Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic

Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic
Metabolism or biotransformation of drugs or medicines is a pharmacokinetic property of drugs which is the irreversible alteration in the chemical nature of a drug. These reactions may be anabolic and catabolic reactions involving mainly endogenous substances like hormones, steroids, etc. but most of the drugs are also undergo these types of reactions and some functional groups are attached or exposed by drug-metabolizing enzymes.
Pharmacology is the study of drugs. Pharmacology mainly subdivided into two main branches pharmacokinetic and pharmacodynamic. Pharmacokinetics is mainly concern with the kinetics of drugs inside the body or simply what the body does to a drug. In contrast, pharmacodynamics is concerned with the effects of drugs on the body or simply what the drug does to our body. So, metabolism is pharmacokinetic property through which various changes takes place in the structure of drug which is done to facilitate its excretion from the body through excretory organs. Drugs metabolic reactions are divided into phase 1 and phase 2 reactions. In phase 1 reactions a functional group is exposed or added to the drug structure while in phase 2 reactions an endogenous substance is covalently attached to the drug molecule.
Covered topics:
Drug Metabolic reactions
Phase 1 reactions
Oxidation
Hydroxylation
N-dealkylation
O-dealkylation
Deamination
N-oxidation
S-Oxidation
Desulfuration
dehydrogenations
reduction
hydrolysis
Phase 1 reactions
Glucuronide conjugation
Acetylation
Methylation
Sulfate conjugation
Glycine conjugation
Glutathione conjugation
GENERAL OVERVIEW
REFERENCES:
Goodman and Gilman
The Pharmacological Basis of Therapeutics
Eleventh Edition
Rang and Dale's Pharmacology, Seventh Edition- H. P. Rang
Katzung - Basic and Clinical Pharmacology
12th Edition
Lippincott Illustrated Reviews, Pharmacology - Whalen, Karen
Sixth edition
Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa
Essentials of Medical Pharmacology(Jaypee) - K.D. Tripathi
Seventh edition
A Textbook of Clinical Pharmacology and Therapeutics
Fifth edition
By: JAMES M RITTER, LIONEL D LEWIS, TIMOTHY GK MANT, ALBERT FERRO
Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa
Links:
Also watch:
drug biotransformaion part 01
• Biotransformation of d...
How drugs act
• How drug act? | Mechan...
Receptor and its types
• Receptor - pharmacolog...
How drug-receptor interact
• Drug receptor interact...
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#glucuronideconjugation
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[@bismyan1019]

At 5:30 you mention the addition of an O-atom to an S-atom, however your mechanism doesn't feature an S on the right. Why is that?

[@MKMediGuideLectures]

We had noticed it from the first but once we edit our video its a lot difficult for us to edit it again. Our video passes from so many phases but mistakes in last phase are very difficult for us to make it right 😊 Thank you soo much for watching 😊

[@MKMediGuideLectures]

And secondly as you noticed, it is "S" instead of "C"

[@veedeedoan4133]

very helpful! Thank you.

[@KalsoomInsights]

Too much beautiful writing styl and color combination ❤ I really appreciate your hard work👍 it's just amazing 🤩

[@MKMediGuideLectures]

Thank you 😊

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[@MKMediGuideLectures]

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[@MKMediGuideLectures]

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[@tariqhassan3046]

Thank you...

[@prettypuff1]

Wow this is great content

[@MKMediGuideLectures]

Thank you 🙂

[@MUHAMMADISMAIL-rd1qd]

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[@MKMediGuideLectures]

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[@malaikamillions]

How can I research aberrant metabolization causing opposite effects? For Example: What phrases can I use to research why Barbiturates have an extreme stimulatory effect on me (think aggressive drunken sailor on speed for many hours). I’m trying to understand how to gain support from a medical system where a majority of drugs cause an opposite intended primary &/or secondary effect. Beyond the redhead gene, and simple allometrics, there must be more useful keywords for me to use in my (as yet) epic blind research. - grateful for any useful insights & references.

[@abbasahmad9449]

Mash'Allah Keep it up dear!

[@MKMediGuideLectures]

Thanks 😊

[@muhammadsayyad203]

great job bro

[@MKMediGuideLectures]

Thanks for watching & supporting 😊

[@sahartawfiq3184]

I need this summary paper PDF, how can I have it, please?

[@geotraveler6867]

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[@akashkamboj9334]

Can you upload pdf of the notes you made please

[@MKMediGuideLectures]

Ok. But notes for this one, isn't available 👍