You're Being Lied To About Ozempic | Truth Complex | Business Insider

[@reikoshea]

The food noise comment is real. When I first got on zepbound I remember being angry that I didn’t enjoy food anymore. No meal made me “happy”. And after a few months I started to realize “my happiness isn’t tied to food”. That tiny shift in how my mind thinks about food was a real game changer. The difference between “I don’t feel happy eating food” and “I don’t need to eat to be happy” is STAGGERING.

[@candihartley]

There are chemicals in food that form compounds in our stomachs. Sugar and gluten form a compound similar to morphine. It is a pain killer. You did not take a weight loss pill or shot. You turned off the addiction part. Those compounds. Stop taking it and you are still addicted. Healing takes time and work. I thank you for your work and may you continue to live and be happy. With or without food. Your body is yours and no one should be able to say it needs to be different. It is just soul clothes and nobody looks the same but all of our souls do. Your clothes are fine.

[@mcbrite]

It's just self calibration... When I've been on Keto for even a WEEK, a candy bar tastes DISGUSTINGLY sweet. To the point I would need to force myself to eat it. But ANY ripe fruit would smash that candy bar easily... Only once you start getting back into junk/sugar do those tastes begin to shift again...

[@reikoshea]

@@mcbrite It really isn't. You talk like I haven't lost more than 100lbs via willpower alone, or 60lbs via keto, or multiple other diet trends. The difference between zepbound and the normal "diet and exercise" advice, in my personal experience, is that NO food produces a serotonin/dopamine response on zepbound. When I was keto, a steak was still a "happy" meal, as was a rotisserie chicken. When I was calorie counting, everything was still a "happy" meal. On zepbound, my favorite foods, like curry, or steak, or etouffee, or sushi are all just sustenance. I have no desire to finish the meal, and often don't. I get a few bites in and often decide to just put the fork down because I don't want it. I'll go to a gas station, and just get a drink, and skip the chips and candy, because they don't seem appealing. Heck, even alcohol is significantly less appealing, which is just another benefit to my health. No matter what diet I was on previously, there was always room for a few ounces of whiskey a week. I don't even want that anymore. What I'm trying to say is, my whole life, food and drink have been my PRIMARY source of dopamine and serotonin, and now, for the first time in my adult life, they're not. They don't give me that feeling, and it's forced me to change how I live, not only with regards to food, but also my personal life. I had to find new sources of happiness outside of food, and I'm a better PERSON for it. Everyone's different, and your results with controlling your diet very well could have produced different results than my own, but to discount it as "it's just self-calibration" doesn't just attempt to discount my own personal anecdote, it also seeks to discount the actual science done studying how the drug functions and it's impacts on those taking it.

[@tarabooartarmy3654]

I had already lost over 100 pounds before Ozempic so my mind shift had already happened, but the food noise thing is real. I still had tons of food noise and Ozempic had helped a ton.

[@GabrielleP310]

First of all, all weight loss and a lot of anti anxiety/ssri’s meds have serious life altering/destroying effects on you and their effectiveness rarely makes up for your suffering‼️ Be very careful. These meds have a short term use benefit, ONLY short term‼️

[@Intoxicatious]

Both of my parents are overweight and diabetic. They were both put on Ozempic. It seemed to work well for my dad, but my mom never got past the initial low dose phase. She got severe gastrointestinal pain and vomiting. So I can see how the drug is not for everyone

[@RadioDjinn]

Great that she stopped taking the drug, unlike the lady in the video who preferred vomit to death.

[@Maureen-MO]

@@Intoxicatious there’s not a single drug on earth that is for everyone. Even ibuprofen. Biology will teach you why. Nature wants to increase diversity and change.

[@yogachick1955]

have your mom check out Retatrutide. It's got less severe side effects and is VERY effective

[@christinahek]

Each drug is different. Some can’t tolerate Ozempic/Wegovy, but can take Mounjaro/Zepbound.

[@SmallBobby]

GLP1 peptides are pro nausea. GIP peptides are anti nausea. She should switch to tirzepatide.

[@NegatingSilence]

It was therapeutic to just see a 20-minute video full of factual information and some reasonable discussion about it. Thanks.

[@jw70467]

There's plenty of good, but there's also at least five minutes of fluff, and some real nonsense. You can't call the compound ordered pharmacy "prescriptions" when you didn't have one to begin with.

[@DoDaDaDaDaCaDa]

How can u tell it's factual?😂

[@SafeEffective-ls2pl]

Looks like a 20 minute ad for big pharma.

[@doragreen3887]

I want to know how much money she made from the drug company🤔

[@mon699]

Honestly so fairly discussed critiqued more of these

[@LovelyLadyLissett]

I initially took ozempic for weight loss however only lost 25lbs in 11 months. However after 20+ yrs as a diabetic I officially have it controlled. I'm no longer injecting insulin 4x a day and no more Metformin! I've had no crazy side affects and blessed to only have to take a once a week injection!

[@taylarhodes650]

insane results, well done!

[@manho9877]

I hear you sister. With the body of a college athlete, keto diet and exercise, I could not control my DM2 until Ozempic arrived. Of course, I am using prescription compounded semaglutide as insurance won't approve Ozempic because I do not have "complex" or "multiple comorbidities" - I eat too well and exercise appropriately.

[@beesquestionmark]

25 pounds in 11 months is nothing to scoff at! That’s still incredible and a large amount of weight. Give yourself some credit cuz you deserve it, and nice job on getting your diabetes under control!

[@morganzoeclanthem2847]

Good job!

[@fuzzyapplebong328]

I just lost 20 pounds in 3 months with zero calorie counting, zero gym time and I rarely even count my sets when I exercise at home.

[@mariec3414]

What I loved the most on ozempic is not even the weight loss is this sense of FREEDOM from food addiction. That I can start my day not feeling like food has an importance. That I can focus my energy on something else than food and the pleasure it brings. This satiety feeling is priceless, the feeling to be full is just really confortable. It made an end to this eternal emptiness and desire to eat snack that I had before. I didn't had to worry about calories , macros.... no nothing, my body was in a state where it can regulated himself without me having to "self control " my hunger, to work on felling satiety ( I was never able to feel it). For the first time I felt like everyone else: Eating a meal , feeling satiety up to the next meal. Then losing weight become easy without those craving !

[@dr.paulwilliam7447]

You take something very important from your body too. It is called hunger. As shown, loss of the feeling of hunger dampens your general activity over longer time spans. Not a smart idea!

[@mariec3414]

​@@dr.paulwilliam7447 Hunger was there , manifesting gently, slowly building,. The medicine is actually not cutting hunger at all but it works with the satiety hormones, it's not the same thing. Feeling full after a meal is what was different from before.

[@mariec3414]

@ hunger and satiety are different things. Hunger was still there. I’m only speaking about the long satiety feeling after a meal.

[@megeek727]

@@mariec3414 Are you still eating the same foods or did you improve your diet?

[@mariec3414]

@@megeek727 Exact same. My diet was already good my problem was the snacking and sugar craving at evening.

[@migueldias8546]

I have a PhD in Genetics and KZbin is not the place to teach genetics to people. BUT, I just want to take 1 minute to explain a basic concept. Next time you are in public, look at people around you. We all look different, you agree? What you have to understand is that it doesn't stop with the outside, it is exactly the same with our cells. We are all different. Even children from the same parents are not clones of each other (even twins). So how can you believe that any given drug (or technique or whatever) is going to work the same for you body and for the person next to you?

[@jreese8284]

How can I give 10 thumbs up to this remark!!

[@megeek727]

Agreed. There are scientific studies showing that some people respond to GLP-1 drugs and some don't.

[@TimelyAbyss]

Your comment highlights the insanity that is the social pressure for everyone to have the same figure of a pro athlete and 1% body fat.

[@migueldias8546]

@@TimelyAbyss Or, when we have Covid-19 (and I apologize for the BS that was said in the news), it is why you have people who are sensitive to the virus (and will die because we don't have the technology, yet, to save them) and others that are resistants... It is the same pattern with all bug, just the percentage of sensitives/resistants change (of course there are some people in between that we could save - and, also, it is a dynamic equilibrium - etc.).

[@migueldias8546]

@@megeek727 Any drug work differently for any single individual... Worse, the recommended dose for drugs is not always adapated to all individual and can sometimes present severe risks (yes, paracetamol, I am talking about you).

[@fakenamerton2568]

I did a wegovy course and lost 54lbs in 6 months. Have been off it now for 6 months and am still down 48lbs with almost all the regain being the first two months off it. I am no longer fat enough to get the insurance to cover it again lol.

[@bok..]

damn thats impressive, good job.

[@whitslack]

So what you're saying is that the insurance system is structured to *guarantee* the "yo-yo effect." The drugs are designed to be used indefinitely, but insurance is designed to resist that usage profile.

[@aaronpeters6209]

Do you know how much muscle you lost?

[@macattack5863]

No they are saying the weight largely stayed off.

[@Fx_-]

Yes damaging your digestive system to freeze up… is perfectly fine? What do we do about all the impulsive fat slobs? Give them receptor agonists…. You know what receptor agonists do? Agonist and antagonists… they block or activate target receptors like anti-depressives etc. There is such thing as receptor dysregulation due to these types of drugs. This happens because its the mechanism behind addiction. Your body has a feedback that will reduce or increase receptor volume depending on how much external or internal agonists or antagonists the receptors engage with. So you might be losing weight but your receptor volumes/balance are 1000% getting damaged. Just like meth heads etc. thats all of you ozempic zombies.

[@WhichDoctor1]

The trouble is that when selling us bandaids makes rich people money. But solving the systemic problems causing the illnesses would lose rich people money. We’re probably never going to get past the bandaid

[@geraldmalik6942]

So true, seems like this video is a marketing gimmick for these companies. Let's tell people to eat less and grow that discipline.

[@user-qz2ld3vt2d]

I am personally convinced ultra processed foods are the reason so many people struggle with weight. We have seen tons of healthy people on all kinds of diets which all focus on different macro nutrients. The issue is, non UPF foods are incredibly time consuming, and its just not possible for everyday people to find the time to make them.

[@BuiltInBrooklyn]

@@geraldmalik6942I came here to say exactly this, it’s basically an ad for Ozempic and other weight loss drugs!

[@movestattoo4561]

⁠@@user-qz2ld3vt2dI’m sorry but I don’t believe that time is the reason for this. You can spend 30min a day on cooking and have tasty home made food and there’s very few people who truly don’t have 30 minutes or even an hour everyday to spare.

[@lynnlamusga]

An ounce of prevention is worth a pound of cure. But nobody's making any money that way. So let's just keep treating the symptoms forever after it's too late to cure/reverse the disease.

[@matthewfensterwald1853]

I have been on tirzepatide for about a year now for type 2, but I went from 215 to 155 in about a year. It had some side effects yes, but I also have great labs now, and I am no longer diabetic. Doesn't work for everyone, but it has changed my life and the biggest thing people are not talking about is how much I have saved on food cost over the last year.

[@Fx_-]

Diabetes is perfectly treatable with a healthy diet. My parent did it. Ozempic is just another dangerous health-for-profit drug.

[@Worldaffairslover]

What would happen if you stopped using it

[@Hypnotoad582]

The snack food industry is going to lobby against these drugs.

[@Extrafancytoaster]

Let them. It won't stop people from realizing the cost of living is cheaper than snacking. This goes beyond some vanity reason to look better. This genuinely curbs potential for heart disease and heart attack in many patients and that benefit alone cannot be emphasized enough.​@@Hypnotoad582

[@matthewfensterwald1853]

@@Worldaffairslover Great question, my guess is I would slowly pack it all back on, I gained all my weight a few pounds a year over years, I snacked at night and drank lots of beer, the meds have made me snack less at night and drink much much less beer. Old habits die hard, I am on a lower does now. Since I have the diabetic diagnosis, as far as I know I will be on it forever. I also take metformin daily.

[@thetom341]

I simply want to say that the host Elizabeth McCauley presents extremely well and clearly, and the subject feels like it was analyzed in depth. An "S-tier" host, as the kids would say.

[@myconoid]

The psychological / "food noise" benefits of these drugs are magical for people that suffer from them.

[@megeek727]

The so called "food noise" is the body responding to a lack of nutritious food. It is screaming for nutrients and fiber. We interpret this as food cravings but the cravings are never satisfied because the food lacks the nutrients the body needs. That is why you see people eat a 3 course meal and still feel hungry 30 minutes later. A lot of folks sabotage their diets with high glycemic foods.

[@SparklesBB]

⁠​⁠​⁠@@megeek727 idk if it's fair or realistic to sum it up so simplistically. As someone who has, at times, had an extremely nutritious diet with very limited carbs and high intake of healthy proteins and fats and fiber, and at other times in my life, had a much shittier diet, the food noise has just always been there. As a constant. We're talking like a voice in my head going *snack snack snack snack get a snack go get a snack when was the last time I ate oh man I really want a sweet and salty snack I need it I need it* All the time, regardless of how "good" I was being at a given time about my overall diet. And that's why all my good, healthy dieting eras never lasted permanently, because of the overwhelming food noise. But in the last 4 months with Zepbound, it's just.... so much quieter. I wouldn't say my internal monologue about snacks is COMPLETELY gone, but I find that I'm able to redirect my attention pretty easily now, in a way I just couldn't manage to before. It's now more like *hmm I haven't had a snack in a while, maybe I should get a snack? Eh, I don't think I need it. I'll just play with my dog.* So I'm pretty inclined to disagree with your suggestion that the food noise phenomenon from GLP-1 drugs could just be replaced with better nutrients and fiber. Especially when obese people have been trying the "just eat better" approach for decades with a 95% overall failure record. In fact, the whole conclusion of this video supports the idea that we should all be avoiding the impulse to overly simplify anything when it comes to obesity, nutrition, and fitness.

[@fredericofaria1285]

Similar to how methadone reduces cravings for heroine in addicts. You replace one poison for another

[@zivzulander]

"Food noise" might be apt and real, but it needs as much skepticism as the "chemical imbalance in the brain" marketing that was used for some medications in the past that had little or no supporting evidence. It might be a useful phrase to describe an addiction, but beware the stealth marketing angle that uses it as a talking point or amplifies that PR messaging. Anything that potentially works that broadly should be as much cause for concern and monitoring, not just seen as a panacea for addiction.

[@aarnehalen1686]

@@TC-zf1jiAnd some people are more susceptible to the noise. Also, the volume differs. What is your point?

[@celloafterdark4173]

I started tirzepitide about 3 months ago and feel so much better. More energy, less food obsession, more clear-headed... etc

[@glalizas]

The US farma is a scam. In Greece my Ozempic costs 10 euro (basically 10 USD) a month with prescription or 100 without

[@Werdna12345]

Another take us US is subsidizing pharmaceutical research and only other countries benefit

[@sassyt1545]

The U.S. arm of pharmaceutical companies, pay for research and development (R&D) of new drugs, hence the “justification” that we in the United States pay more, which is BS. Consider yourself lucky that you live in a country where GLP1’s are affordable.

[@mathieuroy6572]

@@Werdna12345 Ah yes Denmark, the 51st US state.

[@Anonymous-m9f9j]

@@mathieuroy6572 perfectly said. No no it’s the foreign countries who make American healthcare bad! 😂

[@axelotl86]

@@mathieuroy6572 Didn't you know? :D

[@DaddyTi]

I used my savings to be on ozempic for 3 months. I lost 15 lbs but the food noise being quiet changed my life. For once I was like ‘damn, this is how normal people live without being controlled by food?!’ but I couldn’t afford it. $400 a month out of pocket. I wish so strongly it was more affordable.

[@nathanp3366]

Since there’s a shortage there’s online pharmacy’s that sell it for $175-$200 a month. Try hims/hers or just Reddit

[@kiaracodes5166]

Therapy and lifestyle changes will be cheaper in the long run

[@coolintheshade]

Trym health is a compounding pharmacy that offers 3-4months of the medication for about $450 in total. That’s where I got mine. It’s as legit medication. I’ve been on it for about 3 months down almost 20lbs

[@jenrosejenrose7417]

Eventually there will be a generic.

[@teknikgroup7597]

buy it from china...like i did.

[@nate6045]

6:20 it might be a big win for big pharma but it's an L for the junk food industry. I save so much money on food now and I only have a $50 co-pay. Since I eat less, my body is constantly demanding healthier foods to keep me going. The only time I'm eating junk food is when theres literally no other option.

[@HKim0072]

(I’m not being critical and see the benefits of the drug. I’m very pragmatic.) Generally, if people get committed to exercising and getting healthier, it trains your taste buds over time. And, a mental mindset.

[@CamStubbs]

@@HKim0072 I argue it doesn’t train your taste buds, rather with increased good food intake the body adjusts to higher efficiency energy sources which causes the dopamine response to processed sugars to decrease which is perceived internally as the body preferring nutrient dense food sources (or in my case demanding high protein & fat, aka ketones, causing me to feel sick when blood sugar spikes instead of ketones)… Not on ozempic but made the switch naturally.

[@jasonwagner4266]

You should have to pay the whole thing. You got fat on your own, lose it on your own. Glad I pay my premiums to cure your bad decisions

[@aarnehalen1686]

Also, it might very well be a net loss for the pharma industry long-term

[@aarnehalen1686]

@@HKim0072 Exercise trains your taste buds?

[@IlIlllIllIlIIIll]

I got an Arby's commercial at the end of the video. One of the many additional problems Elizabeth McCauley briefly touched on in this video. Great reporting McCauley!

[@texasgermancowgirl]

I have rheumatoid arthritis, when I stopped wegovy, the symptoms got so bad (despite not changing my healthy diet) that my doctors gave me very bad news. Three different drugs to stop the rheumatoid arthritis, nothing is working. I’m back on Wegovy, now my symptoms are calming down again. I don’t know why. We don’t know why.

[@sierralovat5498]

Funny I have Fibro and Athritis - wegovy did the same to ke. I felt great! More energy less pain. got off, all the pain. we don't know why.

[@Ryanneey]

That's fascinating. I am going to pass this on to my mom. I wonder if it would help her.

[@texasgermancowgirl]

@ Hey! Yeah no. I did fasting for years and no, it does not work. Prayer also does not work. You’re talking to someone raised very conservative with parents who mentioned exactly that. Don’t you think I would’ve done all of that before paying $1500+ per month before my insurance kicked in lol.

[@candihartley]

@texasgermancowgirl forgive your parents because they made mistakes. Please. Prayer does not show if you can not see it. It is there. You are fasting when you take the medication, there is an allergy that is attacking your cells. Foods are compounds broken down in our digestive tract. You are fasting. If it is helpful but hard to get then God is helping but there is opposition. Your parents tried ma'am. They cared. Take God out of the box they put him in and find who is he for yourself.

[@candihartley]

@texasgermancowgirl i apologize for the pain you have. You don't have to laugh. You are allowed to cry. It is hard.

[@fabulousfabiano]

On 11 June 2024. I was 101kg and started mounjaro, changed my eating habits and started exercise daily. I reached 72kg on the October stoped it, I kept exercising and eating less and I didn’t put any weight yet. I really happy and feeling a new person

[@rachelmaddowswife8713]

We just need to start treating addictive junk food the same way we treat cigarettes. Health education campaign, banning them from schools, warning labels, and heavy taxes that can be used to offset the healthcare costs. Instead, our government literally subsidizes these addictive foods, making them cheaper than real food.

[@AA-iy4gm]

Same thing with weed, people are completely in denial about how dangerous it is long term if you smoke it, not talking about edibles or thc oil, and even if they're not concerned about themselves the second hand weed smoke is harmful, even more so than cigarette smoke, there was a recent study on it but its not like people in denial will take it into consideration especially if they still say weed skunk smell doesn't really smell bad...when it absolutely reeks

[@lynnlamusga]

Agree 100% Basically there needs to be a "sin tax" put on sugar. That's the shit that is causing most of the T2 diabetes & obesity. Hunts Spaghetti sauce has HFCS as its 3rd ingredient, 5th is corn syrup, and 8th is sugar. It's the hardest addiction for some people to break, even for a short while. Of course, that'll never happen, as we have the best paid politicians that "campaign contributions" can buy.

[@dupre7416]

@@AA-iy4gm I think I received whiplash from this comment. Warn us before going drastically off topic.

[@Adiscretefirm]

You're not addicted to food any more than you are addicted to oxygen or water. You are a compulsive over eater.

[@justanotherjessica]

The biggest improvement would come from getting grocery stores to move back to impoverished areas that only have Dollar General and convenience stores now. It's VERY difficult to buy healthy food when you live 5 miles from a grocery store and don't have a car. Some DG stores have started carrying some healthier food options like fresh produce but it's not enough.

[@leafbelly]

I think you nailed it with your comment "It's almost like people want there to be a punishment for having success on this drug." Bingo!

[@nickbz1303]

I was ready for a fight in the comment section seeing the thumbnail. I was pleasantly surprised to find a quite reasonable discussion and insightful questioning into the topic. Thanks for an informative investigation and rational take.

[@elliotalderson4568]

This was an advertisement for Ozempic, pure and simple. The cost to produce it is less than $1.00 per dose and the pharmaceutical companies are bankrupting health care plans.

[@lizjackson4379]

@@elliotalderson4568 That's only a USA issue. Your healthcare system is a mess. I can buy a month of weight loss drug for £125, 100% private, not involving the NHS at all in the UK. As soon as insurance companies get involved the price jumps up - our animals pay more for drugs than we do because our vets went down the insurance model a couple of decades ago.

[@elliotalderson4568]

@lizjackson4379 We have been taught the fallacy that America is a meritocracy and that the corporations deserve the money so we no longer care to fight back.

[@stefaniec876]

The speed at which you speak is absolutely perfect. I normally have to put videos on 1.5 but yours was great pacing! Lovely

[@zivzulander]

If you've trained your brain to expect that speed, that's possibly setting you up to be impatient and rude to people in the real world who talk more normally. It's (ironically, given the subject of the video) a bit like wolfing down fast food rather than just appreciating a meal.

[@Anonymous-m9f9j]

@@zivzulanderI listen to everything on 2x. Americans typically speak really slowly so speeding it up makes it bearable.

[@rach_laze]

@@zivzulanderorrrr hear me out, I live in a place where everyone talks quickly, and has for many generations, and so my brain is geared towards listening at a faster pace from birth. My typical daily speaking, listening and processing rate is faster than 2x speed on most videos so I struggle to watch/listen to slower videos

[@garou12]

the endocrinologist i saw to discuss taking ozempic was very candid and pointed out that ozempic might be dangerous for patients with depression: he said some of his patients who had depression reported that being on the drug heightened their suicidal tendencies which made me decide that i didn't want to roll the dice to try this drug.

[@sahjeii]

This is super interesting. I wonder if there's a chemical reason or if it's as simple as food being a source of joy and taking it away can make those who already struggle with depression even more miserable. One of my friends who struggles with depression went on an ozempic type medication to lose some weight and it made her feel full constantly, to the point where even though she knew she hadn't eaten in a long time, the thought of having 1 bite of anything made her nauseous. She was on it for 3 weeks before she decided it wasn't worth it. She's also one of those girls who's 10-15 lb.s overweight and thinks she's humungous so she didn't have much weight to lose anyway haha, not sure if that has something to do with it too

[@V_4_Versace]

I’ve heard this, but from the perspective of since the drug makes people ignore hunger cues, it makes depressed people who already struggle to eat or eat healthy more likely to just not eat at all and starve themselves, which I guess technically is a suicidal ideation…

[@nicolamarkus3177]

I've also heard this. On the flip side, I've heard that with some people it helps with depression. Speaking firsthand when I started taking Mounjaro for Type 2 (tirzepatide, not semaglutide), my chronic depression eased and my "normal" mood was more neutral than depressed. I'd previously tried antidepressants and cannabis. Neither option helped me and both had unpleasant side effects. On Mounjaro, it was easier to find happiness in things besides food (and I even developed a disinterest in food. Food has been my drug of choice for over 20 years and just like that I had lost interest in it.) I was so surprised how Mounjaro helped my depression even before I had lost any weight... I didn't expect that.

[@reikoshea]

@@garou12 as someone with depression who’s currently on zepbound, I will say, the first couple months were extremely tough. I’ve always used food and alcohol to push through those severe depressive episodes, and when I got on the drug, food did NOT help. It was always a coping mechanism for me, and I remember being EXTREMELY angry that food no longer brought me any kind of joy. Thankfully my family was there to help me through it, and so far, it looks like I’m on the other side of that problem (at least, for now), but it was scary for a few months there. The plus side is, now I have healthier coping mechanisms, but getting to that point did, admittedly, feel dangerous. It’s also been extremely helpful in reducing, and nearly eliminating my dependence on alcohol. I’m glad your doctor warned you about that potential. Mine did not, he just said I wouldn’t want food, and made no mention of WHY I wouldn’t want food.

[@Alobster1]

@@sahjeii The gut produces the majority of your serotonin. Ozempic slows down gut function, likely also slowing down serotonin production.

[@SinisterMD]

What a lot of people don't talk about is that in the studies, up to 40% of the weight loss is muscle mass. Then the weight that is regained is usually adipose tissue (fat) which leads to a condition usually only seen in older people - sarcopenia. Your overall body composition is far worse off and I fear this will lead to an epidemic of osteoporosis, fractures and frailty. Time will tell.

[@zivzulander]

This is a great point that was overlooked in this video

[@Emmuzka]

But the muscle mass loss isn't any more dire than in any fast weight loss, a person would get the same result with losing weight with bariatric surgery or fasting. So your point isn't relevant for the video.

[@SinisterMD]

@@Emmuzka Incorrect. With a decreased caloric intake the muscle mass loss was due to lack of physical activity which wouldn't be the case with someone who loses weight with proper diet AND exercise. Also, the average loss of lean muscle mass after bariatric surgery is approximately 12 percent, which is significantly lower. Less muscle mass leads to a lower resting metabolic rate. As a physician who actively practices and discusses these issues with patients I can assure you I know the data very well. To that point, intermittent fasting was shown to increase the risk of cardiovascular death by 91% so that's another area of considerable research currently.

[@Gingerrrrsnapps]

I have had barely any muscle loss losing over 30 pounds. It depends on how it is done, not a guarantee.

[@Emmuzka]

@@SinisterMD Interesting. Can you link me a study where the significant difference of 15% from bariatric surgery and 40% from GLP-1 mediacation can be seen?

[@-.-_123]

Ive been on it for almost 2 years. Ive only lost about 35 lbs. But my stomach fat is melting away. I do walk and workout also. This has been a great option for me to get my blood sugar in check. My A1C is better than it has been in years. A bonus is that I no longer want alcohol and save a lot of money on groceries and chasing food cravings. To do this day, I cannot kick the ice cream habit though.😊 Since I need this drug, I pay nothing for it. Its 100% covered by insurance.

[@Maureen-MO]

What makes you “need” this drug? Are you obese?

[@Extrafancytoaster]

Check out frozen yogurt ice cream or a ninja creami to make your own low cal at home

[@HKim0072]

Hurry up! When something is covered by insurance, everyone else is paying for the cost. It's definitely not "free". (half joking / half serious)

[@-.-_123]

@@HKim0072 😂

[@-.-_123]

@@Extrafancytoaster Thanks. I'll check it out.

[@JuniorTobias525]

As someone that naturally lost 180 lbs in the past 2 years, I only heard about Ozempic last year. I had a friend start taking it and she lost an average of 8-10lbs per month, at the time the same rate I was loosing. So we had a super open Conversation about what she ate and literally everything she ate calorically was the same as much as me. The difference is while I was eating and The difference is while I was eating in a calorie deficit and high-protein. She just at less. Less volume food. and was eating Half the amount she usually ate. While my diet was calorie deficient and high volume food I was still very hungry throughout my diet. and still am to this day. This medication basically takes into account willpower it makes it easier because it helps you not feel as hungry.

[@ChantelleHale]

They mention in this video that there's a worry about losing muscle on Ozempic, but it was a little bit brushed aside talking about how if you lose weight through diet and exercise you'll lose some lean muscle mass. I've seen a dietician talk with somebody on Ozempic about their diet, and she was saying the person on Ozempic needed to up their protein to maintain that muscle, because muscle is good for you. If somebody is just eating less of everything, and not looking at what nutrients they're taking in, I can see this having a much greater negative effect on muscle than if they do what you did, which is something I would worry about. I've worked really hard in the past few years to put on muscle, to help with my arthritis and my long term health - I wouldn't want to lose weight but sacrifice that muscle, because that feels ultimately worse for me in the long run than not losing weight but having more muscle than I did before I started strength training, especially if you regain a lot of the weight after taking Ozempic.

[@JuniorTobias525]

@ like 4-5 month into I started I’m eating 1g of protein per pound of my goal weight. Ya super important everyone needs to that if they are on these drugs. It should be the most important part of the diet

[@iTriguy1]

@@ChantelleHale I am on Monjaro and I am generally maintaining muscle. It is effectively impossible to lose significant weight and not also lose some muscle, however, my primary form of exercise for years has been weight lifting and I am simply continuing to do that. Most people who go on any calorie deficit eating plan should monitor protien and add some form of resistance training.

[@peter65zzfdfh]

⁠@@ChantelleHalecertain muscles are simply less necessary if you are lighter. If you’re obese you need good strength or you will have major back issues etc. Being obese is like permanent, enforced weight training. So all else equal, you will lose muscle when you lose a lot of weight because you’re training it less. You can offset this by increasing your weight training.

[@TheAlphaZulu]

More videos with Elizabeth please. She's great.

[@arcan762]

What kind of videos... 🧐

[@CinnastixChick]

People, stop accusing others of "cheating" weight loss by using Ozempic. First, you could be dead wrong, and the person might be losing weight because of chemo, an illness, or something else. Second, they should not feel obligated to explain how or why they lost weight to you. In fact, let me make this real simple: just don't comment on other people's weight.

[@joanna0988]

You're right however it's a valid question when influencers push their diet teas and workouts but actually take a weight loss drug to get their results.

[@covfefe1787]

actaully your weight is everyones buisness because it effects society on a massive scale. it doesnt just effect the obese person or malnourshed person but everyone around them too.

[@VladaldTrumptin]

It is cheating though when you compare it to those who lost weight doing the hard work. Sorry but it is

[@keithnsearle7393]

@CinnastixChick AND, here you are, "commentating" on other people's weight through their own comments. Ohhh, the irony!

[@capablanc]

​@VladaldTrumptin Gatekeeping health is so bizarre. I went from 250lb to my ideal weight of 160 with diet and I don't have a problem with people using Ozempic to do it because why the hell would I? People cry about how unhealthy it is to be fat and that people need to lose weight. Then when people lose weight suddenly it's not about the health, its about not losing weight 'correctly.' People just love putting people down in any way they can. It's just a shift in bullying. 'Oh we can't bully you for being fat anymore but we can invalidate your accomplishment and make you feel worthless some other way.' It's pathetic.

[@marcoescuandolas]

Only in America, is health care and prescription drugs such a rip-off. In most other countries in the world, pharmaceuticals are pretty affordable.

[@David.....]

Because American subsidize the lower cost in the rest of the world. If america had govt regulated pharma pricing... All pharma prices would go up globally. You really think AIDS meds in africa cost only $1? They give the drugs away to poor nations at a loss, because they recoup it in the US @ $1200 per pill.

[@crystalfudalik6977]

I'd like to add that as someone riddled with a slew of chronic illnesses, I became desperate enough to start this about 5-6 months ago. I hoped that if I lost weight I'd get better treatment from doctors, and it would be easier to get further surgery for my dercums disease. The best side effect is my IBS is gone! I had constant daily diarrhea for two years, after five years of having it frequently. Since I'm actually absorbing nutrients and staying hydrated I feel so much better. The downside though has been the terrible cough from acid reflux. Neither of these was covered in the info about the medication when I started, so makes one wider what other benefits or side effects will arrise over time as more people report on it.

[@robinr3666]

Thanks for this... for the last section in particular. So tired of gym bros saying "just burn more calories than you consume" *mic drop* - as if this tautology (fat gain = surplus calorie storage) explains anything. If you are not willing to be miserably hungry with a broken metabolism for the rest of your life it's your fault. That's the mainstream message and it is exhausting.

[@azombieee]

Especially when everything in our environment works against us so heavily.

[@NenaBhinez]

I was put on GLP-1 meds because I had a gastric motility issue, what they call 'rapid gastric dumping' where I digested food too quickly and never felt full.. these drugs definitely helped with that, and I lost a significant amount of weight! But I think what surprised me most about these drugs were how they reduced ALL of my compulsive behaviors, not just overeating.. I don't buy things I don't need anymore, I don't drink more than I should, I don't even bite my nails (a problem I had since I was a child) For a while after I started, I went through a little bit of an identity crisis, because all of my coping behaviors weren't satisfying anymore. I had to reassess what I actually enjoy doing, and I'm still kind of figuring that out.. I still enjoy food, but I enjoy it in smaller portions and it doesn't occupy my every thought like it used to.

[@darcymandryk1785]

I started Ozempic about 6 months ago to lower my blood sugars, as they were about double what they should be. It lowered them to normal within the first month and has remained the same since. I did lose over 30 lbs. as well, but that was not as important as the blood sugars. I still lose at least a lb. a month, but I eat the same as before I started the Ozempic. I am not on any type of diet and eat whatever I want. My sugars are still good and I am slowly losing weight. This is all that I care about. If the only reason you are on it is to lose weight, you will fail. It seems to me the initial weight loss is due to the reduced amount of sugar to you cells. Once your body adjusts to the new level, the weight loss will slow to a crawl. If I did cut out sugar and carbs, the weight would start to drop drastically. I am old and want to enjoy my remaining years by eating anything I want instead of dieting. It took me 15 years to put on the excess weight, so I am expecting it to take that long to lose it. No worries, no stress, no dieting, that is what I am doing to enjoy my life. Lower your expectations and you will succeed.

[@gg-gn3re]

"but I eat the same as before" no you don't, you just feel like you do

[@TehKaiser]

​@@gg-gn3reGuys loses weight but still eats his old junk food diet.

[@roxyred0145]

I lost over 120 lbs on ozempic and mounjaro over a year ago. I’ve been maintaining my weight loss on lower dose

[@flannnl]

Tirz changed my life in 4.5 months. I lost 50 lbs, have never felt healthier, and I have a normal BMI now. I did this while gaining muscle. The other-than-weightloss benefits make me want to take these drugs for the rest of my life anyway. We're all going to be taking them eventually, and once you're on it, you'll realize that this is a great thing.

[@Xe_None]

I take it for weight loss. It is not an “easy way out”, it is a game changer. Feels like a miracle. The side effects hit hard, but I had them only for two weeks (max dose, no ramp-up). Important anecdotal details I have not seen covered: 1. It does not work the same way for different foods. For example, I am physically unable to drink an entire cup (sometimes half) of coffee now, but pizza? I could just keep going. Of course, I don’t because it would make me throw up the next day, but the medicine doesn’t help. Most likely this is different for different people. 2. It helps a lot with self control, but also requires a different form of self control. Sometimes, I have to remind myself to eat when not hungry, because if I go too long, it triggers side effects. Other times, especially the day before a dose, I no longer feel the effects so I have to control myself or suffer the side effects 2 days later.

[@grossartus]

The will power part really helped me, the amput of food i have rejected with no remorse afterwards, also my choices regarding food, since i know i will be full after eating a bit, in choose to est more nutrition densed foods

[@aimson]

The biggest scam to me is telling people that their bodies somehow violate the laws of thermodynamics and that decreasing calorie consumption and increasing calorie expenditure won't change their weight over time. The reason it's so difficult to lose weight is the behavior and psychology, such as cheating on diets (snacking) or eating unhealthy foods because of addiction. It's literally impossible to maintain the same weight by expending more calories than one consumes over a long period of time. That's the exact opposite of how they got obese in the first place over years and decades. That's why bariatric surgery works so well, etc.

[@oasntet]

You're forgetting that humans have little control over their base metabolic rates. It's not as simple as calories in vs calories out, given that calories out is not really under your control. Barring an olympic-style training regimen, exercise is a tiny part of 'calories out'. For a lot of people with weight issues, the first thing their body does when getting fewer calories in is to reduce BMR to compensate. So now in addition to being hungry, they're cold and tired, and still not losing any weight.

[@tinamacintyre2423]

I have taken mounjaro for 3 weeks and going on week 4. I had newly diagnosed type 2 diabetes and im overweight. My sugars are now almost normal and Im down 13 pounds. However, I follow a low cholesterol diabetic diet very strictly and i do walk for exercise. The mounjaro just makes me not crave sweets. I still eat about 1400-1500 calories a day which is what was recommended for healthy weight loss. I think some of the inital weight is water loss bc i am not bloated anymore. It has helped with my asthma and my neuropathy is greatly reduced.

[@k4gsxrks]

16% lost in 5 months. Worked for me and I feel so much better.

[@colemickens]

Wow. I guess I don't know what I expected but this was jam-packed with info and coverage of difference nuances and takes. Really good coverage and content. I didn't expect to learn so much new information. Really spectacular.

[@lisanadile4688]

Ozempic saved my life. I had diabetes and a genetic cholesterol of 300. Both are gone. I’ve been on it for two years. I was 140 pounds and ate low fat, low sugar. I had a heart attack at age 50. Statistically I had an 80% chance of dying after one heart attack. Six years later I am still here and healthy. 130 pounds, cholesterol of 100, and excellent glucose levels. Starting Ozempic was the only change.

[@TheMichaelStarbuck]

The video was a bit deceptive in regards to losing muscle mass. These drugs cause a decrease in muscle mass and bone density. You will notice that the video mentions losing something around 4% of your bodymass on these drugs. Notice that it never says how much actual body fat you lose.

[@stevencooper4422]

Yep. You NEED to exercise when on ozempic to maintain bone density at the very least!

[@BiggieTrismegistus]

​@@stevencooper4422You need to exercise to maintain muscle mass and bone density no matter how you're trying to lose weight.

[@BrokeMyCrayon]

Its not deceptive at all. Losing significant amounts of bodyfat even when done naturally, almost ensures you will lose muscle as well. They "cause" muscle loss because they put people into steep caloric deficits along with the reduction in appetite reducing the likelihood that you eat enough protein to fuel your muscles. Add to this that being on a low calorie diet makes you less energetic and therefore less likely to exercise. The issue is nuanced and you can take steps to minimize muscle loss by logging your food, prioritizing protein, and ensuring you do resistance training

[@stevencooper4422]

@@BiggieTrismegistus Precisely

[@Anothernerdyloser314]

My wife is taking Wegovy. After over a year of rock climbing 3 times a week and healthy eating, she was still 240 pounds. After 3 months of Wegovy with the same amount of exercise and similar foods, just less of them, she has lost 40 pounds. According to our body fat scale, only around 2 pounds of that was muscle. So I think the most important thing that people could be missing while on these drugs is exercise and a high protein diet.

[@rileyallen489]

Honestly thank you for this. The discourse is driving me up a wall. I was diagnosed with PCOS over a decade ago. Type 2 diabetes medications have been part of the standard treatment for PCOS that entire time, yet no one cared until they found out about Ozempic. GLP-1s have been a god-send for me. For the first time since I was 13, I can choose which birth control to be on because I don't have to take one with estrogen anymore. Yeeting the food noise did wonders for my mental health. I developed an ED when I was eleven, which isn't uncommon for women with PCOS. Since starting Zepbound, I've seen a 90% reduction in ED behaviors and urges. Women with PCOS are less likely to find conventional ED treatment effective (I know I did). I'd like to see more research on this side of things because yeah, it's expensive, but it's a lot less expensive that what my insurance paid out for five months of partial hospitalization that made my condition worse.

[@shanghaidiscovery2664]

The real issue that isnt delved in too much is the fact that these drugs are not new. and yet they are sold in the US at incredibly high prices (at least when it comes to list price). Americans need clarity on pricing. I doubt insurance companies are paying over a thousand bucks a month. but those without insurance need to, and these are the people who may tempted to go to shady online pharmacies

[@vegasa2067]

In America you can’t have “freedom” without allowing huge companies to overcharge customers, duh. Freedom isn’t free, it costs 100x as much as it does in Europe bc you gotta please those shareholders!

[@Saraissilly]

I’ve lost 175 pounds (40% body weight) on Zepbound and eating low carb over 2 years. I’ve dieted my whole life and never had these results. These drugs ARE a miracle for many people!

[@supernova743]

The same results can be achieved through diet and exercise. If the drugs are staving off your cravings then as soon as you stop taking the drugs then youre likely to regain the weight unless youve done the work to curb your cravings yourself. So these drugs are only a temporary treatment to what are behavioral issues. They shouldnt be used by people without a specific reason to do so. Weight loss isnt a good reason to use them.

[@merlinious01]

​@@supernova743 At most it is only a temporary fix if you stop taking it

[@tarabooartarmy3654]

I lost over 100 pounds without it, but I was put on it for type 2 diabetes. Losing weight is definitely easier with it. I don’t think about food constantly like I did before. So before I had to have huge willpower to lose. Now it’s just a thing. It’s dropping off without trying.

[@reikoshea]

@@supernova743 This is simply inaccurate for a huge swath of the population. You'll find countless examples in this comment section, myself included among them, of people who've used diet and exercise to lose more than 100lbs, and at no point in that journey do you ever lose the cravings for food, whether nutritious whole foods or processed junk food. I'd cut processed food out of my life years ago, and I STILL gained weight, because I'd sit down to a bowl of curry and rice, and have seconds, and thirds. The most processed thing in that meal was the flour and the white rice. My body/mind found joy in eating. It could be a whole chicken i roasted myself, or a steak, or mashed potatoes made from scratch, all of it brought me joy. When I lost the weight naturally, the cravings for those foods still existed, even white rice, chicken, and broccoli would make me happy to the point where i could consume so much of my "healthy foods" I'd still gain weight. On zepbound, it doesn't just "stop your cravings" it changes how your mind/body regard food. For many people, food releases dopamine. Again, not just junk food. I'd be elated eating plain chicken and rice, to the point where i could consume pounds of both in a sitting. Now, I can take a bite of my favorite foods, curry, steak, sushi, whatever, and feel...nothing. The first few months on these drugs is often frustrating for people because they've spent their whole lives finding happiness at the end of a fork. It's often the most reliable dopamine release people have, and from literally day one (in my case), it vanishes over night. I've become more social with both friends and family as a result, because now that food doesn't make me happy, I HAVE to find that dopamine release somewhere else, and that somewhere else is a much healthier place. I spend more time hanging out with my friends, or spending time with my family, because I have to. I don't have any other sources of dopamine. Food just stops being a source of happiness, and because that's the case, you not only stop eating junk food, you also, often, stop drinking, and you also eat significantly less of even your healthy meals. Now I can sit down to a bowl of curry, eat a single serving, and walk away without a second though. I've been able to FORCE myself to make that choice, but now, my body WANTS to make that choice. That simple difference is liberating, and if it's not a struggle you or someone you love have ever been forced to endure, it's really difficult to find empathy for those going through it. The facts are that, while you're on the drug, you develop a non-destructive relationship with food. You know you need to eat, and you do still, but you don't have a desire to snack, you don't have a desire to overindulge, and you no longer find happiness in food. So yes, you can, and I have, seen similar results with willpower and exercise. The difference is, every day is a mental battle. It NEVER gets easier, and you ALWAYS lose eventually. It may, and in my case, did, take years to take that L, but it does happen, because the entire time, food was always sitting there as an easy out in a stressful situation. It was just election season, a really stressful time for a lot of people, and for me, and at no point, did food EVER seem like it would ease that stress, and that was liberating for me. I expect I'll be on this drug for life, just like I expect to be on anti-depressants for life, and previously expected, and still may, to be on statins for the rest of my life. I'll probably see the same physical results that I've seen many times in the past, where I get down to a healthy weight (I've been as low a 165lbs at 6' tall with 0 drugs), but this time feels different. I don't have to argue with myself about portion control or whether I should go down the chip aisle at the grocery store. I don't have a desire to over eat, and I don't have a desire for snacks, and it's the first time in my 20 years of being an adult that I can say that.

[@Saraissilly]

@@supernova743are you really trying to say that someone who used to weigh 425 pounds shouldn’t use whatever tools necessary to loose weight? You are a fool and clearly have no idea what it is like to struggle to loose weight. My results have been achieved with GLP1 *AND* diet and exercise.

[@suburiboy]

For the “it’s easy; you just need self control” people I always point out that we use self control to do hard things. If it was as easy as reading a book, we wouldn’t need self control. And getting into a better college would have just been self control. But some people who really want to go to UCLA don’t get in when just slightly better grades or SAT scores would have been enough. If we agree that self control is used for hard things and the same goal can be differently difficult for different people, it is a logical consequence that weightloss may take some people MORE self control. How much is too much? At which point they reveal themself to just hate fat people.

[@smokerscough2907]

I lived through the diet pill culture craze. It went from being for diabetes management to helping morbidly obese lose weight to now being used by every influencer and naturally thin star to lose the last 10 pounds they never needed to lose. Every other commercial is for semaglutide whether it's Ozempic/WeGovy or whatever else. This is not sustainable. A local radio DJ who is only in his 40s lost 60 pounds using Ozempic, I listened to him all the time. He just had a heart attack a few weeks ago. I don't know what the situation is but this amount of rapid weight loss is not sustainable over long periods of time and semaglutide hasn't been around long enough to study over a lifetime. We are the guinea pigs for this push.

[@fuzzyapplebong328]

I just lost 20 pounds in 3 months with zero Calorie counting. I just went on a carnivore diet for the first 2 months now I just eat really healthy, meat fruit and vegetables sometimes bread and sugar but my stomach doesn’t like it anymore so it’s not satisfying. I don’t go to the gym at all either haven’t been in 6 years. I just speed walk a mile or two and bought a weight set for 100$ on Amazon. I work out to ease anxiety and most of the time don’t even count my sets. I still haven’t given up sugary sauces on my meat either or fallowed a single workout video all the way through..no way. This is after struggling to loose weight for 6 years. Now that my brain is more linked to exercising for anxiety relief than sugary food, and my body has been feeling the magic of keytones for 3 months now, I feel the effects of fast food to much I don’t opt to feel like shit anymore and waste the money. My stomach is smaller too so eating as much as I used to would make me feel sick not good. Partial fasting helps, or fast for 1 day every month or maybe two also helps get keytones up, and when you eat a nutritious meal after you feel amazing. The key guys, Is patience and getting the message straight in your mind that you don’t actually like crappy food. It’s expensive and makes you feel like shit so why lie to yourself and say you like it? Eat a huge healthy meal instead and take a walk and stretch after. You’ll feel amazing. Stop expecting instant effects aswell with this you’ll start seeing a major difference in the middle of the 2nd month, I lost 20 pounds but 2 sizes and 4 1/2 inches on my waist. I wish you luck guys 3 months isn’t that long and you won’t go back after that.

[@jfaustin1742]

Not far fetched that a company like business insider has its own vested interests and affiliations

[@LabGecko]

Business Insider has done detailed exposées on several industries and companies they have ties to.

[@hieroclesthestoic]

It makes sense that people stop taking it after a year. No insurance covers it and the manufacturer coupon only lasts for a year. It’s not because people don’t WANT to be on it.

[@edsmale]

Where do you get no insurance covers it? Untrue.

[@SickPrid3]

It is easy. I know from my own experience. I was 105kg. Stopped eating fast foods, swapped sugary drinks for water, and started walking for 15min instead of driving for 5min. Went down to 79kg in a year. It's doable when you stop looking g for excuses and start doing things.

[@jreese8284]

I'm happy to hear it worked for you! Chances are, you're a young male. Bodies vary, see the geneticist's note above. My Dad used to say just what you wrote; until he got into his 80s and his body didn't work the same way. He was truly frustrated! You might consider a bit of empathy here, or look out, some fat lady's gonna clock you one!

[@yewo.m]

4:16, 4:41 - What did the real life people do differently from the people in the clinical trials? I think that kinda context is important enough to not leave out

[@CompleteMisc]

Bravo!! This is the best piece of journalism I have seen in years. A truly balanced and fact-based examination of the topic. I am actually speechless because today much of what passes for news and journalism is nothing more than a story shilling for one opinion or another. Just a tremendous piece of work.

[@Vasilia4]

*12:20** You are so right about the punishment. People WANT to believe that those who succesfully lost weight will experience these dreadful side effects because they hate the idea of weightloss being a bit easier*

[@timogul]

It'll be interesting to see the studies comparing the people it didn't work on to the ones it did, and figuring out what's different there. Presumably they have some different causes to their weight, and learning how they differ could help to find solutions for those, and maybe further help others.

[@ReclusiveEagle]

Destruction of physical labor in favor of desk jobs along with the rise of chemical riddled fast food has created the obesity "epidemic". Companies now want to capitalize on a problem they caused by forcing you to pay money to lose weight. Instead of, you know, improving the work place environment. Which they never will, because that would mean a decrease in perceived "productivity" and extracting every ounce of labor from employees is how companies operate. Let's also not get into how these transition from analog to digital has made people lazy to the point where they'd rather rely on drugs than make the effort to change their lifestyles. Because "effort" is too slow and people want instant results even if the results are harmful.

[@simcity0368]

I lost 27kg in two years of Ozempic use paired with a new diet and exercises. I went from obese to slight overweight and I cannot stress enough how my mental health, my self-esteem and my overall health improved. It was under medical prescription and monitoring, and our goal was to use the drug as a tool, not as a clutch. Thus, I’m lowering the dose in order to eventually phase it out and focus solely on exercises, but I cannot deny how transformative Ozempic was, the push it gave me to actually pursue a better life. And in all honesty, looking better is the good side effect for me.

[@TheSwarm666X]

where there is money, there is advancement. i am curious where this all goes.

[@johnpackard1614]

True, so many other groundbreaking meds have come out in the past few years yet Ozempic gets all the attention

[@apocalypse487]

Advancement only happens when there's competition, not money.

[@Hades_Space_Engineer]

Not necessarily. It might just make some rich people even richer which is the first priority. Advancement comes in behind that

[@Bren]

Great non-bias video! 👏🏻 I’m down 15% in 8 months and haven’t plateaued yet. 🤞🏻 I have little digestive side effects but I have some of the weirder ones, like severe dry and bloodshot eyes and increased pulse, but with lower blood pressure. My BP is almost too low now so I can’t take meds to combat the pulse rate. But I know I couldn’t have lost this weight without the meds because I tried and I didn’t. I’ve got all kinds of thyroid and hormonal issues working against me. These meds are a miracle. The only anxiety they give me is the constant worry that my insurance will stop covering them any day.

[@Awesomejustinj]

Why is it when a device is invented that saves lives or makes life more comfortable noone has a problem with the manufacturer making money, but when a drug does the same it's seen as almost criminal?

[@agme8045]

I think it’s mainly because, as you said, these drugs save lives. And the problem is not companies making a profit, the problem is companies being “greedy” and gatekeeping the drugs/treatments in order to make larger profits. Don’t get me wrong, I’m 100% pro-market lol. But I do agree that sometimes, with stuff like this for example (drugs that can substantially improve the health and well being of hundreds of millions of people that have a medical condition like obesity), these companies (more like their owners/shareholders) have the moral obligation to make the drug accessible to as many people as possible. I mean, they have already covered the cost of production and research SEVERAL times over, everyone at novo disk is already rich asf, generational wealth kinda rich. Is it a bit unfair to them? (because they invested a lot of money into the research and development of something that could not work at all and fail) Absolutely, it is unfair! Yet it did work, and they did get richer than they already were, and they can still keep making more money (just not the absurd amounts of money they are currently making) That being said, there’s also many people who are just conspiracy theorists and are convinced “big pharma” is out to get them lol

[@skipfred]

Your brain is cooked, my friend.

[@NiSE_Rafter]

It's not that they make money, it's that the cost is significantly more expensive in the US than it is worldwide since they can get away with it and thus prevents many people who may need it from affording it.

[@robertrouthier2603]

You are presenting it as a binary choice, either the drug companies make "no money" or "all the money". I suspect that they could lower prices substantially and still make significant and worthwhile profits.

[@userJohnSmith]

If people could get it on copay I think people would be singing their praises and thrilled they were getting rich. A lot of people can't, which is baffling.

[@jannor321]

Treating the symptoms of food addiction but not fixing the root problem. It's a big win for processed foods and big pharma.

[@stevencooper4422]

Yep. Mental health is the true cause of obesity. Without addressing the cause, treating the symptoms will just lead to more and more side effects like IBS symptoms

[@ireefree2024]

This!!!

[@natalieiswriting]

My take is let’s help people lose the weight and get healthy now, while also tackling the toxic, processed food industry which will take much longer.

[@kylemills7161]

I've been taking Trulicity, which is similar to Ozempic etc. for over a year now. I haven't lost any weight while taking the medication, but it has been really helpful in managing my Type 1 diabetes. Even though it is technically for Type 2 diabetics, it has helped to keep my blood sugar from spiking drastically after meals, and that has been great because large fluctuations in blood glucose can mess with my cognitive ability and make me feel sick, so it has definitely been worth it even though I haven't lost any weight on it. (edited because I mistakenly wrote Tresiba instead of Trulicity)

[@adoseofcourage]

Tresiba is insulin dear. Totally different mechanism of action than GLP1 agonists. Insulin may in fact cause weight gain. Do you mean trulicity? Anyway, cheers and happy losing!

[@kylemills7161]

Yeah, actually it is Trulicity, my bad. Good catch though

[@gauravmogre]

As someone who have heard about the hype, but was skeptical about it - this video offers a great balanced overview. Thanks for doing the research for the rest of us.

[@Adm906]

I went on to lose weight so I could qualify for a breast reduction (I live in a place that is only now getting rid of BMI requirements). Now I’ve had that surgery, and being able to be as active as I’ve always wanted to be and scaling down my shots because I’ve essentially lost my appetite and I’m not eating enough for my body to stay out of starvation mode.

[@sarahw6054]

This video took a turn…. It really spelled out how these drugs and drug companies take advantage of consumers but its okay to band aid the problem? Some one please explain.

[@BenSullinsOfficial]

Great video! My guess is that since we don't have a financial incentive to fix things like our food system it won't happen. However, making a drug or "band aid" for the obesity due to the food system is profitable so we'll do it. Bottom line, if there's money to be made, we will find a way.

[@annwilliams6438]

I’ve heard one of the big food companies is making ‘Ozempic meals’. Small meals with a combo of macro nutrients and added vitamins etc, at a big price.

[@AgentOffice]

Stop crying people like having an appetite

[@Bigdaddyweldz]

5:16 for me it was harder to lose the weight. It’s been easier to keep it off. I lost 70 pounds on my own over six months. I weigh myself every day and adjust my diet accordingly.

[@johnpienta4200]

My biggest concerns are that it's replacing a hormone which has natural on/off cycles, and it's doing it by basically flooring the gas pedal. Let's hope that signal isn't a growth factor for cancer, or a trigger for some other dire medical issue. And to that second bit, in some people, it slows down the gastric tract in a way that doesn't seem to stop when they stop taking it. That can be good, if the result is therapeutic. It's a disaster if it's too slow, and it seems to cause, what appears to be permanent, gastroparesis. Additionally, the body composition of people losing weight from it appears to be 50/50 fat mass and lean tissue. This is equivalent to the body composition changes associated with starvation. Which means that basically it's just "regular old dieting" and if you stop taking it, and it's effects wear off... You're right back where you started.

[@candihartley]

It is. What happens to a system when you turn up the processors. It over heats. It stops being as efficient. It stops working.

[@MostlyHarmlessNebr-gb6di]

"Let's hope that signal isn't a growth factor for cancer, or a trigger for some other dire medical issue." For some of us in the super-obese category, it's a fair trade. I've dropped over 110 pounds in a year on tirzepatide. Without losing that much weight, I was very likely to die of some weight-related issue and quite young. Neither of my (obese) parents lived to see 65. If I get 20 years of far more active healthy living than I would have without and then some nasty cancer from the drug at 70 and die? Guess what, that's a total WIN, not a disaster.

[@johnpienta4200]

@@MostlyHarmlessNebr-gb6di that's great, and I'm glad it's worked out. And I hope it continues to work out for you in all possible ways! They are incredibly interesting drugs and can be helpful for lots of people, and they are also teaching us a lot about the biology of appetite/craving in ways we did not expect.

[@MrFunnyPenny]

If you are NOT medically obese - meaning, normal thyroid activity, balanced hormones, no biological/genetic reasons, etc... as to how you are obese, why turn to medicine? Why put your body through yet another type of long term medication? What's so hard about overseeing, controlling and becoming more responsible for yourself with diet and SOME frequent exercise? You can think about it as a chore... because if you don't do your own laundry, dish washing, cleaning the floors or whatever, no one else is gonna do it. Same difference

[@squallleonhart470]

I lost 20% in 6-7 months with the drug and I’m not even at the highest doses of the treatment (I’m on 10mg). I didn’t increase my physical activity, diet changed after suffering severe side effects that are now managed well.

[@crashingxhearts]

This drug changed my life! It got rid of my IBS, my anxiety, constant food noise, my A1C went down, systemic inflammation went away. I’m so healthy again. And I lost over 20 lbs of stubborn fat. I was also a super responder and I had 0 negative side effects! No diarrhea, no upset stomach, no headaches, muscle spasms.

[@leegarryallen]

I've lost over 65lb in 10 months without taking this by fasting, cutting carbs and eating clean. However, to get started needed very strong "willpower", and a willingness to suffer. Once my body got adapted to burning fat and got used to fasting it has become effortless. However, not everyone will get through the initial few weeks and months. These drugs 100% have their place. But people need education on metabolic syndrome, insulin resistance, fasting, carbs. If people use GLP1 to help adapt to fasting and a low carb diet then there's no reason why they can't be 100% successful. However, if people don't change their habits and just rely on the drug, the weight will always come back.

[@tristanm8838]

Very annoying to hear this woman say that simple changes wont make you lose weight… losing weight is superrrr simple, eat in a calorie deficit. That doesnt make it easy, its extremely hard to stop yourself from eating, but it is simple. I went from 210 to 165 lbs, just from eating one less meal a day for about 10 months, it was simple as hell, but hard to maintain it. Calories in Calories out will always win in the end.

[@Rudy1150]

I lost 30lbs on a compounded GLP1. For me, the drug helps with addiction. I always had food noise and was thinking of the next meal. That noise has gone away. When I am comfortably full I can "push-away" the plate of food. I also developed sleep apnea which is not cured, but under control. Due to the lack of sleep I drank a lot of caffeine. After 1 week on a GLP1 i drink maybe a 1/2 cup a day now. Others has reported decrease in alcohol consumption. I was never a big drinker.

[@NoctisAquila]

You literally lose all appetite- it is however very expensive anywhere you look and should be much more accessible

[@Persistence_run_444]

Not eating processed food was what helped me. Lost forty pounds in like three months. Also picked up marathon running. So. That helped.

[@AWriterWandering]

Same. There’s two major problems with processed food that contribute to weight gain: the body burns through them too fast, causing you to feel hungry again, and they don’t have a lot of the micro nutrients that you needs in addition the calories, requiring you to consume more to make up for the deficit.

[@KitaIkuyo-k2k]

​@@AWriterWandering Another thing is that many ultra-processed foods contain sugar, a natural addictive drug. Sugar increases insulin and hunger, which causes you to want to eat more, and is a big contributor to obesity. Check the label next time you're at the store, and you'll be surprised by just how much sugar is in almost every food.

[@BoringTroublemaker]

@@Persistence_run_444 I’m sure that avoiding processed food was beneficial, but if you were already at a weight where you could “pick up marathon running” you were no where near the size that you would have any business being on one of these drugs, regardless of how much weight you lost. So, your comparison is moot. Weight loss for a person in an obese/morbidly obese body has already gone through hormonal dysregulation.

[@lokipokey]

​@@BoringTroublemakerThe op did state that he/he lost 40 lb. That's not somebody who didn't need to lose weight

[@BoringTroublemaker]

@ a person who is 20lbs overweight can lose 40lbs. Just because someone lost 40lbs doesn’t mean they HAD to lose 40lbs or were even 40lbs overweight

[@pharmdiddy5120]

Great video! For anyone in the United States that wants to make sure they have a good compounding pharmacist, look for PCAB accreditation. You are absolutely spot on about a lot of this when it comes to emphasizing healthy diet and the temporary benefits that most of these prescriptions confer to the patient. Thanks for putting this out there :)

[@Skysthelimit212]

Ive been on wegovy for 2 months and i lost 20lbs

[@primarysources9002]

The biggest issue I've found is that there is no supply of low doses of Weygovy and that health insurance doesn't cover enough of the med Zepbound. Other drugs aren't approved for weight loss only, and providers will not prescribe other GLP1s. Supply issues and access to the drugs are a bigger issue.

[@mr_fuji_mintsmr_fuji_mints9873]

GLP-1 has beena popular "peptide" in the body building community for quite some time

[@imanalius7691]

Excellent research and reporting. Society needs this. Thank you.

[@valeriephd]

Really disappointing that no one talks about the relation between GLP-1 use and eating disorders

[@Raerae705]

Weight loss isn’t easy. It takes hard work and discipline. But it’s not impossible. Human bodies are also not exempt from the laws of thermodynamics. “Reduce your intake” isn’t some myth or incorrect piece of research. It still very much stands true

[@gabriellegilbert5239]

🗣💁‍♀️HORMONES, Friend.🤗 🐞

[@ray101892]

It's too expensive. I'd rather take Lizzo.

[@Theoryofcatsndogs]

It is significantly cheaper in China and other part of the world, also it is not knock off. It is more like a problem of US health industry.

[@AriAri-fi4ix]

@@Theoryofcatsndogs about 60 dollars in china, france, danmark and germany. here in brazil it's absurd. a monthly cost of wegovy is 2400 reais while a monthly minimum wage is 1400 reais. also no insurance coverage here, every pen is full price out of the pocket.

[@kaylameek68]

😂😂😂 i’m sad the comments under this didn’t understand the reference 👏 😂

[@volbia12]

Thank you for this clear reporting. It's so refreshing to see some clearcut info.

[@rlittleatiiacom]

Thank you for providing a factual video on Ozempic. This is very helpful.

[@bassandtrebleclef]

lol, sucker born every minute. Or a paid poster.

[@ritzrocco494]

Good in depth analysis

[@Josh-d2m]

This vid is weirdly very skeptical of negatives, and extremely permissive of completely anecdotal positives that have zero evidence behind them. It is not well balanced at all, and towards the end it becomes clear this is a sponsored piece. Disappointing this was not said up front.

[@shellie.alamode]

I have to agree. It wants to appear balanced but just sort of brushes off the negatives. For example, it starts off with the, admittedly false, "No" studies for non-diabetic weight loss claim and just says "Well actually there have been studies" and then moves on. Ok, but how long have these studies gone on? Everything that I can find dates only to 2016 (for wegovy studies, with wegovy being approved in 2017). That IS very new. Lots of drugs get approved for a particular use, and then the true impact of side effects only becomes known over 10, over 20, etc years later. We're just coming up on the first 10 n year mark. The non diabetics being given this over the last 7/8 years ARE the test group for the long term effects. Will long term effects on non-diabetics being miniscule or harrowing? I don't know yet. Maybe there's no big worry. But this video just sort of mentioned "yes there have been studies" to discredit the exaggeration of "no studies" but doesn't admit the lack of Long Term study data. Kicking off with that makes me very skeptical of them treating both sides objectively.

[@CathalF1]

Yeah 100% shocking biased presentation of data

[@BiggieTrismegistus]

It would help if people held Ozempic to the same standards they do other drugs. It's obvious that people see obesity as a moral failing and they don't think it's "fair" that people can take a drug to lose weight. That's why there are people flailing around desperately trying to come up with any reason to say these drugs are bad no matter how ridiculous they sound.

[@Josh-d2m]

@@BiggieTrismegistus people rightly disdain medicating lifestyle issues. Obesity is a serious societal issue that we all pay for, it is a moral failing not to take steps to fix the issue quickly. There are few excuses for ballooning to obesity without action.

[@BiggieTrismegistus]

@@Josh-d2m They "rightly" do that? What exactly is it that makes them right? Thanks for proving my point BTW. Drugs like Ozempic can be a huge part of addressing what you yourself admit is a "serious societal issue" but you reject it because you're more interested in being a scold becuase Ozempic is "immoral". What you're saying is completely incoherent.

[@bulldog8934]

Great research and presentation on findings! We need more reporting like this

[@AemondEye]

I started using Suxenda about a year and a half ago and barely saw any results and the fact that it required a daily injection was just too much for me especially with the severe GI side effects constant nausea and about 1-2 vomits daily with no real benefit then I switched to Ozempic which was very similar in results but at least it was a once a week injection so it wasn’t as bad but the real game changer for me was Monjaro (Tirzepatide) it had much less side effects and a much more pronounced weight loss. So the moral of the story I guess is that for those who don’t see results with a certain drug maybe consider trying a different one

[@wmllr3790]

I was put on Ozempic for type 2 diabetes. At first I had stomach problems like I was going to throw up. I tried several OTC pills but nothing worked. So I looked at natural herbs and ended up getting liquid ginger. I added it to my coffee and/or tea and it worked, no more upset stomach. They say after a while the stomach problems go away. Recently I lowered my ginger intake and still no stomach problems. Peppermint tinctures also work.

[@djayjp]

5:47 The rapid weight gain upon cessation strongly implies a withdrawal/tolerance effect. I wonder if there have been any studies checking this effect or if the body's own satiety hormones are permanently affected.

[@alitasdepollo2752]

Yesterday I went to see Wicked in theatres and in the 15 minutes of trailers probably about every 3rd ad was “Ozempic, all I had to do was ask.” Which kind of just goes hand in hand with the experience she recounted with the telehealth doctor to see how easy it was to access it and being provided with zero warnings, side effects or instructions. For reference: in Canada, at landmark cinemas

[@jacobfaso5517]

Business insider GOT PAID

[@kutie216]

yep lol

[@eh2657]

@@kutie216you have a theory and you apply it whenever you see mention of drugs. Simple world view. It’s possible it helps many, many people AND pharma companies are not good actors. Hard to keep two things in brain at once? .

[@Droopysmine]

I wasn't on Ozempic or Rybelsus for long, but both caused me to have suicidal thoughts. Although I have depression, the level and speed of the thoughts was terrifying and unlike anything I had experienced before, medicated and unmedicated. I had no knowledge before taking the ozempic that this was a possible side effect and when I reported it to my doctor she was unaware of it being a known issue in 2023. Obviously I stopped taking it with my doctor's knowledge and we ultimately we found a different medication with more tolerable side effects. Meanwhile, my mom has been taking it for about the same amount of time, fewer side effects and has lost a lot of weight (about 20% of her total starting weight). 🤷‍♀

[@JohnHenryCornett-tx7mw]

Who's paying for this report? It could never be Zepbound parent company

[@sydneybriannataaffe1026]

My issue is that the us gov fronts a lot of money to pay for this

[@AEVMU]

Because it works and they don't want to have to pay medicate costs for an obese ageing population when there is a medicine that helps reduce their over all costs. The US is partially socialized medicine, and the gov wants to use drugs that save them money in the long run. Even though what we really need is better quality food becuase food in the US is shit.

[@sydneybriannataaffe1026]

@ I don’t think I can add links here. But there’s a video on KZbin about how ozempic is very very expensive for a medicine being used as a preventative.

[@sydneybriannataaffe1026]

@ you’re right though about it being a way bigger issue than just some People wanting to take a drug to be skinny

[@megabigblur]

This is a great video that discusses the pros and cons of GLP-1 agonists without scaremongering.

[@joshuaraco]

The FDA also said that opioids are "not likely to become addictive"... I lost 40kg in six months literally from eating less and lifting weights. You couldn't pay me to use Ozempic

[@smokerscough2907]

My first though when this drug got popular was the opioid crisis and Phentermine. Just because you can doesn't mean you should and that's the case here. There's commercials that play in the States day and night singing songs about the brand versions of this drug. People with no business using it are getting it compounded by holistic quacks and doctor feel-goods. The core cause of the crisis is never addressed, just given more drugs to get people dependent on it and spending thousands to maintain their so-called healthy new lifestyle that can never be maintained when they're off injections.

[@brianjackson5732]

I've gone from 233 pounds to 188 pounds and from A1C of 9 down to 5. All of my markers have improved and I am no longer taking any other meds, including insulin. I also began working out with weights a year ago and look better now than I did in my 20s.