Errata: The NBT test is backwards. 15:45 I spelled Peyton wrong. My bad, Peyton!
@lokeshdevalla20606 жыл бұрын
DirtyUSMLE videos on dermatology cases plz
@eman37alqisi325 жыл бұрын
PLEASE ACCEPT MY DEEPEST THANKS ❤❤🙏🙏🙏
@HairRival2 жыл бұрын
Thank goodness for the note, trying to figure out the NBT was some serious Stroop-effect shit.
@abinashshah88752 ай бұрын
@@HairRivalaa
@aidenssillycoolvideos60686 жыл бұрын
I remember CD18 by thinking you're supposed to move out when you turn 18. There's a deficiency, and the neutrophils can't "move out" into the tissues.
@emuwarrior135 жыл бұрын
Charla King also, you’re no longer a LAD at 18
@uni13164 жыл бұрын
helpful for non foot ball fans like few of us; I watch England foot ball so "No.18 is the referee who don't you out of the foot ball court during the game because no body can give him red card unless a LADA taxi come and give them lift! so number 18, refree BooooM, can afford LADA taxi "
@ApplyingForResidency4 жыл бұрын
I like that - parents "cut the cord" when their kid turns 18.
@Be1smaht3 жыл бұрын
So good
@taytayqp8 ай бұрын
I like to think you need to be 18 to get a sticker for voting and you need CD18 for leukocytes to STICK
@jensonmathew84376 жыл бұрын
You know for the visualization of Chediak-Higashi it also works if you make him a The White Knight Chediak-Higashi since it also causes partial albinism.
@DirtyMedicine6 жыл бұрын
love it
@vb94906 жыл бұрын
Or the O could have been for oculocutaneous albinism, while the P would have been for phagolysosome
@seen2035 жыл бұрын
He's fighting White Walkers
@brahmaputramoskva12153 жыл бұрын
A ched who is a white knight
@eriktatos2 жыл бұрын
Racial…I love it ☠️
@bhaumikpatel7771 Жыл бұрын
I also use the " A and E" in the WATER mnemonic to remember that there is increased IgA and IgE in Wiskott
@ASAPUSMLE2 жыл бұрын
As an added bonus, Wiskott *ALL*-DRINK syndrome shows it affects both T and B cell lines (IgG) therefore causing the pt to get all infections (viral, bacterial and fungal). Great video, as always.
@pragyasingh229711 ай бұрын
I love it! Thank you so much.
@nenimarie894 жыл бұрын
the comments section is ALMOST as good as your videos. Bless your heart Dirty
@rianblackwood20814 жыл бұрын
Thanks for the mnemonics! I have one for LAD that helped me remember - "LADs must be 18 to Integrate" LAD - Leukocyte Adhesion Deficiency Must be 18 - CD18 Integrate - CD18 is an "integrin" that is necessary for migration
@DrEktaYadav6 жыл бұрын
"fungus went up your ass? throw some hydrogen peroxide at it" ---I don't think I've ever laughed that hard and not to mention I will never forget the enzyme again. ty ur videos are AMAZING.
@Trish.7863 жыл бұрын
Me too! I’m still cracking up 😂
@rusinoe8364 Жыл бұрын
Just a regular Tuesday for me...
@kabirtorres26725 жыл бұрын
No joke just finished this video and on a random UWorld block, first question is on CGD. Had to pause the block to laugh for a good 2 minutes. Great video!
@gianrodriguez16436 жыл бұрын
Hey! Took step 1 today i get home and see this. I got 2 questions on CGD, one Bruton's and leukocyte adhesion which was baby who umbilicus doesn't fall off. Quick tip: study PARASITES!!!! who said they were low yield. Btw great videos guys... keep it up
@veganwilliams88686 жыл бұрын
wow congrats.what other HY systems How was GIT?
@williemuthui4324 жыл бұрын
Hello
@ThatsWhy-7 ай бұрын
Did you get usmle 1&2 passed?
@lilliereed8433 Жыл бұрын
A in WATER could also stand for "actin" because the WAS gene mutation leads to leukocytes/platelets being unable to reorganize their actin cytoskeleton --> ineffective APC function. Also thinking of it as Wisxott rather than Wiskott as it is X-linked recessive!
@christinaalvarez16 жыл бұрын
YAY!! I requested this one a little while back. Thank you, thank you, thank you!!
@coralreef8966 жыл бұрын
Hi, your videos are amazing + life saver!! For future video topics, could you possibly do them on these: 1) antibiotics overview = when to use which + high yield side effects 2) cardiovascular drugs 3) Dermatology stuff (eg papules/macules etc...) = relevant for step 1 4) GI patho
@tiam88366 жыл бұрын
idk who you are or how you have the time to make these videos but you are my HERO can you make a video about the upper/lower extremity nerve stuff?
@SuperHaind6 жыл бұрын
Wiskott for wisky ..drinking "Ethyl Alcohol "= increase in IgE and IgA
@bretw47545 жыл бұрын
works in the wAtEr mnemonic too. But water is less fun...
@sonny49973 жыл бұрын
@@bretw4754 nice
@jemalgemtamohamed96144 жыл бұрын
You are so clever in how to be adhesive with informations you learn.
@1wertyuiopasdfghjkl6 жыл бұрын
I seriously love this channel
@suomynonaanonymous6 жыл бұрын
Your videos are way better than sketchy path
@DrEktaYadav6 жыл бұрын
sketchy path is ass and it is way too damn long so I agree 100%
@dr.manalsamater37375 жыл бұрын
Actually, in CGD the Nitroblue tetrazolium, if it’s positive meaning it turn blue the patient doesn’t have the disease. In the other hand, if it’s negative don’t turn blue the patient will have the disease. So in exam if they say the test is negative it means they have the disease.
@kirubakaran09stanley5 жыл бұрын
Yes , you are correct
@nooral43153 жыл бұрын
correct. Negative NTB test means the person is lacking NADPH oxidase
@HistoryHive00012 жыл бұрын
Yes you are correct.. I hope he makes correction as I observed it immediately.
@dmitrybaer58733 жыл бұрын
I love you in and out. Thank you so much for your work.
@thanasegaran15 жыл бұрын
Correct me if Im wrong, as for the CGD The nitro blue test Positive = patient have super oxide therefore patient is free from the disease Negative = patient has the disease as the nitroblue remains blue! I think you may have confused us on the positive and negative. Patient has CGD if the test is NEGATIVE not as mentioned in ur video. Do check wiki or correct me if I'm wrong
@ricardoa.pascual97935 жыл бұрын
Not quite! NBT is a colorless dye by itself. He clarifies this in the errata (pinned as the top comment). DirtyUSMLE wrote that the NBT is backwards as per the vid! Here's how it should be: Normal (positive) = turns from clear to BLUE (neutrophils can turn the dye blue because NADPH oxidase is present). In Chronic Granulomatous disease, it's Abnormal (Negative) = No color (indicates that there's No NADPH oxidase). No color = No NADPH Oxidase present Hope this helps!
@pavitraattanayake1011 ай бұрын
CD18 can be remembered as "I ate $hit because I couldn't stop" where "I ate" = 18 and "couldn't stop" refers to adhesion issues
@Dr.Kaseses_hunk Жыл бұрын
Thanks so much doctor,,, ur videos are the videos I needed to make A's... Good bless u abundantly
@marialoukiaanastasiadou79545 жыл бұрын
extremely helpful mneumonics! Please make more of these videos for diseases.
@rayray95082 жыл бұрын
I used "Leukocyte EIGHTEESHIN deficiency". Thanks for the banger as always
@B3bita12153 жыл бұрын
Amazing explanation!!! My goodness sooooo glad I found you guys 🙏🏽🙌🏼
@ezzabashir22788 ай бұрын
Thank you for this. So glad i found it
@Sia.11113 жыл бұрын
This content and your amazing efforts to make everyone understand this ...are grreatttt ....thank you for teaching such helpful and important information
@SanahSaysHello6 жыл бұрын
I've loved your videos for years. Huge fan. Will be sure to donate later today!
@learnteach2learn7296 жыл бұрын
Why did you remove your line weaver plot video? I liked it and it was really helpful
@koolkid46506 жыл бұрын
Thanks Sir.... Please videos on Musculo nerve injuries & All Formula videos of book & Imp Graphs video Thanks
@rjj1515 ай бұрын
Great video as are all your other ones! For the CGD mnemonic, what about naDph oxidase deficiency?
@ericac23556 жыл бұрын
Does the hydrogen peroxide come from the infective organism in catalase negative infections? In CGD they can’t make it themselves right? Awesome video thank you!
@DirtyMedicine6 жыл бұрын
Yes this is correct. Our immune systems hijack the native Hydrogen Peroxide in the virulent organism
@chiahsuantsauo83753 жыл бұрын
I’m finding the pathophysiology of the infection process difficult to understand, like when does Th17 come into effect and how does it lead to Th1 or Th2? I think a lot of text books and stuff teach each part of immunology like T and B cell separate, then antibodies, then complements etc. but nothing tries to explain the whole process as a whole. I’ve gone through First Aid and General Principles Immunology section and I still don’t understand how everything is co-ordinated…
@shokhzodbozorov42524 жыл бұрын
thank you a lot!!!!!!!
@aliyahamid74734 жыл бұрын
Amazing mnemonics! Great work
@praneethamodumudi43916 жыл бұрын
Thanks a ton😄
@nishisatish35395 жыл бұрын
You are amazing.
@fbsdeformedvag89256 жыл бұрын
My Son died from CGD in 99 at 6 1/2 years old.
@hmansaria56325 жыл бұрын
I just came across your post. My prayers are with you. May The Almighty place him among the highest ranks in Paradise and may you and your family be blessed with the strength to bear this loss and emerge from it stronger.
@faiqapirzada3 жыл бұрын
Its helpful. Thanks !
@roshnichiru6 жыл бұрын
Thank you so much Sir 🙏
@nermeenkolta1356 жыл бұрын
thank u so much , ur videos are really helpful , can u consider to make avideo for embryologic derivatives , thanks
@suomynonaanonymous6 жыл бұрын
nermeen kolta yessss
@sohaelsayed82533 жыл бұрын
Correct me if im wrng, but wasnt the purported dysfunction of microtubules proven as incorrect through further research?
@ricardoa.pascual97935 жыл бұрын
he shot the Menke, *WASP*, and G6P... got your XLR song stuck in my head haha
@anyquezada29903 жыл бұрын
i just got 5 question about it in my last NBME thanks
@habib0803 жыл бұрын
for step2 i am seeing Dihydrorhodamine Test being asked for CGD!! just wanted to share
@shayekhabedin44623 жыл бұрын
YOu inspire me! I wanna be like you!!
@Dr.ShubhamPatidar6 жыл бұрын
sir please make a pdf or slides of your video so make easy to revise in last time of exam
@abundanceoffavor13535 жыл бұрын
Thank you!
@angelonicolascaputizuniga14184 жыл бұрын
LAD is a disease with no migration, at age 18 you supose yo migrate from house (CD18), so you stay in home like a baby more time that supose (late umbilicak cord separation). Like if thist helps you
@yosiguevara4 жыл бұрын
Thanks because I won't remember that football player LOL
@akshatsahai35516 жыл бұрын
Thank you so much:)
@praneethamodumudi43916 жыл бұрын
A video on inheritance patterns calculations pls
@myprettygirl913 жыл бұрын
thank you! so helpful :)
@1412Z Жыл бұрын
Thanks!
@il3mendo10 ай бұрын
Leukocyte adhesion deficiency can be triggered by vaccine or infection disease such Varicella, Ebv or Citomegalovirus? Can, in the case of chronic illness such celiac disease, someone has a normal neutrophil count while having eosinophilia ? ( Cd 56 marker highly oresent in my gut flora with no cd18/19.. Thanks
@Lil11045 жыл бұрын
This is amazing!
@abrahamkibret65913 жыл бұрын
Thank you
@SumuduUpatissa6 жыл бұрын
LAD could also cause due to lack of LFA-1 in C3bi receptor.??
@1MinuteFlipDoc6 жыл бұрын
Great tutorial!
@Coverworld-t3y3 жыл бұрын
You may think of bruno fernandes no 18 for Leukocyte Adhesion Deficiency ☺️☺️☺️
@rachelslack94516 жыл бұрын
Vitamins please I beg of you
@suomynonaanonymous6 жыл бұрын
Rachel Slack pllesssseeee
@elsecretopez5 жыл бұрын
you have both lymphhistioCYTOSIS and panCYTOPENIA? :O
@lifes2short4aname4 жыл бұрын
Yaniv Hadi I read on wikipedia that it has “lymphoma-like syndrome, in which defective white blood cells divide uncontrollably and invade many of the body's organs. The accelerated phase is associated with fever, episodes of abnormal bleeding, overwhelming infections, and organ failure” but the histiocytosis part eludes me
@FG-ng1cy6 жыл бұрын
Hello.do u have a video about step 2 ck preparation?or could u give some advice regarding preparation.thank u.
@pfln6 жыл бұрын
vitamins vitamins vitamins please please please
@kfabrice74794 жыл бұрын
Very clear
@wicterwterr42453 жыл бұрын
Very helpful
@vanshajchandra3074 жыл бұрын
Never thought Podrick from GOT would teach me immunology
@HomeHome-he2xq4 жыл бұрын
Love ur work ! But this could have been more detailed and better . Many points are missing out....
@DirtyMedicine4 жыл бұрын
What would you have liked to be included that wasn't? Remember that my primary audience is medical students
@HomeHome-he2xq4 жыл бұрын
@@DirtyMedicine Thanks a lot for ur reply ! You could include the Cells that are defective ( eg B ,T or Both) , the organisms that cause infections in these , like some have viruses / fungi and other bacteria ! Just more details in an easy way. This is wonderful ,but just found it a bit concise. Thanks a ton & loads of love for ur vids :)
@talash65 жыл бұрын
can you make a video on electrolyte imbalance? please pplease please
@thepacemaker81654 жыл бұрын
Awesome!
@gachett20116 жыл бұрын
Could NOT have had better timing! *clutch*
@padmajahawaldar431910 ай бұрын
Hey dirty whr r u mo updates no recent uploads why dear mentor
@matthewmann89696 жыл бұрын
Electrolytes, nutrition, and vitamins
@ibraheemalma4 жыл бұрын
you are amazing
@musicfreakpolina2 жыл бұрын
If you can't remember Peyton Manning - CD18 because your umbilical cord is so late falling off that you're 18 years old by the time it does
@jazzyvidzz42632 жыл бұрын
Awsm
@bnfgh1234 жыл бұрын
OK, so now I know some awesome mnemonics, but if somebody asks me how any of the syndromes works, I still can't explain.
@realblackbetty22046 жыл бұрын
"fungus goes up your ass" hahahahahaha
@GhostofAlanGrant6 жыл бұрын
Hey what happened to your ovarian tumor video? I had that bookmarked to watch FML
@DirtyMedicine6 жыл бұрын
still live. not sure what youre talking about my friend
@محمدتقينبيلظاهرحميدي3 жыл бұрын
Geniussss
@ooooooo4922 Жыл бұрын
I love you❤
@hema119015 жыл бұрын
Nice
@zeshan356 жыл бұрын
awsome
@PH-xw1ri6 жыл бұрын
Guys - donate if you can. I donated $25. Let’s all chip in - student loans or not.