Caffeine and Adenosine Receptors

[@Medicurio]

Hello everyone! Apologies for not posting sooner, I have been swamped with schoolwork for the past few weeks. I can't believe that I got my 1000th subscriber a few days ago! You guys are absolutely amazing and I truly appreciate your supportive comments in my videos. Thank you all so much! I also have a Twitter account now, so feel free to follow me! twitter.com/medicurio

[@ABuriedSynth]

You should do video about LSD, THC and Amphetamine variant ( Medicine prescribe for ADHD )

[@hammoodraad2011]

You are amazing i am studying from you alot of information . Thank you ❤

[@HDDidyne]

Very good organized presentation 👏👏👏

[@annoloki]

"Somehow, caffeine can enhance their painkilling properties" - this will be down to adenosine receptors on the smooth muscles of blood vessels, causing them to constrict (which is what leads to the increase in blood pressure and faster heartbeat rate). One common cause of headache/migraine is caffeine withdrawal, which results in excessive vaso-dilation especially in the brain... this expansion of blood vessels can be very painful, so this pain can be mediated by taking some caffeine (giving people the "slow weening" process) and also anti-inflammatories like ibuprofen which also has a vaso-constrictor effect that counters the caffeine withdrawal through a different pathway (prostacyclin receptors) thus is usually a better option as it doesn't extend the withdrawal process, but may not be sufficient on its own for consumers of large amounts of caffeine.

[@niranjan4231]

so much subs by now.

[@taylorheninger5631]

This was so clear and so visually understandable that it's now got me studying how different chemicals affect the body and brain thank you for your amazing work.

[@bws7532]

I really enjoyed this video. Well-described and explained. Your voice-overs are also very good! Easy to listen to and understand! Keep up the good work!

[@riftis2210]

3:25 "...So you wake up feeling refreshed." No, no I do not.

[@tonyfriendly4409]

• Riftis • me neither

[@MikeSmith-vb8ul]

So?? This is simply related to your adenosine removal rate *during your sleep* . And caffeine actually *increases* this rate too (by keeping adenosine less often bound to receptors and thus more open to removal), which is why some people also consume caffeine before taking a power nap as well.

[@lahtine7431]

I've never actually woke up refreshed. Not once on my lifetime.

[@feelsokayman3959]

lmao same i feel like the adenosine just gets more

[@feelsokayman3959]

@@lahtine7431 i dont wanna call you a liar but i have a hard time believing that. i mean as a baby/toddler/kid that is very hard to believe.....i think youre exaggerating. but i know how annoying exhaustion is, same for me here since a few months.

[@TheKeithkwan]

extremely informative, this saved me hours of time on Google scholar, thank you for your contribution!

[@tyranmcgrathmnkklkl]

Thank you. This deserves to be in a school curriculum. I love biochemistry with a focus on drugs.

[@thedarkerarchery3553]

I love biochemistry with focus on drugs, too...

[@marcc.e.wagner8789]

Xanthine family of molecules such as caffeine cause vasoconstriction which is one way it may help with migraines. Purinergic signaling is a very fascinating field and Alan North and Geoff Burnstock have many videos talking about this topic. The P1 receptors family which comprises A₁, A2A, A2B and A₃ are also expressed on cells of the immune system. It is well worth exploring further. Thank you for a good representation of what occurs in the caffeine inhibition of adenosine pathway.

[@juliepinc9172]

I quit coffee and caffeine myself so i know how hard it can be. I actually have a couple videos on my channel about how ingot through it all and why I decided to step away from it for good! Great video! Thank you!

[@MUCKFOOT399]

you suck

[@MEGATestberichte]

After seeing this ... this confirms my aim to quit it completely once and for all. Always losing control ...dosage higher and higher.

[@joshuac.6437]

😂

[@esotericsean]

So caffeine affects me pretty badly. I can have a tiny bit, like a sip of coffee or a cup of green tea, but if I were to drink a whole cup of coffee I would be jittery to the point where my hands would be shaking, heart racing, and I would feel awful. Is that because I have a low tolerance? Maybe I have very few adenosine receptors? I also have anxiety issues and often have trouble falling asleep. Would having fewer adenosine receptors make it more difficult to fall asleep? It almost seems to make sense that if I were to try and slowly increase my caffeine intake (and thus increase the amount of adenosine receptors I have), I would feel better? Just a thought.

[@Medicurio]

Lower adenosine receptors, slower breakdown of caffeine, or slight differences in your adenosine receptor structures that cause caffeine to bind even better than adenosine are all possible reasons why you may be super sensitive to caffeine. These are simply due to your genetics. I've also read that people who have anxiety issues are usually more sensitive to caffeine, the idea being that the stimulatory effects of caffeine just exacerbate the anxiety. Because of this, generally it is not advisable for people with anxiety issues to take caffeine. In theory, less adenosine receptors could be a reason why you have trouble sleeping, and your idea could possibly work. However, sleep is very complex and does not just involve adenosine receptors, but many other hormones and neurotransmitters as well that may also be affected by caffeine in unknown ways. You should talk to a doctor if this is worrying you, as well as stopping caffeine intake since it may worsen your anxiety issues.

[@iceeyhound3866]

Yep some genetics cause you be sensitive and others can cause you to be more tolerable. A caffeine sensitive person could take 10 mg and feel like it’s was 100 while a caffeine tolerable could take 200mg and only feel like 50.

[@osamaaslam1453]

@@iceeyhound3866 true

[@bishwastiwari4818]

You stole my words🤣🤣

[@zwhitchcox]

If caffeine disappears in 2 - 4 hours, why can I not fall asleep that night, like 8 hours after I've drunk coffee

[@Medicurio]

Caffeine's duration is quite variable between people, so you might just break down caffeine slower than other people simply due to your genetics. I do have to clarify that not all the caffeine disappears within a few hours, only that enough caffeine is eliminated to no longer have a significant stimulatory effect in most people, but if you are genetically more sensitive to caffeine, that residual caffeine may still have an effect and increase the duration of caffeine's effect.

[@sergsfault]

for me one cup of coffee equals 12 hours...or more...i thinkt he ceffeine has long left the brain byt his time but the chaos it caused is still there

[@remybuitenhuis2433]

the 2-4 hours is BS, actually the cafeine just starts working after 2 hours. Cafeine has a halftime of 6 hours.

[@luigi6485]

*drank

[@shahafsagi7257]

it can take up to 2 months for caffeine to get out of your system.

[@BasicallySteve23]

Glad to see you posting again! And just to add my own personal anecdote, I'm pretty sensitive to caffeine. If I ingest it from sources without L-theanine to counter its effect (like soda or coffee) I get really jittery and hyper. It also makes it harder to sleep even if I had it earlier in the morning. Tea and a little dark chocolate are usually fine though. Anyway, keep up the good work!

[@liseraphina2421]

Try a chewable GABA supplement. Stops the jitters.

[@Brookec2410]

Holy. Cow. This is so cool! This was presented in such an easy to understand way and I am mind boggled by how the body operates and adapts. Thank you for this new, extremely clarifying knowledge!

[@RadiationLemon]

Came from Tier Zoo and enjoying it :D

[@RadiationLemon]

Further down the video and I noticed that having music in the back would help during your pauses

[@MegaAppleshit]

Came from. Tier Zoo as well.

[@dhindaravrel8712]

Music will make the voice harder to understand, and if it's simple enough to not be engaging in its own right, it'll soon be repetitive and annoying. Some things are better without music.

[@rahulsawant_pikachu]

Mee too :'D

[@shanelawrence7438]

Me too!

[@temblekec]

BRUUUH WHY DOES THIS VIDEO ONLY HAS 165k views? This info is amazing!! Wow! Im subscribing now! Thanks for all this info man!

[@professorprotonfan7287]

Very informative. Thanks for uploading. A note though, acetaminophen (paracetamol) is not an anti-inflammatory.

[@runetoons2267]

I love how you're finally getting consistent views. You deserve it!

[@bennguyen1313]

Regarding how caffeine is a diuretic (6m)... if you drink 8oz of coffee, will you urinate more or less than 8oz of water? i.e. can you become de-hydrated by drinking coffee? Also, any thoughts on the coffee nap? Supposedly, waking up before the caffeine has had a chance to block the adenosine receptors pushes out the time when you would normally start feeling tired again... as sleep pressure increases during the day, the circadian rhythm is balanced by the brain protein hypocretin/orexin, which drives wakefulness... so bathing tnf-alpha / interleukin nuerons induce sleep!

[@ElDespertar]

This video has been of a tremendous help for me. Very well explained and illustrated, which makes it easy to understand. Thank you very much for sharing it with us!

[@chinmayeechavan5724]

I'm just an undergraduate student, and I just clicked this video, even though I don't have this topic in my syllabus, I clearly understood each and every point you said. The explanations are very clear.

[@Elina00000]

Wow, this was explained in such a simple and understandable way! Thank you!

[@GlatHjerne]

This was a great video! I don't usually subscribe after one video but I've been convinced easily here. I'm sad to see that you have so few videos on your channel, but if they're all as high quality as this one I'll eagerly watch them. BTW, you're one of the top searchers if someone searches for this topic.

[@adiposerex5150]

A cup of coffee will not fix a lifetime of bad food choices. Chronic diseases are lifestyle caused. Love the video - very informative.

[@yourfuturedocburenbeiya]

I'm watching this video at 3:06AM because I might've had a lot of coffee trying to study for exams...I'm always tired though unless I tell myself I need to study :( This was a very informative video; thank you! :)

[@rzeeman]

most underrated channel on youtube! thanks brother.

[@anarky4321]

i went from 2g caffeine / day to quitting caffeine and trust me that first week all you want to do is sleep

[@MistakenMystery]

2000 mgs a day? Jesus

[@nickisson372]

yep.

[@Ana-mp6my]

that must have been so painful omg

[@dianahincu7809]

I cant sleep

[@Doodle-cp6wt]

I appreciate your Informative lecture! Side note: I would recommend editing "7:40", as acetaminophen is not an NSAID (Non-Steriodal Anti-Inflammtory Drug).

[@paulina4925]

such a good vid! Decidedto quit my coffee consumption even tho I " only" have one cup a day.

[@violetcrystal333]

I am doing a report about caffeine, I found this to be very helpful! Thanks!!

[@devonaanderson9105]

I loved this video! I'm an MD studying for a addiction boards and it was a great way to break up the reading and boring lectures!

[@Godresh07]

Most underrated channel ever.

[@garyzhang876]

I love coffee. It is nice to know how it works and how it affects my brain. Thank u.

[@shaylpokle830]

This is the best informational video I have seen on yt

[@TheJProducti0ns]

Thank you!! My Neuroscience Professor breezed passed this slide and I didn't understand it at all. The diagrams helped!

[@pinarellolimoncello]

Thank you very much, I have been trying to get to the bottom of my sleep problem for years, soon as I unwind I fall asleep, it is frustrating to loose so much time so regularly

[@ABuriedSynth]

This is TOP TIER channel and content. Insane Detail and easy to follow !

[@likemboney8649]

It might've already been mentioned but acetaminophen (Tylenol) is not an NSAID, but an analgesic...easily confused! But you were right about aspirin, it is classified as anti-inflammatory!

[@CollinRaves]

Came here to say the same thing lol, great video tho

[@RSeamus]

This was a very well written video, but how come no mention of how Caffeine effects dopamine? If I remember correctly some Adenosine receptors are coupled with dopamine receptors and when caffeine attaches to it it makes it more prone to be activated by dopamine which is responsible for the alertness/rewarding effect of coffee other than preventing sleepiness.

[@AtlasReburdened]

Ok, so follow up question. What are the side effects of chronic high adenosine level in the brain due to habitual coffee drinking? Is the average nights sleep sufficient to prevent any ill effects from masking the brains signals to take a nap so it can clean up house?

[@dcab5302]

I got sleep epilepsy because I got addicted to energy drinks in the night. I've started to get better after a whilst - what's the best way of getting the adenosine mechanism back up a gear after being addicted to coffee for so long and possibly still having bits built up etc

[@axelchalon1798]

Thanks a lot for this very helpful video! However there's something I don't understand: if caffeine simply prevents more adenosin from binding, shouldn't it be that it makes us feel "not any more tired than we currently are", rather than "less tired than we currently are"?

[@ryanwiggs594]

Can anyone link some info regarding the affects of "overworking" the brain? Is this the same as prolonged increased levels of cortisol? How is this related to burnout?

[@insanerampageify]

History, science and great visuals. Keep it up!

[@loganqueenan4937]

So does eating food and increasing ATP in the body technically make more adenosine and tiredness

[@howardlam6181]

Wait, the adenosine don't decompose without binding to the receptors?

[@apolloniuspergus9295]

How didn't I know this amazing channel before?! Your videos are REALLY good!

[@kiranmaddu8006]

A Brilliant video on Caffeine and Adenosine - essential to learn about adenosine receptors and SA node if you are a patient with palpitations and arrhythmias (I am one). Increases heart rate, activates your sympathetic nervous system and creates more ectopic beats. Also, understand the metabolism of Coffee - some among us are fast metabolizers, and others may be very slow metabolizers - the effects of caffeine last very long if you are a slow metabolizer (mainly depends on Liver p-cytochrome 450 and genetic factors). If you are patient with palpitations and also a slow metabolizer of caffeine, stay away from caffeine - Period. I am a physician, a patient of SVT, and a slow metabolizer of Caffeine, so this comment comes with personal experience.

[@DaveThomson]

What's SVT

[@niteshsemwal8833]

How's caffeine related to anxiety, is it anxiolytic or anxiogenic ?

[@ktharamseye2197]

Excellent job. This will be helpful for my patients.

[@dinonichas]

So both of them bind. Both coffee and adenosine. Why does one binding makes us sleep and the other not? i.e. what else happens once adenosine binds, as opposed to when coffee binds?

[@A_Box]

So it only takes one week to recover????? I was stalling my productivity to prevent being non-alert in the future. Screw it, I am going take all the caffeine I can buy until I get my degree.

[@peacecosmonaut176]

It actually takes 2-3 months to fully recover. First week is worst

[@peacecosmonaut176]

I have only been drinking tea for 3 weeks now. It has caffeine but a lot less. Not I am at a point where I don't drink caffeine except from tea, and I don't feel withdrawal on a day without. You can try that.

[@jeremysamuels2858]

Thanks for posting this! Can you comment on why some people experience a greater diuretic effect than others?

[@Medicurio]

A few factors likely play a role. Someone who takes caffeine daily (e.g. drinks coffee every day) will likely experience less of a diuretic effect than someone who rarely takes caffeine simply because of caffeine tolerance (the body is no longer sensitive to caffeine). Another possible reason is due to your genetics. Some people may naturally have more adenosine receptors or slightly different adenosine receptors that affect the sensitivity of the body to caffeine and its diuretic effects, or they may break down caffeine at different rates which changes the amount of time caffeine affects your body and kidneys. Also, it's important to remember that most of the time we are taking caffeine as a dissolved form (tea, coffee, etc.), so the amount of water in those drinks also should be considered. An espresso shot and a cup of coffee both have roughly the same amount of caffeine, but you would probably experience a greater diuretic effect after drinking that cup of coffee because there was just more water in that drink.

[@slimshady8551]

@@Medicurio can you tell me can coffee upregulate gaba receptors after downregulation by drugs? Please reply I'm currently drinking a lot of coffee to upregulate gaba receptors

[@oliviercaron28]

Loved this video. Incredibly well made and explained. Thanks

[@slavabondar4686]

That’s a very very good explanation how caffeine effects our neurons. Thank you so much for such a detailed information. Great work! 3:53 Amazing!

[@maxideep667]

hi can we get some sources if its not too late?

[@berkeaksoy9808]

Does caffeine removes adenosine from receptors that already binded with adenosine? I cant find the answer pls help

[@abbyrose7004]

What changes the number of adenosine receptors and what is the impact?

[@Medicurio]

Chronic caffeine use can cause upregulation of adenosine receptors in the brains of animal models. This is hypothesized to be the cause of caffeine tolerance. Siegel S, Sokolowska M, Kim JA. Caffeine and coffee tolerance. Circulation. 2003;108(6):e38‐e40. Shi D, Nikodijević O, Jacobson KA, Daly JW. Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain. Cell Mol Neurobiol. 1993;13(3):247‐261.

[@fundeadwarrior]

Wow, i'm drinking a cup of joe right now and this (and the effects of caffeine) are blowing my mind!

[@DigsDugd]

Your videos are great! learning about how the body works is plugging into all kinds of thoughts. Thank you!

[@brontee]

Supplemented what was explained in my lecture perfectly!

[@korbikube7958]

Does anybody know, whether caffeine is nonspecific or specific when binding on to the adenosine receptors?

[@paml.6101]

Coffee makes me extremely tired after just one cup and lasts all day. My brain is so tired and I'm not sleeping well to move out the adenosine. Time to give it up for good.

[@ryanfrizzell736]

Thanks. Now I know more about caffeine. And because I know more about caffeine I can enjoy caffeine more responsibly.

[@derkugelschreiber1051]

On the note of caffeine and migraine relief. If I recall, caffeine dilates blood vessels somewhat, which would allow for more painkilling chemicals to pass through the blood. Something I noticed as a type one diabetic is that caffeine lowers my blood sugar levels. I would imagine this is because more blood flow means that the sugar processes quicker than normal and there is still leftover insulin in the blood stream, despite most of the sugar having been broken down. I feel like that's a plausible explanation, but my chemistry is a bit rusty (didn't have to go past chem 2 to get a physics degree).

[@Medicurio]

That is a good explanation!

[@anonymous.youtuber]

In fact , migraine is accompanied by a vasodilation of blood vessels in the cranium and hence can be somewhat alleviated by the vasoconstriction caused by caffeine. Caffeine has different effects on blood vessels depending on circumstances though. In rest, it acts as a mild vasodilator, but during exercise it causes vasoconstriction and increased blood pressure. This had been studied in the SHADE-ONE study. More research is needed. But also, let’s not forget that coffee is a very complex mixture of many substances that can influence our health in different ways. Acrylamide , for instance, is a known carcinogen.

[@Phriedah]

Dude you're about to get swamped with subs from tier zoo

[@SrmthfgRockLee]

;o

[@Fjuron]

Can caffeine kick out and take the place of adenosine in a receptor? In other words: can coffee make you more awake again once you are already tired? (Or will it then just prevent you from getting more tired)

[@Medicurio]

Yes, caffeine is a competitive antagonist, so at sufficient concentrations it can outcompete adenosine for adenosine receptors.

[@공하나-s4y]

in 0:50 the first picture you used is a picture from Japan, not China. Yes, Japan also have been drink tea for a long time but their cultures are totally different. Not all asian are in the same culture region.

[@WhiteDragon103]

How do you prevent the presence of caffeine from triggering the creation of compensatory adenosine receptors in the first place? What is the mechanism that informs the cell that the adenosine receptors aren't "working" and to make more of them, and how do I make that mechanism **** off? (lol)

[@edoc431]

I under stand that caffeine takes the place of adenosine adenosine binds to a1 receptor that keeps brain awake, making it less active adendosine bind to a2 receptor, making you sleepy caffeine binds to the same receptors, but cannot activate them caffeine can only prevent adenosine from binding so how does caffeine make you feel more awake?

[@ClavisRa]

Caffeine makes me sleepy in the same time frame of consumption to effect and dissipation of effect as caffeine makes most people stimulated. I've seen this reported by many people, yet all of the 'explanations' for why caffeine makes people sleepy completely miss the mark and do not match these symptoms. Caffeine makes me sleepy in exactly the same way it makes others stimulated, and I do not see any explanation for this anywhere. One theory that would fit is that perhaps in some people like myself the adenosine receptors are actually fully triggered by the attached caffeine so the effect is the same as if we were flooded with adenosine, making us sleepy. Is this possible?

[@grantshepherd94]

I quit caffeine cold Turkey recently after regular use of 600-800mg a day and holy crap my withdrawal symptoms are insane especially the headaches, but I’m gunna keep at it

[@MUCKFOOT399]

that's not that much, I drink over 2,000mg every day.

[@ministyler100]

hey, i was wondering if i could use some of the graphics for my presentation :) will link the source ofc

[@Medicurio]

Yes of course! The more people who learn, the better.

[@lenarmr4789]

Hi, i have a question about the Video, even though it was Released a year ago 😊🤷🏼‍♀️ How do coffein and adenosin get dissolved and if coffein is similar to adenosin, How come it doesn‘t make you feel sleepy as adenosin is there to make you feel awake but also sleepy?

[@Medicurio]

Caffeine and Adenosine bind to the same receptor (adenosine receptor) but due to their structural differences, Adenosine activates the receptor (causing sleepiness) while caffeine does not activate the receptor when it binds. Instead, it prevents adenosine from binding to and activating the receptor, allowing you to stay awake. Caffeine is what is considered a "receptor antagonist".

[@johndoh1000]

Thank you for the clear explanation of how caffeine works

[@scarletletter4900]

This explains why I sometimes need an afternoon nap, even after my morning coffee ☕

[@kellyarmstrong6950]

In the video you say "A1 receptor and A2A receptor" but in the photo it says A2 adenosine receptor as the first one.....and A2A as the second one. NVM I just can't read that well (upon closer inspection it is A1 but really looks like A2)

[@Medicurio]

Yea sorry about the font, I'll take that into consideration in the future. Thanks for letting me know!

[@neonseacow]

These videos are great! Quality explanations followed by helpful visuals. Could you work on the audio?

[@bossboy1377]

Why do i feel sleep after having coffee. Like 2 years i used to drink coffee during exam season i would feel even sleepier within an hour if drinking that cup of coffee. I would get adequate sleep at night, roughly 7 hours and a half

[@noel1637]

See also the "Caffeine Blues" book.

[@abcek6006]

thanka a lot for this video! you explain it a lot better than my book!

[@FerbyArisaka]

I can't start my day without caffeine, morning coffee is a must ☕️😌

[@lydelgabucan447]

They said that caffeine can only do a temporary insomnia but why my insomnia lasts up to 6 months now?? Can someone answer me please so I will know something to cure mine.

[@monoamin_]

Awesome Channel! This is exactly the kind of content I always wanted.

[@firstnamelastname-bx9md]

When I drink caffeine all the aches and pains I have (eg i bad neck) get a lot worse so i have to weigh up the benefits of being more away and those effects, it may be the extra stress on the body but it's definitely a lot worse with cheap energy drinks vs coffee, also any thoughts of the caffeine causing the calcification of the penal gland the brain? nice vid cheers

[@Medicurio]

If ingesting caffeine is worsening your pain, I would recommend you to go see a doctor and perhaps stop taking caffeine in the meantime. If you are taking caffeine to stay awake, perhaps modify your sleep schedule instead of trying to stay up later at night. Of course, don't stop immediately but rather slowly wean yourself off to avoid withdrawal symptoms. Calcification of the pineal gland occurs naturally as we age. Whether caffeine speeds up or slows down that process is unknown since not a lot of research has been done on it. Most of the websites that say caffeine causes calcification have no references or links to research papers that prove what they are saying is correct, so I would not trust them blindly. However, since melatonin is released from the pineal gland and is associated with sleep cycles, I wouldn't be surprised if caffeine has some sort of effect on the pineal gland since caffeine disrupts the sleep cycle. Whether that effect has any clinical significance is unknown.

[@MrAdrianxian]

Hey thank for sharing , i was wondering if i add in the mandarin subtitle in your video and sharing to our page , we will link the source of course ,btw we are the fitness workshop that from taiwan

[@Medicurio]

Can you reply with the link to your website or page?

[@Games-tx1zc]

These are great! Your videos are digestible and interesting, thanks for making them! I was wondering, what are the odds of you making a video on liver disease?

[@raisedheart]

This was very well put. Nice animations with great facts!

[@Res_me_plz]

I was drinking soda a lot. I had a panic attack recently and the next day I went cold turkey on it and now I still feel anxious and can't sleep despite being sleepy. Any advice?

[@supernice_auto]

don't drink caffeine you'll be fine after a few months

[@meidamx]

Would high amounts of caffeine effect someone in a tachycardic episode, should they need adenosine?

[@Matts130]

good video mate! idk If you are still making these videos, but if you do, can you make one about fat breakdown and weight loss?

[@tundeknops]

thanks for your advice, but strange enough after i drunk coffee i fell asleep. how strange it sounds, i dont know why.🤔

[@rollieray7175]

would if u gotta work nightshifts and gotta stay awake. whats the key there

[@S90211]

omg I really like this video! I've never found such informative and beneficial thing Thx for making this one

[@AtlasReburdened]

My coffee is already a medical substance to me. I mean, it's nice to get that kick in the morning, and I make it taste good, but its purpose is to deliver a naturally medicated steam extract. I use half decent espresso grind and add all the following in bulk so it's easy to just put a few spoons of the pre mixed stuff in the thing in the morning. Turmeric root powder(for the anti-inflammatory properties of curcumin) Galangal root powder(because modern research suggests extracts of it to be effective cancer fighting and regulating compounds). Fresh ground pepper(because curcumin and pepperine boost each others absorption and effect, and I assume that it probably helps do the same with galangal root as it's in the same family as turmeric). A little cinnamon(flavor and metabolic boost) Even less nutmeg(for flavor, but it's probs good for something) I could probably be better about measuring everything out to get stoichiometric uptake ratios of this and that, but I haven't yet. The ones to not add too much of are cinnamon and nutmeg, everything else is just eyeballed for now. Not insignificant but not nearly a major fraction. I use a cheap, unregulated espresso machine with a steam wand btw, and you can get them at thrift stores for pretty cheap. I melt a small spoonful of coconut oil in a cup with the wand, take the first 20 seconds of the drip into that and swap the coffee pot in. I *_carefully_* (because it's super easy to just blast it all out of the cup at this point and it is... So frustrating.) steam mix the coconut oil and medicated espresso together and this is done for a couple of reasons. 1) The curcumin, pepperine and likely the beneficial compounds in galangal root and all _very_ fat soluble so the oil takes them up well, and.. 2) Coconut oil has a high amount of MCTs, which are a preferred energy source for the body and brain, especially after a fast such as what sleeping causes. I'd love to use pure MTC oil, but this is all surprisingly low budget out of necessity. The combination of these factors mean that my body is going to preferentially uptake these fats which are laden with the beneficial compounds I want and distribute them well throughout the body. Then I dilute the mixture with whatever amount of milk I want(because yum) and get it back up to a palatable temp with the steam wand. The result is a distinctly nuttier, mildly earthy, deeply flavored brew with a great mouth feel, 0 bitterness, and a list of heath benefits that haven't been assessed by the FDA (Federal Death and Addiction organization to me). The rest that was brewed off (which contains all the bitter compounds) gets tossed in the fridge and I split that into a bit more milk over the next few mornings so I wind up getting the really good cup 1-2 a week. I personally perceive a reduction in inflammation, less joint pain, and improvements in mood, but it could all be in my head and everyone's body is different anyway so take my experience as anecdote. I do recommend trying a cup though, if not just for the flavor.

[@bigfood2001]

can you make a video about amphetamine?

[@KieranThompsonMusic]

Great video! Cramming for my presentation in a few hours and this really helped!!

[@plebulus]

You should try animating the cell nucleus moving around to simulate eye movements

[@toriasanchez4167]

This was awesome, and extremely helpful !

[@bitflux2]

Ive just had the gnarliest caffeine crash of my life, 3 straight days of sleeping and complete exhaustion fatigue, quitting for sure

[@ajsworld77]

Incredible work, thank you so very much!