Bilirubin Metabolism Simplified

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Bilirubin (formerly referred to as haematoidin) is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged red blood cells. First the hemoglobin gets stripped of the heme molecule which thereafter passes through various processes of porphyrin catabolism, depending on the part of the body in which the breakdown occurs. For example, the molecules excreted in the urine differ from those in the feces.[1] The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdin reductase performs the second step, producing bilirubin from biliverdin.
Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases. It is responsible for the yellow color of bruises and the yellow discoloration in jaundice. Its subsequent breakdown products, such as stercobilin, cause the brown color of feces. A different breakdown product, urobilin, is the main component of the straw-yellow color in urine.
Bilirubin is degraded by light. Blood collection tubes containing blood or (especially) serum to be used in bilirubin assays should be protected from illumination. For adults, blood is typically collected by needle from a vein in the arm. In newborns, blood is often collected from a heel stick, a technique that uses a small, sharp blade to cut the skin on the infant's heel and collect a few drops of blood into a small tube. Non-invasive technology is available in some health care facilities that will measure bilirubin by using an instrument placed on the skin (transcutaneous bilirubin meter)
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[@sudhanshudutt10]

Accurate & precise , this is just what I needed , tomorrow is my test on this topic , thanks for saving my time along with such great information , great voice modulation also

[@coffeecat8826]

Thank you so much, having my year 2 finals in 2 weeks. My lecturer has a VERY strong urkranian accent and he speaks so softly I can't even hear him in the recordings. You did a very good job explaining this! Thank you again

[@miragesharma9062]

I was thinking of escaping this question during my exam preparation.You made it so simple and easy.Thankyou so much.

[@JanEkbom]

This is so insanely interesting. Thank you for making this video.

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So clear both the handwriting and explanation. So simplified. Great Job 👏

[@midhudas3910]

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[@MEDSimplified]

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[@alimbo9436]

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Excellent!!! Sat through 1.5 hours of lecture and still didn't get it. Can write an essay now after your 2 mins video. Thank you

[@MEDSimplified]

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نعم

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[@mohsenakhavantabib9515]

Thank you so much. Deeply Appreciated !

[@07akshayar46]

Your videos are nice. It's so easy and helpful. Put videos for amino acid metabolism and lipid metabolism.

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Exactly what I needed👍

[@thegreatfoodie5389]

Thank you. You saved me

[@1978carpenter]

Loved this explanation. So much easier. Thank you.

[@Sosooization]

well done! simple quick explanation.

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Thank you for making it accessible !!!

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[@hanch96]

beautiful, very grateful

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Great explanation. Thanks. It was really helpful

[@parimalarathinamparimala8783]

Clearly, use full video sir 👍👍

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This helps...thank you.

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Just awesome thankyouu so much🤗

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Sir kya mast explain kiya hai thank you

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Words can't describe how amazing this video is.

[@kanti5119]

Perfect 🙏 thank u so much

[@srikantadash4603]

Very good video sir thankyou

[@suzan7752]

Thanks 😊👍

[@oliulla7978]

Ma Sha Allah Your Teaching Style is Amazing Sir May Allah Reward You with Goodness.

[@vanessasmith4773]

thank you so much,

[@wahmfarad2719]

Dear Sir Your way of explaining is marvelous, from your video my confusion is cleared now , but kindly please tell me that from where you read this text that ( when RBCs/Erythrocytes disintegrates/ ruptures / splits then hemoglobins hemoglobins will be comes out from Erythrocytes) I mean say that please sheer book name / website address because I want reference because from your video my half work is done but half will be done after attain reference . Regards wahm farad

[@varnasaju131]

Tnq so much sir

[@yasminbano4675]

Great.i get bugged up teaching this to my nursing students .sharing this with them will really help.

[@nicewoman2900]

Thank you!!😍❤❤

[@love_jayy]

Please make a video for heme metabolism

[@comradejames451]

Excellent!

[@rashmimahajan5745]

simplified so well

[@MEDSimplified]

+Rashmi Mahajan Thank u Rashmi

[@navjeevanpathologylab9876]

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Amazing

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Great

[@a.7325]

Thank you so muchhow effectively brief it is!

[@John_Smith_Dumfugg]

I'd love to be your student! You're awesome!!!

[@yvonneamon5166]

Thanks much

[@chhavisharma1054]

Thankyou....for the first time I got my concepts cleared in this

[@justinesimone5343]

My Bilirubin is always slightly elevated. After Covid my bilirubin has been very high! Drs don't look at why!

[@Top10Next]

are prabhu kaha the pura internet chan mara fir bhi kuch pata nahi chal raha tha par apke 2 minute ke video ne to kamal kar diya thank you keep up

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nice one. 👍

[@As-ht5rw]

honestly, you are amazing. You just did picture and explain a whole page in few sentences. Thank you.

[@lindafliegel2186]

Your teachings are clear, concise and presented in an understandable fashion.

[@pakben]

Terima kasih.

[@pakben]

I ask permission to use this video for my biology lesson in middle school. Thank you.

[@ati3armyofrobots]

Is biliverdin & porphyrin same

[@madhuparisa6204]

Sir please upload cholesterol bio synthesis

[@kanchanthakur9303]

thanx

[@hoangngan-hs-cantho3816]

Excuse me! I have a question that why unconjugated bilirubin is combined with glucuronic acid?

[@Danger_bro-]

Bro lecture on ketogenesis

[@YousafKhan-j1s]

nice

[@DavidRodriguez-qv5to]

great. You explained it so very well and your voice was nice. May i ask you to perform a video of chirossis of the liver as in scar tissue and the presice mechanism the liver undergoes to become scarred along the names of the chemicals in the process? Please consider it. It'll be very cool if you can do it shortly.

[@levii5217]

Cirrhosis or chirossis??

[@AL-cp2of]

Nice! Edit: at 1:53 stercobilin imparts Brown color to feces, not Yellow

[@Parralyzed]

1:50 I don't know about you, but my shit ain't yellow bruh

[@peridotsun6205]

Thank you! This spelled bilirubin metabolism out nicely :)

[@nirnathan1127]

Amazingly simple, thanks! Helped me a lot

[@tsangpadrema1854]

Tq

[@Orange-ok8gg]

فدشييييي، والزهرة روعة💖💖💖💖💖💖

[@reneilwemoshidi5164]

Wow, this is crazyyy wow.😂❤

[@ron_ning7169]

Very useful video but i still have a bit doubt... .Are heme oxygenase and biliverdin reductase contained inside the macrophage of retinoendothelial system ? How does the macrophage pour out from itself after the successfully conversion of bilirubin? What is the mechanism behind it?

[@sunidhim.ghatikar3625]

I probably can answer the second part of the question.. Basically macrophages are scavengers and when they r filled up with byproducts of their action on substrates usually they put them back into circulation. You may even take diff gradients working here... If this is impaired things go out of the way as in case of foam cell formation that is seen in M.I.

[@mourilshah2054]

Yes they are present in our Reticule Endothelial system especially in Liver and Spleen Macrophage cells namely Kupffer and Cords of billroth

[@nikhatara4987]

Amazing really thanks soooo much I lost all my queries 😇😇😇😘😇😇

[@777Rowen]

Thanks for explaining how this works. What does it mean if your billrubin levels are high?

[@maphistoplayz2351]

Liver disease or problem In blood

[@kcreid5390]

"By George I think y got it"! Thank you, great explanation.

[@rallyworld3417]

But why kidney need bilirubin waste compounds?

[@anilkumar-hf6lj]

Is urobilin conjugated or unconjugated

[@calvinklein6903]

Very clear and succint!

[@AsadKhan-lm6yr]

Fantastic video and animation. Well done and thank you.

[@spreading_education235]

Oh my god this video is very very good

[@gowsikaselvakodi1357]

Thank u so much. Helped me at right time . A clear crisp video.

[@biowordings]

Nice video.. Inspirational for my channel.. Thanx :)

[@منوعاتعالمية-ل4خ]

Thank you very much because you make medicine easier 👍😁💕❤️

[@mackysaviour106]

This video helps me a lot

[@ChukkalaDeepika-qf3bg]

Tq ❤❤❤❤❤❤

[@katemayclem9]

clear and concise - you are awesome. super helpful

[@jennifersalazar6837]

Why would my Bilirubin and RBC be high?

[@uzmeddublaj_videolari]

Wow, always i was sleep lecture, because this video.... Respect for you.

[@balamurugan1032]

தமிழல சொல்லுங்கடா டேய்'

[@walaamohmed1513]

very fantastic and helpful video. Thanks alot

[@MEDSimplified]

+Soha Muhammad U r welcome soha