Can We Make A Vaccine Against Smoking?

We've all heard of a flu shot or a COVID vaccine, but there's a whole bunch of other health issues that researchers think we can use vaccines to prevent. From high cholesterol to substance abuse, researchers want our immune systems to tackle all kinds of things - even our own allergies.
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[@TacComControl]

There's a vaccine being developed in Japan for cats that retrains their body in how they produce AIM-9 proteins. In cats, the way they are normally produced causes them to get stuck in the kidneys. The vaccine basically causes them to create a recombinant version of the protein that doesn't, which is expected to effectively double the lifespan of housecats, as the fact that their kidneys get choked up with this protein is basically a ticking time bomb, and why cats die so often from kidney failure.

[@fghsgh]

@@hugoanderkivi Having seen your other comment, your attitude of "everything can be fixed with diet" sounds a lot more "reductionistic" than "let's target specific problems we have evidence for". It almost feels like you must be trolling.

[@nothingclever7582]

Someday.. stem cells!

[@classarank7youtubeherokeyb63]

Damn, both of my cats died of kidney failure. I hope this comes soon because I already have another.

[@S8tan7]

WE NEED TO FUND THIS 40 YEAR OLD KITTIES

[@Nefariously_ignorant]

I haven't heard of that but I have an autoimmune disease called IGA nephropathy and it does exactly that which you described My body creates misshapen IGA proteins and they get stuck in my kidneys, that caused enough damage that they failed when I was 22

[@mikamekaze]

A vaccine for my latex allergy sounds like a terrible idea. Nothing would stop me from spending all of my money at Ikea anymore

[@fuzzyspackage]

"Let only latex stand between our love" 🍆

[@lewispontremoli1219]

What does IKEA use latex in? I can't think of anything

[@Joe-Dead]

@@lewispontremoli1219 high density foams and some medium density foams, not latex necessarily but a synthetic analogue can trigger a reaction as can some similar molecules. a latex allergy can be an effin minefield, a mousepad, a seemingly innocuous object had some analogue that triggered my reaction to latex >.< hives all over my wrist and the heel of my hand.

[@gaygekko]

@@Joe-Dead I've never seen foam in IKEA products, I just built an IKEA table (IKEA NORDEN) yesterday, and it was packaged using only cardboard, paper and a couple of plastic bags 😅

[@Hexlen]

​@@Joe-DeadThe heel of yo-.... do you mean the palm of your hand???

[@DeadZone318]

So, so, so, so, so, so, so glad to see you thriving after your cancer journey. You are a trooper, not only a survivor. Again, I am so glad to see you back to being you. Be well.

[@joshiahphillips9219]

I think this might b an old recording. Hank post Hodgkins has a beard and has nerdy Jason stathem vibes

[@maksimatic]

@@joshiahphillips9219 it’s definitely post Hodgkins Beard and nerdy vibes notwithstanding His hair alone is a dead giveaway

[@kitefan1]

@@joshiahphillips9219 Recently he got rid of the facial hair. TG. I think he just needed to grow some because he could.

[@thecolonel6394]

I recently lost my grandmother to the monster that is Alzheimer's - It's great to hear that a vaccine is being worked on that could prevent all that suffering.

[@animeartist888]

In the same boat. Watching the slow downhill struggle was horrendous; took a real toll on the entire family to watch her slowly lose herself to it. Absolutely stoked to hear that there's a real possibility of a preventative and a treatment both in one.

[@Casualfulltime]

The Covid VaX caused it! Wake up.

[@teelakovacs208]

I'm so sorry you lost her, these new developments could've saved both of mine as well- who knows how far-reaching this vaccine will be and how many could be saved from so much pain? My heart goes out to you

[@ajoshdoingthings541]

Currently taking care of my grandfather-in-law due to that very reason... It's really nagging on my mentals to see him degrade ever so slowly, every day a bit less of him in there...

[@aaro96live]

Sorry to hear that!

[@bluexwings]

God, I would LOVE a vaccine for an allergy to dogs. It's a recently developed allergy, but its so disruptive. Even with inhalers and antihistamines, I can't breathe when I visit family. (Plus I love dogs!)

[@patrickmccurry1563]

At least with allergies that appeared suddenly, they can also disappear just as quickly. I was severely allergic to dogs from my late teens to my mid 30s. Now I have zero reaction to them. So keep hope alive.

[@kaylahbkitty9691]

I have a dog allergy but some breeds are easier on me then others

[@chantellekirk2993]

I became allergic to my dog when my workplace changed disinfectants to quaternary ammonium compounds. Apparently, my old dental amalgams played a role as well.

[@patrickmccurry1563]

Combination allergies are really weird. My GF developed an allergy to a spice mix, but not any of the ingredients alone.@@chantellekirk2993

[@bluexwings]

@@chantellekirk2993 That's interesting! Would you mind expanding on that a little?

[@oliviamoore3426]

I got a mutated gene, apo-b, meaning that my body can’t get rid of cholesterol too well. 5 years ago I went into cardiac arrest due to a major heart attack. Those anti bodies are keeping me alive now, keeping my cholesterol levels relatively low

[@Wakka144]

Let me guess, you are taking Repatha? That was what I was given because no matter what I did or what I ate, my cholesterol was always high.

[@oliviamoore3426]

@@hugoanderkivi actually there are 2 types of cholesterol. Good and bad cholesterol. I went on meds without the anti body at first and changed my diet and I exercised even more than I did before. It got my cholesterol levels down to about 4. I used to have a value of 6. The. I got the anti body combined with eating well and exercising and I got my value down to 1.4. In my case the meds are working and they are keeping me live, due to the mutated gene I need that anti body to keep my cholesterol down. Had I been a regular person I’d be fine with regular heart attack medicine exercise and a good diet, but because of my faulty gene, just exercising, eating right and taking regular meds will not get my values down enough. You’re factually incorrect. I’d suggest that you read up about familial hyper cholesterolemia

[@oliviamoore3426]

@orenelbaum1487 thank you. My mutated gene makes what Hugo said completely irrelevant.

[@oliviamoore3426]

@@ReinerEvans thank you. This 100%

[@oliviamoore3426]

@@Wakka144 yep, I’m on repatha, it really worked miracles. Ah, so you also have familial hypercholesterolemia?

[@xerk2945]

I read the thumbnail as "We've got a wax for that" and I was really confused about why they were trying to pass peanut butter off as some kind of wax.

[@Jp138233]

That is exactly the same thought process I went through for a moment

[@blogdesign7126]

Vax I saw that given how politically loaded that word has been in the past 4 years with COVID-19.

[@CWorgen5732]

I saw Tax, pretty confused until I saw a vial and syringe.

[@razzar508]

Would love to have my immune system stop attacking my thyroid

[@dianahuang4991]

I was shocked to learn recently and confirmed w a pharmacist that thyroid medication is the top dispensed meds if not #1… I had no idea how common thyroid disfunctions are… 🥺 let’s hope it’s on the list of fixes 🌈🌈🙏

[@nemudere]

same

[@Dradeeus]

Any one of these sounds like it'd be a massive boon to humanity. I'd really love that Alzheimer's one in my lifetime.

[@oliviamoore3426]

This 😃

[@TheWetdonkey]

Dementia in general is more often seen in correlation with infections, like getting pneumonia after having the flu. So in a way a partial vaccine already exists :)

[@bennyb.1742]

Yeah, I'd be pretty hyped on that. Family history, personal history of TBI, bad run of the Cov', ect. I've got all the warning factors and I'm terrified.

[@seeleunit2000]

That would sound wonderful.

[@psdeas7530]

YES PLEASE, FFS!!!!!

[@potatoeoverlord9430]

If I had Alzheimer's, I'd want that vaccine NOW. I know it's important to test things thoroughly, but it's such a terrible disease and it's always ultimately fatal, so I'd jump on anything that offers a chance of making such a significant difference.

[@psdeas7530]

RIGHT?!?!

[@modestoca25]

They didn't test COVID vaxxes throughly and look at all the problems that have arisen from it

[@ShainAndrews]

Living is fatal.

[@clogs4956]

@@ShainAndrewssarcasm? Obviously you’ve never visited a specialist dementia care home…

[@DawnDavidson]

Absolutely. My mother is currently living in a dementia care facility. I want that vaccine YESTERDAY.

[@anyascelticcreations]

Hank sounds downright chipper today. I guess surviving a near death experience will do that to a person.

[@lmost]

lol Hank sounds positively radiant nearly _every_day. That's Hank for ya!

[@anyascelticcreations]

@@lmost He does. Even when he's ranting he does. 😂 But tonight there seems to be an extra air of happiness.

[@everetthancock2043]

I mean, he's not entirely out of the woods, but yes a great victory.

[@Arthur-vo9kt]

What happened?

[@everetthancock2043]

@@Arthur-vo9kt his blood cancer has entered remission

[@smivan.]

While the substance abuse vaccines like the anti-nicotine ones are interesting in concept, I feel like they (at least as discussed in this video) are sidestepping the core problem of what frequently causes substance abuse - things like stress and anxiety. Even if a smoker takes a nicotine vaccine they will still need to seek out *something* to substitute the calming effect that smoking provides, so chances are they'll just hop from one addiction to some other addiction, or otherwise switch to a different kind of problematic lifestyle - without additional therapy in parallel to the immune treatment that is.

[@animeartist888]

I think you're jumping the gun on when people would want these. Think of how many people you know that smoke. Statistically, at least some of those are past the point in their life where they need that outside calming effect, but are stuck still smoking becaus eof how addicted they are. I worked at a gas station, sold many cigarettes to older folk and young alike. The old ones always told me not to ever try it simply because stopping is so difficult. Those are the sort of people who would want this vaccine, not those who just started smoking because something in their life went really wrong and want to forget for awhile.

[@wickast4941]

Yeah but they could get addicted to something that won't give them lung cancer. Seems like an upgrade even if it's not a perfect solution.

[@smivan.]

Oh don't get me wrong, I'm not saying this vaccine is a bad idea, I'm just saying that it may require most people more than only the vaccine to get out of a substance abuse situation in a healthy way.

[@gavshox]

Agreed. I don't like the way they frame substance abuse.

[@mariannetfinches]

I hadn't thought of that aspect. That makes sense. It's excellent to see this technology develop, and humanity as a whole needs to work on metal health

[@a-aron2276]

I've always thought it'd be cool to back up our DNA when you're healthy and if anything goes wrong later in life you have a record or whatever dna was damaged, like a big reset for whatever cells aren't doing what they're supposed to be doing, like cancers, Alzheimer's, coeliac disease, leukaemia, ms, battens disease and so on.

[@murkje]

This seems like a great idea for a sci-fi story, if it's not a trope already :)

[@gsreads]

DNA has to be updated in all the cells??!!

[@TukPsyche]

I believe this is part of why people bank their stem cells

[@RokeJulianLockhart.s13ouq]

​@@gsreads You might be surprised by how achievable that is - at least, converting the DNA in a sufficient amount of cells to save the patient's life.

[@Praisethesunson]

I bet big pharma is looking into that but for something stupid and marketable like curing baldness.

[@The_Cyber_System]

All of these are awesome. I'd love to just have a vaccine for my allergies instead of my 5-year extremely expensive immunotherapy. It's definitely working and I appreciate it, but it's expensive and tiresome, and the more options the better. Also sucks that my family has a genetic risk of heart disease, despite being healthy in every other way - reducing risk with a vaccine would be amazing!

[@Chris-hx3om]

" I'd love to just have a vaccine for my allergies instead of my 5-year extremely expensive immunotherapy." And this is why it'll all be squashed. Why would a company produce a $10 shot that you only need once a year (even 6months) when they can have you on a $1000 a month 'treatment plan'? Name one disease that has been cured/eliminated in the last 40 years with a single (or even a series) of vaccines. Plenty of (expensive) treatment plans available that weren't available 40 years ago....

[@I-will-teach-you-1to1]

What is Immunotherapy? A pill?

[@nirfz]

I'm curios, as i had a 5 year treatment for pollen allergies too a while ago. (But mine didn't help sadly) What do you mean by extremely expensive? (I am from central europe, and while we always complain at the state of our health care system, the only thing it cost me was the time and effort to get to the doctor each week and wait for 30 minutes after the shot, to see if there is an anaphylactic shock.)

[@cbpd89]

I'm a couple years into my immunotherapy for allergies. It is a real life changer for me to be able to function in the spring/summer/fall, but a single vaccine would be miraculous! For folks who don't know, it is building up a tolerance to the things you are allergic to by getting frequent small doses, usually in the form of a shot or something edible if it's a food allergy. You start out small and work your way up to higher doses till you reach a "maintenance dose" and it should minimize or eliminate allergic reactions. It doesn't always work, and for folks in the US it is pricey. I think it initially cost like $500 and then is an additional $10 per dose for every visit because insurance usually won't cover it. If it's a food allergy and the therapy works, you may have to be very consistent in eating that food every day forever basically. I know someone who, after years of building up a tolerance had their peanut allergy come back because they stopped eating a couple every day.

[@marcylynn3703]

My grandma had Alzheimer, I'm so scared of getting it aswell. Good that is being investigated I hope I live to see the day it's curable

[@xionmemoria]

It likely won't ever be curable. A destroyed brain is destroyed. It's *prevention* that they're going for.

[@Engrave.Danger]

Focus on your metabolic health and it's unlikely you'll ever have to worry about it. Look into why researchers are referring to it as type 3 diabetes. 😉

[@rikuleinonen]

@@Engrave.Danger I don't even have to look that up to know that the issue is way more complicated than that. Simply not ever having heard that term is already enough to know. It'd be making headlines left right and center.

[@Engrave.Danger]

@@rikuleinonen if you rely on mainstream media, rather than the health and nutritional research community, you're unlikely to hear anything about it until there's a medication to treat it. There's a first time for everything.

[@MonkeyJedi99]

I used to be dangerously allergic to bee (and wasp, hornet, etc.) stings. I went through a long process of weekly desensitization shots, and wouldn't you know it, I have not been stung since. But I have noticed that some smaller insect 'encounters' have resulted in smaller swelling than many other people get.

[@Ryukachoo]

We wanted tiny nanomachies that patrol our bodies repairing damage and eliminating threats... Turns out he had that all along but only now can program them.

[@RokeJulianLockhart.s13ouq]

Indeed. Machines like CRISPR demonstrate this.

[@creme923]

I want nanomachines that harden in response to physical trauma

[@beckybooboo600]

I don't want nano machines! I'm actually against that idea of having machines in our bodies

[@Ryukachoo]

@@beckybooboo600 that's crazy cuz you're basically made out of them, they just happen to be made out of meat instead of metal

[@Thaythichgiachanh262]

Thank you for covering the topic so comprehensively.

[@FriendlyChemist907]

"Monkeys thay were dependent on heroin" That certainly is a sentence

[@nonsensicalhumanoid]

My first thought was, "Why the hell are there monkeys dependent on heroin?!"

[@GabrielPettier]

they just happened to be dependent, no idea how that happened 🤔.

[@IceMetalPunk]

@@GabrielPettier *Surreptitiously foot-slides the bag of heroin under the table* 🙃

[@alien9279]

Laughed at that part too 😂

[@liamcol09]

God bless those monkeys and what they do for science.

[@meinelust]

I also see the darker implementation of this tech

[@ZappyOh]

I'm convinced that dark implementation is what some at the top sees as well.

[@bertilandersson6606]

I was part of a medical test for a vaccine against nicotine 16years ago. I got paid, i was hoping it would become effective to save people from being addicted to smoking

[@cherylhuhn6180]

I take it it didn't work ?

[@thecodemachine]

Are you allergic to it?

[@thecodemachine]

I don't smoke, but this sounds very problematic. What if someone blew vape in your face, what happens? Should your health insurance have the ability to force you to get it for lower premiums?

[@chrisbbc09]

@@cherylhuhn6180a side affect is telling only half the story

[@AnonymousAnarchist2]

​@@thecodemachineOh god. I didnt even think about health insurance.

[@captainahab5522]

These vaccines seem like they can do a lot of good, but I do worry about making the immune system attack proteins that are produced inside the body, as this could lead to an autoimmune response, or chronic inflammation. I am hopeful for the vaccines to be effective.

[@henryptung]

The reach of this approach is widespread and touches many severe diseases that plague us today - cancer, Alzheimer's, severe allergies (to more than peanuts), etc. Think in many cases, the benefits will be worth it, and I see a (possibly distant) future where managing/directing the immune system becomes a cornerstone of medicine.

[@NZKiwi87]

I mean I’m sure it’s not related in any way but I took Zyban to help me quit smoking and for me it was literally a magic pill. I just completely lost interest in smoking as if by magic, after decades. It blew my mind that a pill could do that, really changed up my idea of what (some) medication could do.

[@TheMrPopper69]

iirc Zyban got banned in the uk because of purity, I might try whatever the new one is called, smoking is killing me, sigh

[@oliverkrell9290]

I'm surprised you didn't mention the recent study on personalized mrna vaccines to treat pancreatic cancer. That could could be a game changer for cancer. Unfortunately, even if it does continue to do well in trials, it will likely be so expensive that it is out of the reach of most people.

[@nikkiewhite476]

In America ya sure but other countries have universal health care not a health industry.

[@SBcard]

​@@nikkiewhite476Who do you think is going to set the price of such a vaccine? What government do you think is going to foot such a large bill? What country is notorious for stealing technology and inventors and then marketing it under one of their own? Edison? Graham Bell? Einstein? Fleming? You think they were the first to come up with their respective ideas?

[@NekoBoyOfficial]

​@@nikkiewhite476Supply or budget can also be an issue.

[@Tsumami__]

That pricing is by choice. They very purposely price life saving treatments so that most cannot afford them.

[@davidd2661]

​@@Tsumami__ no, they price it so, that the average person has to give up and give their whole house to the state...

[@RightOverWrong]

Everyone in this chat has had their eighth Covid Booster.

[@preciousmourning8310]

I don't think even the oldest people have had that many boosters yet.

[@RightOverWrong]

@@preciousmourning8310 AARP just told its 38 million members to get their 8th shot of mRNA.

[@filonin2]

@@RightOverWrong Ok. So? Does the big number "8" scare you? I know big numbers and science are scary to your kind.

[@mdb3102]

@@filonin2 Awww, you're soo cute! The pharmaceutical giants have only good intentions for mass populations, when you become rich and powerful you only desire to help others and not hinder them or extend your wealth and power. Life is scary without science and powerful corporations to help direct it's flow

[@thomasel9171]

No, there are a few of us that used our brains first.

[@DavidZMediaisAwesome]

one of these sources is missing. the webpage is blank

[@OmateYayami]

Vaccine against having fun sounds like brave new world. Great potential, good or bad.

[@thomasel9171]

Just wait for that pesky "free-will" vaccine, the government cant wait for that one!

[@Lorentari]

I came in like "Oh this is quite new and still niche" - and then Hank just starts spewing tons of different vaccines in clinical trials

[@AvacadoChan]

I'm lowkey concerned with the hypothetical ethics of substance related vaccines. Like are parents going to be able to administer these to children when they are too young to consent and take away the ability for them to experiment later in life? Or governments forcibly vaccinating prisoners, patients, etc. A lot of people have very puritan ideas about subtances and think that experimenting with or using a drug once = substance abuse. I don't think that's the case.

[@Rockzilla1122]

there is ongoing research in the field of allowing the body to 'forget' things that its set to go after- such as in type 1 diabetes where the immune system erroneously targets pancreas cells. a similar process could be used to reverse these kinds of vaccines if inhumanely applied

[@XX-tn8zw]

You sound like one of the 20 million people. Drug culture is what’s ruining American culture, even if you’re just “trying” cocaine you’re part of the problem. Thats why America has the highest single parent rate in the world.

[@mnxs]

​@@Rockzilla1122While that'd be great in itself, the issue at hand is moreso that they could be applied inhumanely in the first place.

[@VPCh.]

It reminds me of that Tintin comic where Haddock eats the pills that make any alcohols taste terrible

[@jakeyuskow8414]

looking good bud! nice to see you with all your energy like back in the old days. wish you health and long life. thanks for all you do. hope you're feeling much better

[@jessrose4301]

I know one of the researchers working on the lung cancer vaccine. I was quite tipsy at a wedding with him and I may have annoyed him with my questions 😂

[@animeartist888]

Most science-y types actually really enjoy finding people who are genuinely interested in their work. That said, being that you were "quite tipsy" the questions you asked may have been... less than ideal haha

[@jessrose4301]

@@animeartist888 he was also "quite tipsy" so he was more than happy to ramble on to my benefit.

[@Wakka144]

That’s funny, I take a monoclonal antibody injection every 2 weeks for my cholesterol currently. It is the only medication I have been prescribed that has actually worked to lower my cholesterol.

[@KjKase]

@@serena6740 lol

[@kinpandun2464]

​@@serena6740 - or you could stop being classist and ableist. Many vegans have to step down to vegetarianism or pescatarianism due to poor health from a vegan diet which cannot normally supply all needed nutrients to a human body, which is an omnivorous thinking biomachine. We evolved to be omnivorous, you absolute Karen. Also, avoiding animal product is more expensive, which is why I'm calling your heckling classist. I'm also calling it ignorant.

[@xerk2945]

​@@serena6740 Did you not watch the video? Some people gave genetically high cholesterol and it doesn't matter what kind of behavioral changes they make, their cholesterol is high.

[@Engrave.Danger]

​@@serena6740there's no legitimate evidence to support doing so and animal products are the most bioavailable source of nutrition.

[@oO0catty0Oo]

The comments sure are...something...

[@TonboIV]

If only we had a vaccine against misinformation... though of course all the idiots wouldn't take it anyway.

[@tristanmorris5646]

The crazies, the cynics, and the bootstrappers come out when you start talking about vaccines

[@IceMetalPunk]

Yep. The amount of Dunning-Kreuger, paranoia, and "my freedom is more important than your literal life" folks on a SciShow video is... depressingly higher than expected.

[@mdb3102]

@@IceMetalPunk Well you're gonna have to get people to take a vaxxine for Freedom then, that should solve it. Personally I don't care and I like my Freedom more than I like other people's lives so it doesn't bother me if they pass on or not.

[@joejanota707]

This is huge! Why do I get the feeling it will be ridiculously expensive?

[@anotheraggieburneraccount]

I can already say I am immune to pregnancy. I am male.

[@SeanLamb-I-Am]

But if that cholesterol vaccine makes the liver turn stuff into bile, how would that affect those of us who have had our gall bladders removed? The bile is stored there until its needed, and when it's not there, the excess bile is just fed into the intestines to be excreted with everything else.

[@danjoy2]

Answered your own question.

[@psdeas7530]

The excess bile would just flow through, as it does after surgery. Might make your poop yellow-y.

[@joshiahphillips9219]

I guess we just get more steatorrhea and diarrhea 😢

[@NoctisTheBogWitch]

You get the shits homie.

[@wakjagner]

You probably wouldn't be eligible for the vaccine then.... Like, what's your concern? That someone's going to force a vaccine on you?

[@edwardecl]

they can probably already do everything in this video, they just have to find a way to monetise it so you need repeat injections once a week.

[@david_1214]

Hm... just like an addict. Wasn't there a ceo of some big pharma once said they want us taking pills like chewing gum?

[@rikuleinonen]

They can't already do it, sadly, but yeah I figure it'll be monetized once the time comes.

[@filonin2]

Yeah, it's all just a conspiracy. You guys are looney tunes.

[@mdb3102]

@@filonin2 You're totally right! People who have power don't want to use it against others for their own benefit, when you get rich all you wanna do is help people. It's like a natural religion based on money

[@thomasel9171]

Fair

[@johnc.392]

Yikes possible permanent immunity to pregnancy kind of raised a red flag and reminded me of like dystopian settings... it rly sounds like a sterilizing agent haha

[@kylekirkparick426]

I appreciate being able to view these videos. Here's some love for everyone involved. This video is great, and I appreciate all the work that went into making it. Thanks guys and gals, all the love for you.

[@repkar5828]

Fun facts, I'm on a cholesterol study and there is a way to cure hypocholesterolemia for infants in the womb, I can't imagine what the price would be for it to be done though lol. I say this before watching the entire video :P

[@NavnikBHSilver]

The more we are able to engineer and craft our own body, the better. Not to the point of immortality, but at least to the point of proper control of suffering, and proper in-depth analysis of ones condition. Vaccines like these are a big part of that I feel by effectively enforcing our will upon our own biology.

[@lekhakaananta5864]

Actually immortality sounds good.

[@LiamMotes]

Good to see your in good health my man. Always love the content from this channel.

[@tstricklin4808]

I'm in no rush for any new totally safe and effective drug

[@thomasel9171]

Lol. We know how loaded "totally safe and effective" are these days

[@dtracers]

but is PCSK9 is used anywhere else? Like is this something we actually need in our body?

[@xnossisx5950]

As commented below (and from wikipedia), PCSK9 is primarily expressed in the epidermis in order to integrate cholesterol into forming skin tissue. Although decreasing PCSK9 would presumably mess with that, since treatments don't remove *all* the PCSK9 and don't get *all* of the cholesterol reabsorbed, this process remains effective enough to not cause significant issues. It's a bit of a task of threading the needle, but it seems like PCSK9 doesn't even need to be reduced very much.

[@IceMetalPunk]

Yes, so it's a good thing none of these treatments are all-or-nothing 😁 Like everything, there's a balance, and too much expression is as bad as not enough. This doesn't fully eliminate PCSK9 from your body, it just reduces it.

[@AdrianCuyubambaDiaz]

This sounds good and all, but you should make a video following up on all those interesting studies and technology advances you have covered over the years. I wanna know if any was actually successful.

[@judithdomangue9995]

I always enjoy your talks, thanks!

[@prestinryan5373]

I had heard that there were clinical trials undergoing in the UK for a Crohn's Vaccine. Not sure what has come of it though. Fingers crossed good things

[@Engrave.Danger]

Carnivore Diet. ✌️

[@Ryukachoo]

6:29 Wait doesnt this imply that neurons are not actually "dying" from plaque build up but are just being smothered, and removing the plaques reactivates them?

[@virginiamoss7045]

That's what I'm thinking.

[@IceMetalPunk]

Not necessarily. Once the plaque is removed, new neurons could be regenerating.

[@preciousmourning8310]

Alzheimer's does cause neurodegeneration, it wouldn't be able to heal the destroyed neurons. Maybe it would give the remaining ones a chance to work more normally.

[@rikuleinonen]

They're dying, but the plaques act as blockades to neuroplasticity as well as killing more neurons as time goes on. This could potentially both stop the progress of the disease as well as help in recovering most cognitive functions.

[@eSKAone-]

Teaching the body all kinds of new ways to turn against itself. What can go wrong.

[@filonin2]

How do you think the body regulates itself normally?

[@sixten7920]

@@filonin2 by balancing its natural functions, not by working against itself.

[@mdb3102]

@@filonin2 You guys are gonna screw up your whole family genome and leave only the Amish to survive with intact organic genetics. Nice job science!

[@thomasel9171]

Science is their new religion.

[@eliakimbenishchayil]

Making a vaccine for cholesterol would be counterintuitive since cholesterol is necessary.

[@Engrave.Danger]

Right? I feel like 'vaccine' is the wrong word for most of these concepts but what they'd need to get the results they seek is a treatment to prevent the arterial damage that roots the buildup in the first place. Every cell in our body is made from cholesterol, so it's no wonder we find it wherever an attempt to heal is made. No one's gonna argue that a scab is worse than having a cut that continually bleeds, yet the healing of every wound we've ever had was healed was only possible because of cholesterol, as well as every sickness we've fought off and every hormone we've produced.

[@SegmentW]

Looking and sounding great Hank! You're a *fantastic* presenter.

[@lillypilly6440]

We should be teaching people how to handle their emotions and deal with their trauma. Addiction is complex and you can't fix it with a vaccine. Perhaps if therapy was actually affordable in places like the US and Australia people could get help. It is hard work dealing with addiction and there is no quick fix.

[@nicoazevedo3581]

I bet they will be safe and effective, and the manufacturers will not be liable. You know because they believe it’s safe and effective. Medical industry puts profit over well being of patients. I love science but people who pretend science can’t be corrupted are doing science a disservice.

[@archangel996]

Not sure how I feel about giving ourselves what is basically medically induced autoimmune disorders

[@geeksdo1tbetter]

7:21 I definitely want more research on that one preventing pregnancies from continuing after conception! It would be a great addition to our current back ups for when barrier methods fail or weren't able to be used.

[@emily-rb5dk]

I would like more research on it too. I'm wondering how it will effect the future fertility of those who take it. He said it's temporary and reversible but how temporary is it and how do you think your body would react if you do have a future pregnancy? It'd be cool though if it was safe and affective

[@spiderplant]

I feel like any one of these could be an autoimmune nightmare

[@karlhenke91]

Yeah, at the beginning of the Last of Us tv show, they play a clip from a decade or three before the show, where a mycologist is talking about Cordyceps, and it kind of feels like this could be at the beginning of a show like that. Life isn't a story but this is genuinely some weird biotech.

[@emewyn]

Actually, the last example made me think otherwise. If we can essentially retrain the immune system to not attack allergens, that's one step closer to retraining it to stop attacking other parts of the body.

[@hotcreamyfart]

Oh good, nightmares beyond the human imagination.

[@gorgondork]

Fun video. Haven't watched the channel in like maybe forever. One could only hope for such a world.

[@ivytarablair]

This is AMAZING stuff!! As someone who turned out to desperately need the option of the Novavax covid protein-based vaccine because of poor reaction to the mRNA covid vax, I'm super excited to hear about all these other protein-based vaccine technologies! Both types of vaccine research have been accelerated dramatically by the pandemic, and by god it's good to think of good things coming out of something so non-good :) My mother's side of the family has a tendency toward alzheimers and I'm so encouraged that should I develop symptoms in a decade or two, there will be options that will allow me to live a mentally sharp life into triple digits :D

[@nirfz]

Had the "normal" allergy shots for 5 or 6 years every winter before allergy season started, and it didn't change anything with my pollen allergy. And since, my pollen allergies have become worse, way worse. So hearing this sounds like there's some hope still.

[@cbpd89]

I'm so sorry! Allergy shots worked very well for me, but my mother in law said they didn't work well for her either. And it's such a big time commitment to then have it not work...a vaccine would be a lot less intensive.

[@nirfz]

@@cbpd89 Exactely. But to be honest i wouldn't even mind to put in the same time effort if it would just help.

[@kennethleitch8709]

After what has happened with the covid vaccine, I who in their right mind would entertain a vaccine for anything.

[@OoLiiMiiT3D]

All these people in the comments here. One would think people learned their lesson, but here are these 4x jabbed people happy about more jabs

[@jarskil8862]

Uh. You do realize the vaccine worked? During the peak stage of Covid, 80% of hospitalized people were non vaccinated despite making only 12% of population. Ofc one could argue that reason why so many antiwaxxers got hospitalized, is that in general antiwaxxer person has unhealthy livinghabits making them more vulrnable for Covid.

[@thomasel9171]

The leftists that ignore anythign but what they are spoonfed by whoever they get their entertainment from. Not a whole lot fo critical thinking goes on there.

[@thomasel9171]

​@@OoLiiMiiT3D"science" is their religion

[@Vulpolox]

@@thomasel9171- you have just described conservatives

[@akashsinghrajput2943]

4:32 Thank you to whoever posted this clip. Brightened my day

[@majun26]

Any day now they'll come out with the one that makes you nauseous when you hear the sound of Beethoven.

[@Rebar77_real]

Cool! Do scoliosis eventually, please!

[@kaylahbkitty9691]

Frrrr

[@Dirk_Mcgurk]

hank, you are my favorite person that gives me my science news.

[@mateusjoaquim9122]

I was listening this video on the gym and I almost screamed of joy when you said vaccine for allergies

[@cjboyo]

if there was a vaccine for Post-exertional malaise it would change my life forever. I got it for the first time in years this week and it makes me unable to function 😭. Usually it only lasts 3-5 days for me but a couple of times it has set me back for MONTHS. Pray for me

[@TigersRforever]

You guys are amazing. Please keep doing what you're doing

[@MisterFanwank]

You have helped utterly redefined what a vaccine is to the point of utter meaninglessness. Congratulations. I hope you were paid well.

[@thomasel9171]

They want to make people as comfortable with them as possible. Less questions the better

[@argenteus8314]

I have my own skepticism about the substance vaccines and the potential for them to be misused, for example by pre-emptive use on children, but there's no sinister reason they're calling it a vaccine, it just literally is a vaccine. It works the same way, teaching the immune system to attack something, the target is just something other than a virus. I agree that this will complicate the discussion around vaccines, potentially in harmful ways in the case of substance vaccines as people may extend their justifiably positive attitude towards vaccines against viruses to a domain where that sentiment may be, at present, less justified (or equally dangerously, cause greater fear and doubt around vaccines against viruses, which already is growing at a concerning rate), but that's no reason to assume foul play on the part of Hank or anyone else. At worst, Hanlon's razor may apply.

[@bruv1039]

​@@argenteus8314 Well said. The term vaccine may be too broad. Results from use of one type of vaccine technology affect attitudes towards different vaccines even if they use an unrelated mechanism.

[@andreallard4844]

Thank you Hank. Nice to have you around bud😊

[@chloewatson8759]

I'd love for my immune system to not attack my gut if I ingest gluten

[@Engrave.Danger]

Gluten is trash for human health. People are better off with celiac.

[@IamGhede]

Very interesting. As a smoker who has failed to quit multiple times, I always found the hardest craving was the mental cravings. I smoke after I eat, when every I drink coffee, and to kill time at work. Chantix worked for me to stop smoking but didn't stop the mental cravings so I only made it a week without nicotine using it.

[@heathercarter9741]

I started a medication a couple months ago to help with my diabetes called terzepitide. It instantly killed all my cravings and even helped with areas of impulsiveness I'd sometimes struggle with. I've talked to other people on reddit who had similar experiences and I'm convinced it will be prescribed eventually to help people stop smoking/stop sugar cravings etc.

[@mahnamahna3252]

Well this is all terrifying

[@lvcifer-616]

How is no one screaming zombies yet? This would be great zombie movie plot

[@helenchen6308]

Oh my god some good news from the world I needed this today thank you scishow

[@manguy01]

_"Vaccines against pregnancy"_ Um... that seems like something we would never want society to become desensitized to.

[@thomasel9171]

Cmon now, these people are not long term thinkers

[@awaredeshmukh3202]

As with all topics in reproduction, informed consent is key. If someone WANTS that, that's fine. Coercion, as in all cases, is unethical and should be illegal.

[@manguy01]

@@awaredeshmukh3202 Laws and ethics are broken all the time. Especially by governments. "We'll use it for good" is a promise that's worthless once it's inevitably out of your hands.

[@awaredeshmukh3202]

@@manguy01 people do unethical things all the time, but that doesn't mean we remove the choice altogether so no one can do it ethically either. Also, doctors are among the best at maintaining compliance with privacy ethics, thanks to HIPPA. At least where I was, my parents couldn't see my health record after I turned 13, and any accompanying adults were told to step out of the room for part of the appointment so I could speak freely. We've done some terrible things with reproductive rights in the past, but that doesn't mean we take away options in case they might be abused. Birth control was first tested in massive doses on women who didn't know they were part of clinical trials, but we didn't abolish that. People have been forced to get sterilized before, but we didn't ban hysterectomies. People have been forced to abort AND to not abort fetuses-we can't ban AND mandate abortions.

[@manguy01]

@@awaredeshmukh3202 Naive. Your country isn't the only one that exists. And 100 years from now, all of those people you trust with that power will be dead. Tyranny is always just one crisis away. And this generation is already ignorant enough to say "what's wrong with eugenics?"

[@buddhabrot3]

I kind of find it problematic, especially if they become broadly available and if e.g. children are vaccinated. Hey man you want to stay and smoke a joint with your friends? -no sorry that doesn’t work on me, I was vaccinated by my parents….. My leg broke I am in so much pain. Well too bad my parents vaccinated me against opiate use disorder. Want to go to a bar? No I don‘t understand bars I can’t drink my parents were really strict…

[@vixxcelacea2778]

You're preventing the addiction part of it. Not one of those things are good to be addicted to. Are you suggesting that parents would get their kids vaccinated against alcohol so that they couldn't partake? In which case, who cares? They could still drink, they just wouldn't get much pleasure from it.

[@argenteus8314]

@@vixxcelacea2778 These vaccines wouldn't just prevent addiction. Like Hank said, they'd target the molecule before it binds to the receptor it targets, thereby preventing getting intoxicated. As for "who cares", I do. People should have the freedom to take mind altering substances if that's what they choose to do, and it's a fundamental violation of bodily autonomy for a parent to have the right to decide for someone whether they'll be able to do so as an adult.

[@rikuleinonen]

Yep this is definitely the problematic side of things, but I'm hopeful that it doesn't happen and that the consent of the party taking it is mandatory.

[@awaredeshmukh3202]

​@@rikuleinonen Which really necessitates being a legal adult. Children can be coerced into "giving consent".

[@rikuleinonen]

@@awaredeshmukh3202 it's already widely established that children's consent can't be trusted. Plenty obvious.

[@Valtrach]

To all the mice in the world; thank you for your service. We couldn't have done it without you. Good show. Thank you.

[@blargh8085]

it is so nice to see you healthy!

[@NewEnglandGaming413]

Unfortunately, a lot of people won't trust stuff like this.

[@vixxcelacea2778]

Then they can suffer with whatever they could be cured of. Usually I'm a lot more empathetic and polite with this stuff, but anti-vaccers are a special kind of upsettingly regressive and harmful group. In the case of these things, most of them will be voluntary. So if they don't want their allergies, addiction, Alzheimer's, immune issues or whatever else treated/cured, that's their problem.

[@thomasel9171]

Pretty hard to trust people that cant say what a women is, where covid came from, or the fact that herd immunity was much much better than the ten rounds of vaccines they cooked up in five minutes.

[@lady_draguliana784]

does the substance vax also reduce/eliminate the withdrawals?

[@turtlebutt711]

Glad to see you in some new videos! Hope you are doing well. We miss you!!

[@francesca9770]

Glad to see you looking well again ❤ hope all is well 🙏🏼

[@montypythonator]

Or they can cause liver failure because the reason it build up in other areas means the liver is at capacity. Wouldn't a better solution just be a better diet and exercise?

[@filonin2]

That's not how that works as he explained in the video the liver does not store the cholesterol to some sort of capacity; it converts it to bile. Maybe leave the science and doctoring to the scientists and doctors when you cannot even manage listening comprehension?

[@mdb3102]

U-tube is hiding a reply to this post. Why do all that when you can just go to your drug deale.. I mean Doctor and get a needle stabbed into your body with who knows what in it? Science is great!

[@thomasel9171]

Dont tell the leftists that, they always want a miracle panacea to cure them from their bad choices.

[@Enigma-Sapiens]

"Can We Make A Vaccine Against Smoking?" I sure hope they can and do...

[@JohnFighterman]

I hope they make it mandatory worldwide.

[@Enigma-Sapiens]

@@JohnFighterman, I do not. Everyone should have the choice.

[@thomasel9171]

​@@JohnFightermanyou want government overreach?

[@JohnFighterman]

@@Enigma-Sapiens And what choice is being given to me when I'm walking in the crowd and someone else is smoking? What choice do I have when I'm leaving a cinema or a restaurant and there's a bunch of people puffing this stuff at my face literally two feet by the exit cause "they couldn't take one more second without nicotine"? So yeah, I'd love it if this vaccine was made mandatory. Alternatively, they could make punching a smoker in the face legal whenever they light a cigarete in public without consent of everyone in sight.

[@Enigma-Sapiens]

@@JohnFighterman, You have a plethora of choices, choose wisely.

[@Chris_da_fro]

And thank you hank, for being hank. Appreciate ya bud!

[@stefanmuehlbauer7047]

Good to see you recover, Hank! Keep on rocking!

[@isa-kw4lw]

I feel like we shouldn't be reliant on vaccines. Also, there are always new and changing ideas in terms of health for things like cholesterol and fats. We are learning so much from diets and diseases that we shouldn't just go with one way without further looking at consequences. So permanently changing something without even more research and scrutiny is not going to be prudent. May lead to serious life-altering changes. And then we have to go right back to square one.

[@rikuleinonen]

And we are doing research constantly on it's effects. Diet can only go so far and has been researched to it's limits. We're going to need some new technology going forward.

[@filonin2]

Wow, it's almost like we need medical trials or something? Vaccines train your immune system how to fight and they are EXACTLY what we need to be relying on more.

[@mdb3102]

U-tube is hiding a reply to this post

[@MarijnvdSterre]

So... Does PCSK9 have other effects on the body? If it is basically only a negative one, why would our bodies make it anyway? Of course it can be a leftover, but we probably should make sure right? (if they haven't already of course) Or don't we make it, but only eat it?

[@IceMetalPunk]

It's not only a negative one; allowing cholesterol to not get absorbed can also be good for skin, as cholesterol helps form some of the skin's barrier properties. But as with everything, it must be in moderation: too little or too much PCSK9 activity are both bad. Keep in mind that this treatment is not all-or-nothing; it won't remove all the PCSK9 from your body. It just causes your immune system to attack *some* of it, leading to a reduction, not an elimination.

[@rikuleinonen]

Yep, this is what clinical trials are for.

[@NeutronStar9]

coming soon near you at Mc Donalds? "Get a cholestrol buster vaccine shot with your every "Happy Meal""

[@Youdontknowshityet]

Love you Hank! Well done🙂

[@ChrisMorton]

What happens if 'totally safe' turns out to be wrong and we accidentally create a deadly virus with long incubation period.

[@thomasel9171]

Then they will use it as a means of control.

[@Louis-kw6yk]

In Brazil they developed, or are developing one for crack/heroin, it's pretty interesting

[@cosmoplakat9549]

There's a new monoclonal antibody treatment for arthritis and it works wonders! My doggie just had his 3rd shot and is doing so much better. Unfortunately, the shot that costs $100 a month for my doggie would cost me $9,000 a month. ☹️

[@Eltoyotacorolla]

HANK!!! I know you beat cancer recently but I hadn't seen you here before (to be fair, I haven't watched the show in quite a long time) but I'M SO GLAD YOU'RE BACK!!!

[@SoirEkim]

Nature already made a vaccine for all addictions: 🍄

[@filonin2]

Mushrooms don't make you stop doing other drugs lol. WTF you on, mushrooms?

[@SoirEkim]

@@filonin2 No point in trying to inform the ignorant. The research is out there with test subject’s results to review. One simply needs to study.

[@mdb3102]

@@filonin2Don't do you research on natural substances huh? No trust in nature, only the Government and it's pharmaceutical reps

[@thomasel9171]

​@@SoirEkimyeah ive seen this guys other comments, he is just another one of those "science is my religion" types that only follows what science they peddle on cnn or colbert, whatever lame brain they get their funnies from. No actual thought involved.

[@WormholeNavigator]

I think we have lost sight of what vaccine means... and by far.

[@AndrewClunn]

By making the term "vaccine" such a politicized term, it means that it becomes an automatic sales pitch for those who "fing love science" without knowing anything about it. Simultaneously, a few laws can be passed (or edicts made via executive orders) to force sales via government agencies, even if not everyone wants them. Crazy that so many comments like this flood the "new comments" section, but all the "top comments" are from the sheep side... well not odd at all really. Big pharma owns "science" now, so shut up and stop complaining.

[@mdb3102]

U-tube hiding a reply to this post

[@WormholeNavigator]

@mdb3102 of course they are. That's what they do.

[@jeanmartin963]

we know what it means but they prefer to use this word still loaded with positiv views instead of the true word : genetic modifications. They marketed the covid vaccines, which is not a vaccine, this way, and a lot of people were OK wih it.

[@itsge2521]

@@jeanmartin963 what are you on about

[@Tockrellman]

This is great news! Keep up the positive stuff, please!

[@tinamclaughlin1991]

Happy New Year!