Celiac Disease Pathogenesis (Described Concisely and in Detail)

[@evanmilby6995]

Probably the best animatic about Celiac disease

[@simonmandel2621]

Thank you for this video! I work in an Immunology Lab and am giving a presentation about coeliac disease to my team. This has given me a lot of help articulating it, so thank you 😊

[@joc4709]

Amazing. I'm a student dietitian and this was presented more clearly than a recent lecture.

[@DamjanManevski]

I'm a Nutrition and Biomedicine Master and wow, what an explanation! Really good job mate

[@dr.noir27]

i appreciate the time you spent on making these animations

[@BenDabber]

Playback speed at 1.5 is about right.

[@ryanmichaelhaley]

I like 1.25

[@aliceeleonor2911]

Awesome video! The pathophysiology is explained on point. Thanks!

[@howtomedicate]

Seriously, amazing videos. I am a 6th year Medical Student and this videos still help me! You even inspired me to make a channel on my own! I make YT videos on medical topics. And today I posted a video about celiac disease as well. Thanks for all the knowledge bombs, and thanks for the inspiration. Keep it up, So will I!

[@physiopathopharmaco4190]

Awesome 😎. Best of luck to you

[@Edward-ko9pn]

It's amazing what us humans know about how the body works

[@physiopathopharmaco4190]

It truly is amazing

[@brightdz2403]

Nope we know less than 1 percent and every now and then we know more new things about that 1 percent.

[@petersosa268]

@@brightdz2403 That “1%” is a whole lot though lol

[@brightdz2403]

@@petersosa268 I said less than 1 😂😂😂😂

[@Enthalpy--]

Laugh at neuroscience and genomics

[@AngryAmygdala]

You guys are the best, up there with Osmosis. Please, keep up the great work. I am fully supporting you.

[@physiopathopharmaco4190]

Thats so kind of you - thanks for all your support and all the best!

[@mariaveresova8169]

fantastic video, thank you very much

[@beautybeautyqueen6522]

Thank you for such an amazing explanation♥️♥️

[@angusmack.2202]

Thank You too much 4 this! You really saved my project!! Very Clear Explanation :D

[@petertriantafillou8058]

Great explanations Thanks so much!

[@thatsverycool8264]

Just a quick question about AntiTTG, where do these come from? Are they due to mutations in B cell genes? Do people without celiac also have them?

[@alysa4968]

how was all of this going on inside me for 19 years and I didn't even know it

[@alysa4968]

also... really great video.

[@physiopathopharmaco4190]

Thanks for the comment, hope you're feeling better after going gluten free

[@shamshahussein883]

Alysa gluten free reverse able

[@asmajama7947]

Thank you so much for this amazing explanation🙏🏽

[@physiopathopharmaco4190]

You're so welcome!

[@xbieberlicious]

really nice

[@tanmaymurur2377]

Great video 👌 Isn't dermatitis herpetiformis also a manifestation of celiac disease owing to cross reaction of antibodies?

[@jamyd7849]

Yes it is

[@lazymedic5988]

Brilliant..plzz upload videos on bone pathology..ua awsome

[@physiopathopharmaco4190]

Do you have a particular pathology of the bones in mind and Ill get started

[@lazymedic5988]

PhysioPathoPharmaco it would b great if u upload video on detailed pathology of osteoarthritis n osteoporosis with complications..plzzz

[@giorgiobozzoni8681]

thank you very much for your videos from Italy. i have a question for you and i hope you have time to answer me becuase this doubt stopped me to keep going studying. what happen to those who dont suffer coeliac disease, once the gliadin is inside the lamina propria of the gut? how do they break down gliadin to get its amminoacids? i mean gliadin goes intact into the lamina propria also for those who dont suffer coeliac disease, so they should have a way to digest it and get the AA. many foods have many allergen inside that cause immune response to those who actually havve food allergy for that specific allergen. but if i dont have allergy and i eat the food with allergen, and the allergen goes intact in the lamina propria without being digested by gut enzyme, how do i get its amminoacid anyway? my body wont waste them? thank you again

[@physiopathopharmaco4190]

There is decreased absorption for those with celiac disease due to morphological changes including Villous blunting and decreased surface area. Some don’t have these morphological changes despite having positive antibodies on a blood test. These may not have issues with absorption.

[@xleo4096]

Helps a lot!

[@Elbuho17]

BEAUTIFUL !

[@asmaarady2829]

thank you ,it was awesome

[@زهراءحسينجباررفيش]

رحم الله والديك

[@khankaseparhnahagee9530]

Scientist should do something for this

[@grizzy315]

khan kase parhna ha gee yes, but there is not enough awareness for most scientists to research on the disease. its sucks but hopefully in the long run treatment is more effective.

[@matthewhill6949]

Great video. How did you illustrate this? What programs did you use?

[@leavesofchange]

Does secalin get deamidated by tissue transglutaminase?

[@GauravSingh-tx4dt]

Sir can you please share the source of information..

[@physiopathopharmaco4190]

Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.

[@fuscaotunado1337]

Can you give us the references you used? @PhysioPathoPharmaco

[@physiopathopharmaco4190]

Much of that came from the Review article "The Role of Gluten in Celiac Disease and Type 1 Diabetes" published in the journal Nutrients.

[@fuscaotunado1337]

@@physiopathopharmaco4190 tks

[@meryamlazrak1329]

thnk you sir

[@sondosalmadhlouh7872]

thank you!

[@bio366geethasankar7]

🙏❤️

[@sheilamacpherson4948]

Way above me.

[@nj2147]

Thanks a lot..😊😊

[@physiopathopharmaco4190]

Most welcome 😊

[@هدىعلي-ش1ز]

That was great thanks!

[@physiopathopharmaco4190]

Thanks glad it was helpful

[@Shilaan111]

great one thank youuu:))

[@physiopathopharmaco4190]

You’re welcome

[@MoustacheAlexander]

Celiacs need to use hookworms. They put my celiac into full remission.

[@tahiransari3917]

Helpful

[@physiopathopharmaco4190]

Thank you Tahir

[@NadineBotterman]

Is it true that your intestines FULLY heal after a glutenfree diet?

[@physiopathopharmaco4190]

Yes but it can take up to at least a year.

[@khankaseparhnahagee9530]

Celiac is also spreading v quickly in the world like corona

[@wem3121]

So the things that get the Disease started is a genetic predisposition of HLA II molecules AND an overexpression of CXC3 cytokines. Is that how it starts? And what about LT that escaped tolerance? Oh is that all those mechanisms at once? Thanks a bunch for the video. Im grateful 😍

[@physiopathopharmaco4190]

Yes several genetic factors can increase the risk - DQ2 and DQ8 and CXC3 cytokine expression

[@Cr7goat.85]

Could you speak a little bit slower next time?

[@khawla-ez6cv]

Thanks you

[@physiopathopharmaco4190]

You’re very welcome Khawla- all the best to you. 😀

[@UmeshKumar-xu2ng]

Sir i have celiac disease and suffering from lack of sleep is this normal?pls reply🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🏻