Click Chemistry (Nobel Prize 2022) - Periodic Table of Videos

The 2022 Nobel Prize in Chemistry is awarded to three scientists for pioneering "Click Chemistry".
More links and info in full description ↓↓↓
Featuring Martyn Poliakoff, Miriam O'Duill and Christopher Merrett.
Details of Christopher's experiment here: periodicvideos.com/extra/click...
The Nobel Prize in Chemistry 2022 was awarded jointly to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry"
www.nobelprize.org/prizes/che...
See our previous Nobel videos: bit.ly/periodicnobel
Safety Glasses video: • Why you need to wear s...
Videos on all 118 elements: bit.ly/118elements
Support us on Patreon: / periodicvideos
More chemistry at www.periodicvideos.com/
Follow us on Facebook at / periodicvideos
And on Twitter at / periodicvideos
From the School of Chemistry at The University of Nottingham: bit.ly/NottChem
This episode was also generously supported by The Gatsby Charitable Foundation
Periodic Videos films are by video journalist Brady Haran: www.bradyharan.com/
Brady's Blog: www.bradyharanblog.com
Join Brady's mailing list for updates and extra stuff --- eepurl.com/YdjL9

[@thewilltheway]

This Nobel prize is a godsend because my project works with click chemistry. Now I don’t have to explain what that is to my colleagues because everyone knows now.

[@tomwatts703]

My undergrad literature review is on click chemistry - specifically the azide-alkyne reaction - so it was really great news to hear that three authors whose work I've been studying had won the prize!

[@Djinn_Tonic]

Click chemistry with copper and azides! I used it when i was graduating as a way to attach denaturated DNA to solids for later analytic use. That was 10 years ago, but I remember it as an interesting and very useful tool. Well deserved Nobel prize!

[@stevie-ray2020]

Even though I'm not a chemist & only have a rudimentary understanding from high-school (50yrs ago) & of course your great YT videos, I still find all these discoveries fascinating especially when they're so well explained by your presenters!

[@sheldonaubut]

@Stevie-Ray -- I'm sitting here in the same boat as you. The only chemistry that I use almost daily is in the kitchen, although I am facinated by, and only understand the processes in some of these videos. "Periodic Videos" and "Objectivity" are amongst my very favorite channels and ones that I actually watch repeatedly to get a better understanding of the content. I too haven't formally studied any Chemistry since high school in the 1960's.

[@sergiosaucedo5834]

As an immunologist I can say, Carolyn Bartozzi’s work has been crucial in the development of immunotherapy. A Nobel Prize very well deserved!

[@abigaylegonzalez3490]

I’m an undergrad working on some organometallic synthesis, and purification is by far the hardest portion. After 20+ H-NMR spectra it’s easy to read and do data analysis. What is impossible is subliming my compound without breaking and frying it. So either I use liters of solvent testing what would clean the best or I keep burning it. Organometallics in GC/MS would even be more of a struggle with ordering the right column. One day I hope to publish my first paper and someone being able to extend it further with their 20+ years of experience

[@MrHeroicDemon]

Almost 2 Million subs, i've been here since like 2009-2010. I was in Chem U 11 when I found this channel. Obsessed with all Brady's channels since.

[@piplow1]

Wooo keep the episodes coming guys! Thank you all

[@JCtheMusicMan_]

Excellent video! I was only previously familiar with click-bait chemistry 😅 💜

[@ooooneeee]

😂

[@bruceanderson7762]

Click bait chemistry...the one that smells like anchovies?...lol

[@dylanvellut]

I did a click reaction for my studies 5 years ago. I was impressed by the expedient reactivity and the bright yellow insoluble product at the end. One of my best reports due to the simplicity of set up and purification process .

[@RaunienTheFirst]

One of the projects I was involved with in my undergraduate studies involved the Cu(I)-catalysed azide-alkyne reaction. We were making ligands for metals with the intention that they could be dyes for solar cells. That is, the part that has an electron excited by being with a photon and pushes that electron into the circuitry.

[@Pongant]

I can see why biologists are super excited about click chemistry. The whole setup reminded me of regular work in a biolab

[@andreascasablancas3574]

Im a pharmacist/modeler so my chemistry isn't the best but I'd appreciate to know how can the alquine and azide groups can be easily added to biomolecules in the right place.

[@GuillotinedChemistry]

I enjoyed your colleagues' experiences and perspective with actual click chemistry reactions. So happy to see Dr. Sharpless that won it again... He seems to have never lost his curiosity and wonder. 😄

[@ProfessorWaltherKotz]

In memory of Rolf Huisgen (1920-2020), who never got the attention he deserved.

[@killermonkey1392]

This comment needs to go to the top.

[@samuelallen6220]

Very cool to see click chemistry in the spotlight now and especially some chemistry that I actually know and understand! I tried to use it in some of my postgrad biology very similarly to the experiment Christopher showed (complete with THPTA and fluorescent ligands), though I didn’t get as nice results as we saw in the video.

[@Veptis]

Hearing Brady asking the questions I have on my mind is usually reassuring. But now I am left with questions I didn't realize I had.

[@graemeroberts2935]

So inspiring and informative! Thank you!

[@AustralLabs]

Like key pairs matching in a search system - this is probably how ribossomes are so efficient in generating extremely low probability products - each catalytic locus is very low energy, but the chain is large an the combined energy of weak partial matches makes the chain termalize into a reaction.

[@invisibledave]

Didn't like how this video was segmented out. It kept flipping back and forth from the experiment to the chatting. I had to keep fast forwarding so I could try to see the entire experiment as one sequence.

[@sauravchoudhury7567]

So the type of ligands which are to be used is dependent on what the reaction is being done for right?? I feel so excited as I myself am studying about the click chemistry as soon as I got to know and it's all over the air because of the Nobel prize 😂

[@essentialgmbesttoday9109]

Your effort is to warranty your human's kind, it's warranty your humanity , honor and prize are an identical separate your knowledge from the whole- Your job is help to solve world's problem. it's help us, it's educate us - Congratulations! and keep working to find something to challenge the worlds.

[@louwclaassens4988]

This is truly deserving of accolades! However my question now is: How much effort and reaction time is spent on the precursors (reactants) for a click reaction. If they are indeed strained or reactive molecules, surely a lot of energy and chemicals went into prepping them?

[@bigsarge2085]

I've read about this! Always fascinating.

[@Mikkelltheimmortal]

A very well deserved Nobel prize.

[@A.JamesDavenport]

Well done Chris! 👏

[@ginj8134]

I’m a student who still doesn’t know a lot about chemistry but I’m incredibly interested and these videos are continuing to introduce me into its amazing world I suffer from pretty bad ADHD and I struggle to concentrate but chemistry helps me out with concentration and I enjoy it so much happy I subbed you have a really calming voice and your way of explaining is amazing it’s unfortunate the uk education system for high school doesn’t do chemistry as much as other countries

[@pawankalyanbotgaming3294]

Beautiful explanation

[@pyrinikos3477]

Hello periodic videos thanks for the great video today they are always of such high quality it’s just amazing. Also a video idea would be a video just compiling a bunch of chemical reactions and molecules, compounds and the like.

[@makoyoverfelt3320]

Oooooooooh yeah I been waiting for this! Love to see the wonderful Professor P.

[@theultimatereductionist7592]

Amazing that Barry Sharpless has worked for 52 years as a chemist, winning a Nobel Prize, TWICE, since losing sight in one eye!

[@quackerzdb]

That multichannel pipette looks like it's due for calibration

[@9bbalgopal937]

I was waiting for this one!

[@blainelanders2361]

Wonderful video on new science. Wonderful suggestion for eye protection. I am no chemist but I wear safety eyewear when mowing, or wood working in my garage or under my Jeep doing maintenance. I can confirm that habit has saved me from eye injury dozens of times!

[@BobMotster]

Been researching the sugar layer my whole life too. Have the feeling that diabetes will beat me to the discovery at the end though.

[@arlindbanushi]

I immediately recognized the 3 pirani (vacuum sensor) from Pfeiffer. I miss working with mass spectrometers, although now I work with NIR and XRF.

[@rmbt]

This is exactly what I expect how a professor and his office should look like 🙂

[@lewistempleman9752]

I can't believe this has happened!

[@SoNoFTheMoSt]

Is there any practical application for any click reactions?

[@woofowl2408]

So interesting, almost bridging the gap between organic chemists and molecular biologists

[@petevenuti7355]

THPTA? What was was the lignend? What about all the work that goes into the precursors?

[@michaelwolf9885]

I really don't want to share my pipettes with this PhD student. Great video tho!

[@FourCues147]

Click Chemistry was introduced to me by an excellent lecturer, Dr. Lowe. This is bringing many memories of Click Chemistry reactions, where it was explained "Don't muck about of it could explode due to the Azide!"

[@privard89]

I'm protesting the Nobel prize until Martyn wins

[@ErolMazharAksoy]

QSAR and Click Chemistry are they similar?

[@dhindaravrel8712]

I thought click chemistry was seeing a new chemistry video on youtube and clicking on it. ;)

[@chloehennessey6813]

Not shy you haven’t won a Nobel. You guys have done so much for Chemistry the last decade.

[@joeflosion]

You don't know what the Nobel prize is for, do you?

[@pimphatwaggoner1655]

oh cool, justification for a 9th edition of lehninger biochemistry that can be sold for $400

[@venkybabu8140]

Does it allow for different life types.

[@coverfrequency2305]

Chemistry is wild. Hopefully not too many fume hoods were harmed in the discovery of click chemistry.

[@andrewmirror4611]

TL;DW: Wear glasses in the lab.

[@411Adidas]

Freaky, Iread this as he was saying it. 👻👽

[@PushyPawn]

😎

[@michalchik]

Please show the diagram for the demo reaction

[@MichaelKingsfordGray]

How is this "efficient"? It is like the seat-belt analogy, without taking the smelting of the buckle-steel, the chrome plating energy, the mining of the petroleum used for the webbing, (etc), into account!

[@Harpoquondrax]

Fascinating!

[@tahashahid8145]

You forgot to talk about co-laureate Morten Merdal’s contribution?

[@_bambi_420_za_]

The explosive possibilities ..

[@allanfitz3535]

the most scientific looking scientist I have ever seen. love it.

[@arunavadasgupta2147]

Send me Question On On Applied Chemistry On Inorganic And Organic Both Should I Established My Own Formula On New Chemistry Equation

[@jasonchiu272]

For a name like "Barry Sharpless" he has quite the sharp mind.

[@alexanderharrison7421]

5:25 I love his Tool Expectations Chart, I remember saving that image ages ago and still remember the last two of "You should've Listened" and "It can't be locked if it's Liquid"

[@mumiemonstret]

Beware of testing chemicals by means of enema... (5:40)

[@FergalByrne]

The cell membranes are made from lipids (fats) not sugars

[@vincejohnm]

Membranes are decorated with sugars which cells use for tagging and recognition. A membrane without sugars adorning it would be a rather faceless object with which an organism would have trouble signaling to/communicating with.

[@Videoswithsoarin]

yes made of but not coated with

[@ahooper99]

Professor Poliakoff has a great dandelion look going :-)

[@adampm1]

that multichannel pipette worked well didn't it hahahaha

[@patrick247two]

Now that is a TEA cup.

[@styxa_2]

What happened to Pete Licence?

[@davidmackenzie9701]

Professor of Chemistry and Director of The GlaxoSmithKline Carbon Neutral Laboratory, Faculty of Science, School of Chemistry, University of Nottingham.

[@sarashaw3625]

I am glad I did not "click" away!

[@jMsism]

Great video as always! 2:30 *Grabs P1000* So that's 1.25 MICROlitters into there... hehe i see you

[@Hexakinase]

I want whoever calibrated that pipette to work on the ones in my lab.

[@ashwilliams8518]

I saw the same thing lol. But he used the right pipette for the later small volume. Maybe he misspoke?

[@Stevethebear]

467 downvotes... id love to see if they all came from around 13 min in....

[@excavatoree]

"There is no more important safety rule than to wear these: Safety Glasses." -- Norm Abram

[@mikoajkopernik916]

Very chaotic video.

[@abnrmlmind]

You couldn't find M&M's???

[@arunavadasgupta2147]

I have established Formula On Mercury Venus and Earth And Mailed To MIT USA

[@AviPars]

Epic hair and epic video

[@Klaevin]

"imagine human cells are like m&ms. I don't have m&ms, so imagine they're like malteesers"

[@gethplatform2392]

Yeeesss!!! I wanted to watch that video since the Nobel Prize was announced, because I don't understand what is Click Chemistry!

[@darkcrazyleg]

subtitles in Portuguese, please! Thanks

[@sleepyfutchtgirl470]

@8:00 guest appearance by TARDIS

[@cronobactersakazakii5133]

I like this channel Dr Poliakoff and you are a delightful person, so I am very sorry to tell you that if you want to be a double nobel, you’ll have to shave your head 😢

[@arunavadasgupta2147]

Tell me Elements So that I can Generate Formula With Equation Of Chemistry

[@AkiSan0]

Two tipps for Mr. Bennet: 1) get a automatic pipette if you do this more often 2) dont bent your back to your plate! bring your whole body down with a small stool or chair. im speaking from experience... your back will thank you later on. ;)

[@social3ngin33rin]

I wish I could get a Nobel Prize in something useful :(

[@DonMayfield]

Wear a seat belt when driving too. I learned that about 1972.

[@arunavadasgupta2147]

Any way Let me make New Chemistry Equation And Mail To Nobel Committee

[@ArunJayapal]

Hope someone can validate my understanding...Through click chemistry we can mark individual cells?

[@TheAlps36]

Not exactly - you can use it to look for certain proteins/receptors that are on the surface of cells

[@mduckernz]

@@TheAlps36 Well, you could absolutely mark a single cell, you’d just need to isolate it first :)

[@MyYTwatcher]

"1.25 ul in that" and holding 1 ml tip... Sure :-)

[@RockHudrock]

Will Chris ever be awarded his PhD?! 🙏🏼

[@blinkingmanchannel]

I’m new here. What strikes me is the amount of hit-or-miss fiddling around. I’m sure I simply don’t understand what I’m seeing. But I contrast these explanations with engineering discussions and physics. Is it because we’re talking about molecules? In other words, we can’t put things in a vice, so we’re literally tossing a salad and hoping for the best.. (?)

[@phonotical]

Well why not use an alpha form and oil

[@rahulCoding]

10:31 🙏

[@janetf23]

👍for depth perception -- wear your 🥽

[@thomasbooth4635]

So I'm behind with my Periodic videos. Is Chris the new thirst trap star of Periodic?! More please.

[@A.JamesDavenport]

Back off! He’s taken

[@thomasrogers8239]

If Sir Martin Poliakov doesn't get a Nobel prize then there's no justice

[@Dolandtromm]

You haven't read a full standard book of chemistry..........i bet.

[@alphonsokurukuchu]

yay! explaination

[@demoror5585]

Well then let’s gooooo!!!!

[@robbybobbyhobbies]

Bit of biochemistry going on in that mug at 4:30. It’s alive I tell you!

[@brucet9799]

Many KZbinrs are not having Closed Captions lately. The speech is not always easy to understand.

[@Scrizati]

If they're using auto generated captions it can take some hours or days for the system to add them it seems. No idea why

[@catradummy_alt]

It's also harder now because the community can't contribute captions anymore. That was helpful in alot of situations

[@AkiSan0]

blame youtube. as "inclusive" as they are, they are removing a lot of features that made stuff inclusive..

[@AquaWeiner]

Grow ears then 😂

[@Videoswithsoarin]

@@AkiSan0 because it doesnt fit the agenda of inclusive. its all LGBT and that but nothing actually helpful or important

[@ThopazProductions]

where can i contact yuri oganessian

[@dangerdackel]

What about scale up to 1 kMol, Lots of problems here

[@essentialgmbesttoday9109]

I have no space to breath... if you are hurting my forehead----Stop Pls... don't you love your own " I "