Beyond Statins: New Lipid Goals, Targets & Treatments to Reverse Atherosclerosis

Emory Medicine Grand Rounds - 5/30/2017
TOPIC: “Beyond Statins: New Lipid Goals, Targets, and Treatments to Reverse Atherosclerosis"
LEARNING OBJECTIVES:
1. Review the evidence base for statins as the cornerstone of LDL-lowering therapy and ASCVD prevention
2. Apply evidence from new clinical trials with nonstatin therapy (ezetimibe, PCSK9 inhibitors) into practice
3. Compare and contrast current Cholesterol Guidelines (2013 ACC/AHA, 2015 NLA, and 2016 ACC Non-Statin Expert Consensus)
4. Understand how future targets of lipid-lowering therapy may further reduce residual cardiovascular risk
SPEAKER:
Terry A. Jacobson MD
Professor of Medicine, Emory University Division of General Medicine and Geriatrics
Director, Lipid Clinic and Cardiovascular Risk Reduction Program, Grady Health System
Past President, National Lipid Association
MORE GRAND ROUNDS VIDEOS: Visit www.bitly.com/dom-grandrounds
APPROVED CREDIT:
This activity has been planned and implemented in accordance with the essential areas and policies of the Accreditation Council for Continuing Medical Education (ACCME). Emory University School of Medicine is an ACCME-accredited sponsor to provide continuing medical education credits to physicians.
Emory designates this enduring material for a maximum of 1 AMA PRA Category 1.0 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This seminar is valid for three years from the original seminar date. Expiration date: May 30, 2020.
*Any financial disclosures are included in video.
Questions? Please contact [e-mail].

[@jazzsnare]

Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology.. Vol. 8, 2015, issue 2. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase, serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, ...Statins are contraindicated in diabetics as statin administration did not prevent diabetics from CHD (ASPEN [55] and 4D study [56]), and statins worsen diabetic control [7]. Detailed mechanism of statin effects in diabetes has been published [7,19].

[@toddk2737]

This guy is a pharmaceutical company salesman. Continually lowering the numbers to continue selling drugs. Covid has taught me to trust no one pushing drugs

[@victordasilva5255]

Minimum benefit (unless your on the big pharma payroll)

[@chrisbarnes10]

What do you do with someone who's cholesterol is normal but their CAC score is 900?

[@fun_at_work]

This research is fundamentally incorrect and outmoded. Low Carb Down Under has a bunch of meta-analysis which demonstrate the terribly errors. Statins are bad. High LDL is correlated with increased life expectancy no matter what your diseases. Lowering your cac is not difficult. This guys channel has great info. He has weekly q&a. There are several ways to heal your plaque problems. Low carb/no carb and vitamin d + K2 are placed to start looking kzbin.info/www/bejne/n4W8ioCPnrJ6Z7c

[@fun_at_work]

Idk what our where you are in your research, but this as well. kzbin.info/www/bejne/l529ZWqanNpmgrc

[@allencrider]

You don't need expensive medications. Adapting to a whole food, plant-based diet will reverse atherosclerosis and provide greater health in other areas.

[@btudrus]

@Lil Anthrax Reversing metabolic syndrome and abstaining from sugar will reverse atherosclerosis. Insulin is much more important than LDL.

[@richt6353]

Lets sell more drugs and get Richer!

[@dariamancini963]

Are lipid experts in existence to justify mandating statins?