Can we create life in the lab from scratch? | Lee Cronin and Lex Fridman

Lex Fridman Podcast full episode: • Lee Cronin: Origin of ...
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GUEST BIO:
Lee Cronin is a chemist at the University of Glasgow.
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[@aaronscottmatthews7883]

Consider the simplest form of metabolism (never-mind ATP synthase) Imagine the sequence of events required to generate that from *scratch*

[@kenaaronbabbit9987]

You Clearly know nothing about dormant spores

[@211212112]

It was anaerobic I figure. Maybe even more like the pathways of sea vent organisms. I don’t think self organizing life just pops up. I think we were seeded by the older universe especially considering the molecules they found in space.

[@kenaaronbabbit9987]

@@211212112 he said there is a scientific lineage even if we don't understand or comprehend it in order for us to compose first the cells had to come to be in a unicellular fashion...then theyd evolve and become multicellular for one reason or another. Before that the dormant spores would have soaked up the hydrogen and oxygen and reignited. Think if it like a dry grain of sand thsts in the garden....when it's on the top and sun baked it's not actively taking on moisture because it's all dried out....but as you water it each day it softens and becomes able to hold water like a mini sponge....now inside are little crevices with dried spore particles....at the end of the day fungi are the building blocks

[@robberlin2230]

Yes exactly, but the theory requires support more than thought. The abiogenesis process skips the critical area as a small part "we don't know much about, a fuzzy area, but once complete.......

[@Radrook353]

They avoid imagining that in order to avoid reaching conclusions they consider unacceptable. In short, they avoid practicing science in order to evade feeling emotionally harassed by the inevitable consequences.

[@sferrin2]

I wonder how far off we are from actually knowing how DNA works. Right now we're basically replacing scorched wires in an old TV with new wires. A far cry from an electrical engineer who could DESIGN the thing. Being able to create a custom DNA sequence from a clean sheet and KNOW what it will make. . .it makes my head hurt just thinking about it. Which piece of code do you put where to make sure that the seed will sprout but only AFTER it passes through the gut of a mammal, and why?

[@_P785_]

Not only that but the dna strand is long asf like there are trillions you’d have to peice together perfectly

[@4D2M0T]

Soon we can ask AI to answer this question for us....

[@WayneLynch69]

Cronin mutters Craig Venter's name. Here's Venter's express opinion on "life from non-life": kzbin.info/www/bejne/rnqrfqF6Z6t3m7s "IMPOSSIBLE humans will EVER know life's origin". FOLLOWED by Nobel laureates in biology Leland Hartwell & Sydney Altman saying EXACTLY the same. BUT MOST EXTRAORDINARILY, RICHARD DAWKINS SAYS NOTHING!! It's his sine qua non. He has no reason for being absent "natural etiology of life", as supported by HIS biology bona fides. I accept pursing funding and fame...but this fool is going no where.

[@sferrin2]

@@4D2M0T That's not how AI works.

[@deanalbertson7203]

So life might be more rare than we thought originally.

[@larrybutler8794]

James Tour!

[@MrKydaman]

It's all fun and games until you create the blob.

[@pdxeddie1111]

It was sure a lot easier to explain a hundred years ago when we didn't know how complicated the problem is

[@pauldirc..]

So can i conclude we should believe in magical space daddy ?

[@marksackhaarberg1822]

@@pauldirc.. I mean if you don’t I promise you will end up very depressed and miserable 😂

[@pseudonamejacobs9146]

If we could create life it would give us a big insight on what life can be on other planets one of my biggest questions being is DNA a natural phenomenon or will other forms of life do it differently with their own version of dna or w.e it is we find

[@anewman]

sure, let's say we find out creating life is easy.. but then you have to ponder how easy is creating habitable conditions ( sun at right distance, axial tilt held stable by large moon, guardian jupiter etc)

[@Raiddd__]

@ianpalacios6154 i dont think youve done the math brotha. Dont just take it for granted that "big ass number" is "close enough" to "other big ass number"

[@TC-jo2vj]

lol what do you mean, we’ve found out creating life is incomprehensibly complex and the math for our current misunderstanding of evolution and origin of life is laughably wrong. Even billions of years is nowhere near enough time for Darwinian evolution to be true.

[@TOLOFFICIAL]

well said

[@Lola_bunny215]

I always say we are the creators of the aliens we want to meet … if we start making life now in many ways, making many species , let thousands of years pass and life will be like Futurama … becuz we started it. Idk I’m high asfuck

[@_GuzJ]

I hate that theory because they leads me to believe we will create our own form of heaven essentially, and there isn't one in charge after all. (more scary because of lack of understanding) All those that go to hell stay trapped underneath the Earth's main surface layer as they didn't believe in facts/knowledge and were "cleaned" by Earth/Gaia. They were more so for selfish reasons and owning, so they were left with the Earth. Heaven, in my opinion, would be a virtual world where everyone can kinda do whatever they want without actually causing any physical harm. This can all make sense in the idea that we are God. Idk how I feel. I love knowing we are capable of endless realities, but scary to know what we interpret as "bad" can be "in charge" for awhile as no one is truly guiding us but ourselves.

[@4D2M0T]

Yeah me too, but all these species will need to kill each other to survive or for whatever instinct makes all other species kill each other and even themselves as humans proven good at, but wouldn't it bee cool just like the wild west in space lets build those life bombs

[@deokspatch8458]

reddit momment

[@HebrewsvJohnv]

Look up Dr James Tour's latest series on KZbin, he is going against a few of the origin of life researchers, the series is brilliant.

[@michaeldonnelly6747]

So we still can't do something that happened at random in nature?

[@distilledfreedom1840]

No, it's infinitely unlikely to have happened.

[@marksackhaarberg1822]

no😂

[@NishanT_ACM]

bro that random process takes 500 miillion years

[@mrn8645]

@@distilledfreedom1840 - It has literally happened!

[@tripplethicc626]

Isnt it natural for humans to do what they do??

[@dylan-2169]

What if we’re the result of “origins of life bomb” from a long gone, or just distant civilization, that could possibly still out there spreading those “bombs” in other galaxies. Maybe the reason we can’t find other life is because we were the first products of the “bombs” to become technologically advanced enough to actually search for other life.

[@Lesminster]

By the definition everythin new only after it's discovered it is being analyzed and our knowledge develops further. So, knowing this, it is simply not possible to predict if someting kills us all or not.

[@00sh0tay]

From scratch? How about from nothing? That happened . Can you imagine the power that being has?

[@videomontaggenerator]

I hope we would befriend or kill it.

[@Radrook353]

The Bible doesn't say he created things from nothing. Where did you derive that idea from?

[@00sh0tay]

@@Radrook353you read much?

[@00sh0tay]

@TiMMY 2PHONE5 nothing is before Matter.

[@ApostolicEchoes]

Ex nihilo is Latin for “from nothing.” The term creation ex nihilo refers to God creating everything from nothing. In the beginning, God created the heavens and the earth (Genesis 1:1). Prior to that moment, there was nothing. God didn’t make the universe from preexisting building blocks. “Through faith we understand that the worlds were framed by the word of God, so that things which are seen were not made of things which do appear.” ‭‭Hebrews‬ ‭11‬:‭3‬ ‭

[@bimjim2536]

I can make life from scratch. All I need is some cinnamon rolls, a car battery and some pizza pizza creamy garlic dipping sauce.

[@austinaussiec]

Pizza Pizza is an incredibly efficient way of saying Little Caesars. Just know you have touched someone today. *giggity*

[@beefdavidson]

@@austinaussiec Pizza Pizza is a chain in Canada independent of Little Caesars

[@brandonmcneeley2233]

Boston Dynamics: Boy do we have a surprise tomorrow!

[@robiulahmed]

The trouble with building life from scratch is that you need homochiral nucleotides, homochiral polysaccharides, you have to battle degradation and once you have the nucleic acid, they have to functional enough to code for functional proteins, which means you need functional ribosomes. Also, the cell needs to be metabolic and be able to replicate. That's just scratching the surface, it's actually way more complex than that.

[@sinthason]

Are chemicals, particles, and elements considered living things? Because bonds, and reactions, still exist even if organic doesn't. So in that terms what would be the definition of life.?

[@ricomajestic]

No.

[@anunluckyguy7586]

Yes.

[@janbittner1465]

Life is a difficult concept to define, so it's mostly defined as a sum of properties of thing we consider living, such as: cellular organization, the ability to reproduce, the ability to respond to environment... The idea is that while a thing that has one of these properties may not be considered a living thing, once it has most if not all of them, you're without a doubt looking at a living thing.

[@obbzerver]

To save you almost 11 minutes - so far the answer is no.

[@johnpatmos1722]

I sure hope that Cronin isn't supposing James Tour or Stephen Meyer, for example, in this dumbed down dismissal of creationists' critique of OoL research. And as to good faith, you all have made exceedingly bold claims of what you have and will accomplish in this area of research which have grossly mislead the public.

[@marksackhaarberg1822]

Cronin is incredibly delusional

[@piddlepond]

Is there any evidence that life has originated more than once on earth outside of the first evolutionary chain?

[@Xendindrome]

What's preventing new life forming on earth all the time?

[@wertytrewqa]

No there is no evidence for that type of thing.

[@robberlin2230]

Other than we exist, there is no evidence for abiogenesis, it's a theory

[@anunluckyguy7586]

@@Xendindrome i dunno, maybe it does but just dies instantly?

[@elvinmateo6408]

this is how pokemon began LOL

[@Noobmaster-sd1qm]

Fascinating topic, wonder if they can create life and that life can create some more life :D

[@jasonking1284]

It might go wrong and end up like...... The Thing....

[@Noobmaster-sd1qm]

@@jasonking1284 haha

[@JumboH]

Guys what do you think is more likely to happen first? The creaton of nuclean fusion or the creation of a self-replicating life form like a cell from dust?

[@johnpatmos1722]

I wish Lex Fridman would invite Steven Meyer onto his show.

[@mcmanustony]

Why? You can hear him deliver the same schtick he's been peddling for decades all over YT. I have a drinking game where I take a shot every time he says "nanotechnology", "inside the cell" "digital code".....I'm now on my fourth liver. He's a lying religious hack. Nothing more.

[@Lexi2019AURORA]

I doubt it.

[@JasonAlexzander1q47]

Do it from atoms and real building blocks.

[@MrPeterFranc]

It’s already been done. Non results. Just accept it. There is a creator. Life is too complex

[@robberlin2230]

That alternative is too complex in every other part of life for consideration it seems. Best to scrap a creator and continue doing what you would

[@johndonaldson8549]

Surely that can be achieved on a super computer,

[@kentclark9616]

Did he honestly say “ put sand in a box and wait for life to come out” maybe I didn’t hear him properly because that would be incredibly stupid.

[@estebantorres1547]

No and we are not close

[@sarfarazkhan8157]

We even can't creat life from life out side body.we provide environment for test tube babies but we don't grow them out side body as young ones so why don't believe someone is present who created the life from scratch.

[@blueredbrick]

Amino acid would be still the same as Miller Ulrey showed.

[@ricomajestic]

Never replicated so most likely was not created. Contaminated flasks.

[@UncleScratchnSniff]

The first person to create life inside a lab is probably going to be Bret Chrysler. He does horrible things to dogs.

[@zach_harrison]

I wonder what intelligent life would look like that lives not on H20, but on methane, or something else.

[@robberlin2230]

You are describing the Clintons

[@user-zd7ox7ej7v]

I honestly feel like we was a lab creation by another civilization of beins and it cycle keeps going which explains the infinity theory of the universe.

[@understanding.everything]

Read Hinduism

[@DigitalVovoghure]

Life is so complexed. Just create an atom of Oxigen out of scratch, means joining quarks.

[@bradenward4231]

What if it isn’t possible to create life from a sterile environment. That would mean life came from somewhere else. Maybe it came here on an asteroid. Maybe there is a completely different realm of the universe with different rules where life can be created from nothing.

[@froesefamilyadventures4616]

Hummm. That sounds like God. Welcome to creationism my friend.

[@janbittner1465]

The generally accepted answer is that the water and salts which created the first protoproteins did get to earth during meteor rains.

[@jemj-]

no it doesn't. saying a different realm of creation from nothing does not mean a all knowing all powerful god deiced to create us. i can see some of the overlap but its not mutually necessary @@froesefamilyadventures4616

[@chauhanrajput4733]

Interviewer is interrogating like a spy😅

[@GC-nm3og]

7''00"....By the way, whos the guest? Let the man talk!

[@eaf888]

🌍🌍

[@beadoll8025]

Answer: NO Because that would require God-like intelligence and we are severely lacking there....ALL OF US!

[@Radrook353]

Amazing how being illogical has become an emblem of being highly educated!

[@finsic8453]

Please explain your comment sir

[@marksackhaarberg1822]

@@finsic8453You can’t create Life from scratch. It’s a billion times more complex than Lee Cronin describes it. Doesn’t matter how much technology you have and how many scientists simultaneously work on that goal. It’s more likely to create a bridge to the Mars than creating a living cell from scratch. Just won’t happen.

[@nowar9220]

It's already been done using frequency... some dude did experiments in the early 1900s and he put a test tube in a beaker, the test tube had pure fresh distilled water, and the beaker had dna suspended in the solution, using frequencies he was able to form the exact same DNA in the test tube.. there was also more testing done with microbes and such getting similar results.. I guess it's not creating new life, but he did create life forms from clean water, obviously his research was rejected by the mainstream and his colleagues, the research never ended up going anywhere just like the countless other researchers that either got ridiculed or had funding pulled and labs shut down, there's plenty of tech that's been hidden and kept from public.. it's undeniable and if you believe everything is open and nothing has been supressed, then you my friend are a fool and just simply havnt studied history..

[@ricomajestic]

Experiment has never been reproduced

[@jasonking1284]

HP Lovecraft?......

[@johnpatmos1722]

This is a joke, right?

[@rhys4303]

Better question, why would you want to? Science can probably create manbearpig, but that doesn't make it right. Do science majors just sleep during the required ethics class?

[@dbitely01]

Ethics is different then the law.

[@dbitely01]

Ethics is different then the law.

[@violent_bebop9687]

Gain if function has proven ethics has died long ago.

[@Mooorino]

If you could become "god", would you say "no thanks". Of course not, you would say "fu** yes!". Same thing as asking anyone if they would like to have 1 million dollars? How many, in percent, do you think would say "naaah, im good!"?

[@ricomajestic]

If we can make life from scratch then we could eventually make hearts, livers, kidneys, etc that would all help very sick people without the need for transplants

[@pseudonamejacobs9146]

God lex is kinda asking some slow questions

[@michelangelopainters5519]

Is Lex stoned?

[@KrystelSpicerMindArkLateralThi]

This wonder is on words 'beginning' & 'end' not regarding from 'birth' to 'death' but from both ends of a spectrum where either pray or eaten, & between where not defenseless. Re. retrocausality. I'll explain this in layman's terms using nature as a guide rather than machines & particles & scientific terms which I tend to think keeps people in the dark. I"m said to take an interest in quantum' mech. I wonder it's actually quantum that took an interest in me. No one seems to be able to tell the difference. Suits me just fine. So here goes..✍️😉🌞✍️ The feathers over some birds, & the human head of hair come speckled, meaning rings of glowing light expand & retract upon it under sunlight as an observer approaches or backs away. We appear as though we're (1) watching an observer with eyes in our blind spot as does a butterfly & (2) are an observer between ourselves & an observer, shadowing them, as retracting & expanding rings give the illusion something without body be same proximity to them whether we remain still or not or whether they're backing away or drawing near. Does a butterfly which can't see have circles that look like eyes on its wings, to compensate for those wings making it appear bigger than its body & the colours they are making them look more spectacular in the daylight to be eaten for, then what is it we can't do when we be an invisible shadowing creature besides ourselves? Perhaps we can't see we live in a uni-multirealm of different sized same universe, not unlike the expanding & retracting rings of light in our hair. Are Alpha & Omega proximity relative & not relative to birth & death? The way we're born relative to the way we die may not be relative to life as lived about the uni-multirealm which has neither beginning or end besides at what point observed at. If God & our & the uni-multirealm be expansion had used deduction & vice versa (expansion & retraction both are once when 'beginning' just means from when so close observing us our shield be active, & 'end' mean where from we're observed from either too far or so close it inactive, then does it make sense that one would die should they see god if to die is all there is left to do besides begin & end as in expand & retract which go on forever? Is to be Alpha & Omega (as in expansion & reduction both) proximity relative & not relative to birth & death, however is birth & death also proximity relative otherwise but have to do with when too far or too close we're able to be observed? A predator stalks its prey from a distance the light ring defence be down, to race close enough to that prey the light ring defense be down too. Our only seeing this one universe & not the uni-multirealm of different sized same universe, might this mean we're either too close or too far from it or both, & that 'beginning & end' to who see their home as theirs alone & defenseless could only mean 'birth to death'? Is that we're blind to what & where we are proven by the rings of light we not observe ourselves being other than ourselves, the way that the butterfly being colourful & larger than itself proves it's blind to how it's observed & as to its proximity? So. Once were blind & now we see? Or is it we're like the butterfly, with defence mechanism respective & irrespective of we're born prey, where beginning & end could only mean from birth to death? ✍️😉✍️ All I write is free. please help yourself. Free. From scratch.

[@radicaIarchitect]

I create life every night 😊

[@garrydion8907]

Moral obligation to create more life in the universe,yet we kill our unborn children on the alter of inconvenience

[@4D2M0T]

If we could create biological life from sand imagine where this research could eventually lead to, what if we discovered/created the ultimate biological life form that can survive on Earth, I wonder what it would be like

[@Blobby192]

yeah like a xenomorph

[@yarar-ct9lh]

You can’t make carbon or electrons

[@santiagop23]

Lol this kid was demolished by James Tour… get him on.

[@maxtaylor1026]

Its never going to happen. What ever you create guy, if it cannot replicate its not life. Good luck. And your "poor" description of a life form seems to be a foreshadowing for what you would like to deem life but won't be.

[@UFO_PILOT]

Look up "xenobots".

[@MS-od7je]

Blahaha

[@ronaldmorgan7632]

We're nowhere near, and, there's really no benefit to doing so.

[@jemj-]

by creating life that means we may be able to create organs for transplants or bring back extinct creatures to dying ecosystems

[@pdxeddie1111]

but thats the point it is a terminator tomorrow I mean if ya can't figure out how it began in PRIMORDIAL earth which should be relatively easy if it was that easy then it shouldn't be that difficult to replicate. I know throw some stuff in a sterile water drum and wave some magic spells over it. Maybe that'll do it.

[@ricomajestic]

Abiogenesis.

[@distilledfreedom1840]

A myth

[@beadoll8025]

Where is the actual evidence for that? It's mythical bullsh*t. Even the evolutionary theory is illogical and unscientific. 14 billion years ago blah blah blah and no evidence and no eye witness accounts but believe because we said so and oh yeah you're crazy if you believe in a God but trust our adult fairytale. 😂

[@yarar-ct9lh]

You can’t don’t waist your time

[@Canyon2023]

Can’t you just keep perfecting the sex robot…and robots designed to kill people….which are men’s two favorite things to do in life!!! Can’t you just perfect that - and create sports robots for your personal entertainment, who can fight each other in arenas? Do that with your billions instead of feeding the starving, and don’t solve the pollution problems whatever you do!!! DON’T DO THAT!!

[@shadymcnasty5920]

What are u implying

[@muneebiqbal5584]

(22:73) إِنَّ الَّذِينَ تَدْعُونَ مِنْ دُونِ اللَّهِ لَنْ يَخْلُقُوا ذُبَابًا وَلَوِ اجْتَمَعُوا لَهُ O people, an example is presented, so listen to it. Indeed, those you invoke besides Allah will never create [as much as] a fly, even if they gathered together for that purpose. And if the fly should steal away from them a [tiny] thing, they could not recover it from him. Weak are the pursuer and pursued.

[@stevenfoleyuk9404]

God created Life from Nothing no Atoms no nothing . Good luck with your science and your Quantum Computers 😂😂😂😂

[@aminzarei1557]

U see this is the problem , When our scientists instead of solving current problems, would create life or play with viruses just to prove something to some fanatics 😑

[@ammavumchild5935]

Harbouring psychopath and talking about philosophy about life??? No MERCY for any Criminal not even life sentence.

[@prvtlongarm]

This guy spitting up nonsense.

[@spamm0145]

Only the creator can make life from non life, all any scientist can do is take Gods work and manipulate it using the laws he created.

[@bubbafowpend9943]

We'll see. If they end up creating life in a lab (they wouldn't bother with the research if they weren't confident) you may have to eat your words.

[@davidrichmond21]

@@bubbafowpend9943 Are you serious do you know how much money is in this research.

[@bubbafowpend9943]

@@davidrichmond21 And that means it's not viable? Do you begrudge the probably trillions that's gone to cancer research, because there's no cure yet?

[@marksackhaarberg1822]

@@bubbafowpend9943no, we won’t see. I promise 😂

[@bubbafowpend9943]

@@marksackhaarberg1822 citation needed

[@dougtibbetts857]

Short truthful answer…. Not even a clue…. Not even in right field in the tall weeds!!

[@JorgeTorres-mh7wy]

Humans will never duplicate the lord's creation no matter how hard they try.

[@human678]

Wouldn't be so sure about that.

[@hooch87]

Wait till you hear about sex. It'll blow your mimd!

[@anunluckyguy7586]

oh but they will

[@anunluckyguy7586]

@@karinarnaud4093 someday, but sadly you're never gonna see it

[@Sniper-cf1vv]

God is fiction you fool

[@user-tn6ge6tw2p]

01jst3 VUN.RENT