Simple, concise, and extremely elegant explanation. Amazing video!
@abebarnes32694 жыл бұрын
Finally! An inversion video which clearly describes the ramifications in meiosis and crossing over. Just what I needed for my midterm. Thank you! Amazing video!
@TheCodegram4 жыл бұрын
Yo this video was a game changer. Thank you so much. Some profs just can't explain concepts clearly but this solved all my problems
@sunshine27414 жыл бұрын
From very complicated to very simple! Thank you so much 💖
@gorsich14 жыл бұрын
You're welcome. Good luck with your studies.
@sunshine27414 жыл бұрын
😁✌🏻
@lesoul7002 ай бұрын
Wow… the first time I understood this mechanism clearly.. thank you so much
@earth2k663 ай бұрын
6 year old video, still the best and easy to digest explanation. 👍
@magnuslikestanks60442 жыл бұрын
Thanks a lot. Best explanation of the inversion loop I could find.
@anhvy83445 жыл бұрын
Oh my gosh this is just so good it solves my problem which i had had through years
@gorsich15 жыл бұрын
Good luck!
@karentchatchoua19663 жыл бұрын
merci franchement j'ai pas les mots mais cette video m'a sauver en 20 minutes
@gorsich13 жыл бұрын
vous êtes les bienvenus, bonne chance
@eileenfindley16836 ай бұрын
My daughter has this inversion. Chromosome #9 broke off and reattached itself at the bottom. Was told at 4 months preg. I should probably think about abortion. So happy I choose to let nature take care of itself.
@amethystanna6496 Жыл бұрын
I couldn't understand my professor but you explained it way better. Thank you!
@suparnahari82413 жыл бұрын
Life saver honestly. True help. Really thank you
@francescacaporaso6076 Жыл бұрын
Not all the heros wear cape. Thanks from Italy. Saved my life 💗
@gorsich1 Жыл бұрын
Ha ha. Good luck.
@oussamarezzouk98694 жыл бұрын
You didn't talk about how they happen exactly great video btw love it
@masabathisis78294 ай бұрын
Phenomenal explanation! Thank you so much.
@SHIVAMKUMAR-hy2ij4 жыл бұрын
Love from india Well explanation
@ishanibose43514 жыл бұрын
Amazing video and explanation. Thank you so much
@PrabhakarKumar Жыл бұрын
*Thanks for very easily explaination sir 😊* *I'm from India and basically knowing* *Hindi language well but i understand from this video easily.* *Very very thanks for easily explaination 😊*
@jacquelinelabovitz46134 жыл бұрын
really great explanation! thank you!!!
@mvk_lakshmi4 жыл бұрын
You r the best teacher steven sir Thank u soo much sir...
@techhridom60754 жыл бұрын
You are Best
@papridas55424 жыл бұрын
Very useful. Thank you sir
@Iffatzaka4 жыл бұрын
It helps me alot.. Thank you Steven sir
@gabbygarcia1772 жыл бұрын
thank u for this. so much better than my teacher
@InsideOutofNATURE4 жыл бұрын
Thanks a lot ... It helped a lot to understand very easily...😊
@kawtharalbashrawi88257 жыл бұрын
Very well explained thanks for this great video
@gorsich17 жыл бұрын
You're welcome. Good luck.
@sougatadas38874 жыл бұрын
Thanks sir from India
@anycolouryoulike8567 Жыл бұрын
Beautiful. Wow. Thanks very much!
@DigitalOutlawed3 ай бұрын
Amazing, SImple, Awesome, Thanks!
@linalaith96 жыл бұрын
I finally understand now. Thank you!
@gorsich16 жыл бұрын
You're welcome. Good luck.
@hookem37685 жыл бұрын
The Acentric chromosome fragment you drew that would not produce a gamete, contained genes D, G, and H of the green strand. Wouldn't this Acentric chromosome also contain E, F, G, and H of the red strand, forming HGDEFGH?
@samlee66045 жыл бұрын
thank you so much ! your video really helps
@gorsich15 жыл бұрын
You're welcome. Good luck to you.
@Manisha-mf2qe Жыл бұрын
Thank you so much Bhagwan Ji and you 😇🤗🌼🌼💓🙏
@peaceofjah95643 жыл бұрын
Thanks. Its very clear.
@ImranKhan-un6zo5 жыл бұрын
Very helpfull
@nolanramanjulu67969 ай бұрын
17:03 What about a pericentric inversion with a cross over event? What would be the percent viability of the gametes?
@godblesssikawa61585 жыл бұрын
Great explanation
@gorsich15 жыл бұрын
Thank you. Good luck.
@kantnesragnarok61283 жыл бұрын
I liked every comment. I'm fan of science and people who do it
@yoyon37749 ай бұрын
Great video
@azharjoy30613 жыл бұрын
This is a good lesson...but the subtitle upon the figure irritated me
@surupakarmakar17742 жыл бұрын
Thank you!!
@bikrammajhi72783 жыл бұрын
Ohh man, really nice video. ThankyOu !!
@emmanuelanthony2594 Жыл бұрын
saved my life
@krithikams42826 жыл бұрын
sir ur explanation was really great is there any vedio on preicentric inversions.. plz...reply
@snortymcgout6 жыл бұрын
Were you also studying for the genetics quiz today? lol
@gorsich16 жыл бұрын
Krithika. I currently do not have a video on pericentric inversions. However, you would set it up the same way as a paracentric inversion (except of course with the centromere in the inversion loop) . Then just follow the chromosomes from one end through the crossover. As with paracentric inversions, there is only a problem if there is crossing over in the loop. If no crossing over then there is no issue. Unlike paracentric inversions with crossing over, pericentric inversions do not produce dicentric or acentric chromosomes they produce chromosomes with too much or too little chromosomal material. Good luck.
@krithikams42826 жыл бұрын
Steven Gorsich .it was so kind of u thank you so much sir....
@snortymcgout6 жыл бұрын
Steven Gorsich: I just finished my quiz and there was a paracentric inversions question just like this asking for all gametes and their viability. I wouldn’t have got it if it weren’t for me watching this great video the night before :)
@dhilipanloganathan32282 жыл бұрын
Nice sir 👍
@birrowtechАй бұрын
Hello Sir, need a video for double crossovers please 🙏
@samsoma39282 жыл бұрын
Thanks
@pan1681685 жыл бұрын
Thank you Steven for your great video. But I have one question. How this inversion form in the first place? From your video about duplication and deletion, I can understand how they form during meiosis crossing over. But how about inversion? I guess the mechanism is much more complicated.
@gorsich15 жыл бұрын
Not really more complicated. Inversions are causes by the chromosome getting cut twice and the middle portion flipping 180 degrees. This is often caused by various mutagens (like X-rays) that are known to cause double strand breaks. They are also incredibly important evolutionarily because they can cause gene mutations and can lead to new genes or altered gene expressions. Hope that helps.
@pan1681685 жыл бұрын
Steven Gorsich thank you for your prompt reply. So after double strand break, i have a question about how it “stick back”? is it a simple 180 degree flip and join by ligase? It would require a +/- chain switch right? Or is it by homologous recombination?
@lisherry45002 жыл бұрын
Great video !!!!
@safieesskcollection11742 жыл бұрын
Great job 👍
@DPH13014 жыл бұрын
Can the body fix a chromosome inversion on its own?
@eileenfindley16836 ай бұрын
I would not think so....
@shaghayeghsoudi186 жыл бұрын
very helpful, thanks a lot
@gorsich16 жыл бұрын
You're welcome. Good luck!
@bokamosomorema949 Жыл бұрын
understood, thank youu
@alexanderdiederichs73322 жыл бұрын
fantastic
@monikak15724 жыл бұрын
Vry helpful
@midnightstar33404 жыл бұрын
UP?
@AliAli-lw1ei3 жыл бұрын
Thx🙏
@dhunganalaxmi8277 Жыл бұрын
Wow great
@layaldergham45 Жыл бұрын
good ass video my guy
@smashez083 жыл бұрын
Can you please explain about chromosome 9 pericentric inversion. My partner has it. What are our best bets for healthy kids? Should we do ivf with preimplantation genetic testing? (I had 2 miscarriages and no kids yet) Thank you for your work and effort!
@gorsich12 жыл бұрын
This is actually a fairly common inversion in humans (up to 3% of the population). This can lead to infertility. However, after my name is a PhD and I should not give out medical advice. I do think it's important that you talk with a genetic counselor and your OB. They will be able to give you a more precise answer and should be able to tell you if there are any ways to overcome the infertility. Luckily (speaking from first hand experience) there are other great ways to be a parent. Hang in there and good luck to you and your partner. I hope to hear good news in your future.
@lets_start_preparing32166 жыл бұрын
Very helpful.... Thanks a ton💖
@gorsich16 жыл бұрын
No problem. Good luck.
@nibrasulhaque9168 Жыл бұрын
THANKYOUUUU
@sumantamohapatra67276 жыл бұрын
Thanks,great one...
@gorsich16 жыл бұрын
You're welcome. Good luck.
@Good_Nurse2 ай бұрын
Perfect
@ans64412 жыл бұрын
hey nice video , had a question , does paracentric inversion increases the chnace of anueploidy ?
@gorsich12 жыл бұрын
Good question. I'm going to give you an answer off the top of my head, and lead you in a direction that might be helpful. In case this is an homework question, I don't want to give you the answer. Remember with paracentric inversions that there are usually no problems as long as there isn't a crossing over event in the loop. Now, if there is a crossing over in the inversion loop then it becomes more interesting. Remember, one of the gametes that forms is a dicentric (having two centromeres) chromosome. What becomes of this? Could this lead to a trisomy or monosomy? I could see an argument for an aneuploidy or no aneuploidy. One is more correct. What do you think?
@nareshgoswami5336 Жыл бұрын
भारत माता की जय🚩
@user-yq7on5th6z6 жыл бұрын
thank U sir 😊👏👏
@gorsich16 жыл бұрын
You are welcome. Good luck.
@themadlad55774 жыл бұрын
Please stop saying synapse, it's not healthy for us to cringe this hard. Complementary base pairing is its own phenomenon. The word "Synapse" in biology is used explicitly and exclusively as an implication of a neuronal Axo- somatic/axonic/dendritic junction (i.e. a neuronal synaptic junction). It's not too big a deal I guess, as your context is very different and this doesn't hinder your capacity to convey your lecture (good video btw) But it's just incorrect terminology and it's best not to be passed on to students.
@themadlad55774 жыл бұрын
I now realize you might have been referring to Synapsis/ Syndesis. If this is the case you should use the terms correctly. Hope you don't mind the constructive criticism, even if you decide not to take my advice I still think your vids are very helpful and you have my gratitude regardless.
@gorsich14 жыл бұрын
@@themadlad5577 Thanks Archie. Don't mind at all. I often say synapse as a verb describing synapsis. I don't know if using it as a verb is correct, but I think it's probably ok. When I remake this video I will keep that in mind. I do appreciate how if someone is coming from either the neurobiology field or the cell biology field that the noun synapse means something different. Have a good one.