Central Sensitization and C Fibers

[@TheTakcheng]

thanks for summarizing a 2 hour lecture in 10mins =) keep it up!

[@NeuroDocUniverse]

You're welcome and thanks for the kind words!

[@benji-5796]

Thank you for your video. So the C fibers have their own neurons also?

[@JoBlakeLisbon]

Great explanation. Is there anything patients can do to stop this process once they have a serious injury? I suffered a bi-lateral brachial plexus injury three months ago. This week I got a burning pain in my foot. It's utterly bizarre. I'm bereft - no idea what to do.

[@Amalioji2]

Excellent. Please bring some more on the neuro subjects. Thanks.

[@bommoiful]

Great video overall - However: 1. substance P is commonly thought of as primarily causing sensitization at a central level, can you refer to studies that shows a retrograde transport of this substance to the periphery and its importance in peripheral sensitization? 2. Wind-up is a different phenomena than what you are describing. Wind-up is caused by temporal summation and is a perfectly normal physiological feature, however it might be increased under the conditions you describe.

[@joshboston2323]

sanne andersen---wind up= a temporal summation. it is not caused by it.

[@NeuroDocUniverse]

Thanks for your comment and glad you liked the videos! Can you tell me what you mean by "facilitated spinal cord segments?"

[@NeuroDocUniverse]

You're welcome, Tak! Thanks for the kind words!

[@NeuroDocUniverse]

...Windup refers to the progressive increase in the magnitude of C-fiber evoked responses of dorsal horn neurons produced by repetitive activation of C-fibers." Great article: Windup leads to characteristics of central sensitization. 1999. Pain. Volume 79, Issue 1, 1 January 1999, Pages 75-82. I hope this helps!

[@NeuroDocUniverse]

Hi Almas, Thank you for your question. 1. Wallerian degeneration usually follows a nerve injury where the axon is separated from the cell body. Central senisitization results from chronic activation of C-fibers. The two processes are different. 2. This isn't simialr to Huntington's which is a hereditary degeneration of brain cells. 3. Based on the literature, the glutamate receptors increase in number in response to increased c-fiber bombardment and glutamate production in the dorsal horn.

[@olgalawyerabogado9642]

Glutamate has anything to do with glutamate natural in" healthy food" like nuts or chicken?

[@NeuroDocUniverse]

@@olgalawyerabogado9642, glutamate the amino acid is the same glutamate that acts as an excitatory neurotransmitter. Let me know if you have any follow-up questions.

[@serinadelmar6012]

This is fantastic. Thank you for the video!

[@albybarman]

Was soo useful! explained in perfect way with right tone of voice! thanks:)

[@TooOverrated]

Hello, am curious is there any articles on how Chronic Bombardment by the C fibers causes spouting of the dorsal horn and how does spouting cause disorganization? Thank you for the amazing video!

[@NeuroDocUniverse]

Hi, "Central sensitization refers to enhanced excitability of dorsal horn neurons and is characterized by increased spontaneous activity, enlarged receptive field (RF) areas, and an increase in responses evoked by large and small caliber primary afferent fibers. Sensitization of dorsal horn neurons often occurs following tissue injury and inflammation and is believed to contribute to hyperalgesia....continued

[@drina4706]

My body yearns for needles to be stuck in my spinal cord. No joke. I have fibromyalgia and psoriatic arthritis and just visualizing needles being put into my spinal cord and the rest of my back (especially the muscles) but not damaging the nerves, therefore not losing the ability to control lower body muscles (no parapalegy) soothes me. Yep, my C fiber nociceptors as well as other nociceptors are very downregulated. The imflammatory pathway is also downregulated as I have a lot of "angry" cytokines attacking my organs, connective tissues, joints--- ughhhh....you name it. Around my menses, perimenses the imflammatory processes are even more downregulated and inflammation increases systemically. Then the fibromyalgia pain gets worse. The exhaustion is beyond belief. I don't know how much delta-wave sleep I actually get but it can't be a lot as I do not regenerate and as I am always exhausted.

[@tenminutetokyo2643]

Drina Chronic cytokine production is associated with adipose tissue. You need more hard exercise. It has also been linked to insulin resistance and diabetes.

[@youknowcrimedontpay9257]

Hi, I have severe FM & ME 39 yrs. FM patients do not acheive stage 3 or 4 Delta Slow Wave Restorative sleep. Myalgic Encephalomyelitis which is Chronic fatigue Syndrome. ME is likely caused by non restorative sleep. Check CDC, new name for FM. This lady is arriving at the diagnosis of FM or ME, or CA

[@jasonmarchione9981]

If there is a increase in Glutamate why are drugs like pregablin and gabapetin used in pain disorders , aren't these drugs known to increase glutamate in the brain. Wouldn't these drugs possible contribute Central Sensitization?

[@tousifk3138]

That's exactly my question, did you find any answers

[@DS-fi4hf]

No, they don’t increase glutamate, they actually lower it. They also raise GABA levels. GABA is the yin to the yang of glutamate.

[@callumirving1359]

Hi Lisa Bloom, thanks so much for putting together so many videos. They really link the neurology to tangible clinical features. I was wondering whether you have put together any references for the videos? I understand that utube is not the best source of evidence despite your obvious expertise, so I was hoping to have some resources to refer to that supports your videos? Thanks once again.

[@callumirving1359]

Just saw you had posted an article earlier.

[@Cr6bapple]

Whats the difference between central sensitization and wind up phenomena

[@riverbum1]

I have been diagnosed with central sensitization syndrome.... What medications, therapies and treatments do you recommend? Thank you, great video.

[@tenminutetokyo2643]

riverbum1 Ride a bike. 15 miles every day. And no processed food.

[@galens9364]

Thank you for this explanation!

[@mattidle6]

Outstanding video. Thank you.

[@NeuroDocUniverse]

You're welcome!

[@greatnationnow]

So how is this condition reversed??

[@crackhead187]

Check out the pain gate theory video on this channel.

[@Gpacharlie]

greatnationnow If you find out you will become very wealthy.

[@crackhead187]

@@Gpacharlie One way would be to work out pain free movements and repeat these before pain is felt. Avoid the painful movement triggers, slowly increase the pain free movement duration over time, increasing pain free capacity.

[@Gpacharlie]

Raj Yep that’s the theory behind desensitization. Deemphasizing pain algorithms and replacing them with non-pain programs. I’ve been suffering with s full blown case of CS for 20 + years now. I had to diagnose myself. VA and private medicine were of little help.

[@SA-ru8kw]

Thank you, I wanted clarity on what triggered C fibre bombardment

[@NeuroDocUniverse]

C fibers are also known as chemosensitive nociceptors. These fibers depolarize with chemical or inflammatory changes to the immediate environment. Chemical changes can result from tissue damage as intracellular fluid is exposed to the extracellular environment. Inflammatory chemical changes can also occur with diets high in omega-6 fatty acids which break down into arachadonic acid and eventually into inflammatory prostaglandins. Chronic depolarization of C fibers is clinically significant as it is directly linked to central sensitization. I hope this helps!

[@SA-ru8kw]

NeuroDocUniverse thank you very much indeed, this has made it so much clearer. Your videos are great.

[@hazzae]

Great video. Thank you!

[@kelvincheung5230]

Very helpful

[@NeuroDocUniverse]

Synthesis, and central and peripheral axonal transport of substance P in a dorsal root ganglion-nerve preparation in vitro: Brain Research Volume 231, Issue 2, 14 January 1982, Pages 379-385 There are numerous articles on this topic. Search "Substance P and axonal transport for more...

[@Truerealism747]

Most people have hypomobilty have this high glutimate in the brain and most have OCD before anxiety because if this low glutimate diet meditation etc exercise can cure this which I believe takes few years also linked to Asperger's done a lot if reasearch I hope this helps others cause the pain is hell

[@yoyyo2000]

Amazing explanation Thank you

[@mosharofhossan8117]

Wei When Xxc BC

[@NeuroDocUniverse]

Substance P and ANTEROGRADE Axonal Transport: Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo. Neuroscience Volume 49, Issue 3, August 1992, Pages 693-698 Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig: Brain Research Volume 191, Issue 2, 9 June 1980, Pages 443-457 Continued...

[@johnathanabrams8434]

SO WHAT. WHAT IS THE POINT OF THIS ? What is the point of this is it there are no practical solutions ?

[@NeuroDocUniverse]

Clinical application of this material directs care to reduce c fiber bombardment of the cord. Basically, increasing movement to tolerance, increased water intake, anti-inflammatory diet, mindfulness training, etc.

[@johnathanabrams8434]

@@NeuroDocUniverse there's little to no evidence that anything can be done dietarily to effect central sensitization. This has to be for the obese, high impulse no self control westernized patient. Responses like this are undeniably the reason people don't get better. Durrrrr , gluten free blue berry vegan diet with yoga. Kick rocks you ignoramous.

[@NeuroDocUniverse]

Hi, Check out this article by Latremoliere and Woolf to give you a full response to your question: ww /RSD/JPain2009_10_895_CS_REV.pdf

[@NeuroDocUniverse]

Also, I respectfully disagree with your definition of wind-up. See Juan F. Herrero*, Jennifer M.A. Laird, Jose A. Lopez-Garcia. Wind-up of spinal cord neurones and pain sensation: much ado about something? Progress in Neurobiology 61 (2000) 169±203 I think our disagreement is merely a matter of sematics. Best regards, LB

[@a.m.a5122]

thanks a lot :))

[@curtiskline8214]

8:13 I think there is some pun intended

[@NeuroDocUniverse]

+Curtis Kline :-)))

[@m.g.358]

CS has been 'diagnosed' as a psychological problem, not as a (cervical spine) "Bio" problem. Secundairy Victimisation??