

[@mahnoor7726]

GREAT EXPLANATION

[@MedicosisPerfectionalis]

Thank you 🙏

[@NawshadMirza]

can some one tell me this software that used in this video pleas ?

[@Dr_Dubey]

That Hendersooooon Hesssselbaaaack❤

[@MedicosisPerfectionalis]

:)

[@Happy-yf8bc]

pH remains constant as pKa decreases due to HCO-3 increase.

[@sulky-s]

How does neostigmine antagonize the effect of the depolarizing drug in phase 2 while it augments it's effect in phase 1?

[@LagoCamair]

I think because in phase 1 where it is depolarising, the action of ACh increases(d/t increased inhibition of AChE by neostigmine) hence aiding phase 1. And in phase 2 where the cells are tired of firing and want to stop, neostigmine would be opposing that effect. Hope it makes sense.

[@rimshaabdullah8373]

Plz make GIT playlist

[@MedicosisPerfectionalis]

Ok!

[@stanbanic3365]

big dog medicosis, you have a talent for teaching, thanks my guy.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@Mr.MAS24]

Sir, don’t worry! You won’t have to smack my gluteus minimus 🤣🤣

[@ziadnaji7985]

❤️❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@jamicarpenter8760]

Dang….had a MI during last surgery so I thought I would be safe under local….maybe not so much? Thank you 🙏

[@MedicosisPerfectionalis]

So, did you receive local anesthetics?

[@jamicarpenter8760]

@@MedicosisPerfectionalis No. I was going to have elective surgery under a local anesthesia, thinking it wouldn’t effect my cardiovascular system 🙄. I’m a medical student so I should have known better, but you set me straight. I will live with my saggy chin!! 😂

[@MedicosisPerfectionalis]

You’re so nice to talk to! You’re funny 😁 Just try to think of the pros and cons to local, and make your own choice. Good luck 🍀

[@afrah0073]

Local anaesthetics cause hypertension via intrinsic sympathomimetic acitvity and hypotension in cardiac toxicity, so what is it overall?

[@edwardherrera846]

Local anesthetics don’t cause hypertension. That wouldn’t make any sense. Now cocaine, the only naturally occurring local anesthetic, has some sympathomimetic properties. But the other local anesthetics don’t unless you mix epi with the local (which is done every day).

[@mediclov1719]

I got a 1st degree heart block listening to your lectures 🥰

[@ahmedelsakka9548]

Why C fibers are most susceptible to local anaesthesia ?

[@MedicosisPerfectionalis]

Because they are the smallest in diameter (and unmyelinated), so the local anesthetic agent will penetrate the C fibers the easiest.

[@ahmedelsakka9548]

@@MedicosisPerfectionalis Thank you Another question How A fibers are metabolically active more than C fibers although A fibers consume less Na/K Atpase pump less than C fibers ??! I think Na/K pump needs more O2 therefore metabolically active,, right ???!

[@1pabitrarai]

❤

[@MedicosisPerfectionalis]

Thank you 😊

[@holisticrudie9278]

👏

[@MedicosisPerfectionalis]

Thank you!

[@reddybargav1972]

11:52 😂 😂😂

[@CmklotsaOkmlitsa-i8p]

Marilyne Pines

[@alaaalnadhary1773]

Shut up it's easy 😂😂😂😂😂❤

[@proudsanatani461]

So it means chinese people eats neuromuscular blockers? man-curian 😂

[@The-advicer]

Commenting for the algorithm recomindation

[@MedicosisPerfectionalis]

Thank you!

[@thilinaalagiyawanna3680]

Thank you very much

[@MedicosisPerfectionalis]

My pleasure 😇