Cancer Revealed: How the Immune System Sees and Destroys Tumors, with Jeffrey Weber

On June 16, 2015, Jeffrey S. Weber, M.D., Ph.D., discussed the cancer immunity cycle and the importance of antigen release and presentation to maximize the potential of immunotherapies.
Jeffrey S. Weber, M.D., Ph.D., is a senior member, director of the Donald A. Adam Comprehensive Melanoma Research Center of Excellence (MRCoE), and professor in the department of oncologic sciences at Moffitt Cancer Center. As a tumor immunologist and immunotherapist, he focuses on translational clinical trials, including the development of novel trials in melanoma. His laboratory interests are in the monitoring and characterization of T cell responses in patients with cancer, and the establishment of in vitro models to facilitate the understanding of how immune modulation via abrogating and activating antibodies amplifies adaptive immunity in patients. Dr. Weber earned his Ph.D. in molecular cell biology from The Rockefeller University in 1979 and his M.D. from New York University Medical Center in 1980. Dr. Weber has published more than 100 articles in the top peer-reviewed journals in his field.
This webinar, which is part of the Cancer Research Institute's Breakthroughs in Cancer Immunotherapy Webinar Series, was generously supported by Amgen. It is offered free to the public and feature informative updates from leaders in cancer immunotherapy, followed by a moderated Q&A. For more information on this webinar, or to register for upcoming webinars, please visit www.cancerresearch.org/webinars.

[@rejanemarcoux3845]

J'ai moi-même été opérée pour un mélanome au stade 4. en 1980 J'ai ensuite été traitée par immunothérapie avec des comprimés sur une période de 5 ans. On m'avait avertie que je serais traitée par immunothérapie à titre d'expérience, et j'ai accepté. Tous les mois j'avais des prises de sang et j,étais surveillée de très près par la Société Canadienne du Cancer. On ne connaissait pas cependant les effets secondaires du médicaments. Tout s'est très bien passé et ça fait maintenant 45 ans. Merci à la Société Canadienne du Cancer.

[@jeffreylancaster3219]

Superb resource. Excellent clear and concise presentation.

[@bettyboob7167]

Very kind of you. Thank you

[@LonDanDoc]

Thanks Professor

[@Shadow-bx8ri]

Very well explained....thanks a lot sir.

[@abicumaranuthamacumaran1544]

Brilliant. Thanks!

[@mahatai9904]

This is brilliant! Thank you so much. I watched it some time ago and will definitely watch again to remember things. Thanks.

[@CancerResearchInstitute]

Glad you enjoyed it!

[@myyube81]

Very nice and through presentation.....thank you.

[@user-sc7lg1fy7i]

if the combination treatment can shorten the course of the treatment dramatically, then hopefully the cost will be the same or less..

[@russelmiller7311]

Immune checkpoint inhibitors relies on the mechanism explained in the video to boost the immune system and fight against tumor cells. Thanks for the detailed explanation laid a good foundation on the understanding of immune system.

[@egs8545]

Thank you for making this, very clear.

[@hildairena3564]

dr.Weber, would you mind explain how the NY-ESO-1 works as an immune based therapy?

[@nahidghisel549]

Thank You very much for Explanations I appreciate that Sir

[@CancerResearchInstitute]

Thanks for watching, Nahid!

[@juancarloslopez-corbalan]

Great video...

[@CancerResearchInstitute]

Thanks for watching!

[@carlettagoodrich-mann1377]

Tumor cells have many influencers . Suppressor cells T cells Immune cells check point proteins. Antigens are expressed on tumors. Viral antigens please express the treatment modality. What role do INTERFERON’S play ? Interleukins 1 -2 IL 10 IMmunoglobins express their interactions in tumor necrosis.

[@treplay8846]

Any progress? This was 8 years ago

[@aureliabono5123]

About car t cell therapy: the nasty cytokine, are they released by t-cell or by killed neoplastic lymphocytes?

[@munkh-undrahganzorig8596]

20:00 so interesting !

[@ericbarritt304]

Is something happening to the T & B cells long before a tumor appears? Maybe a foreign invasion like some bad cancer infection blood that activates the immune system. Maybe it changes the immune cells. Just wondering. I had a very strange neurologist do an unscheduled emg on me in a very remote room in a hospital. That was in 1995. He stuck the needle into the palm of my thumb. When I got back to the office the gauss was full of dark blackish blood. Today 2021 I have adenocarcinoma hhs. My ascending colon was removed. They also found the cancer in my lymph nodes. I'll be starting chemo in July.

[@erichankins4892]

Can cancer cells ever reverse some of their mutations? Do they just turn faulty genes on/off? How do they change back and forth from being a differentiated cancer cell to being a cancer stem cell. I don't understand some points.

[@mohammadelsharr1423]

which immune cell is first to appear against cancer cells NK cells or cytotoxic T cells ? thanks

[@marciawelleslesley3090]

Z cells

[@CanaleYourGame]

According to en.m.wikipedia.org/wiki/Natural_killer_cell If the cancers projects MHC1 than the answer is T cells

[@CanaleYourGame]

Well great you asked two years ago... Ups

[@stefanignat4460]

Any new Information in 2023?! Any new discoveries that has potential?!

[@CancerResearchInstitute]

Hi there, We are constantly updating our website and our social media with the latest immunotherapy news! Visit our website to take a look: www.cancerresearch.org

[@carlettagoodrich-mann1377]

NEO-antigens CDA T cells passenger cells. Blocking PDL AAMD PDL1 head to head trials can I Google clinical studies ? Where can I find this data. Growing TIL cells sounds promising for tumor receptors.

[@CancerResearchInstitute]

Hi there- you can learn more about immunotherapy by visiting our website! www.cancerresearch.org/en-us/immunotherapy/what-is-immunotherapy

[@richmohhtc]

new cancer patient share Cancer Revealed: How the Immune System Sees and Destroys Tumors, with Jeffrey Weber

[@eyebrowdimension]

Then why do doctors recommend chemotherapy?

[@CancerResearchInstitute]

Hi! While immunotherapy is an effective treatment for many cancers and many patients, it is not yet an effective treatment for everyone. Oncologists make treatment recommendations based on the latest data and results from various studies, factoring in multiple variables about the patient and their cancer (genomic testing, biomarkers, progression, metastases, etc.). The field is changing rapidly and there are new studies coming out every week. Guidelines for treatment are revised continuously and adapted to each individual patient. We're excited about the future, including combination therapies that may combine chemotherapy and immunotherapy or surgery and immunotherapy. Learn more on our website: www.cancerresearch.org

[@lll5610]

In the book Leviticus 🐝God says we are to detest shell fish🦉maybe this is why

[@kogiemoodley6557]

I have bladder cancer, I took chemo which was not successful doc put on keytruda immunotherapy treatment ,tumors shrunk after 20 treatment 1 tumor swelled up ,Please advise

[@CancerResearchInstitute]

Hi there, Please visit our website for more information regarding immunotherapy treatments for bladder cancer: www.cancerresearch.org/immunotherapy/cancer-types/bladder-cancer

[@Omom-zn9nf]

Sir my mother detect cancer in 2015 as liver cancer sprade in left lung and ascites Dr said approximately she live one month but I found some hearb and I started to give my mother now she is fine and healthy. I wish to discuss with you more with medical reports of my mother petscan I wish to send you

[@RickLewis]

May I ask what herb?

[@jameshopkins3541]

QUE FUE ES ESE HORRIBLE RUIDO AL CAMBIAR DIAPOSITIVA???

[@mdizhaan1066]

What I s non hodgkin lymphoma it's a type of cancer

[@CancerResearchInstitute]

To learn more about lymphoma and immunotherapy, please visit this webpage: www.cancerresearch.org/immunotherapy/cancer-types/lymphoma

[@vxf603]

What causes cancer? What is cancer? That's what you need to talk about first. You don't know the cause you can't heal it.

[@canadiankin]

Body rot and white verses red blood cell war.

[@serg3y]

Check wikipedia/youtube, this video is long enough, if it started with what is a human, and what is DNA, and what is a cell.... He is presenting results of leading studies.

[@michaelbelt8768]

As a person diagnosed with the disease and chose to use natural therapy instead of conventional therapies, I learned that cancer is series of viruses that mutate and overwhelm the immune system. When those viruses grow every 120 days. Kill the virus by trying to maintain a ketogenic diet that promote the accelerators and limit the suppressor during the natural process called apotosis.

[@aleksandarantonijevic813]

what causes liver?

[@lamaripiazza5226]

Cancer is caused by cells that divide to much or uncontrollable.Cancer can be caused by smoking or radiation or uvray