Cell Biology | DNA Replication 🧬

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Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about DNA Replication. We hope you enjoy this lecture and be sure to support us below!
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[@shan8613]

The best part about his style of teaching is the storyline and narrative visuals. He doesn’t just point out and explain, he makes you UNDERSTAND the whole biological process regardless how abstract the concept is. He paints a picture that you will remember, and that in itself, is a true talent. 💯

[@shunfun5576]

Ok

[@shunfun5576]

Beautiful

[@ayomideawodeyi3025]

@@shunfun5576 it is in,i

[@egbejustine]

Certainly

[@enzamamahmed277]

Yes,

[@aayushitiwarii]

I need his enthusiasm for my studies!!!! His passion for Medical Science is contagious and so his happiness while explaining concepts. How even the most complex of topics start appearing lucid. Such a kind soul... I owe him so much !!

[@n-acetylglucosaminephospho7584]

+1

[@ornulusoundeffects6423]

Chup karo aur parho baaji

[@meggielino-.-]

I know this is an old video but I really want to say thanks. I'm literally going to cry omg I always hated biochemistry in my veterinary medicine studies but I finally got it and your video is so detailed yet so understandable. I searched forever to find videos that explain this topic/ Genetics and include all the information they test us on. Your channel is like a gift from god. Especially with the clinical references omg it's so helpful to connect the dots. I`m so happy, sitting in my room crying happy tears. I never knew biochemistry could be enjoyable but watching you explain everything is so much fun. Asking "me" questions and knowing the answers repeading the stuff by watching and being able to remember it omg you saved me. Lots of love from Germany

[@SM-or2rm]

I am currently preparing for my veterinary medicine exams - i couldnt agree more! I owe this guy my whole degree!

[@twelvenine6449]

I'm at a point where I watch your videos for fun. you make learning so easy and fun, thank you so much!

[@aishaabid292]

Exactly, same.

[@dalwaalinizi3145]

okay aiden......

[@ashokbunkar8952]

Hii

[@lmtrevino7]

Same :P

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[@cameronhetzler5407]

I'm a dentist. Passed my boards years ago and am fully licensed but... man, I feel like a student all over again! This is a phenomenal presentation and a great review! I hope you consider becoming a university professor one day. (I like studying USMLE material to make me a better overall provider - in case you may wonder why a dentist would be on this video).

[@NinjaNerdOfficial]

Check out our Discord! We have an entire section setup for Dental topics and lively discussion is always welcome! We also have a USMLE section which you might find useful.

[@sarfinasarfina4314]

@@NinjaNerdOfficial kindly share thelink plzzzz I really need tht

[@justme2423]

I am a 70 year old woman. The kids are raised and I want to learn new things. I have had no college, just high school. I'm here because I have always had a curious mind. This is like therapy for me... stretch those brain cells! Love it!

[@dinosus26]

​@@justme2423🎉

[@frozenartss3770]

@@NinjaNerdOfficialHii ninja nerd could you do replication in eukaryotes too

[@TheLolitabernal]

Hi, I am a med school student and I hadn't been able to grasp the whole concept for my bioscience class until now. Just wanted to thank you for helping me prepare for my final exam which is coming soon!

[@ItsGraceDiamond]

Have you taken it? If yes... How was it?

[@TheLolitabernal]

@Matthew Namie in my country is like a mix of biochemistry, biophysics and molecular biology all in one.

[@TheLolitabernal]

@@ItsGraceDiamond GOOD! I passed with a pretty good grade!

[@sssss294]

How many ATP is required to cut H- bond by DNA helicase?

[@sssss294]

@Matthew Namie Yes, very logical as H-bond is weak..... Is it true that 1ATP molecule breaks 5 H-bond during DNA unwinding.

[@aligoudarzi3724]

Been super deep into your Neurology playlist these days. was watching your "Descending Tracts: Overview" right now. saw u uploaded this one. came here just to say thank you. words can't describe how much thankful i am.

[@yogawithmericka1125]

You have the ability to make things so simple and easy to grasp. All my years of schooling and professors and I still go to you when I need a concept broken down. Thank you.

[@aanghshaykhan7691]

This is the best lecture ever i had heard since my 18 years right now.....Thankyou man!♥️

[@MoonMm-zr4uf]

This video is just amazing !!!! U explained a whole lecture taken in 4 hours in just an hour and so smoothly!! We can’t thank u enough and literally ur the one who is helping me pass my medical years !!! Thanks a lot !!

[@asuari7305]

The dedication! The excellent diagrams! The personality!!! I am blown away that this is free THANK YOU from the bottom of my heart for helping me graduate

[@catzgalore]

This came at the perfect time! I'm in Microbiology all summer and this has helped so much! Thanks again for another great lecture!

[@mamoha4635]

I can't call you a lecturer anymore, you are a super lecturer!. Thank you for your incredible explanations.

[@katerinakarachaliou2715]

I was starting to doubt why i study biology because having to study off of 1000 page books was just miserable and made me feel stupid for not remembering a thing afterwards. Your videos have been extremely helpful making me understand and memorize the subject better! Thank you so much for reigniting my passion for science and reminding how interesting and cool molecular biology can be!!

[@alexander8987]

When someone explains something with so much passion 28:00 it makes the argument so much more interesting and easier to understand.

[@jesusesquivel4293]

I am so grateful for how you broke this whole concept down! Thank you and I hope you keep making more helpful videos!

[@fdrisgreat]

Thank you very much you have explained these complicated concepts in a clear and concise manner my college Biology Professors cannot explain in a million years. I feel a sense of relief when you explain scientific concepts. Thank you very much.

[@diyali7057]

You've saved me throughout my nursing school and now again during MCAT studying!!! WOW CAN'T SAY THANK YOU ENOUGH!!!! YOU AND YOUR TEAM ARE AWESOME HUMANSSSS!

[@NinjaNerdOfficial]

Thanks for your support!

[@dhanasreevb1484]

Dont know how to be thankful for u..your classes are very much helpfull for my pg exams.The way of teaching itself made the entire concept remind in the mind .and does not required any extra time for studying.your explanation made me to understand with complete process and does not requires any extra time for preparation.Like an artist paints a picture .for me your a gift from god.Thankyou so much sir for helping to complete my postgraduate so smoothly.🙏🙏 Love from India

[@cristinadelrosario1]

Hi ,I just want to thank you for all the lectures in science.I am a retired nurse and I have been reviewing and learning again by watching your videos.I always enjoy learning so I make watching your videos part of my daily schedule.I love the drawings and your passion in explaining the difficult parts.More power to you.

[@hayman2412]

when u say(support by commenting on the comment section) my mind becomes confused,thinking about which words u deserved. we really appreciate it,thanks ♡

[@Mennamohamed-wz5ug]

1st year med student here and a big thank you for all the effort around embryology biochemistry and even in phisyology you are really making it easier and I am really thankful Much love and respect your nerd from egypt

[@INTUITIVENORSK2303]

God bless you dear Menna! I wish you only the very best with your studies. I carry many wonderful and fond memories, of beautiful and amazing Egypt. The Egyptian's were always very intelligent, not to mention, multiple languages must be fluently learnt @ school, before reaching a pass level. I graduated many moons ago now, but i still get excited, when i watch Medical Science lectures. It takes me right back, to where i once began my lifelong career. Take care, stay focused and stay positive. x

[@Mennamohamed-wz5ug]

@@INTUITIVENORSK2303 oh thank you that really made me smile wish you the best in your life to that really made my day thank you .

[@ryze1715]

Sameeeeee

[@brittanywilliams8480]

I absolutely love all these lectures, you are seriously the best teacher that I have ever had. I am in NP school and you are teaching me just about everything. I have developed a habit where I read the material watch your video over and over than go back and read again, and everything makes complete sense. Thank you sooooo much please never stop posting !!!!!!!!!!!!!!

[@StriKe1066]

Love the videos! I´ve been struggling to understand this theme, but after I have watched this video, It all made much more sense. Thank u for being so good at learning and you make biology actually fun and understandeable. Keep up the work! :)

[@amandadierenfeldt7052]

This professor has NO IDEA I’m one of his students! I’m here for the unmatched enthusiasm! The drawings and great explanations. Can’t wait to take a test tomorrow. 🤣 Dunno how he makes it a whole hour without half times or time outs. 😊 thankful I can pause and re-play explanations over and over until I get it!

[@kanikasharma2294]

I love love love love your videos, my friend. I have watched them and learned from them since my high school days. I am doing my Master's in Zoology currently, and I still watch your videos for a lot of my topics. You remind me why I love Biology and I hope you continue to post more. Great work.🥰🥰 I would love to meet you someday in person🤩🤩

[@sky_tina]

OH GOd, literally the best translation EVER, now it's so easy to understand and connect all of that information. It blows my mind that this is actually possible to understand and memorise.

[@jacquelinemartinez8555]

Currently mid video and I just had to stop and comment...WOW! My brain is on fire! Not only are you delivering content, but you're making it make sense in such a simple way. So happy I found your channel!!

[@jarednicholas3180]

You are the GOAT bro. I also help students in A&P and physics and I have learned a lot from you and your "easy-to-comprehend" teaching style. I bought a shirt to bring you in some extra cash. I will buy many more in the future if you can do different materials! You help a lot of people, so thank you for all your hard work!

[@safiaali962]

The topics with which I was struggling , u clear those very smoothly.. Thnk you so much Zach ❤️

[@meghanac6128]

I have never seen anyone explaining like you You are simply extraordinary I don't have words to say how good your teaching is. The way how u make us understand the concept is amazing.

[@ariannybelmonte8571]

This video is incredibly good. I'm a senior high school student from Spain, and I have my bio test next week. I've been looking for videos that explain the DNA replication properly and easily, and I hadn't found any in my language. But THIS ONE. Perfect explanation, super easy to understand every single step. Thank you so much Professor Murphy!

[@mohammadkhalifa9149]

Look, I want to thank you to the infinity; you have managed to make me love medicine with your fantastic explanations of things. You are a wonderful lecturer keep going and remember that there are many people who appreciate what you are doing. I'm a medical student by the way

[@miannekaastudillo3460]

You inspire me! I watched your videos and made me think about taking up masters. I’m a clinical laboratory scientist. Thank youu ❤️

[@ivanaleksic8141]

I've never seen in my life such a perfect simplification, I'm delightful...thank you so much

[@mahmudahoque5543]

I've no words, I can't thank you enough. You came as a blessing. I'm crying in happiness finally I understood everything.

[@user-my8gs8zp8q]

literally i watch the whole video without getting board for a second, Thank you!!

[@laurag3763]

im a med student and these genetics lectures save my life while studying! keep up the good work!

[@heyitzhannah_]

legit a lifesaver! I am studying for a final and could not find a video that explained this concept step by step! this was so helpful and he broke it up step by step! thank u so much!!

[@SoloJedi_]

I don’t know how you don’t have more followers. Your videos are ALWAYS on point & clear. You have helped me 10 folds. Thank you!!

[@alih6953]

Wish my High School teacher was like him (back in the day)

[@lindatullos9430]

They don't pay high school teachers enough to attract this caliber of teacher. That's a rare bird that will teach high school when they have the background and ability to get much higher salaries in other places. (Which job would you choose when the salary is so vastly different).

[@lindatullos9430]

The KZbin presentation can make money also and the person only has to make the presentation once . (plus no distractions from attention seeking young folks). lol

[@lmriana]

As a genetic engineering major I've been studying this particular subject as a core course part. Each year it progresses on to the more advanced aspects. I can vouch that this hour long video perfectly encapsulates 3 year long course progression. Well done.

[@r.studio6170]

Hello you are genetic engineer so please answer my doubt..11th student in India 1.number of dna in chromosome..2number of histones to wrap one dna.3how is centromere formed to attach 4.dna replicate..ok..but how it unwrap from histones..and what happens to histones

[@DanNyBxt]

@@r.studio6170 acetylation

[@youtubechannelthejigsaw6802]

​@r.studio6170 lol I am late ? How did you do in tests ?

[@juliabochinina8305]

You are a brilliant lector and teacher! Even with not advanced english I understand such a difficult material. All because of your talent. Thank you a lot for this work!

[@amutuhairepatience6890]

ooh, i cant express the love i have for your videos. for sure am just in first year of medicine but your videos have really helped me to understand most of the medical course units. i thank you very much ninja Nerd.

[@kiranfatima7673]

i just love your each and every lecture the way you teach

[@mahya8450]

JUST WOW! I'm a clinical laboratory scientist and I’ve been struggling with biology since ever! before I find this channel, I find biology sooo hard to understand. now I even enjoying it! Thanks, Zach You’re a great teacher💯And this channel is incredible 🤩

[@Majnon7]

He is the best ❤️Never miss his videos, it am really enjoying with his lectures🤩

[@kofipapa2886]

How did you become a lab scientist then?

[@mahya8450]

@@kofipapa2886 I was struggling, not failing 🙂

[@Zamdir92]

wasted several hours on long videos without understanding the basics of the subject, but in an hour you made me understand the subject and love it. Thank you so much.

[@talasolh8017]

I like your style, your way of teaching, and how you relate basic scientific facts and processes to medicine.Time literally flies when I am watching your videos!!!

[@user-lj1zx5kt7k]

Waaaaaah!!!! Finally FIIINAALLLYYY GENETICS! 🥺🥺🥺🥺🥺 I was waiting for this looong time ago...i am really happy and waiting for transcription, and translation 🙏🙏

[@arryin_]

I'm in no particular need to know this, but goodness! Your lectures make any topic so fascinating and understandable. Thank you.

[@Supersup.campos]

I totally agree with you.

[@oliviagomez1811]

At this point I don't know how many videos I have watched. This one is by far blowing my mind the most and is absolutely getting me through my chiropractic basic science material. I utilize your lectures every week to better understand the concepts as I struggle with this type information. Thank you so much for what you do. Proud to be a ninja nerd :,)

[@NinjaNerdOfficial]

Proud to have you in the Ninja Nerd family! - TG

[@shambaviyogendran1560]

You are incredible! Thank you so much for sharing your brilliance with us! You are saving a lot of us!

[@yeoppunsiregi3226]

4 months of my biochemistry professors lectures vs a few hours of zachs videos, and I see a big difference in my learning. thank you Zach for making learning so easy. I've said it before and ill say it again if I die and you want my organs pls take them.

[@youtubechannelthejigsaw6802]

💀👈

[@Studywithelii]

I appreciate this channel as a molecular biology and genetics student. thank you so muchhhh

[@lucyb5028]

I love this channel so much its entertaining and taught in the way I typically learn drawing as we go prevents me from getting overwhelmed and helps as I can watch the process build and understand why everything is there not just what it does. Plus you covered so many areas, i'm studying veterinary so tying the points to illnesses keeps me engaged! Absolutely brilliant!!!!!!

[@burns1606]

Studying for USMLE having a hard time with cell biology and genetics topics but you are awesome and a real lifesaver!! I can not thank you enough. thank youuu!! I would like to see video of antiretroviral please!

[@user-qj3ed7lu4d]

I swear to god that I’ve never seen someone explain this better than u I will advise my doctor to watch ur videos 😂😂

[@sachanorsworthy1265]

So grateful for you guys. you are unarguably amazing. if i ever get anywhere close to your level of knowledge, enthusiasm and sheer awesomeness i'll be grateful. carry on self actualising!!!

[@ba-fe1kx]

Thank you so much, this was incredibly helpful for my biochem class! And the additional clinical notes? AMAZING. Keep it up ninja nerd!

[@tennistassie]

Ok, you've made some seriously epic videos in the past Zak but this....... 🤯🤯🤯🤩 just next level and I didn't think there could possibly be a next level. You're making your own levels now. Thank you!

[@VeniseStPaul]

This is cool and I am learning so much about cell biology thank you!

[@egaga-]

Regarding telomeres, presumably after telomerase has extended the parental lagging strand, the DNA polymerase will extend the incompletely finished daughter strand to match the extended parental strand. I was confused about that but otherwise great overview!

[@reshmasaerah6591]

I dont know how u garner such intricate understanding of all this. Biochem goes whoosh above my head! But you! You make things easy for my tiny brain! Thanks a lot. Really grateful!

[@charu341]

In India we have lots of exams, I really wished to have a teacher like you. I really appreciate your teaching. Thank you so much. Stay blessed.

[@amira9914]

I'm in high school and we take advanced biology this year and your videos are so simple and easy to understand thank you sooo much !!

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انت من مصر 😂😂

[@amira9914]

لا 😂​@@Zeyadhany

[@MH-pj2bq]

It's really hard to find the right words to say, bcz thank you is really an understatement.

[@ronelaguilar8554]

Informative, comprehensive, and easy to understand. Thank you, sir! ❤

[@chandnibakhsh5916]

Whenever I watch your vedios learning totally becomes fun and you make everything seems so simple that I just wanna watch all of your vedios at once and gain everything.♥️

[@beautifulbeautiful6363]

turning off ad blocker for your videos. massive props

[@sangitalala9133]

Download teh video

[@ll2323]

@@sangitalala9133 we watch his ads to support him and the channel.

[@przyjacielswistakow6301]

Why aren't you the most popular chanell on youtube xD? I asked people, which are learning biology in the high-school do they know you. They didn't xD. But some of the med students in Poland said that u helped them to pass the exam :D. We are super thankful

[@Trulsbk]

What a freaking life safer you are. Revision of biochemistry became a breeze once I found your channel. You're a real one.

[@jasminkasilajdzic6425]

Thank you Zak, so passionately explained that it makes you wanna listen and learn. Thank you!

[@ObjectivelyBias]

On spring break this week and start DNA next week.

[@anishsrirangam845]

I’ll become best doctor because of u man

[@zubeida05]

You are a true hero I really can’t thank u enough I don’t like biology but I’m a med student and i really started liking it thanks to your videos, your passion when u talk is truly inspiring

[@petrapurja8824]

the way you explain these concepts is making me be even more passionate about this field! thaaank you! I think most of the doctors of the next generations will have to thank you for eternity :)))))))))

[@choj111210]

Hi thank you so much for this lecture! There is one thing I wanted to clarify, I hope I can ask about it here. So when you were talking about the leading and lagging strand I just wanted to clarify that the Okazaki fragments are in fact present in both top and bottom parental strand. Is this correct? What I understood from the video is that the leading strands are found in the top parental strand while lagging strands are found in the bottom parental strand as the synthesis occurs 5' to 3'. But the replication is bi-directional so this means Okazaki fragments must be present in both parental strands right? Am I correct in assuming that when you were talking about the leading and the lagging strands, you were just looking at one direction of replication for simplicity sake to explain the concept? I hope what I said makes sense. I just wanted to make sure my thought process isn't wrong. Thank you!

[@AbCd-kq3ky]

You're absolutely right, no strand is truly ONLY leading or lagging (except perhaps at the very end of a chromosome), this concept only holds true if we're looking at one replication fork or a replication bubble where one strand has a primer somewhere in the middle. Okazaki fragments occur on BOTH strands.

[@chaitanyalonare2259]

I do have a question : Doesn't Helicase work on both ends so wouldn't the leading strand will also have few nucleotides left like the lagging strand?

[@adit27j]

Yes that’s what I was also about to comment ☹️☹️☹️☹️

[@woah1887]

Same question

[@sanaamirza7]

No, the direction in leading strand is from 3_5 just the same direction of Helicase work so as the Helicase open strands the process will remain at same direction , which is the opposite of lagging strand

[@AleksandrSharashkin]

Good bless you Zach! Your lectures helps us a lot. Greetings from Lithuania!

[@fireyflower6643]

Think you guys rock! You manage to explain complex medical matters making it easy to comprehend, without dumming down

[@anonymousplayer6378]

Thank you so much for your video. But I still have a small doubt, can you tell the difference between DNA polymerase 123 and DNA polymerase alpha beta gamma delta and Epsilon? Are the number polymerases same as the polymerase with Greek letters? According to what I read from a book, it says that the numbered polymerases are for replication in bacterial cell but the Greek lettered polymerases Are for replication in human cells. Can you please clear this doubt?

[@expertofeducation1521]

Yeah this is a very common doubt!!! Try to get the answer for the same!!

[@edtishlier7513]

Another error found. The terms, “leading,” and “lagging,” strands apply to the newly synthesized DNA strands, not the parent strands.

[@vitorialuisapavonikansha4259]

Muito obrigada, aula perfeita! Por favor, continue fazendo esse trabalho maravilhoso! (from Brazil)

[@parthnaik8231]

Wow! the introduction of topoisomerase was like unwinding of my brain circuit. Kudos and thank you for the lecture.

[@deokkie1839]

I wish you're my prof instead

[@user-rf3iu2vr6l]

Free free Palestine

[@tasnimsusme9646]

Thank you so much for clearing this concept with that level patience

[@harerimanapapias5265]

Great work .I have just got DNA replication to my best before attending physical lectures.thanks very much for the great work

[@ArtificialOverload]

I really really enjoyed your lesson. I've always believed that teaching is an art and not everyone is good at it but you are clearly a master! thank you for making this series.

[@shahiramohammadi7284]

Now I understand this mechanism rightly! thank you so much Zach.

[@sanyerysdiaz6371]

This guy is amazing, I couldn't understand anything in lecture about this but he made it so easy to understand! Thank you

[@RohitPant04]

That beautiful depiction followed by the explaination of how Telomerase works to help solve the end replication problem was phenomenal. Thanks, i will not forget that for a long time! 🙏😊

[@victorkikson6857]

I’ve been wondering when I’ll comment about your videos, but damn I love your style and teaching method. The joy in my heart as you decipher and integrate concepts is remarkable. Best of all, it’s free. You got more rewards coming your way!!!

[@fabiothebest89lu]

That was brilliant. I studied DNA replication in the past, but many years passed and I need to revise it for a test. I read a chapter of a book, but it wasn't complete and I had some doubts. After watching your video all my doubts are gone and I even learnt something new. I'm gonna watch also your videos about transcription and translation. I'll support your channel. Thanks for the great job!

[@sofiamunoz6439]

Thank you so much for the amount of detail you include! I have an exam coming up and this was so helpful for review.

[@rajalakshmit4474]

One of the best videos I have seen and understood by far the most, Thank you very much🙏

[@aditib5635]

This is phenomenal! Thank you so much. Your presentation and lectures are SO HELPFUL!!!

[@saraaslam4568]

Thanks sir for such amazing lectures..you are one of the best teacher I have ever seen

[@drpham6596]

As a physician, I am almost not clear about molecular, biology and things like that but since I have known your channel, submerging in your lectures, I was able to understand that challenge knowledge. Thanks very much for your dedication. Love from Vietnamese fan

[@NinjaNerdOfficial]

We all never stop learning! Check out the Discord! We have all sorts of discussions happening and would love any insight you might be able to provide!

[@chiemelieifediora9021]

Thank u Zach, u have no idea how much you've helped me prepare for my exam