Making Fluorinated Empathogens (RC, Designer)

F L U O R O
rotovap? donate: paypal.me/chem...
correction: bottom structure in catalytic cycle should be Cu(I), not Cu(III)
First reaction pubs.acs.org/d...
Bisulfite adduct general procedure used
Second reaction general procedure used
Literature about fluorinated derivatives with different procedure (from aldehyde): doi.org/10.100...
These fluorinated derivatives are fully legal in most countries, but always check local regulations. The product in this video is legal in my jurisdiction. For educational and documentation purposes only, not a tutorial.

[@carelessanonymous6570]

This synthesis is awesome but please dont fly too close to the sun, you're my fav chem channel on YT

[@Chad-Giga.]

DEA will not like this

[@Tigerprowltactical]

Someone’s gotta spread that knowledge to get more people into chemistry

[@BillAnt]

"For this, I'm going to use this compound to make that compound...." lol Brilliant!! :D :D

[@fee8422]

@@Chad-Giga. fortunately for him, he's dutch.

[@C0lon0]

​@Chad-Giga. Only muricans fear the DEA, normal people is above all the powers of the DEA

[@adamantris2]

bro is really playing with fire on youtube 💀

[@czarnyksiezycrogaty]

Naaah. Science and harm reduction are good ;)

[@Litepaw]

And the feds 👀

[@fmdj]

This is going straight to my RAID backup hard-drives ;)

[@thestr0m548]

​@@fmdjhero

[@TheHeavyassaulter]

Download these videos fast.

[@TheWTFbomber]

1 for the Money 2 for the better Green 3,4-Methyl​enedioxymethamphetamine

[@BothoHohbaum]

You should become a rapper, bro!

[@LunarLaker]

tell him it's from Medellín then use oxyacetylene!

[@dankwot5871]

@@BothoHohbaum its an MF DOOM bar vro

[@The_Ascension]

Clever indeed

[@kiyoponnn]

one for the money by escape the fate

[@talkingdot]

I realllllly hope this channel doesn't get axed because this is all interesting as heck but man, be careful what you synthesize

[@civilizationkills3138]

Rip it download it save it

[@m3talgame20]

its okay, youtube is left as hell. drugs are okay

[@eriklarson4082]

​@@m3talgame20Haha you are 100% correct.

[@jirischimer9540]

Hey excellent video. Just a quick advice - when doing reductive amination it is much better(gives better yields) to use NaBH3CN or NaBH(OAc)3. I have done a lot of these reaction on different scaffolds and you should not be using nabh4. That is main reason for your shitty yield (you are reducing the keton to alcohol). In normal reactions you can also drive the equilibrium by maling the imine with dean stark apparatus or using anhydrous solvents and adding molecular sieves. But ofc for that you cant use 40% methyl amine as you mentioned. Also PLEASE get a rotavap. The short path distillation is jist bad practice - yhe mantle overheats the sides and you burn your products. If you need one contact me and i will se what i can do

[@hasselnttper3730]

CONSTRUCTIVE, professional criticism👌🏻👏🏻👏🏻

[@felixfelicis_ll]

I disagree with your main claim. First of all, he SHOULD NOT use cyanoborohydride at least bc there is no proper ventilation system. Yes, you usually work with basic quenches at this point, but it is a very dumb idea to play with cyanide ions in the home lab. Even if you are going to drink corn syrup constantly, it's just an accident waiting to happen. Another thing is that both cyanoborohydride and acetoxyborohydride react too slowly, sometimes you need to heat the reaction and that's again not safe for the home setup. I've done all sorts of RA (borohydride, STAB, cyanoborohydride, hydrogen on palladium, etc., ketones and aldehydes, preformed imines and in situ formed ones, tons of hydroxylamines, etc.), and 99% of the cases the main reason for the shitty yield is not the borohydride itself, but rather the imine not being formed completely. Unless you have another reducible group that's afraid of borohydride, it should not make any major difference if the imine/iminium is formed. Lastly, short-path distillation is not a bad practice. Idk what's your background, but it is quite obvious that you didn't work that much with volatile compounds. Yes, it is not as convenient as a rotavap, but short path distillation is a completely viable option AND used in industry quite often when you're afraid to lose your precious product -- and the mantle should not overheat the sides of your reaction flask unless you crank it up to 300C to distill off DCM. It is literally the same thing as a rotavap, just in a different setup.

[@Bludgeoned2DEATH2]

@@felixfelicis_ll As a chemist myself I fucking love these comment sections. So so much to learn in the back and forth between us chemists.

[@Chemiolis]

@felixfelicis_ll I do have proper ventilation, I have worked with much worse and my hood is fully capable. I agree it's mostly an 'issue' if your imine is formed, so anhydrous MeNH2 is likely best and then many reducing agents are appropriate. Short path I think is totally a fine alternative and it's also really easy to setup, it's just rarely used in academia for this purpose. Most people prefer rotovap ig as it will also spread out your product more and allow for better drying and potentially flowing powders. I don't mind switching, they're just expensive and I prefer a proper one that would actually be less of a 'hassle' than short path and give noticable improvement. For drying celite-product mixtures I think it will be a lot more convenient for sure.

[@randomguy2210]

​@@Chemiolis A bit offtopic, in general is there a way to predict precisely the steps for synthesis of any molecule just by knowing the structure of the final product?

[@C_TheVOid-wf6wx]

Wake up babe we got new molly

[@MichaelThomas-te1jd]

Which will be extra neurotoxic. Look at mefquione. This is such a terrible idea, because halogenases will still lead to the same metabolites.

[@tylerhortenbery7920]

​@@MichaelThomas-te1jdI was actually thinking the same. Not chemz id ingest and I've ingested a lot

[@alanomofo]

@@MichaelThomas-te1jd hol up lemme put on a system of a down song

[@tylerhortenbery7920]

@@alanomofo aeriels in the sky

[@brentoncarter4275]

@@tylerhortenbery7920life is a waterfall

[@walterbunn280]

As an adult with CF living in the USA, I can tell you that none of the raw products are cheaper than a finished bit of Ivacraftor. The medication, to which it is only the majority component, is around $24K a month before insurance. After insurance it's around 1500 a month and they have charity programs that forgive the rest of the medication cost. I was a chem major in college, and the dire need to be able to make Trikafta in case global supply chains die has been a major interest of mine since the drug was first formulated as Orkambi. Edit: clarifying costs.

[@stevengill1736]

Wow! That's pricey! Hopefully like some hep c meds it'll be covered by insurance soon. Looking at the structure I'd say you're right - you could hire a custom synthesis lab in China to make a kilogram of Ivacraftor for a few thousand dollars...

[@hammerth1421]

Yeah, Vertex is controversial for a reason. They've invested a lot of money and brain power into these CF medications, but now that they're approved, they come with a hefty profit margin that goes way beyond recouping those costs.

[@walterbunn280]

​@@hammerth1421 Ehh.... patently false. Ivacraftor was already developed decades before being approved as a drug for the treatment of CF as a HIV protease inhibitor that failed to prevent infections or curtail the spread of the disease. It was already proven to be safe and even effective for one particular iteration of the Human Immunodeficiency Virus, but it's safety wasn't really inquestion. The effectiveness of the drug was actually proven well before the drug came to market, so... Vertex hasn't really done anything to earn the right to charge 30K a month for the drug (which was the cost of Orkambi when it first came to market.). Don't get me wrong, I don't think they should be giving the stuff away for free, but,even at 15K a month, a full time employed person with 90% drug coverage plan in the USA can't afford the drug. there's nothing that justifies that kind of cost, and i hope every pharmacuetical exec that signs off on that price enjoys hell.

[@cvspvr]

"living in the usa" there's your problem right there

[@michaelhicks8603]

It’s honestly disgusting. I am from a country with normal health system where these drugs are literally a few dollars. I don’t understand how people in the US havnt rioted in the streets to fix their system. It’s so bad and costly, and all it really does is fund insurance executives lifestyles. It would cost your economy orders of magnitude less money and probably result in huge economic growth if you fix this. And yet here you are… hope anything works out for you man :(

[@Baileyyyyu]

Selenium MDMA when

[@petevenuti7355]

I just recently watched a video on that, apparently the sulfur substituted ones are bioactive longer...

[@CDCI3]

What does this even mean? Where would selenium substitute in MDMA? At the oxygen?!

[@-r-495]

Nope, its eyes get tied by Se. There is a paper out there, can‘t remember the authors nor name but it was an interesting read.

[@AsherBrandt]

@@-r-495 It's the McCorvy paper.

[@AsherBrandt]

@@-r-495 pubmed.ncbi.nlm.nih.gov/38645142/

[@ottowalter2519]

This channel is evolving constantly into a really professional synthetic blockbuster. Thank you for your work. Are you planning to provide some analytical data? Maybe you could include a TLC of your products to show the purity of compounds.

[@michaelhicks8603]

Agreed on all points here. Fabulous channel, every video he does is amazing. I would love to see a heap of his videos be re-visited with some follow up analysis.

[@somnitek]

I had a god awful experience with 2-FMA where I ground three teeth many years ago and ever since then I've been highly scared fluorinated analogs. Then again, I concede I didn't synthesize it myself and I was young and reckless with the dose (I guess you could say I treated it like kids treat street meth). I don't know what I was thinking. I was a real mess in those days long ago. I don't actually touch any of these things anymore. Haven't for many years. I do LOVE the chemistry and chemistry videos though! Keep it up! 😊

[@hammerth1421]

The problem here essentially is the same as with shoving alcohol-drenched tampons into various orifices, you're circumventing the easiest route of elimination. While the metabolic products are neurotoxic, they no longer have the activity of MDMA. With this fluorinated derivative, you're getting the effect of the full dose for way longer until it's finally eliminated via other routes.

[@Sentient_Goose]

2-FMA was my absolute favorite analog

[@hasselnttper3730]

@@hammerth1421 2-Fluorodeschloroketamine also lasts about twice as long as ketamine. I would want everyone to replace their ketamine with 2-fluorodeschloroketamine, as it's far easier to reach the perfect effect when it doesn't fade away in between lines. It's also slightly more potent (5 - 10%), but that's not important. Wikipedia says this about the metabolism of 2-FDCK vs Ketamine: "The metabolism of 2-FDCK is analogous to that of ketamine: the enzymes CYP2B6 and CYP3A4, the latter to a lesser extent, metabolise 2-FDCK to Nor-2FDCK via N-demethylation. This is further metabolised either to dehydronor-2FDCK by CYP2B6 or to hydroxynor-2FDCK by CYP2A6 and CYP2B6." "In general, the 2-FDCK equivalent shows stronger docking to CYP2B6 in simulations, as well as slower metabolism rate, than the more well-known ketamine. The lipophilicity is observed to be lower for 2-FDCK than for ketamine. In vitro to in vivo extrapolation predicts that in the body, 2-FDCK shows a lower intrinsic hepatic clearance than ketamine. Both of these characteristics would suggest that the effects of 2-FDCK last longer than those of ketamine." This is basically an AD for 2-FDCK, but also other fluorinated... molecules. There's something about them, seemingly regardless of class of drugs (whether it'd be arylcyclohexylamines like ketamine, amphetamines, benzodiazepines, etc).

[@voxelsofsorrow]

​@@hammerth1421maybe you could do something with the other end of the molecule so MAO could metabolize it more easily? I'd be curious about the primary amine (drop the N-methyl) and the beta-ketone. or other ways to make it easier to oxidize.

[@chemistrycapital]

Such a cool synthesis

[@tuxedopig7940]

When are you gonna interview Hamilton Morris man Great quite tedious total synthetic pathways and work up being shown. Bravo

[@AdamIvie-gz6cg]

That would be a fire episode for hamilton Morris's podcast

[@michaelhicks8603]

100%

[@yxbxi]

How does he keep doing it, next up he's going to make MXE

[@wytsewolf]

Fluoro mxe of course

[@kid_missive]

😢 i miss mxe

[@twiston7]

MXE is banned in the eu, but DMXE is an option

[@Josezwitterion]

The BEST Channel of orgánic chemistry

[@aqua-op]

Thats some trusting friends you got mate. Or some fiends. Ive got some friends id trust with almost anything. Ive just realized that one of those not things is preparing me a first attempt synthesis of an unstudied fun compound.

[@liveyourdreammedia]

yeah, kinda setting yourself up by adding that into the vid really. this could potentially end badly.

[@Tyresio12]

IIRC from the Japanese paper (first on this type of reactions) the iodocompounds gave better yields than bromo-ones. And given that the aromatics can be iodinated on their ring by the iodine+oxone...

[@Tyresio12]

@@theKashConnoisseur What neurotoxicity? The iodine atom doesn't stay in the molecule, same as bromine in the video. It only serves as a "connector" to acetylacetone in the reaction.

[@BirnieMac1]

This explains so much; I noticed during pharmacology undergrad that fluorination tended to yield higher potencies but didn’t get why it didn’t change the effects given they’re at opposite ends of the electronegative spectrum

[@The_Ascension]

I believe the Shulgins have already bench marked this Florine derivative in the 1991 publication of PiHKAL.

[@markhays170]

This is honestly the first video of yours Ive seen. I especially loved orgo and medicinal chem at school, and want to further earn a phd in organic chem soon, and apply it toward medicinal chem. But this is really cool, and I look forward to more videos. I'd love to be able to spend some of my free time doing random syntheses like this. Having access to a suitable lab for such things would also be cool...a man can dream. 😮‍💨

[@chemistryofquestionablequa6252]

Lab equipment is cheap on eBay and similar sites, it really just comes down to having space to do it.

[@zzzluvsk]

"Lets do a little cost analysis to see if it can compete with the illegal circuit" Bruh 🤦‍♂🤣

[@Kxkxkxkxk88]

we created an analogue of X with fluorine before the release of GTA 6

[@michaelhicks8603]

Hahahaha this so good!!!

[@kevinl8440]

Thank god this guy doesn't sound like he is in the US. The DEA would absolutely raid him for making analogs of MDA and MDMA

[@lumpygasinavacuum8449]

The gasing method you used at the end is totally new to me 🤯

[@cvspvr]

have you ever heard the story of -icarus- chemplayer?

[@voxelsofsorrow]

Chemiolis are you on any other platforms? You should really really consider diversifying, just in case... But thank you for taking the risk with this video! I've wondered about fluorinating the methylenedioxy bridge before, so this is lovely.

[@psychedelicfoundry]

This is pretty sweet. I "know" someone who has tried some other fluorinated entacogens of their own creation, and they were pretty decent. As well as the 2-bromo. But that one is a pretty selective SSRA in comparison. NaBh4 is great and also sucky. Just adding 3 eq of of acetic acid to it and make triacetoxy borohydride for these reations seemed to improve the reductions I've tried with it.

[@rileysimmons9886]

Username checks out

[@Parasclepius]

You're a madman. I love it.

[@madcatz3d]

Dude please back up all your videos 😭😭

[@gabrielalx]

In the catalytic cycle of the first reaction (5:05), the bottom intermediate should be Cu(I) not Cu(III)

[@Chemiolis]

Oopsie you’re right!

[@alanomofo]

were all on on the same dea watch list

[@valacarno]

Not sure what dea stands for :jk:, but I am certainly on many of a list of progressivism and satanic influences. On n'arrête pas le progrès!

[@AdamIvie-gz6cg]

Yayyyy were on the friends list then we all DEA watch list homies now

[@ForageNorthAmerica]

Man, I love your channel. I hope it doesn't get narked.

[@The_alchemistress]

I’ve seen some procedures use dibromomethane as a reagent to use with catechol which can give a dioxle ring. Di-iodomethane would also work as viable reagent

[@RobsMiscellania]

I expect this particular compound would require the use of dibromodifluoromethane or difluorodiiodomethane to prepare the precursor benzodioxole.

[@madansharma2700]

1. Would it be worthwhile to make and use your own triacetoxy borohydride. It will work better than borohydride. 2.,when are you going to resolve the product.

[@michaelhicks8603]

Going to download this, freaking awesome video man. Hope someone doesn’t get butt-hurt and invent a new rule and apply it retrospectively to your channel.

[@Sandymouseguy]

Hey is there somewhere else that you upload your videos to keep them safe in case you get Chemplayer'd? Like bitchute or something? P.S. - Love the work you're doing and it's so nice to see this kind of content on KZbin again!! My friends and I have been saying that it feels like we are back in the KZbin chemistry Golden era..... A KZbin chemistry Renaissance!!?

[@merbst]

there exists a peertube auto-mirror tool somewhere

[@meaker9410]

lmao first the benzo video and now this, chemiolis is on his Walter white arc

[@meaker9410]

@@williamackerson_chemist yea true. although the tryptamine he made didn't have psychotropic effects if im not mistaken

[@sirfapalot9957]

Since a lot of fluor compouds seem to react more agressive in certain situation's isn't the risk of creating something more toxic equally high even if it does not interact with the cyp p450 enzymes but just in binding in receptors and potential permanent damage? A lot of these substances have a lot of unknown parts in how the body gets rid of them by kidneys or renal route? And in some potential situations even create permanent neurotoxic damage? I am not educated enough on the pharmacology on this , also know way to little for chem/biochem , I am more on a personal experience based run in psychoactive substances and i have some unfunded fears for some fluorbounds.

[@MasterOffTenshi]

As a Pharmacist i can simply confirm - fluorides and chemicals with fluor attached are stuff not to touch even as a psychonaut. Fluor itself is harder to be metabolized by cup p450, increase lipophilicity which will cause easier penetration blood/brain barier, it increases stability of organic compoud as its binding realy strong with Carbon atoms> TLDR: longer half-life, store in tissue, hard to metabolize, longer effect-more toxicity. Thats just brief view.

[@randomencounter-]

As I've understood, because fluorine is so angry and reactive, the bonds it creates in the process would require equally strong energies to take apart. For this reason fluorine bonds are very strong and the compounds it forms can be very stable and non-reactive. If I recall correctly, the toxicity of PFAS and other fluorine containing compounds arise from the fact that they are hard to break down, so they can mimic other molecules that are necessary for life, but then throw a wrench in the works because they can't be metabolized the same way. In this case the fluorine should prevent a metabolic process that produces toxic compounds, so it might be beneficial.

[@MasterOffTenshi]

@@randomencounter- yes, also they are paring with receptora witch higher affinity. I dont know why by it seems my previous commet was deleted??

[@sirfapalot9957]

@@randomencounter- But since a lot of interaction on hormones/pharmacology are somewhat unknown and it is more like guessing/bruteforcing receptor bindings and testing what variations of receptors do in various combinations have as a potential therapeutic result are somewhat guess work? So I am really interested on how these substances could improve current medications for example , or create other risks on pharmacological base on long term use.

[@joki7352]

no

[@Thailerr]

We got new molly before GTA6

[@Quinn-m5d]

Nah GTA 7

[@christianrockey4457]

Good shit brother, thanks for the morning pick-me-up!

[@VG-or1nu]

Most sigma chemist on KZbin rn

[@Quinn-m5d]

For real bro.

[@Joseanfer-zs9zm]

The conversion of the ketone to imine releases water, so usually it gets removed (i.e with a Dean-Stark apparatus) in order to shift the equilibrium. By using an aqueous solution of amine, you get the opposite effect, which may affect yield. For the reduction to amine, usually sodium cyanoborohydride, Na(BH3)CN is used, as it reacts with imines but not with ketones (in theory). Maybe using these cnages you can get a better yield.

[@石头-d4f]

NaBH4 gives good yields, but methylamine needs to be in methanol, then drying with silicagel or molecular sieves after imine formation.

[@mattcarnevali]

I’d love a reaction sequence that’s super colorful. Like no specific synthetic target, just stringing as many reactions together that all have rich beautiful colors

[@grebulocities8225]

I'd look up sreetrips if that's what you're interested in. It's all transition metal chemistry because the channel is all about precious metal refining, but transition metals are where the beautiful colors are.

[@kid_missive]

sticking to what you're used to is for saps

[@science_and_anonymous]

You want to finish my undergrad research on di-thiol tryptamines at this point? I'm a PhD student and never got to see the final product. Would love to see if they smell like their precursors. I'll send you the papers on it if you'd like.

[@indecisivechisel1335]

If you can get your hands on it, you can try replacing NaBH4 with sodium cyanoborohydride (NaBH3CN), which cannot reduce ketones, only imines. Love your videos man!

That last sentence 💀

[@petitkus4408]

Of only i could synth my own lysergamide and empactogen to eventually peacefully trip on my own in my private place

[@michaelhicks8603]

There’s some SICK biosynthesis stuff out there, so soon you won’t have to. Imagine if those MO’s escaped into the wild 😂

[@derenjoy3r]

Chemistry goat just posted!!

[@tom23rd]

I have always wondered about this synthesis. Interesting work sir.

[@schillerh]

Can you use an Eschweiler-Clarke reaction for reductive amination instead of methylamine?

[@stevengill1736]

The literature on the desmethyl analog (DFMDA) is in Wikipedia...funny, I thought Sasha had made it but I can't find it. The advances in fluorine chemistry have come a long way since I was a kid - there's some hepatitis C meds that have three or even four flouro groups. That trifluoromethylthio analog of 2-CT may be in use before long - that's one on my bucket list. ;*=[}

[@oii_3768]

Trachsel claims DFMDA and DFMDMA are not really active in the book "Phenethylamine - Von der Struktur zur Funktion". That CYB210010 does look juicy though. Bummer that the established routes are quite expensive though. I hope you haven't licked blood though!

[@SimonBlokky]

The low yield during the copper catalyzed reaction can be due to the sensitive nature of Cu(I) compounds. I’ve always struggled with getting good yields in these types of reactions. The rapid color changes of the solution right after addition of the copper iodide might be evidence for it. Addition of ascorbic acid and stricter oxygen free conditions might help keep it in Cu(I) state and help increase yields!

[@CAPTAINCAPSLOCK111]

Cool! Yesterday I wanted to ask you if you could perform a reductive amination in one of your future videos, but forgot about it, and boom! Here we go! Thanks for that one! (But I would still like to see you use STAB the next time!)

[@petevenuti7355]

Interesting how all the watch list words like methylamine end up as Blue Links with a magnifying glass? Good for tracking I guess.

[@ruperterskin2117]

Right on. Thanks for sharing.

[@MaartenHeskamp]

This could actually be an extremely vile substance with extreme neurotoxicity. Things like 4-Iodo, Bromo or Chloro amphetamine are very neurotoxic (4-fluor being the least toxic). This one has increased size and similarity to the other halogen amphetamines. Not advisable to taste.

[@antagonista8122]

don't think so. in case of 4-substituted amphetamines - 4-fluorinated stand no chance compared to the rest when it comes to neurotoxicity, and I suspect that even the 3,4-methylenedioxy derivative may be more toxic than 4f. however, fluoro-substituted benzene ring is a completely different story than fluorine placed anywhere else.

[@hstl1x]

@@antagonista8122 Can speak from past expierence, this reply is 100% legit

[@fastbre4ker]

@@antagonista8122 real

[@again5t.your53lf6]

You sir are bonkers. I love it. Please be the leader of our chemical revolution

[@StephenMcGregor1986]

TMTFA MDMA when?

[@mschst9733]

I'd love to see Ibutamoren next

[@Nicolas-up4xp]

If you're gonna be covering designer opioids next, maybe you could try making O-desmethyltramadol.

[@Quinn-m5d]

some fent analogs are legal

[@sciencoking]

2:56 only the finest juices go in this potion

[@ZettabyteGamer]

Never stop, I love you gave some friends the stuff to test. Next make LSD!

[@Spencisuar]

1-flouro-LSD

[@kid_missive]

@@theKashConnoisseurblah blah blah. lots of ppl do RC's. cry harder

[@kid_missive]

@@theKashConnoisseur Serious humility issues.

[@kid_missive]

@@theKashConnoisseur No, you're just being an elitest. Read the works of Alexander Shulgin - pihkal and tihkal. Without this man, and his friends, carefully and responsibly trialling novel analogues - chemicals literally "cooked up in his shed", we would not have the vast majority of synthetic empathogens, or even refined natural ones. Without the works of his wife Anne, we would not have the language of psychedelic assisted therapy. I think it's incredibly brave to be doing this kind of work in the modern age and standing up for what's right, stepping out of the shadows, and documenting it on youtube. That's just me though.

[@ZettabyteGamer]

@@theKashConnoisseur All your points are valid and I agree, however people already consume research chems from dubious sources all the time. There are websites on the clearnet that sell known psychoactive chemicals that are pretty much completely untested for safety. As long as Chemiolis was clear on the potential issues I dont really have a moral issue with him sharing this stuff with freinds. People take what they want to take. Edit - I didnt even read the thread above till now and it seems like you guys already talked about exactly what i said lol. I do still agree with all your points @theKashConnoisseur but also @kid_missive. People already take RCs, if he was clear on the safety implications of taking this compound I don't personally have an issue with it.

[@AsherBrandt]

Genuine question where did you get the methylamine from?

[@mxxrci4174]

maby self made.. If I remember correctly he once made it

[@AsherBrandt]

@@mxxrci4174 Yeah you can make it but it requires formaldehyde which is quite toxic.

[@boothbytcd6011]

@@AsherBrandt Lots of things he makes are quite toxic. He has a hood and is a chemist.

[@aidanarbaugh1248]

babe wake up Chemiolis makin Folly

[@12times24]

So let's get going chem guys.. I'll buy an ounce

[@brentoncarter4275]

Easy to find the feds

[@johnthomas2970]

40 pounds more like

[@quint3ssent1a]

Today I learned that uhhhh ... Yeah, that thing about bioisosteric analogs was pretty new to me, ngl. Especially if fluorine and hydrogen are nothing alike in chemical sense.

[@shadowX9365]

Benzofurans been around iykyk, shulgins pupil was the one to create 5/6-APB

[@ligmabaldrich485]

More fluorine chem

[@ligmabaldrich485]

nvm, he started off with the fluorinated product

[@jimsvideos7201]

I wonder how they sort the list we’re all now now.

[@michaelhicks8603]

Lawyers do it for extortionate prices when you end up in court. Aside from that they don’t, and don’t really care. Well, except advertisers :/

[@markharvey1843]

I love this guy

[@gaetanozorzi2055]

Now it’s time for a bioassay…

[@californium-2526]

7,7-difluoroecstasy, the sixth in the [REDACTED] powder series.

[@hytago3338]

Finally!

[@LegaliseFinland]

Nooooo you can't just dismiss The 1988 Vienna Convention like that😭😭😭

[@cjay2]

How about just using well the ones that already exist?

[@kooolainebulger8117]

cant believe adding fluorine makes it safer

[@bladee512]

It also makes it worthless to get any kind of high you would need to take 1-2g and even thern you would probably also need to use it alongside a MAOI

[@MichaelGottloib]

@@bladee512combining an amphetamine (a SUBSTITUTED amphetamine, no less) with a MAOI sounds like pure hell. Granted, I have only combined substituted tryptamines with a MAOI but I would assume you wouldn’t be able to sleep for days on that combo.

[@stevengill1736]

Have you heard human data? The desmethyl analog apparently has activity, at least by receptor assay....

[@FK-ng2gf]

I have never seen such a sort of Copper Catalysis. What is that called?

[@sagichnix]

Please do some mxe

[@CDCI3]

I felt the "...moderate."

[@Mong-Clizzy]

Edging the DEA with this

[@Quinn-m5d]

DEA is evil and shouldn't exist

[@chanheosican6636]

It is very interesting in terms of Amphetamine -Meth chemicals. However KZbin is getting harsher and harsher on people who make drugs like this. I disagree with YT policies like what they did to PMC with the Kratom extract but they may be very hard to stop. I think this is quite cool.

[@brendanguymer3885]

Where do you buy your methylamine? Asking for a friend

[@Dankatinone]

Would leuckart reaction work for the final step

[@robina6645]

ONC when??

[@Bludgeoned2DEATH2]

You and Thy Labz are my favorite Clandestine chemists haha

[@timevolentisback6840]

Dude works for lizard labs

[@ChristianGeske-yn3mr]

They have brought me great times, great times lol.

[@tylerhortenbery7920]

My boy synthing up the next diddy drug.

[@Quinn-m5d]

Nah he's not doing that. This stuff is good and is not a Diddy drug

[@Quinn-m5d]

👎👎👎👎👎

[@Lukesab3r]

You are a fucking God.

[@rezaalijanianzadeh4202]

Very very nice

[@ho0t0w1]

DAMNIT JESSE! I said ANHYDROUS Methylamine!!!

[@Quinn-m5d]

Breaking bad is a good show

[@benmcreynolds8581]

I've always been curious if it's possible for someone to figure out what compounds would be psychoactive? Like is there a way to tell if something could be psychoactive before it's ever been made or before anyone has even tried it?

[@Quinazolinking]

Mice

[@ChristianGeske-yn3mr]

Yes but it’s not a perfect science.

[@benmcreynolds8581]

@@ChristianGeske-yn3mr Interesting. I wonder what new discoveries someone might stumble upon in the near future..

[@AmaroqStarwind]

What the hell is an empathogen?!

[@Quinn-m5d]

It's a dr@g like molly.

[@AmaroqStarwind]

@@Quinn-m5d That actually doesn’t tell me anything.

[@jackofalltrades3378]

You're the man!

[@TerrariaiOSTAIOS]

how are you able to have access to a lab to do this? not US right?? do you test these substances on yourself?

[@TerrariaiOSTAIOS]

ok i watched till the end. i hope the subjects enjoy it

[@Flumphinator]

My dude FLUORINATED METH.

[@MoonberryJam93]

Bro what is this trend of chemtubers making drugs 😂

[@NonyaBiz-t5f]

im just gonna throw this out there. the 90s were crazy. if mdma was neurotoxic, all ny neurons would be toxified. ive literally eaten my body weight in the stuff and im still kicking it. what happened that made people so scared of mdma? out of the thousands of people i used to eat beans with, nobody ever complained of any neurotoxic effects ever, and it wasnt for lack of trying. wee didnt havec any 3 month rule, we rolled wed-mon every week from say 1992 till the fla ban in 1997. i think the whole mdma is toxic troupe is played out... maybe it is technically, but in practice, no. show me someone that mdma has been neurotoxic to. please.

[@Quinn-m5d]

That's wild bro make the reason why people thing it's neurotoxic is because people took molly that is cut with other things like research chemicals.

[@glorck7064]

i thought you were gonna use a different thumbnail

[@rileysimmons9886]

Fluorination is a good method for metabolic protection, but... deuteration next? 😂