Clodagh O'Shea - Cracking the Nuclear Codes: Finding Order in Chaos

At the Salk Institute, O’Shea established a highly interdisciplinary program that blends virology, structural biology, biochemistry, cancer biology, multi-modal imaging, synthetic biology, and genomics. Her lab has made foundational discoveries that have impacted multiple fields, invented disruptive technologies, and translated this knowledge to develop transformative therapies. A recurring theme is her use of viruses, both as powerful tools to reveal critical tumor targets, and agents that can be rationally designed to seek and destroy tumors. Her work has revealed the underlying logic of genetic circuits that are disrupted in viral replication and cancer growth.
This talk was given at the 2023 Symposium on Physical Genomics at Northwestern University, sponsored by the Center for Physical Genomics and Engineering and the Robert H. Lurie Comprehensive Cancer Center.