BrainCancer.org's "Brain Tumors 101 Series": MGMT Methylation in Glioblastoma Brain Tumors

[@simontrucker3624]

Thank you. I am going through treatment at the moment....started cycle 5/6 Tmz follow up last night in fact. I am MGMT Methylated, and the clear way you explained this gives me a bit more hope.

[@arunaj7732]

Hi, how are you now?

[@asish5425]

God bless you, may you recovered soon.

[@Sobesworld]

Just helped me understand a Uworld question thank you!

[@saudsama88]

same

[@jasperchen2148]

Fantastic explanation doctor

[@emmaward8022]

Thanks so much for this explanation. It was a great explanation - you are helping me soooo much with my MSc dissertation

[@FatimaHamid-c6w]

Thank you you’re great ❤

[@AdnanKhan-nr6ty]

At 1:48 wrong statement that methylated MGMT equates to poor prognosis

[@connie6118]

No he is correct

[@ryansmith6197]

@@connie6118 You are correct

[@flattenthestupiditycurve4811]

methylated = no much MGMT produced = DNA less likely be repaired after gets distributed by TMZ (vs if unmethylated). So the statement should have been "the UNmethylated MGMT has a poorer px"

[@katiereed1595]

@@flattenthestupiditycurve4811 Agreed

[@IfeomaEkenna]

@@connie6118 who is correct?

[@sahelaayanee5505]

what is the point if there is no link to publication ?!

[@frogprincessss]

In a nutshell: TMZ is more effective if MGMT is inactive. MGMT becomes inactive if its promoter region is methylated.