Can We Make A Vaccine Against Smoking?

[@TacComControl]

There's a vaccine being developed in Japan for cats that retrains their body in how they produce AIM-9 proteins. In cats, the way they are normally produced causes them to get stuck in the kidneys. The vaccine basically causes them to create a recombinant version of the protein that doesn't, which is expected to effectively double the lifespan of housecats, as the fact that their kidneys get choked up with this protein is basically a ticking time bomb, and why cats die so often from kidney failure.

[@fghsgh]

@@hugoanderkivi Having seen your other comment, your attitude of "everything can be fixed with diet" sounds a lot more "reductionistic" than "let's target specific problems we have evidence for". It almost feels like you must be trolling.

[@nothingclever7582]

Someday.. stem cells!

[@classarank7youtubeherokeyb63]

Damn, both of my cats died of kidney failure. I hope this comes soon because I already have another.

[@S8tan7]

WE NEED TO FUND THIS 40 YEAR OLD KITTIES

[@Nefariously_ignorant]

I haven't heard of that but I have an autoimmune disease called IGA nephropathy and it does exactly that which you described My body creates misshapen IGA proteins and they get stuck in my kidneys, that caused enough damage that they failed when I was 22

[@DeadZone318]

So, so, so, so, so, so, so glad to see you thriving after your cancer journey. You are a trooper, not only a survivor. Again, I am so glad to see you back to being you. Be well.

[@joshiahphillips9219]

I think this might b an old recording. Hank post Hodgkins has a beard and has nerdy Jason stathem vibes

[@maksimatic]

@@joshiahphillips9219 it’s definitely post Hodgkins Beard and nerdy vibes notwithstanding His hair alone is a dead giveaway

[@kitefan1]

@@joshiahphillips9219 Recently he got rid of the facial hair. TG. I think he just needed to grow some because he could.

[@mikamekaze]

A vaccine for my latex allergy sounds like a terrible idea. Nothing would stop me from spending all of my money at Ikea anymore

[@fuzzyspackage]

"Let only latex stand between our love" 🍆

[@lewispontremoli1219]

What does IKEA use latex in? I can't think of anything

[@Joe-Dead]

@@lewispontremoli1219 high density foams and some medium density foams, not latex necessarily but a synthetic analogue can trigger a reaction as can some similar molecules. a latex allergy can be an effin minefield, a mousepad, a seemingly innocuous object had some analogue that triggered my reaction to latex >.< hives all over my wrist and the heel of my hand.

[@gaygekko]

@@Joe-Dead I've never seen foam in IKEA products, I just built an IKEA table (IKEA NORDEN) yesterday, and it was packaged using only cardboard, paper and a couple of plastic bags 😅

[@Hexlen]

​@@Joe-DeadThe heel of yo-.... do you mean the palm of your hand???

[@bluexwings]

God, I would LOVE a vaccine for an allergy to dogs. It's a recently developed allergy, but its so disruptive. Even with inhalers and antihistamines, I can't breathe when I visit family. (Plus I love dogs!)

[@patrickmccurry1563]

At least with allergies that appeared suddenly, they can also disappear just as quickly. I was severely allergic to dogs from my late teens to my mid 30s. Now I have zero reaction to them. So keep hope alive.

[@kaylahbkitty9691]

I have a dog allergy but some breeds are easier on me then others

[@chantellekirk2993]

I became allergic to my dog when my workplace changed disinfectants to quaternary ammonium compounds. Apparently, my old dental amalgams played a role as well.

[@patrickmccurry1563]

Combination allergies are really weird. My GF developed an allergy to a spice mix, but not any of the ingredients alone.@@chantellekirk2993

[@bluexwings]

@@chantellekirk2993 That's interesting! Would you mind expanding on that a little?

[@thecolonel6394]

I recently lost my grandmother to the monster that is Alzheimer's - It's great to hear that a vaccine is being worked on that could prevent all that suffering.

[@animeartist888]

In the same boat. Watching the slow downhill struggle was horrendous; took a real toll on the entire family to watch her slowly lose herself to it. Absolutely stoked to hear that there's a real possibility of a preventative and a treatment both in one.

[@kodithebear]

The Covid VaX caused it! Wake up.

[@teelakovacs208]

I'm so sorry you lost her, these new developments could've saved both of mine as well- who knows how far-reaching this vaccine will be and how many could be saved from so much pain? My heart goes out to you

[@ajoshdoingthings541]

Currently taking care of my grandfather-in-law due to that very reason... It's really nagging on my mentals to see him degrade ever so slowly, every day a bit less of him in there...

[@aaro96live]

Sorry to hear that!

[@oliviamoore3426]

I got a mutated gene, apo-b, meaning that my body can’t get rid of cholesterol too well. 5 years ago I went into cardiac arrest due to a major heart attack. Those anti bodies are keeping me alive now, keeping my cholesterol levels relatively low

[@Wakka144]

Let me guess, you are taking Repatha? That was what I was given because no matter what I did or what I ate, my cholesterol was always high.

[@oliviamoore3426]

@@hugoanderkivi actually there are 2 types of cholesterol. Good and bad cholesterol. I went on meds without the anti body at first and changed my diet and I exercised even more than I did before. It got my cholesterol levels down to about 4. I used to have a value of 6. The. I got the anti body combined with eating well and exercising and I got my value down to 1.4. In my case the meds are working and they are keeping me live, due to the mutated gene I need that anti body to keep my cholesterol down. Had I been a regular person I’d be fine with regular heart attack medicine exercise and a good diet, but because of my faulty gene, just exercising, eating right and taking regular meds will not get my values down enough. You’re factually incorrect. I’d suggest that you read up about familial hyper cholesterolemia

[@oliviamoore3426]

@orenelbaum1487 thank you. My mutated gene makes what Hugo said completely irrelevant.

[@oliviamoore3426]

@@ReinerEvans thank you. This 100%

[@oliviamoore3426]

@@Wakka144 yep, I’m on repatha, it really worked miracles. Ah, so you also have familial hypercholesterolemia?

[@xerk2945]

I read the thumbnail as "We've got a wax for that" and I was really confused about why they were trying to pass peanut butter off as some kind of wax.

[@Jp138233]

That is exactly the same thought process I went through for a moment

[@blogdesign7126]

Vax I saw that given how politically loaded that word has been in the past 4 years with COVID-19.

[@CWorgen5732]

I saw Tax, pretty confused until I saw a vial and syringe.

[@Dradeeus]

Any one of these sounds like it'd be a massive boon to humanity. I'd really love that Alzheimer's one in my lifetime.

[@oliviamoore3426]

This 😃

[@TheWetdonkey]

Dementia in general is more often seen in correlation with infections, like getting pneumonia after having the flu. So in a way a partial vaccine already exists :)

[@bennyb.1742]

Yeah, I'd be pretty hyped on that. Family history, personal history of TBI, bad run of the Cov', ect. I've got all the warning factors and I'm terrified.

[@seeleunit2000]

That would sound wonderful.

[@psdeas7530]

YES PLEASE, FFS!!!!!

[@Potatoe-f6u]

If I had Alzheimer's, I'd want that vaccine NOW. I know it's important to test things thoroughly, but it's such a terrible disease and it's always ultimately fatal, so I'd jump on anything that offers a chance of making such a significant difference.

[@psdeas7530]

RIGHT?!?!

[@modestoca25]

They didn't test COVID vaxxes throughly and look at all the problems that have arisen from it

[@ShainAndrews]

Living is fatal.

[@clogs4956]

@@ShainAndrewssarcasm? Obviously you’ve never visited a specialist dementia care home…

[@DawnDavidson]

Absolutely. My mother is currently living in a dementia care facility. I want that vaccine YESTERDAY.

[@Thaythichgiachanh262]

Thank you for covering the topic so comprehensively.

[@MonkeyJedi99]

I used to be dangerously allergic to bee (and wasp, hornet, etc.) stings. I went through a long process of weekly desensitization shots, and wouldn't you know it, I have not been stung since. But I have noticed that some smaller insect 'encounters' have resulted in smaller swelling than many other people get.

[@smivan.]

While the substance abuse vaccines like the anti-nicotine ones are interesting in concept, I feel like they (at least as discussed in this video) are sidestepping the core problem of what frequently causes substance abuse - things like stress and anxiety. Even if a smoker takes a nicotine vaccine they will still need to seek out *something* to substitute the calming effect that smoking provides, so chances are they'll just hop from one addiction to some other addiction, or otherwise switch to a different kind of problematic lifestyle - without additional therapy in parallel to the immune treatment that is.

[@animeartist888]

I think you're jumping the gun on when people would want these. Think of how many people you know that smoke. Statistically, at least some of those are past the point in their life where they need that outside calming effect, but are stuck still smoking becaus eof how addicted they are. I worked at a gas station, sold many cigarettes to older folk and young alike. The old ones always told me not to ever try it simply because stopping is so difficult. Those are the sort of people who would want this vaccine, not those who just started smoking because something in their life went really wrong and want to forget for awhile.

[@wickast4941]

Yeah but they could get addicted to something that won't give them lung cancer. Seems like an upgrade even if it's not a perfect solution.

[@smivan.]

Oh don't get me wrong, I'm not saying this vaccine is a bad idea, I'm just saying that it may require most people more than only the vaccine to get out of a substance abuse situation in a healthy way.

[@gavshox]

Agreed. I don't like the way they frame substance abuse.

[@mariannetfinches]

I hadn't thought of that aspect. That makes sense. It's excellent to see this technology develop, and humanity as a whole needs to work on metal health

[@The_Cyber_System]

All of these are awesome. I'd love to just have a vaccine for my allergies instead of my 5-year extremely expensive immunotherapy. It's definitely working and I appreciate it, but it's expensive and tiresome, and the more options the better. Also sucks that my family has a genetic risk of heart disease, despite being healthy in every other way - reducing risk with a vaccine would be amazing!

[@Chris-hx3om]

" I'd love to just have a vaccine for my allergies instead of my 5-year extremely expensive immunotherapy." And this is why it'll all be squashed. Why would a company produce a $10 shot that you only need once a year (even 6months) when they can have you on a $1000 a month 'treatment plan'? Name one disease that has been cured/eliminated in the last 40 years with a single (or even a series) of vaccines. Plenty of (expensive) treatment plans available that weren't available 40 years ago....

[@Yourfriendinlearning]

What is Immunotherapy? A pill?

[@nirfz]

I'm curios, as i had a 5 year treatment for pollen allergies too a while ago. (But mine didn't help sadly) What do you mean by extremely expensive? (I am from central europe, and while we always complain at the state of our health care system, the only thing it cost me was the time and effort to get to the doctor each week and wait for 30 minutes after the shot, to see if there is an anaphylactic shock.)

[@cbpd89]

I'm a couple years into my immunotherapy for allergies. It is a real life changer for me to be able to function in the spring/summer/fall, but a single vaccine would be miraculous! For folks who don't know, it is building up a tolerance to the things you are allergic to by getting frequent small doses, usually in the form of a shot or something edible if it's a food allergy. You start out small and work your way up to higher doses till you reach a "maintenance dose" and it should minimize or eliminate allergic reactions. It doesn't always work, and for folks in the US it is pricey. I think it initially cost like $500 and then is an additional $10 per dose for every visit because insurance usually won't cover it. If it's a food allergy and the therapy works, you may have to be very consistent in eating that food every day forever basically. I know someone who, after years of building up a tolerance had their peanut allergy come back because they stopped eating a couple every day.

[@razzar508]

Would love to have my immune system stop attacking my thyroid

[@dianahuang4991]

I was shocked to learn recently and confirmed w a pharmacist that thyroid medication is the top dispensed meds if not #1… I had no idea how common thyroid disfunctions are… 🥺 let’s hope it’s on the list of fixes 🌈🌈🙏

[@nemudere]

same

[@Aa-ron01]

I've always thought it'd be cool to back up our DNA when you're healthy and if anything goes wrong later in life you have a record or whatever dna was damaged, like a big reset for whatever cells aren't doing what they're supposed to be doing, like cancers, Alzheimer's, coeliac disease, leukaemia, ms, battens disease and so on.

[@murkje]

This seems like a great idea for a sci-fi story, if it's not a trope already :)

[@gsreads]

DNA has to be updated in all the cells??!!

[@TukPsyche]

I believe this is part of why people bank their stem cells

[@RokeJulianLockhart.s13ouq]

​@@gsreads You might be surprised by how achievable that is - at least, converting the DNA in a sufficient amount of cells to save the patient's life.

[@Praisethesunson]

I bet big pharma is looking into that but for something stupid and marketable like curing baldness.

[@marcylynn3703]

My grandma had Alzheimer, I'm so scared of getting it aswell. Good that is being investigated I hope I live to see the day it's curable

[@xionmemoria]

It likely won't ever be curable. A destroyed brain is destroyed. It's *prevention* that they're going for.

[@Engrave.Danger]

Focus on your metabolic health and it's unlikely you'll ever have to worry about it. Look into why researchers are referring to it as type 3 diabetes. 😉

[@rikuleinonen]

@@Engrave.Danger I don't even have to look that up to know that the issue is way more complicated than that. Simply not ever having heard that term is already enough to know. It'd be making headlines left right and center.

[@Engrave.Danger]

@@rikuleinonen if you rely on mainstream media, rather than the health and nutritional research community, you're unlikely to hear anything about it until there's a medication to treat it. There's a first time for everything.

[@ivytarablair]

This is AMAZING stuff!! As someone who turned out to desperately need the option of the Novavax covid protein-based vaccine because of poor reaction to the mRNA covid vax, I'm super excited to hear about all these other protein-based vaccine technologies! Both types of vaccine research have been accelerated dramatically by the pandemic, and by god it's good to think of good things coming out of something so non-good :) My mother's side of the family has a tendency toward alzheimers and I'm so encouraged that should I develop symptoms in a decade or two, there will be options that will allow me to live a mentally sharp life into triple digits :D

[@oliverkrell9290]

I'm surprised you didn't mention the recent study on personalized mrna vaccines to treat pancreatic cancer. That could could be a game changer for cancer. Unfortunately, even if it does continue to do well in trials, it will likely be so expensive that it is out of the reach of most people.

[@nikkiewhite476]

In America ya sure but other countries have universal health care not a health industry.

[@SBcard]

​@@nikkiewhite476Who do you think is going to set the price of such a vaccine? What government do you think is going to foot such a large bill? What country is notorious for stealing technology and inventors and then marketing it under one of their own? Edison? Graham Bell? Einstein? Fleming? You think they were the first to come up with their respective ideas?

[@NekoBoyOfficial]

​@@nikkiewhite476Supply or budget can also be an issue.

[@Tsumami__]

That pricing is by choice. They very purposely price life saving treatments so that most cannot afford them.

[@davidd2661]

​@@Tsumami__ no, they price it so, that the average person has to give up and give their whole house to the state...

[@jakeyuskow8414]

looking good bud! nice to see you with all your energy like back in the old days. wish you health and long life. thanks for all you do. hope you're feeling much better

[@kylekirkparick426]

I appreciate being able to view these videos. Here's some love for everyone involved. This video is great, and I appreciate all the work that went into making it. Thanks guys and gals, all the love for you.

[@anyascelticcreations]

Hank sounds downright chipper today. I guess surviving a near death experience will do that to a person.

[@丫o]

lol Hank sounds positively radiant nearly _every_day. That's Hank for ya!

[@anyascelticcreations]

@@丫o He does. Even when he's ranting he does. 😂 But tonight there seems to be an extra air of happiness.

[@everetthancock2043]

I mean, he's not entirely out of the woods, but yes a great victory.

[@Arthur-vo9kt]

What happened?

[@everetthancock2043]

@@Arthur-vo9kt his blood cancer has entered remission

[@Ryukachoo]

We wanted tiny nanomachies that patrol our bodies repairing damage and eliminating threats... Turns out he had that all along but only now can program them.

[@RokeJulianLockhart.s13ouq]

Indeed. Machines like CRISPR demonstrate this.

[@creme923]

I want nanomachines that harden in response to physical trauma

[@beckybooboo600]

I don't want nano machines! I'm actually against that idea of having machines in our bodies

[@Ryukachoo]

@@beckybooboo600 that's crazy cuz you're basically made out of them, they just happen to be made out of meat instead of metal

[@bertilandersson6606]

I was part of a medical test for a vaccine against nicotine 16years ago. I got paid, i was hoping it would become effective to save people from being addicted to smoking

[@cherylhuhn6180]

I take it it didn't work ?

[@thecodemachine]

Are you allergic to it?

[@thecodemachine]

I don't smoke, but this sounds very problematic. What if someone blew vape in your face, what happens? Should your health insurance have the ability to force you to get it for lower premiums?

[@chrisbbc09]

@@cherylhuhn6180a side affect is telling only half the story

[@AnonymousAnarchist2]

​@@thecodemachineOh god. I didnt even think about health insurance.

[@teddytaylor5315]

Thanks

[@francesca9770]

Glad to see you looking well again ❤ hope all is well 🙏🏼

[@archangel996]

Not sure how I feel about giving ourselves what is basically medically induced autoimmune disorders

[@captainahab5522]

These vaccines seem like they can do a lot of good, but I do worry about making the immune system attack proteins that are produced inside the body, as this could lead to an autoimmune response, or chronic inflammation. I am hopeful for the vaccines to be effective.

[@henryptung]

The reach of this approach is widespread and touches many severe diseases that plague us today - cancer, Alzheimer's, severe allergies (to more than peanuts), etc. Think in many cases, the benefits will be worth it, and I see a (possibly distant) future where managing/directing the immune system becomes a cornerstone of medicine.

[@SegmentW]

Looking and sounding great Hank! You're a *fantastic* presenter.

[@Eltoyotacorolla]

HANK!!! I know you beat cancer recently but I hadn't seen you here before (to be fair, I haven't watched the show in quite a long time) but I'M SO GLAD YOU'RE BACK!!!

[@akashsinghrajput2943]

4:32 Thank you to whoever posted this clip. Brightened my day

[@geeksdo1tbetter]

7:21 I definitely want more research on that one preventing pregnancies from continuing after conception! It would be a great addition to our current back ups for when barrier methods fail or weren't able to be used.

[@emily-rb5dk]

I would like more research on it too. I'm wondering how it will effect the future fertility of those who take it. He said it's temporary and reversible but how temporary is it and how do you think your body would react if you do have a future pregnancy? It'd be cool though if it was safe and affective

[@NZKiwi87]

I mean I’m sure it’s not related in any way but I took Zyban to help me quit smoking and for me it was literally a magic pill. I just completely lost interest in smoking as if by magic, after decades. It blew my mind that a pill could do that, really changed up my idea of what (some) medication could do.

[@TheMrPopper69]

iirc Zyban got banned in the uk because of purity, I might try whatever the new one is called, smoking is killing me, sigh

[@FriendlyChemist907]

"Monkeys thay were dependent on heroin" That certainly is a sentence

[@nonsensicalhumanoid]

My first thought was, "Why the hell are there monkeys dependent on heroin?!"

[@GabrielPettier]

they just happened to be dependent, no idea how that happened 🤔.

[@IceMetalPunk]

@@GabrielPettier *Surreptitiously foot-slides the bag of heroin under the table* 🙃

[@alien9279]

Laughed at that part too 😂

[@liamcol09]

God bless those monkeys and what they do for science.

[@LiamMotes]

Good to see your in good health my man. Always love the content from this channel.

[@helenchen6308]

Oh my god some good news from the world I needed this today thank you scishow

[@IamGhede]

Very interesting. As a smoker who has failed to quit multiple times, I always found the hardest craving was the mental cravings. I smoke after I eat, when every I drink coffee, and to kill time at work. Chantix worked for me to stop smoking but didn't stop the mental cravings so I only made it a week without nicotine using it.

[@heathercarter9741]

I started a medication a couple months ago to help with my diabetes called terzepitide. It instantly killed all my cravings and even helped with areas of impulsiveness I'd sometimes struggle with. I've talked to other people on reddit who had similar experiences and I'm convinced it will be prescribed eventually to help people stop smoking/stop sugar cravings etc.

[@TigersRforever]

You guys are amazing. Please keep doing what you're doing

[@VPCh.]

It reminds me of that Tintin comic where Haddock eats the pills that make any alcohols taste terrible

[@mateusjoaquim9122]

I was listening this video on the gym and I almost screamed of joy when you said vaccine for allergies

[@andreallard4844]

Thank you Hank. Nice to have you around bud😊

[@nirfz]

Had the "normal" allergy shots for 5 or 6 years every winter before allergy season started, and it didn't change anything with my pollen allergy. And since, my pollen allergies have become worse, way worse. So hearing this sounds like there's some hope still.

[@cbpd89]

I'm so sorry! Allergy shots worked very well for me, but my mother in law said they didn't work well for her either. And it's such a big time commitment to then have it not work...a vaccine would be a lot less intensive.

[@nirfz]

@@cbpd89 Exactely. But to be honest i wouldn't even mind to put in the same time effort if it would just help.

[@Dirk_Berserk]

hank, you are my favorite person that gives me my science news.

[@joejanota707]

This is huge! Why do I get the feeling it will be ridiculously expensive?

[@gorgondork]

Fun video. Haven't watched the channel in like maybe forever. One could only hope for such a world.

[@LukaSauperl]

Yo Mr. Green, you look amazing! I would never have guessed you've had health complications! Keep up the great work and stay strong! 🥰

[@AdrianCuyubambaDiaz]

This sounds good and all, but you should make a video following up on all those interesting studies and technology advances you have covered over the years. I wanna know if any was actually successful.

[@kyokazuto]

*CHAPTERS* 1:04 Cholesterol 3:42 Substance (ab)use 5:36 Alzheimer's 6:45 Pregnancy 8:07 Allergies

[@filonin2]

ADHD

[@kyokazuto]

@@filonin2 ?

[@Wakka144]

That’s funny, I take a monoclonal antibody injection every 2 weeks for my cholesterol currently. It is the only medication I have been prescribed that has actually worked to lower my cholesterol.

[@KjKase]

@@serena6740 lol

[@kinpandun2464]

​@@serena6740 - or you could stop being classist and ableist. Many vegans have to step down to vegetarianism or pescatarianism due to poor health from a vegan diet which cannot normally supply all needed nutrients to a human body, which is an omnivorous thinking biomachine. We evolved to be omnivorous, you absolute Karen. Also, avoiding animal product is more expensive, which is why I'm calling your heckling classist. I'm also calling it ignorant.

[@xerk2945]

​@@serena6740 Did you not watch the video? Some people gave genetically high cholesterol and it doesn't matter what kind of behavioral changes they make, their cholesterol is high.

[@Engrave.Danger]

​@@serena6740there's no legitimate evidence to support doing so and animal products are the most bioavailable source of nutrition.

[@Tockrellman]

This is great news! Keep up the positive stuff, please!

[@OmateYayami]

Vaccine against having fun sounds like brave new world. Great potential, good or bad.

[@thomasel9171]

Just wait for that pesky "free-will" vaccine, the government cant wait for that one!

[@prestinryan5373]

I had heard that there were clinical trials undergoing in the UK for a Crohn's Vaccine. Not sure what has come of it though. Fingers crossed good things

[@Engrave.Danger]

Carnivore Diet. ✌️

[@NavnikBHSilver]

The more we are able to engineer and craft our own body, the better. Not to the point of immortality, but at least to the point of proper control of suffering, and proper in-depth analysis of ones condition. Vaccines like these are a big part of that I feel by effectively enforcing our will upon our own biology.

[@lekhakaananta5864]

Actually immortality sounds good.

[@kennethleitch8709]

After what has happened with the covid vaccine, I who in their right mind would entertain a vaccine for anything.

[@OoLiiMiiT3D]

All these people in the comments here. One would think people learned their lesson, but here are these 4x jabbed people happy about more jabs

[@jarskil8862]

Uh. You do realize the vaccine worked? During the peak stage of Covid, 80% of hospitalized people were non vaccinated despite making only 12% of population. Ofc one could argue that reason why so many antiwaxxers got hospitalized, is that in general antiwaxxer person has unhealthy livinghabits making them more vulrnable for Covid.

[@thomasel9171]

The leftists that ignore anythign but what they are spoonfed by whoever they get their entertainment from. Not a whole lot fo critical thinking goes on there.

[@thomasel9171]

​@@OoLiiMiiT3D"science" is their religion

[@Vulpolox]

@@thomasel9171- you have just described conservatives

[@blargh8085]

it is so nice to see you healthy!

[@ianmatos7823]

A couple months back there was a breakthrough for crack vaccines that made waves in Brazil, it would have been nice for this news to have been included in the video to give more visibility for international researches!

[@DragoNate]

to the title, NO. that's not how that works. to your opening statement, NO. did you not see the amount of... _opposition_ over the past 5 years?

[@AvacadoChan]

I'm lowkey concerned with the hypothetical ethics of substance related vaccines. Like are parents going to be able to administer these to children when they are too young to consent and take away the ability for them to experiment later in life? Or governments forcibly vaccinating prisoners, patients, etc. A lot of people have very puritan ideas about subtances and think that experimenting with or using a drug once = substance abuse. I don't think that's the case.

[@Rockzilla1122]

there is ongoing research in the field of allowing the body to 'forget' things that its set to go after- such as in type 1 diabetes where the immune system erroneously targets pancreas cells. a similar process could be used to reverse these kinds of vaccines if inhumanely applied

[@XX-tn8zw]

You sound like one of the 20 million people. Drug culture is what’s ruining American culture, even if you’re just “trying” cocaine you’re part of the problem. Thats why America has the highest single parent rate in the world.

[@mnxs]

​@@Rockzilla1122While that'd be great in itself, the issue at hand is moreso that they could be applied inhumanely in the first place.

[@Ryukachoo]

6:29 Wait doesnt this imply that neurons are not actually "dying" from plaque build up but are just being smothered, and removing the plaques reactivates them?

[@virginiamoss7045]

That's what I'm thinking.

[@IceMetalPunk]

Not necessarily. Once the plaque is removed, new neurons could be regenerating.

[@preciousmourning8310]

Alzheimer's does cause neurodegeneration, it wouldn't be able to heal the destroyed neurons. Maybe it would give the remaining ones a chance to work more normally.

[@rikuleinonen]

They're dying, but the plaques act as blockades to neuroplasticity as well as killing more neurons as time goes on. This could potentially both stop the progress of the disease as well as help in recovering most cognitive functions.

[@Chris_da_fro]

And thank you hank, for being hank. Appreciate ya bud!

[@stefanmuehlbauer7047]

Good to see you recover, Hank! Keep on rocking!

[@SeanLamb-I-Am]

But if that cholesterol vaccine makes the liver turn stuff into bile, how would that affect those of us who have had our gall bladders removed? The bile is stored there until its needed, and when it's not there, the excess bile is just fed into the intestines to be excreted with everything else.

[@danjoy2]

Answered your own question.

[@psdeas7530]

The excess bile would just flow through, as it does after surgery. Might make your poop yellow-y.

[@joshiahphillips9219]

I guess we just get more steatorrhea and diarrhea 😢

[@NoctisTheBogWitch]

You get the shits homie.

[@wakjagner]

You probably wouldn't be eligible for the vaccine then.... Like, what's your concern? That someone's going to force a vaccine on you?

[@RightOverWrong]

Everyone in this chat has had their eighth Covid Booster.

[@preciousmourning8310]

I don't think even the oldest people have had that many boosters yet.

[@RightOverWrong]

@@preciousmourning8310 AARP just told its 38 million members to get their 8th shot of mRNA.

[@filonin2]

@@RightOverWrong Ok. So? Does the big number "8" scare you? I know big numbers and science are scary to your kind.

[@mdb3102]

@@filonin2 Awww, you're soo cute! The pharmaceutical giants have only good intentions for mass populations, when you become rich and powerful you only desire to help others and not hinder them or extend your wealth and power. Life is scary without science and powerful corporations to help direct it's flow

[@thomasel9171]

No, there are a few of us that used our brains first.

[@meinelust]

I also see the darker implementation of this tech

[@ZappyOh]

I'm convinced that dark implementation is what some at the top sees as well.

[@Valtrach]

To all the mice in the world; thank you for your service. We couldn't have done it without you. Good show. Thank you.

[@majun26]

Any day now they'll come out with the one that makes you nauseous when you hear the sound of Beethoven.

[@Lorentari]

I came in like "Oh this is quite new and still niche" - and then Hank just starts spewing tons of different vaccines in clinical trials

[@eSKAone-]

Teaching the body all kinds of new ways to turn against itself. What can go wrong.

[@filonin2]

How do you think the body regulates itself normally?

[@sixten7920]

@@filonin2 by balancing its natural functions, not by working against itself.

[@mdb3102]

@@filonin2 You guys are gonna screw up your whole family genome and leave only the Amish to survive with intact organic genetics. Nice job science!

[@thomasel9171]

Science is their new religion.

[@Rebar77_real]

Cool! Do scoliosis eventually, please!

[@kaylahbkitty9691]

Frrrr

[@FloozieOne]

This was fascinating. I could really use that cigarette shot. puff, puff, hack hack. 55 years of smoking certainly hasn't done my lungs any good although I'm still young enough (71 y/o) that it would be great not to have to worry about getting cancer any more.

[@judithdomangue9995]

I always enjoy your talks, thanks!

[@MisterFanwank]

You have helped utterly redefined what a vaccine is to the point of utter meaninglessness. Congratulations. I hope you were paid well.

[@thomasel9171]

They want to make people as comfortable with them as possible. Less questions the better

[@argenteus8314]

I have my own skepticism about the substance vaccines and the potential for them to be misused, for example by pre-emptive use on children, but there's no sinister reason they're calling it a vaccine, it just literally is a vaccine. It works the same way, teaching the immune system to attack something, the target is just something other than a virus. I agree that this will complicate the discussion around vaccines, potentially in harmful ways in the case of substance vaccines as people may extend their justifiably positive attitude towards vaccines against viruses to a domain where that sentiment may be, at present, less justified (or equally dangerously, cause greater fear and doubt around vaccines against viruses, which already is growing at a concerning rate), but that's no reason to assume foul play on the part of Hank or anyone else. At worst, Hanlon's razor may apply.

[@bruv1039]

​@@argenteus8314 Well said. The term vaccine may be too broad. Results from use of one type of vaccine technology affect attitudes towards different vaccines even if they use an unrelated mechanism.

[@lousielouise8716]

This is an interesting change in the framework. Immunizations have usually been for public health for communicable disease. People accept that we need to get one because it protects others. Pretty straightforward. Is it really the same thing to have an injectable treatment that isn't strictly an immunization? Should we be using the same word for those things? Take substance abuse, for instance. The incentives to use those drugs are not just chemical dependency, but a complex blend of social and economic factors. A single injectable treatment won't change those things, but you can bet it will be happily covered by insurance. I don't know. I wouldn't call these treatments the same things as we call immunizations which have been so life saving.

[@EricaGamet]

Don't we call the shot we get for tetanus a vaccine? I just usually call it a shot, but I equate "shot" to "vaccine" for the most part.

[@lousielouise8716]

@@EricaGamet Very true! In the case of tetanus, though, it's still an immunization against a pathogen. I guess my point is that this emergent technology is riding the coattails of safe and effective immunizations, and is being marketed the same way. One-and-done type deal. In reality, they're a much more complicated technology which just also happens to be injected.

[@EricaGamet]

@@lousielouise8716 Admittedly, I know very little about tetanus or vaccines in general. I love the idea of "vaccines" for dependency, but I'm sure there are many issues that will arise... whether we call them vaccines, etc. I find the notion of "just take X and all your troubles are over" solutions to be a little rose-tinted. It will be interesting to see where it all goes!

[@dtracers]

but is PCSK9 is used anywhere else? Like is this something we actually need in our body?

[@xnossisx5950]

As commented below (and from wikipedia), PCSK9 is primarily expressed in the epidermis in order to integrate cholesterol into forming skin tissue. Although decreasing PCSK9 would presumably mess with that, since treatments don't remove *all* the PCSK9 and don't get *all* of the cholesterol reabsorbed, this process remains effective enough to not cause significant issues. It's a bit of a task of threading the needle, but it seems like PCSK9 doesn't even need to be reduced very much.

[@IceMetalPunk]

Yes, so it's a good thing none of these treatments are all-or-nothing 😁 Like everything, there's a balance, and too much expression is as bad as not enough. This doesn't fully eliminate PCSK9 from your body, it just reduces it.

[@TheStaggpaul]

Hey there Hank! I love how your hair is coming in after your treatments. Looks a bit curly now. Have you found that your hair changed?

[@teresaellis7062]

I really like the line "Sheep in wolves clothing." I am so happy to be living in this time period where I get to see solutions to long time problems coming out, or are on the way!

[@jeanmartin963]

"long time problems" not really. Alzheimer, tobacco or drugs addiction (except alcohol), cardiac arrest and cardiovascular diseases, allergy, cancers... are emergent diseases that did not exist 150 years ago, they were extremely rare.

[@jessrose4301]

I know one of the researchers working on the lung cancer vaccine. I was quite tipsy at a wedding with him and I may have annoyed him with my questions 😂

[@animeartist888]

Most science-y types actually really enjoy finding people who are genuinely interested in their work. That said, being that you were "quite tipsy" the questions you asked may have been... less than ideal haha

[@jessrose4301]

@@animeartist888 he was also "quite tipsy" so he was more than happy to ramble on to my benefit.

[@repkar5828]

Fun facts, I'm on a cholesterol study and there is a way to cure hypocholesterolemia for infants in the womb, I can't imagine what the price would be for it to be done though lol. I say this before watching the entire video :P

[@dacisky]

I've read they are working on some for c diff and h pylori and ibd. Pretty nice.

[@WILDWILLXD]

No thanks, I choose to smoke. It brings me back to my childhood and I'll trade time for that. I grew up in a big city and my parents raised me in a bubble but whenever I visited my grandparents who lived in the middle of nowhere, I got to actually live. Now I live everyday and I'm not worried about when it ends, I'm happy. My grandpa was a full blooded creek indian and grew up on a farm, he smelt like cigars and dirt.

[@lvcifer-cloverfield]

How is no one screaming zombies yet? This would be great zombie movie plot

[@isa-kw4lw]

I feel like we shouldn't be reliant on vaccines. Also, there are always new and changing ideas in terms of health for things like cholesterol and fats. We are learning so much from diets and diseases that we shouldn't just go with one way without further looking at consequences. So permanently changing something without even more research and scrutiny is not going to be prudent. May lead to serious life-altering changes. And then we have to go right back to square one.

[@rikuleinonen]

And we are doing research constantly on it's effects. Diet can only go so far and has been researched to it's limits. We're going to need some new technology going forward.

[@filonin2]

Wow, it's almost like we need medical trials or something? Vaccines train your immune system how to fight and they are EXACTLY what we need to be relying on more.

[@mdb3102]

U-tube is hiding a reply to this post

[@DavidZMediaisAwesome]

one of these sources is missing. the webpage is blank

[@lillypilly6440]

We should be teaching people how to handle their emotions and deal with their trauma. Addiction is complex and you can't fix it with a vaccine. Perhaps if therapy was actually affordable in places like the US and Australia people could get help. It is hard work dealing with addiction and there is no quick fix.

[@Chris-hx3om]

Really great to see you looking like your old self...

[@automaticmattywhack1470]

The drug Chantix is the reason I quit smoking. I lost a foot due to smoking and I kept smoking. Chantix really helped me.

[@SlavaSesh]

So basically, you want to remove the ability for people to make personal choices? If someone wants to smoke or use drugs, neither you or I should be telling them that they can't, or forcing their choice with a vaccine, which is what would happen to people if they want to be accepted to homeless shelters. Just because you don't like having fun doesn't mean other people shouldn't be allowed to.

[@UnluckyLilly]

Hey. I just want you to know, you’re talking nonsense. The words you’re saying make no sense

[@argenteus8314]

@@UnluckyLilly What they're saying makes perfect sense. Just because you disagree doesn't make it nonsense.

[@UnluckyLilly]

@@argenteus8314 no one is taking away your ability to smoke. No personal choices are being lost. A homeless shelter isn’t for everyone in the world. Murders aren’t allowed at homeless shelters. I’d assume a homeless shelter would probably not accept a klan member either. Also these aren’t the same type of vaccines for preventing the spread of disease. No homeless shelter is going to force you to take them. They are speaking nonsense

[@rikuleinonen]

No, this comment is just plain objectively wrong. That's not what they want and it's very clearly stated in the video. They want people to have the choice to help *themselves* quit. Not to forcibly give people the vaccine.

[@rikuleinonen]

@@argenteus8314 it does not. It is indeed nonsense, or at least objectively incorrect which is pretty much nonsense.

[@kathyh4804]

Not everything can be fixed with a shot!!!!! Not even Covid obviously

[@CometAura]

The covid vaccine isn't meant to stop you getting it, its to reduce the severity of the symptoms so you dont f ing drop dead from it.

[@edwardecl]

they can probably already do everything in this video, they just have to find a way to monetise it so you need repeat injections once a week.

[@david_1214]

Hm... just like an addict. Wasn't there a ceo of some big pharma once said they want us taking pills like chewing gum?

[@rikuleinonen]

They can't already do it, sadly, but yeah I figure it'll be monetized once the time comes.

[@filonin2]

Yeah, it's all just a conspiracy. You guys are looney tunes.

[@mdb3102]

@@filonin2 You're totally right! People who have power don't want to use it against others for their own benefit, when you get rich all you wanna do is help people. It's like a natural religion based on money

[@thomasel9171]

Fair

[@tinamclaughlin1991]

Happy New Year!

[@DrewTNaylor]

This video was genuinely mindblowing, I never knew you could use vaccines in these ways.

[@heyspookyboogie644]

If it meant we could still do things without the negative health consequences I’d be all for it. But using it for behavioral based things sounds like a REALLY REALLY bad precedent to set.

[@mahnamahna3252]

Well this is all terrifying

[@Enigma-Sapiens]

"Can We Make A Vaccine Against Smoking?" I sure hope they can and do...

[@JohnFighterman]

I hope they make it mandatory worldwide.

[@Enigma-Sapiens]

@@JohnFighterman, I do not. Everyone should have the choice.

[@thomasel9171]

​@@JohnFightermanyou want government overreach?

[@JohnFighterman]

@@Enigma-Sapiens And what choice is being given to me when I'm walking in the crowd and someone else is smoking? What choice do I have when I'm leaving a cinema or a restaurant and there's a bunch of people puffing this stuff at my face literally two feet by the exit cause "they couldn't take one more second without nicotine"? So yeah, I'd love it if this vaccine was made mandatory. Alternatively, they could make punching a smoker in the face legal whenever they light a cigarete in public without consent of everyone in sight.

[@Enigma-Sapiens]

@@JohnFighterman, You have a plethora of choices, choose wisely.

[@Sdnaurs]

There is (sort of) a daily pill for alcoholism that makes one very nauseous upon ingestion of alcohol.

[@wsn111]

There hasn't been a moment since I was a teen were my many skin allergies haven't made me miserable. I would love to have access to this in my life time!

[@nicoazevedo3581]

I bet they will be safe and effective, and the manufacturers will not be liable. You know because they believe it’s safe and effective. Medical industry puts profit over well being of patients. I love science but people who pretend science can’t be corrupted are doing science a disservice.

[@AlphaGamerDelux]

Substances used in substance abuse mimic neurotransmitters (They are structurally similar enough to fit into the receptors)... if one were to become immune to the effect of the substances would one also become immune to the normal neurotransmitters? Idk if I would take that risk.

[@Wyvernnnn]

That would get spotted instantly during trials

[@10kanutt]

Yeah, seems dicey. But they're aware of that risk, and likely looking for those kinds of side effects to make sure they don't cause more harm than good. Or perhaps it's one of those treatments where the dangers of that side-effect are worth the risk vs the risk of continued substance abuse. At the end of the day, monoclonal antibodies don't induce any memory cells in the immune system, so any application of them as a "vaccine" would be a temporary thing. Some people may risk a temporary side effect if it meant breaking them out of a cycle of substance abuse.

[@Wyvernnnn]

Google FDA

[@AnonymousAnarchist2]

​@@WyvernnnnWe have issues spotting mood changes in animals that are held in captivity for clinacal trials. mostly because thier moods range from really bad, to terrible. So for mood dependant addiction no, we would not notice. And look at that, the trials for Nicotine are the most promising... the one thats strictly a mood dependancy.

[@mrdonetx]

Not necessarily depending on how closely it resembles the body's molecule. Just like there is strep bacteria all in/on your but are helpful and your body ignores them but doesn't ignore the bad strains. There are numerous strains of bacteria good for you. A lot of illegal drugs have some similar compounds but the majority actually trigger your body to produce more of the transmitter rather than replacing it. For drugs to be effective they would need to bond with the receptors much stronger than the natural ones. Mostly the natural ones bond much better.

[@michellecoleman5577]

that's all very exciting, but I can't help but be afraid of our human tendency to get ahead of ourselves and figure out 50 years and 100's of lives later that we really needed that enzyme.

[@blueberry_dance1246]

I'm not an expert in hormones, but I think that I might have some ability to put your mind at ease. For the first one, our diets have rapidly changed in the past 100-200 years, far faster than evolution can keep up with. Chances are, that hormone was evolved for a very different diet, and messing with it probably would make the hormone levels closer to what they should be for the modern diet and lifestyle. Also, it only decreases the hormone by 33%, which could be very helpful to people with cholesterol issues, but hopefully not too dangerous if we really do still need that much. The Alzheimer's hormone has two explanations for it, both stemming from the fact that the force of selection is weaker as you get older, as when you're young you have all of your children ahead of you but if you even make it to old age, you have few to no children in your future. The simpler explanation is that the end of life selection is too weak to get rid of the Alzheimer's hormone (or it might even be selected for: sexual aggression is a symptom of Alzheimer's). The slightly weirder explanation is that the hormone does something useful early in life (which is selected for strongly), then causes Alzheimer's in later life (which is selected against relatively weakly). However, any ill effects from that possibility could be mitigated by administering the vaccine later in life, as with the shingles vaccine. I'm also slightly worried about the potential pregnancy vaccine. I imagine that it would be mostly the preserve of women who never wanted children for at least the first couple of years.

[@angrypastabrewing]

Like out tendency to get ahead of ourselves with AI development and its uses

[@filonin2]

Better not do anything cause it might be scary or bad in a century, maybe.

[@thomasel9171]

In a world where science is corrupted by ideology to the point doctors will destroy childrens lives forever because they "were born the opposite sex" i wouldnt trust any of this.

[@aliengeo]

I've been hearing about similar vaccines for celiac disease and type 1 diabetes (both autoimmune conditions) in the works and I'm hopeful that future generations will be able to look back on some of these as old-timey diseases nobody gets anymore.

[@Engrave.Danger]

Celiac is a blessing. There's nothing advantageous about eating those grains, unless someone's just trying not to starve to death.

[@lazarus_3116]

I was reading a book recently. And inside the book was the famous author John Green. And i read abou him and it said that he has a brother named Hank. NIce. He was a straight A student, it wrote. And then I began thinking. Hank Green, that sounds familiar. Went on google found you, and then I found John listed as you sibling. I have been watching you for almost two years and never connected the dots even though your brother was featured on your channel multiple times. I just think it is funny that i never noticed.