Glycosylation and Glycoproteins

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[@Daahlern]

This is the best, most concise and to the point presentation, I've ever seen

[@danabenjamin3864]

Wow I wish you were my professor. Something I was supposed to learn during the week you taught me in 12 minutes. Thank You. Not everyone has the ability to teach but you got that talent.

[@AKLECTURES]

Thank you so much for your kind words Dana!

[@tim47396]

What are you studying?

[@zidouri7956]

You are honestly a legend

[@irenecordero9775]

Mi profesor de la universidad nos ha mandado el video y he entendido todo mejor en 12 minutos que en 1 hora. THANK YOU

[@alexisjones419]

I've never heard anything explained this clearly in my life!

[@kennethlopez6334]

If I would have discovered AK early in the semester my grade would have been much higher. Thank you so much.

[@-..l]

Made more sense then my instructor and reading books. You are god-send thank you for this valuable information. Now I understand what Glycosylation actually is.

[@mariapayro2523]

Wow, best class video I've seen in my entire life. Thank you very much

[@Wandelaarke]

Much appreciated by humanity!

[@smittywerbenjagermanjensen9281]

this was absolutely amazing, im researching hep b for a highschool internship at a biotech lab and i wanted to know more about the actual concepts we were exploring and this video was absolutely perfect. thank you so much this answered all of my questions (:

[@Muuip]

Excellent presentation! Excellent teacher! Thank You, much appreciated!

[@negarniknam3652]

It was awesome absolutely helpful, I have tried watching all the step 1 lectures none could help me to understand as much as I did after watching this tutorial!

[@ramikassar]

you give people like me where proper education cannot be found a new hope, Thank you very much for your effort I hope i can repay you one day

[@daisywillis5982]

I am currently taking biochemistry and cell biology at the same, and it is kicking my butt. But you seem to have a video for every concept and topic that I am/have been confused about. Your videos are extremely helpful!

[@priyadarshinighosh6461]

Day by day I'm turning into a huge fan of yours sir! Thanks for all the awesome video lectures , it's helping me a lot .

[@mihirmakwana9012]

True💯🔥❤

[@stephenodora4203]

Very good explanation of MBChB biochemistry I'm really amazed by this lecture

[@liewhaoyu1761]

Wow, this is the most wholesome content I've ever seen on youtube.

[@TheMegaKidBoy]

Very compact with information and very clear to understand! Thanks man! :D

[@jernixlim302]

Really a big thank you i finally understood this topic ! please upload more lecture videos

[@nadimaarahimii4073]

👍.I found two video ak videos really helpful and also another channel biology and genetics just it is new and has made one video about DNA topology supercoiling concept it really helped me.

[@rudolfgyorkei9558]

clean resolution, I thought you were in my room

[@Muzee123]

I finally understood this topic after 6 years I only watch ur lectures now no need of big and heavy books 👍

[@mirelabilali7394]

Omg so well explained, thank you so much!! My teacher left out so many important details that would have helped me understand this.

[@jchae9820]

man ur the best actually... A LIFE SAVER

[@sumanagupta2452]

very helpful! you're lecture was actually too in depth, but the writing on the white board help me understand the general concepts, and the rest filled in the gaps. Thank you!!

[@abefromansausagekingofchic6480]

You're lucky if you thought this was too in-depth!

[@emmamerry6222]

In my 3rd year college exams and freaking out, this helped so much, thank youuu!

[@nikolavideomaker]

Damn studying this in the 3rd year. You've got it easy

[@krokodilledertasche8412]

absolutly amazing! thank you very much for your efforts :) a real legend , pls keep on!

[@andreasolano3071]

Your videos are the best! Thank you for making them.

[@piyushpreetomgogoi6218]

This video is life saving

[@patiencechepkorir5596]

To remember where the linkages occur:;: En-(N)doplasmic reticulum...N linkage glycosylation g-OL-gi apparatus...(OL).. O-linkage glycosylation

[@운동이좋아-x4z]

I appreciate your lecture, sir

[@JKhan-ef4ri]

This lecture is priceless for me. God bless u, u r legend

[@kennypk-t3j]

Very well explained.

[@pallavi07100]

amazing.. such a difficult topic explained so simplisticaly..

[@isabelluo8752]

wonderful explanation

[@RehamSalama98]

Thank you so much. Your videos have been helpful to me since high school and now that I'm a sophomore in college and I find your videos very clear and straight to the point which reinforces the concepts I learn at school. I have one question though, why is it only Asparagine that is capable of forming the -N linkage, aren't Glutamine & Arginine -NH2-containing amino acids as well?

[@Sm1l3y805]

Thank You, very helpful! definitely helped me understand glycosylation

[@sallyro9539]

God!! Amaaaaazing and clear! Thank youuuu soo much sir✨

[@lifeshortsostandtall]

Omgee you saved my life thank you so much, and waay better than Khan Academy. I mean, they're good, but anyway

[@Sorrskywalkerr]

omg, saved mine aswell

[@marceloabatti6945]

lifeshortsostandtall is

[@gloriagmail3561]

khan academy is for physiology but nothing else

[@pinkiekiss587]

@@gloriagmail3561 Bullshit, I learn from khan academy and get 90s in my exams at university. They are so thorough that it just sticks. Stop bitchin y'll.

[@youssefmakram4913]

wow great explanation

[@richswanger2042]

Thank you so much, keep that spirit

[@frodobilbo918]

thanks, was quite helpful. But sadly not enough. Can you make a video on the actual process of the formation of the N-glycosylation in detail? That would be awesome!

[@RohitPant04]

The cis face of a Golgi stack is the end of the organelle where substances enter from the endoplasmic reticulum for processing, while the trans face is where they exit in the form of smaller detached vesicles. Incase, anyone else was revising too!

[@mihirmakwana9012]

🔥😂💯

[@yair4616]

you're the best

[@Vishal5171]

Thanku sir .. love the way of explanation

[@StayExtraVirgin]

Keto Diet for the win ! Sugar Carbs in excess are the cause for inflammation and most diseases fasting is the best reset

[@gengchengyang5338]

very good talk

[@akandwanahoallan5252]

awesome video, all is perfect. thumbs up

[@nadaalmangosh873]

I really appreciate it❤

[@drumandball]

This is one of the only videos of yours that you dont sound angry in hahaha

[@amanimohammed2185]

YOU ARE THE BEST!!!! Thank you so much

[@ehtx]

Well done

[@周园-s2j]

bravo thank you so much

[@luthfifadhlillah6487]

Clearly to the point! Like it, Keep it up :)

[@applewhite9403]

Thank u so much sir ,keep up the good work

[@krishcielkalata3073]

you're so awesome!!!!

[@rikwil21]

Super helpful, thank you!

[@hayaalmly6083]

Thank you for the nice explanation. Quick question that pertains to the conses seq.. Why the arbitrary X (AA) must not be proline?

[@xchg_107]

Very helpful, thank you!

[@mrniceguy4277]

I guess there are to things that can be misintepreted. 1st, the formed protein doesn't just move to the Golgi complex. Instead, it is packed into a versicel and activly transported to there. 2nd, the transmembrane proteine are already formed into the membrane and then transportet as a vesicle to the Golgi or cell membrane. So they are not put into it later...

[@Jefftaylor2114]

this is brilliant

[@prashantj50]

THANKS A LOT AK

[@Abhirawks]

Nicely explained

[@kiss45978]

very helpful !!!!! Thank you!!!

[@vaibhavkumar8541]

Based on ncert..very nice

[@w.almansori466]

"Legend"

[@jawadal-dyab7253]

Applause!!

[@358gin]

Thanks for the great video! Is it right to say that "a N-glycosidic bond is formed in one step"? (for a multiple choice question)

[@ranjeethabm7002]

Amazing sir 😊

[@rokayaahmad7617]

From master degree student's thank you

[@ilhemdr7220]

thank you sooo much ... it's a very helpful video

[@mr-wc3xq]

thank you so much

[@Berfin-n7r]

Thank youuuu🙏❤️

[@lelabb4110]

the GOAT of solving the unknown one pays thousands to schools to achieve ..do you erase the white board, thats painful to imagine!

[@yuliakehayova3574]

Great video. However, collagen is glycosylated to form an O-glycan and that occurrs in the ER so that bit where you say O-linked glycosylation only occurrs in the Golgi apparatus is not 100% true.

[@elliechaabi9753]

Thanks

[@JonathanWirth-c3p]

Have a good day productions ideas 😀

[@witheredsky1255]

as one of the major significance of carbohydrate is protein modification, attachment of carbohydrates gives functionality to the proteins, so are those oligosaccharides used during protein modification, obtained from our diet? the glucose intake, does our cell polymerize the monosaccharide into oligosaccharide?

[@wardalyasmeeb7035]

Thats helpful video

[@AKLECTURES]

Ward Alyasmeeb awesome

[@gabriellayao2671]

thank you!!!

[@MASKerAYD]

q: when the golgi complex modifies the proteins by adding carbohydrates through the o-glycosidic bond, it doesn't "modify" the work the ER already has done by changing the N-bonds to O-bonds right? By modify you mean it adds new o-bonds?

[@aprilhicks3474]

wow!

[@ishitajainhehehe]

Lysine is also glycosylated right during synthesis of collagen 2:30 ?

[@orvaghazi9248]

manyyyy thanks ....I was wondering about how organic molecules become glycosylated inside cells .. so could you please wright me an explanation about it or could you tell me where can i find the answer please

[@petermerageas9710]

Question: Im looking at my BRS Biochemistry book and it says that both N-linked and O-linked bonds are both the ER and the Golgi. Why does the video say that O-Linked happens only in the Golgi?

[@chongjingxuan2660]

Good lecture . However it’s a little bit uneasy for non native speaker of English . As sometimes you included some words that we don’t understand.

[@derekcarter2645]

If the asparagine allows for glycosylation because of the amino group then could you do the same thing with glutamine since it also has an amino group? And then with regards to the other kind of glycosylation why wouldn't other amino acids like tyrosine, glutamate, and aspartate also work since they have hydroxyl groups available in their structures just like serine and threonine.

[@jenniferpaltiyan-bugtong8680]

Sir, may I know the references you used for this lecture? Thank you.

[@yannishamani1834]

Jen 01 your mom

[@ahmedpatel7220]

Maybe textbook of biochemistry thomas devlin

[@giselle8867]

I believe he uses the textbook by Berg, et al called Biochemistry. I say this because I have this textbook and use it as reference and notice sometimes his language is exactly the same as the book. It is also a very well regarded book for biochem.

[@BakrAli10]

Only asparagine can form a N-glycosidic linkage? What about glutamine? Glutamine has the exact same functional group so why it can’t form N-glycosidic linkage??

[@samiyanaaz5006]

Sir why X is any amino acid but not proline???

[@annie4880]

Excuse me, so the O-glycosylation is nothing but the "continuation" of the N-glycosylation opered by the Golgi apparatus?

[@kingsexo9559]

just wanted you to know that you saved my sorry ass thank uuuuuuu

[@cooperdodd9788]

Does O-linked occur at the cis golgi?

[@paigehalverson3358]

king

[@soheilza3244]

Isn't asparagine an amino acid ? So why should it be made by the ribosome of the endoplasmic reticulum... isn't the ribosome for making protein not the amino acids?

[@ishitajainhehehe]

These are post translation modifications which are done after peptide is made and hence done by ribosomes

[@yaralbrahem9762]

I have a child who suffers from this mutation, is there a cure?

[@insafmarwatiah7945]

We need French translator please?!!

[@doctorsdoctors5721]

👍👍👍

[@maleen5990]

Can more than one carbohydrates attach to s single protein ??

[@yikichong]

Malee N yes, sometime it is more than 2, 3 and more.

[@AmalAlodainiP5]

Thaaaaaaaaaaaaaaaaaaanks

[@alexajazmin7559]

I love you

[@mihirmakwana9012]

Love u too❤😍😍