Can we cure cancer with CRISPR?

CRISPR these days refers to the suite of technologies that can edit the DNA of living cells by adding, removing, or changing segments of it.. Cancer, by definition, is a genetic disease caused by DNA mutations, changes within the sequence of DNA. So, can we cure cancer with CRISPR? That is the hope of many researchers, but a current promising solution that we’ll take a look at in this video, is perhaps not the straightforward solution you were thinking of. Let’s investigate.
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TIMESTAMPS:
Cancer - 00:00
CRISPR is - 03:30
CAR T cells - 04:45
References:
asheekeyscienceblogcom.wordpr...
Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumors - doi.org/10.1101/2023.08.03.55...
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
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[@TheSheekeyScienceShow]

i plan to make an extended video on the CAR T cells to explain deeply the potential. stay tuned!

[@SlamminGraham]

Maybe it's time to abandon the notion of a clinical trial for a specific drug, and rather do clinical trials for a specific *procedure* involving a customized drug for each patient (which hopefully can be synthesized rapidly) which can be administered within a reasonable time frame. I'm kinda sick of clinical trials always being the excuse why nothing effective ever happens. Personalized medicine promises so much more for us.

[@sunday6371]

I am very grateful to Dr Abiola on KZbin for curing me permanently from hiv with his herbal medicine #drabiola 💛😊

[@BakamonNO]

Love the video. But the sound effects and the sound of the video clips are set to high fam 😊

[@Big_brain_bio]

I absolutely love your videos. They are very informative and they generate ambition in a mind of a young science student. Keep posting such useful videos. Kudos. Love from India🇮🇳

[@ogeoge6000]

I'd love to know your thoughts on Professor Thomas Seyfried's work on cancer.

[@deadwalking100]

Thank you! Interesting potential for sure. Indeed one of the many things I have learned through your many excellent video presentations; being the immense complexity of the human body, and challenges that such cancers present to modern science. Loved the emphasis using sound effects and support graphics, speaking of which.... Oddly the cancer cell swirl graphic with no sound invoked in me the batman (showing my age Adam west 1960s TV series) sound, when they cut between a scene.

[@alexz1104]

Another great video! I would love to see you do one on distributed/volunteer computing projects in medicine like World Community Grid or SiDock.

[@robertkelleyroth409]

Excellent video. Potential upgraded modality for anti tumor therapies. One of your best of 2023.

[@paulollerhead]

Fantastic work yet again, thanks

[@ArticBlueFox96]

Incredible. Hopefully this leads to a new generation of cancer drugs far superior to current treatments.

[@GodfreyMann]

Sheekey, please explain how the *plethora* of different DNA mutations all give rise to the same phenotype of uncontrollable cell replication…it makes no sense. And why is it that the almost all cancer cells have damaged mitochondria? In light of this, surely it makes more sense that it’s mitochondrial dysfunction that causes cancer via excessive ROS that damages DNA, especially as the cell cycle (cell death) is mediated by mitochondria? The nuclear transfer experiments carried out by Prof Thomas Seyfried of Boston College seems to prove this beyond all doubt, no?

[@MW2xX]

What if the plethora of DNA damage causes the mitochondrial dysfunction? This then leads ROS production and then more DNA damage. In this since the DNA damage is the driver of cancer where the mitochondrial dysfunction is a distinguishable phenotype to acknowledge. There could be cancers where it’s the other way around or they are inextricably linked together? There is DNA in the mitochondria too?

[@rigaleb]

well, when energy metabolism doesn't work anymore, things go sideways. Of course mithocondria have the master switch. Micromanaging T cells ain't gonna solve all of it, we need to take care of our mithocondria, we are nothing without them.

[@GodfreyMann]

@@MW2xX the mechanisms of mitochondrial dysfunction are well understood and nuclear DNA mutation has nothing to do with it.

[@MW2xX]

@@GodfreyMann is it 100% that mitochondrial DNA is not damaged?

[@GodfreyMann]

@@MW2xX in some cases mitochondrial dysfunction arises from mtDNA mutation, but that’s not what Sheeky was talking about - her assertion is that cancer is caused by nuclear DNA mutation.

[@walidoulondon8107]

Can you do a video on sirt6 activator please 🙏

[@robertkelleyroth409]

That Murray et al paper is exciting - just 6 edits to go after solid tumors.

[@BK-dy8jk]

I love your show, but I hate those short little musical inserts that are extremely loud and interruptive. Not fun for listening.

[@kingsize1182]

👍🔥💯

[@lonelyelectron5283]

I think car t cells is more promising therapy for blood disease like leukimia or autoimmune, they proven to be effective againts few type of blood cancer like lymphoma but not for solid tumo,t cells known have hard time to infiltrate solid tumor and struggle in tumor micro enviroment

[@sunday6371]

I am very grateful to Dr Abiola on KZbin for curing me permanently from hiv with his herbal medicine #drabiola 💛😊

[@Enhancedgenetics]

Sounds dangerous man fooling around with nature will end badly... 🙄😐

[@basedchad6035]

no risk no fun

[@Enhancedgenetics]

@@basedchad6035 risk to do what destroy yourself we are already unintouched with nature ... 😐

[@blkshk2466]

@@Enhancedgenetics I hope neither you or no one in your family is taking any prescribed medications or going to hospitals then, gangatron

[@basedchad6035]

@@Enhancedgenetics itl Happen no matter what so idc what u type of people think anyway

[@Enhancedgenetics]

@@basedchad6035 I know humans hate nature & think they can do better yes,😊👍

[@atomicsockbombs]

Cure Cancer? Where's the money in that?