Cell and Molecular Biology: Protein Insertion into the ER Membrane

Learn how transmembrane proteins import into the endoplasmic reticulum (ER) and embed themselves in the ER bilayer.
Visit www.drawittoknowit.com to find more tutorials, quiz questions and an interactive drawing pad!

[@kayliamiller5489]

Thank you so much! This was EXTREMELY helpful to understanding the topology, especially the multipass membrane-spanning domains.

[@paturulekharamani9710]

The best explanation i ever had on this topic

[@DownSouth954]

Clear and concise. Thank you for you time and effort!

[@mikiahstorm8138]

Thank you! This was difficult to understand in my lecture, as diagrams and explanation weren't as clear as here. I appreciate this :)

[@김밍뭉]

Thank you! I was in difficulty to study this part because my professor had... VERY SAD lecture skill. Now I can help other friends in study group :D

[@ibz2836]

very helpful video thanks

[@zhenzipeng5056]

Thanks very much！Extremely helpful for me to understanding. The drawing is outstanding.

[@ecthescientist]

This was sooo helpful! Thank you very much!

[@arijitbiswas6478]

Thank you so much.

[@juandiegodistefano335]

That analogy was so accurate

[@virens16]

Oh sir at last find someone who guide me to understanding anatomy thank you very much sir Sir why not you upload development biology ,and biochemistry video once again thank you very much sir God bless you 🤗

[@peachlife5118]

GOD BLESS YOU

[@avalonp6469]

I love the drawings!! thank you for a great explanation!

[@flight-at-the-speed-of-light]

Such clear explanation ! Thanks a lot ❤

[@nichapatp1928]

Thank you soooo much! This helps me a lot

[@kajalpandey6071]

thank you very much. helped a lot

[@aidanmcfarlane9261]

Rarely comment on these types of videos but wow, great explanation. My textbook was quite confusing but this made it really easy to understand.

[@pigeonlove]

That's a really original comment...for someone who takes the effort to say they rarely comment on these types of videos

[@gingertea659]

You're a genius that was a helpful method thank you now i get it

[@lf8737]

Great visuals. Thank you.

[@nelsonayre8651]

Finally makes sense. Thanks!

[@foggy551]

Finally a great explanation! :)

[@amanpreetkaur1533]

thank you very much!!! it was so well explained

[@zainabkhanzainab296]

Plz clear poly topic integral membrane protein in detail

[@sandalbasotra5765]

This is the best.

[@Kevinsu1997]

Really helpful, thanks

[@girikowshik3724]

Thank you Sir

[@khadija500]

Thank you so much ! This is really well explained !

[@drawittoknowit]

Many thanks for the kind words!

[@monurajput-od5qz]

Zzzzzhuuhh

[@Ps3COD4Fan]

Amazing!

[@ayesha7404]

Is it the same process for when the protein is inserted into the plasma membrane?

[@lifewithanime2192]

In step 2, why internal signal sequence did not stop transfer of nascent peptide through translocon ?

[@animelover8801]

is there a difference between type I and type III MPs? The textbook seems to define Type I as single pass cytoplasmic C terminal, Type II as single pass cytoplasmic N terminus, Type III as single chain multipass and Type IV as assembly of multiple chains

[@laur_bk]

For multipass proteins - does the c terminus always end up at the cytosol side?

[@keerthireddy01]

❤️❤️

[@ZezimaTruth]

confused :(