Neuroinflammatory Hypotheses of Depression

[@OllertonMD]

I graduate medical school and get my MD in a couple weeks. Starting my psychiatry rotation at the University of Washington. Super excited. I have been reading about the cytokine theory of depression in and anhedonia for years, and I’m very excited to see all of the new research coming out to support this. I hope in my lifetime inflammation becomes a big part of the diagnostic workup and treatment of psychiatric disorders if thats where the evidence leads

[@OllertonMD]

@White Wolf yep! Just about to finish intern year. Still as interested as ever in the topic too! I gave a presentation including info on inflammation and depression earlier this year to residents and attending MDs, people seemed to be very interested in the topic

[@danashannon8234]

What is an anti inflammatory that could be used now?

[@OllertonMD]

Dana Shannon there have been promising results with ibuprofen, declofenac, aspirin, minocycline, low dose naltrexone, remicade, high EPA omega 3 fatty acids, curcumin, Mediterranean diet, exercise, fixing insomnia

[@danashannon8234]

Yes....trying to get a Dr in my state to prescribe LDN has been....well not accomplished as of yet... : )

[@OllertonMD]

@White Wolf i would never suggest any treatments in a youtube comment, and my mention of ibuprofen is simply pointing out that there is scientific evidence something as simple as an NSAID like ibuprofen might help people with an inflammatory type of depression. I agree though, ibuprofen causes intestinal hyperpermeability and is likely not a great med to take long term daily

[@robertmoore2374]

Wow yhank you for such great information is very hard to find information like this

[@OllertonMD]

Just finished the entire presentation. Wow. So excited to become a psychiatrist over the next few years! Thank you Dr. Sheline!

[@douglaswatt1582]

Pretty basic review and a decent enough one as it stands but it's disappointing that it didn't cover our groups work or the work of Slavich and colleagues showing that social stress, separation distress, and loss of social attachment are both depressogenic and pro-inflammatory. Also does not discuss depression directly as first cousin to sickness Behavior which I believe is the proper perspective. Both depression and sickness behavior are conserved and evolutionarily related shutdown mechanisms. We have suffered not merely under the confining and distorting effects of the monoamine hypothesis but under the notion that depression is always an illness as opposed to how it exists as a conserved mechanism, one that becomes disinhibited and removed from its normal terminators to create depressive illness. Also bungled is the handling of what the ventral tegmental dopamine system really does - it is not a pleasure system, it is a motivational system, but it is valanced because evolution decided that it was important to make motivational arousal a positive state. Moderate activation of this system yields psychological energy and enthusiasm not sensory pleasure. It is about the pursuit of pleasures, not about pleasure per se although again enthusiasm is pleasurable or to be more precise, positively valanced. Going strongly against the notion that is a pleasure system is the now overwhelming evidence that the system is also activated when we are trying to avoid aversive or painful events in other words again motivated to minimize negative affective states as well as chase positive ones. Unfortunately, the author of this video is not alone in these conflations, which are, unfortunately, rather widespread due to the unfortunate label that the VTA DA system is a 'reward system'.

[@JohnDoe-nj6ef]

In Germany it's a Standard test to look for inflammatory factors in your blood.

[@ittech4714]

That makes a lot of sense

[@Guidus125]

@@ittech4714 Depends. It adds information, but inflammation isn't specific to any disease so as a diagnostic tool it has limited value.

[@ittech4714]

@@Guidus125 I also agree with that

[@nikkid4890]

Very good idea! And definitely ahead of its time

[@mv8908]

What biomarkers?

[@stevesedberry]

I have found that various herbs, spices and foods reduce inflammation, for instance curcumin is a natural ingredient in Turmeric, which can be grown and harvested in many home gardens.

[@treytrey6011]

~30:40 when you mentioned combination therapies for depression. What are the Anti inflammatories used in the combination antidepressant - anti-inflammatory treatment? Is there a study that you can cite? Any current studies going on?

[@elinmansson5535]

Wow this was an awesome presentation!

[@Alan-megan]

Great video

[@raniadizikiriki8935]

At 44.30 she is saying alternative treatments did you hear them? Sound is not clear

[@lindasplaylist100]

I have Arachnoiditis which is caused by activated mycrogleal cells. But spinal taps are not an option. I have major depression an have been on Prozac for yrs then switched to cymbalta due to pain and it doesn't work. I also have hx of an ulcer so cox 2 is not an option. But I did hear that ADHD meds help with neuroinflamation. Could you elaborate. I was a psych nurse and had to leave my position due to Arachnoiditis. Great presentation.

[@RowOfMushyTiT]

EMSAM patches are the best for neuroinflammation, as they inhibit MAO-B which is responsible for peroxide production and tonic inhibition.

[@stevesedberry]

at 35:00 cyllacocsis? what is the correct spelling?

[@nicholashaines8481]

Policy interventions that would reduce emotional pain on a vast scale: providing high quality housing to everyone, lifting income support payments above the poverty line, eradicating unemployment, and upgrading public goods to make them universal and convenient and free. The United States has the real resource capacity to do these things. It has the labour, the raw materials, the technology, and the knowledge that are needed. The constraints are entirely political. It wouldn’t require any technological breakthroughs to eradicate poverty, unemployment, and housing insecurity. Those problems are eminently solvable. If we made wise public policy choices the mental illness burden in the community would plummet. There would still be some mental illness but the scale of it would be small and very manageable with the current mental health workforce (or even a considerably smaller one). The social determinants of population health are the low hanging fruit of health care. It is not technically hard to implement the right policies. The problem is that power brokers don’t want to implement those policies. Poverty is a policy choice. Unemployment is a policy choice. Housing insecurity is a policy choice. Inadequate public services and public infrastructure is a policy choice.

[@Indiah-fb2eq]

Hi how can o get help f from you with testing me for inflammation off the brian pls

[@franciscafazzo3460]

they talk a lot. havent found anything available.

[@raniadizikiriki8935]

Does anyone knows more about rTMS?

[@anonmouse956]

Is her pronounciation of tryptophan correct?

[@hparamesh]

Wonderful lecture I learned a lot. Thanks 🙏🏾

[@Bergersplace]

Might want to revisit the the comments about red meat. Check out Dr Paul Saladino's KZbin channel. He only eats animal products.

[@dmackle3849]

Not any longer. He’s copping some flak now for adding fruit. His advice is still worth considering but I think Amber O’Hearne is a more thought provoking guide to anyone not thriving on carbs. Georgia Ede also addresses the mental health impact of inappropriate diet. There is a wealth of information out there now on the psychological effects of food. But beware it is not a one size fits all. The advice given in the Q&A regarding veganism and grain consumption could be extremely counter productive for some. Anti inflammatory diets to study include vegan, zone (Barry Sears), gluten free (Dr Peter Osborne), paleo, keto, carnivore (L. Amber O’Hearne). About the only thing they all have in common is avoiding processed food and the combination of high fat with high carbs. Meet your human biological macro and micro nutrient requirements, while excluding any personal anti nutrients. Don’t dabble without informed guidance and effective monitoring.

[@DennisBolanos]

Dr. Paul Saladino is about as impartial and credible as Dr. Michael Greger-in other words, not at all.

[@patricianoll1229]

Im in menopause so sleep deprive stress and stupid covid rules lol anything else