Caliper Labchip DNA fractionation system

[@jarrettdoesstuff2318]

Two Mike videos in a week????? It's a christmas miracle

[@msylvain59]

or teardown Stakhanovism.

[@Nexfero]

20:20 "Things are always better with LASERS on them. The only thing better than a laser is, four lasers." -Mike

[@DonkeyLearningIT]

Yeah, even sharks are better with *frikin LASER beams attached to their heads*

[@Anvilshock]

Why not to their teeth? LASER TEETH!!!

[@joshmyer9]

At 13:05 or so, the autogenerated captions seem to think this is a different sort of apparatus: “…considering how little it is really doing, it’s basically just applying high voltages and turning ladies on, the making measurements out TSP…”

[@DonkeyLearningIT]

I though he said "turning LEDs on". The other meaning with ladies is really funny ;)

[@MarkTillotson]

Amazes me how such an expensive high end piece of kit was designed to look like a cool-box! Thanks for another interesting piece of kit.

[@ndyag100]

DNA sequencing kit gets obsolete incredibly fast. You can now get your personal genome sequenced for £600 IN 50 days. Original human genome project cost $3 BIILION and took 13 years

[@dannooo548]

Why would software for a many-thousand-dollar machine need a dongle? Shouldn't the device itself be enough of a verification?

[@paulpillau5858]

They might be worried about the chinese copying the hardware and make it compatible with their original software

[@DonkeyLearningIT]

You would be *surprised* how expensive those softwares are next to the hardware. Even for an average optical microscope which barely does some post-processing with the images taken from biological samples will cost a fortune, and the hardware will not work without them. In fact, most of the time the price of the software is not even on the webpage, you will have to ask them for a quote, since they do not want to scare poeple. Manufacturers can get away with it, since it is a super niche market.

[@brainndamage]

Something weird happened with the audio at 1:28

[@mikeselectricstuff]

I had some mic issues & had to re-record and bodge some parts

[@mikeselectricstuff]

Vegas is also terrible for inserting & patching stuff

[@Darieee]

mikeselectricstuff maybe not worth it if it’s the only thing you’d be in for, but final cut pro is very well polished and friendly

[@imeakdo7]

Darieee and needs a $2000+ mac to run

[@Uli_K83]

I think Mike might have selected the wrong audio sample for this part. At 1:28 is the sample of 6:44 repeated :)

[@tHaH4x0r]

Ohhh it sure is christmas with two videos from Mike in just a few days.

[@o0julek0o]

You should call this series; "Formerly expensive lab equipment". Great concise name.

[@mikeselectricstuff]

Formerly...

[@o0julek0o]

Good shout, horrid phonetic typo.

[@staticfanatic6361]

Having serviced medical equipment for 30 years, the price of the equipment is usually "whatever the market will bear". Of course, your looking at limited run equipment. There might be only a couple of thousand pieces made world wide and as you they have to pay for developement costs.

[@sanches2]

brian nelson erhh.. the prices are such because guys like me love to get high salaries, so they could buy nice gadgets more often;) and of course - it is "medical/science" gear it should be expensive, right? ;)

[@firstlast8902]

“What the market will bear” is the price for pretty much everything. That’s how markets work.

[@karlfimm]

Interesting teardown. Came up on my KZbin as "recommended videos - Hip Hop Music". Perhaps because DNA, Hip, and Hop all have 3 letters?

[@sanches2]

Mike, thank you for the video! I worked on a similar device in 2008 and it was one of my favourite projects so far. Mine just had more motors and microfluidics inside but in general the science/lab gear is one of the most interesting things an engineer can work on. Now i work in automotive .... it is well paid and boring ;) Thanks for all the effort you put in to make those videos! Have a happy new year, mate!

[@DonkeyLearningIT]

How many engineers are involved in the development phase of one of these things? Even for this small device what we see here has thousands of hours of work going into it. It looks like different boards were designed by different teams.

[@martijn4740]

Happy new year Mike thanks for all the awesome vids last year

[@RWBHere]

Those photodiodes are $282.29 _each,_ not for five. They will be making them to order, with that price and lead-time. Semiconductors can take days to dope for each layer, plus the days of cleaning, photoresists, etching, contact deposition, testing, packaging and final testing. We made certain devices to order, with delivery times starting at about 4-6 weeks, extending up to maybe 14 months if 100% survivability of 8,000 hour life tests were required.

[@andrewschannel3635]

Interesting that the device is constructed of a few different things that all talk to the pc separately, I have come across more mundane devices that install several drivers but never thought about it before.

[@Bodragon]

(5:39) - Is a 16 segment display, not 14. Not that it really matters...

[@trey1531]

I love your teardowns! So interesting!

[@trey1531]

Also the barcode reader was cool!

[@iwtommo]

Any plans for any reverse engineering/how to/project type videos again Mike? Really miss the days of the xray baggage / ipod nano screen ect type videos. Nothing but teardowns just aint the same :P

[@mikeselectricstuff]

Yes - plenty of things to do on that front but they take more time & effort

[@iwtommo]

mikeselectricstuff Understood - and youre a busy man. I dont think anything else teaches better than a good reverse engineering video, and for those of us like me without degrees your videos have been the best teaching ive ever found. Cant wait to see whats in store :-)

[@chrispychickin]

If I'm not mistaken, mike doesn't have a degree either, he's just a friggen amazing self-learner :O Pretty shameful that I spent 2.5 years in uni doing an EE diploma, and I don't know a tenth of what he does. I do learn a hell of a lot from all of these awesome videos though!

[@Hungarianscene]

Holy-moly! I remember those nano videos, but I didn't know it was Mike. It was many years ago when I saw them, but man those videos are awesome!

[@DonkeyLearningIT]

*283$ for a single photo-diode* ??? Wow, for that money it better be special...

[@DasIllu]

Green laser and a matching optical notch filter... You could build a surface spectroscope with that :)

[@yanikkunitsin1466]

Large Area Photo Diode - LAPD

[@iamdarkyoshi]

Greenth. Lovely term. Also yeah 50 quid for a really nice USB code scanner? I'd totally go for that!

[@briant333]

Why would they cover the laser in the barcode scanner when they could just disable it? Would you be interested in an AIT tape library for teardown.

[@witeshade]

Brian Taylor in case someone shows it the barcode to turn the laser on, or some glitch makes it start. A little hardware safety.

[@T3sl4]

Hazard a guess that main board was created in PADS or Allegro or something like that

[@MarkTillotson]

Altium I suspect? They can afford it at least!

[@T3sl4]

That font's not in Altium, but I've seen something very close in the others.

[@DUIofPhysics]

Hey, what were the other diodes on the block, or was there only actually one unit (the green diode?)

[@mikeselectricstuff]

four green lasers

[@DUIofPhysics]

Oh right~!

[@scottyleics]

Hi from 2021

[@KadahCoba]

I could possible use those encoder chips. I'll buy them if your willing to salvage and ship them. Left a message on the patreon post. Cheers

[@RicoElectrico]

13:31 EEVBlog reference? ;)

[@AureliusR]

That's actually a reference to Back to the Future........

[@1st_ProCactus]

There's not enough lasers on things these days, We need more, much more.

[@wesleybecker834]

Quetzal is a colorful Mexican bird that was sacred to the Maia, so indeed probably a funky internal project name. Out of pure coincidence I watched a video right after this one that explained it: kzbin.info/www/bejne/ap-afoVqg5angZI

[@imeakdo7]

i would like to see mike taking apart a photolithography stepper or a mask aligner and see why they cost soo much... (specially the steppers)

[@mikeselectricstuff]

No problem, just send me one.

[@DonkeyLearningIT]

I thought that those steppers are all "just boring piezomotors" and nothing else... Is there something "special" in them?

[@imeakdo7]

Donkey Learning IT very fast linear motors with nanometer accuracy

[@imeakdo7]

Donkey Learning IT and it would be interesting to see why something so apparently simple sells for several million usd

[@MarkTillotson]

Nanometer accuracy "simple"? Have you any idea what that means?

[@emsservices6090]

Audio is all wrong at 1:28 onwards for about 20 seconds

[@Muonium1]

YAAAAAAS daddy uploaded again!!! bigclive for relaxing mindless tat teardowns MES for awesome big science teardowns

[@ChongMcBong]

thanks Mike :)

[@zvpunry1971]

I always think about bad pixels and ruined sensors when lasers are pointed to cameras. ;)

[@MalinCruceru]

photon has lots of videos where he has a burned pixel on his camera

[@zvpunry1971]

Not really, only the few videos before his few laser-videos and the "what were the 3 dots" video, where he ripped the camera apart. But this was 5 years ago. There are many videos before and after the that camera. Unfortunately for us (not him) he has discovered something that is more interesting than blowing things up with angry pixies. He has a unlisted video where he explains his absence from youtube. :)

[@AureliusR]

Aw, can I get the link to that video? I'd love to know what's up

[@zvpunry1971]

Aurelius R: I searched for it but it is gone, but here are some remains www.reddit.com/r/Skookum/comments/60rtan/good_news_photonicinduction_is_back_hes_alive_and/

[@youdonotknowmyname9663]

@@zvpunry1971 He is back (again)

[@axag101]

WOW! that camera is definitely a good score.

[@mikeissweet]

That filter was remarkable

[@MarkTillotson]

If you like high-end optics stuff, checkout a supplier like www.edmundoptics.co.uk/products/ (careful not to purchase anything by mistake!)

[@Ryan-wz4un]

Yay teardown time

[@commonmogoreanu7135]

It's $283 per diode and $1415 for 5 of them. Wow.

[@DonkeyLearningIT]

Reading through the comments I just noticed that I am not the first who made this comment. Yeah, those things are super pricey for a darn photo diode...

[@MarkTillotson]

High end optics devices are expensive because they are not volume, the price only comes down for mass production (millions of units). Even that dichroic filter is probably in the 100's of $ range.

[@hellraiser666666]

thank you for this, v.interessting !

[@dtiydr]

$24000.. Holy fuck..

[@NurdRage777]

Reverse engineering the barcode scanner. Nice haha

[@matthiasBdot]

it's a 16 seg display

[@vincei4252]

second

[@gotj]

First!