Parkinson's disease | Dopamine and the basal ganglia

[@yahyamushtaq852]

This doctor is giving me motivation to ace my exams as well as joining the gym next month after exams

[@Shravs333]

Yup

[@idronethings7786]

God dam! give this man an award... or money... or a cuddle or something. These videos are so easy to follow along. I wish I had a teacher like this back in the day. Thanks again for the great content

[@ghull544]

He's a ripped doctor. He's paid enough 😂

[@sanjanaasengupta9175]

I've wrecked my whole brain for the past innumerable years.. To understand this pathway..... And here comes this God of a man to explain it in 4minutes!!!! Thank you so very much

[@learning_with_Vik]

better than the teachers of a school i pay an absurd amount to go to

[@mohamedorayith4626]

ouch

[@rosejay7370]

I don’t longer get herpes outbreak after using [e-mail] natural herbs medication ..🌿🌿🌿❤️✅💊

[@sonali8528]

hundred percent!

[@22arabulnisar34]

THIS IS WOW, MAN YOU HAVE DONE IN 4 MINUTES WHAT OTHERS WERE NOT ABLE TO DO IN HRS, THANK YOU SO MUCH FOR SUCH A NICE, BEAUTIFUL AND CRISPY EXPLAINATION.

[@petert.x1]

I'm a speech therapy student learning about Parkinson's Disease. This video is so well explained!

[@SamunIqbal]

This has, by far, been the easiest video to follow through. THANK YOU SO MUCH!!!

[@bhaskarrao2517]

Very nice Doc.. very simple..i wish i had a teacher like you to teach neurophysiology..i have seen a few other videos of the neuroscience... extremely helpful..

[@zes3813]

wrr, no stress etc nmw

[@John-wm5pe]

this is the only video that I could find that does a good job of explaining how dopamine affects motor control

[@stacekane4065]

Your videos are amazing, a 2 hour lecture all summed up in 4 minutes....thankyou so much 😊

[@koenhouse]

I have given you the 800th thumbs up! My teacher didn't explain crap! Now I finally understand Parkinson pathophysiology.

[@aasif296]

This video is a work of art, I was SO confused 😭 THANKYOU!!

[@SG333_]

Your teaching style is unmatched and you make learning so easy and fun! Thank you 🥹❤

[@SOSO7539]

this is by far the best video on this topic that i have found on yt. thanks a lot. now i actually understand the clinical presentation :)

[@BLADE777X]

I love you so much, been searching for this concept but couldn't find it. And then stumbled upon this video. You made it look so easy.

[@neilkiang2091]

your explanation is much better than my teacher!! you saved me, thank you!!

[@vinitabangera9047]

Amazing explanation! This makes so much sense, thank you so much for the work you do!! Much love

[@zerkphd6951]

Preparing for my PhD prelim, going over some basics, and this was a very nice and concise description of these brain regions and their interconnectivity in PD. Thank you.

[@faialnashmi4710]

I’m speechless. This was very well explained thank you!!

[@maiyang5295]

Love the way you explain complex topic. Thank you for posting your videos.

[@CryoBio]

Sooo many of your videos have helped my pathophysilogy course over this last semester, thank you so much Doctor!!

[@rosejay7370]

I don’t longer get herpes outbreak after using [e-mail] natural herbs medication ..🌿🌿🌿❤️✅💊

[@kanulucy6138]

Dr Mark & Dr Matt God bless you people for me Well understood sir

[@LaloboJDavid]

magnificent .THANKS ALLOT DOC

[@rachealtaylor1497]

Helpful content Hey I would love to discuss more concerning this disease, my grandpa has it If yes kindly send me a email or message me on hangout [e-mail] ...🇺🇸will look out for your text or email by tomorrow bye

[@177jahdha]

So simple yet the best and most understandable Thank youuu

[@Bimbolalaoshe]

I love Dr Mike's lectures 🎉🎉🎉🎉

[@nathanstrogulski9432]

Really good, excellent way to show how the basal ganglia work; only, the projections between the basal ganglia and the thalamus aren't inhibitory neurons? so actually the direct pathway leads to an inhibition of those neurons, leading to increased thalamic activation; whilst the indirect pathway gives an excitatory feedback to the same projections, activating the inhibitory neurons and reducing thalamic neutrons activation and halting movement?

[@monaabdat1296]

Thanks for your teaching by this marvelous way I’d like to ask how can I inhibit the dopamine inhibitors please mention some drugs

[@Sammy.a1287]

SUCH AN AMAZING EXPLANATION! LOVE IT! GREAT TEACHER

[@kanyo078]

wow.... Your video is so helpful... it helped a lot seriously. Thank you. Your explanation is so clear

[@denshe945]

you are such my hero doc huhuhu. thank you for this one again

[@142.vijaykrishnanaravazhi5]

Thanks for making me understand the d2 receptors

[@immanuelcarterb2060]

Thank you..it was helpful🔥🔥

[@chillyzibra7836]

I have an exam tomorrow, ur saving my life ♡♡

[@vanoralobo]

this made me understand the topic so easily. thank you :)

[@Zdashti]

Just what I needed. Thank you sooo much!!!!

[@Lovemypiano1]

I totally get it now. Thank you...

[@benittachandra61]

excellent explanation ... just what i needed to clear my doubts.. thanks a lot Sir!!!

[@praveenmadhubhashana4185]

You saved few hours of my study time 😍😘

[@greenottri1783]

Thank you Doc

[@bonfirebits]

This was awesome. Thanks guys.

[@almorais971]

thanks for this easy explanation

[@reorio7376]

Finally i understand why we get cogwheel rigidity!!!

[@reorio7376]

I keep on coming back to this video to get that "aha! Clarity" every time i revise Parkinson

[@MarvelMedicalMnemonics]

Great explanation. Thank you!

[@daphnelatu8043]

This was so helpful. Thank you!

[@ahmed086]

Thanks. Keep it up doc

[@Livmas1234]

SO helpful. Thank you!

[@bruhlol6792]

i love u, i legit understood in 2 seconds

[@deancurson3424]

Great explanation, thank you for keeping it simple!

[@KyawLinHtun-o6z]

Enlightened on this one thanks to u.😊😊

[@kellykeali2452]

Helpful indeed.

[@kvj84]

crystal clear!

[@yassirtouissi5501]

Thanks for the great video, really helpful.

[@samiulazimraheem223]

Thanks so much

[@jh1720]

Such a great video to understand PD !!

[@Trusfrated02]

You saved me! Thank you

[@AnnaHayat-z2h]

Thank you ❤

[@aleksandracirkovic294]

You are amazing , thank you so much!

[@mirableadu393]

Aww God richly bless you

[@garydesesa6996]

Excellent video to be sure. But I am so curious as to the actual methods, tests, scans, procedures that science uses to determine the fascinating and important information you present. How do scientists scan the living human body to find out how all these intricate chemical pathways work? Thanks so much!

[@Sammy.a1287]

Great question. The answer is that disease when a patient is living combined with a postmortem and dissection of the brain with examination under the microscope helps determine the cause of the disease. Everyone with Parkinson disease has pale substantia nigra on postmortem - tonnes of information then leads to our understanding via deduction

[@mohamednoorrilwaan6085]

I really like how you smile at us before every video c=

[@owo4526]

Quick question. When you say start stop which processes are you referring to? The motor cortex signal and then the absence of dopamine?

[@prajwal_1402]

Thank u

[@calebrutan4893]

Dude, great video! Very distilled and understandable. Thanks!

[@nicol3875]

Wow you are brilliant thanks a lot 🤯 👏👏👏❤❤❤❤

[@wkkong88]

Watching this video and finally understanding gave me dopamine

[@Enty94]

Very helpful thank you for the video

[@DrewAlexandros]

You explained this so simply it makes me want to DIE

[@SadeekaPiyumali-tj7wr]

Amazing explanation .thank u so much ❤from 2024

[@jasmineweg2051]

Thankyou so much!!!

[@hrasa3827]

Nicely done . bravo

[@kellycriterion1019]

It's the moustache for me😂You look funny in a moustache😂 Nice video❤

[@hussnaingujjar8937]

Ohh. Finally someone make this shit look easy.

[@helenahorvat4050]

Thank you!!

[@docsaab7050]

You save my vivas🙌🔥

[@bethelonely2629]

Please, why this start/stop function in the first place?

[@ivynya29]

This was excellent

[@er8017]

I don't get it. If pathway started with person deciding to move how comes that he has "resting" not "intentional tremor" ?

[@hakaromer]

there are some misconceptions actually!! dr.mike when signals are sent from the Globus palidus internus (GPi) to the thalamus is to carry an inhibitory message to the thalamus and GPi is involved in the indirect pathway whereas the GPe is involved in the direct pathway by releasing GABA on subthalamic nucleus to inhibits it as the function of subthalamic nucleus is to activate the GPi which is involved in the indirect pathway!!

[@arshdhange8770]

Fantastic vid

[@ralsharp6013]

😭Gosh this feels very scary to me, as somebody with movement disorder.. I was given Maxolon aka reglan and it affected my basal ganglia.. TD parkinsonism stiffness cramps spasm and tics. It can happen from a dopamine suppressor. When I went to the neurologist, I asked if this could be the reason our two youngest children have tourettes. Taking anti-nausea dopamine suppressor during pregnancy. His answer was, most likely but more study needs to be done.. if this truly is the case, This kind of study is always worth more government grants. Please be careful of dopamine and serotonin suppressor medications during pregnancy. PubMed has hundreds of studies in this area. Also encouraging Professionals to join one or two support groups in the area they specialise in. Often very beneficial on both sides, to be a fly on the wall. I'm saying all of this because parkinsonism means drug-induced Parkinson's and we have to start paying attention to labels like environmental factors. We rely on you guys, Not to encourage medications that will make our movement disorder worse. If it says may or may not make it the condition worse, it really needs to be explained properly. I encourage everybody to listen to the pharmacists when they are explaining prescription medications If your prescriptions instructs you to wean off the medication and never go cold turkey. Please always pay attention to that.. This is such a huge subject on both sides full stop and three huge keywords in the upload title thank you

[@brandygriffiths8396]

You guys are amazing

[@mikram2273]

The best 👏👏thank uu

[@tinytaylor1109]

I was not expecting that mustache after seeing him clean shaven in so many videos 😂 Had to do a double take 😂😂

[@DrMattDrMike]

👨🏻

[@minaa8713]

great video!!!

[@madihailayas2452]

Oh my God .. finally 😫

[@glennshibu5776]

legend and nice stache

[@joodsaad6113]

very helpful thank u❤

[@pritamshil5765]

Sir,does Prefrontal cortex inhibit sexual motor response with the help of basal ganglia in human being?

[@TannazMobasheri]

Does Dopamine have any role in first path? normal situation? or it just plays a role in Parkinson situation?

[@SalehElavi]

Make it simple🙏

[@rexking6184]

Genius !!!!!!!!

[@karnisouvalian3838]

the bestest! thank you

[@themagnificent512]

Thankyou sooo much sir

[@keitymarley733]

Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms. My Dad is well again…

[@ElijahNyok]

My uncle is suffering from Parkinson disease. What drug can I buy for him?

[@pujapachchigar6713]

Really helpful, Thank you :)

[@Onyxandfriends.4467]

Love it! Thank you Dr.!

[@haideralyasiri627]

Thanks man

[@haejinl463]

THE BEST

[@antondelacruz9362]

So the shaking is comparable to flicking the lights on and off repeatedly? Huh.