Coagulation Cascade - Easy Way To Remember Intrinsic vs Extrinsic Pathways | PT or PTT?

The coagulation cascade is easily forgotten. I show you an easy way to remembering intrinsic vs extrinsic pathways, as well as whether PT or PTT
is the test needed. I also go through how different anticoagulants work on the coagulation cascade.
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Video Timestamps:
0:00 Intro
00:27 Intrinsic vs Extrinsic Pathways
00:57 Common Pathway
1:37 Easy way to remember intrinsic vs extrinsic pathways
2:08 What is the difference between PT and PTT?
2:48 What are the Vitamin K dependent clotting factors?
2:55 What causes a prolonged PTT?
3:09 What causes a prolonged PT?
3:30 What causes a prolonged PT and PTT?
4:04 Where in the coagulation cascade do different anticoagulants work?
5:45 What are the antidotes to anticoagulants?
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Other Questions answered and video tags:
What is the difference between the intrinsic and extrinsic coagulation pathways?
Which factors are in the intrinsic and extrinsic pathways?
what is the difference between pt and ptt?
what is the difference between pt and aptt?
Where in the coagulation cascade do anticoagulants work?
which are the vitamin k dependent clotting factors?
easy way to remember intrinsic v extrinsic pathway
what causes pt to increase
what causes ptt to increase
what causes pt and ptt to increase
causes of prolonged pt
Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.
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[@PiyushKumar-lg9is]

Play table tennis and play tennis, what an excellent way to remember diagnostic tests. Amazing clear and concise information

[@RhesusMedicine]

Picked that one up in Medical School, has stayed with me!

[@icymoorge]

This video is very good. Clear, gives good mnemonics, I feel like I remember everything, I will be back in a few months when I forget it all again

[@RhesusMedicine]

The life of a medical student!

[@rozekafiaz9244]

paleyan bn yana

[@FishoeShoe_da_great]

that tennis mnemonic is just beautiful

[@dumisanzama3901]

Vitamin K dependant factors: "1972 was the disco era" (1=10) 9,7,2 and diSCo=protein S&C) this has worked for me instantly after I had tried and failed to memorise them. I would always confuse them and would sometimes mix up the numbers after some time.

[@gagagig2895]

Awesome! I try to read this topic by myself for half a day and still confusing but u make it clear in 6 mins. Thank you so much.

[@razanabdullah1016]

Clear, simple ,short and highly informative 👏🏼👏🏼👏🏼👏🏼 thanks

[@krutika8656]

So beautifully explained!! And you guys have managed to cover everything, in such a short time!! Thank you so much for this video! :) :)

[@RhesusMedicine]

Thank you!

[@JK-jd1ir]

This helped me recap the coagulation cascade for post-graduate exams. I especially liked how you included the clinical side of things with the blood tests and medications. Keep it up!

[@RhesusMedicine]

Thanks for the feedback, glad the video helped!

[@rafidcurrim6649]

FL

[@chibzyt5699]

BRILLIANT BRILLIANT BRILLIANT video. The effort and ease for everyone you considered is just heartwarming. Really love this video.

[@RhesusMedicine]

Thank you for the feedback, and for watching! 😊

[@wellermasong6984]

Thank you for this. Brief and concise. God bless!❤

[@angrygunther2569]

Excellent video! I really love these mnemonics.

[@adamwalsh1977]

Ur am you so much you make a complex algorithm more simple & REALLY liked the mnemonics. It’s the best way I learn & they defo stuck 👍🏻

[@shadysid5570]

Wow, this video has every bit of information I needed

[@arnavupadhyay5970]

Really covered it all in so less! Great work!!

[@RhesusMedicine]

Thanks Arnav! 👌

[@yadums1448]

This was about 2 hours of reading compressed to 6 minutes. All the needed points and mnemonics .tysm

[@RhesusMedicine]

You're welcome 😁

[@lorifondren5583]

This video is absolutely AMAZING! Thank you so very much for sharing it with us.

[@RhesusMedicine]

Very glad it was helpful, thanks for watching :)

[@naveenkumar9215]

This video really helped me now! Thanks a lot for your contribution for medical education!

[@wael9704]

Fantastic video! Love the clinical correlation and drug action mechanisms. Perfect for post-grad exams. V nicely done.

[@RhesusMedicine]

Buy Us A Coffee!: www.buymeacoffee.com/rhesusmedicine For more medicine videos consider subscribing (if you found any of the info useful!): kzbin.info/door/Rks8wB6vgz0E7buP0L_5RQ Video Timestamps: 0:00 Intro 00:27 Intrinsic vs Extrinsic Pathways 00:57 Common Pathway 1:37 Easy way to remember intrinsic vs extrinsic pathways 2:08 What is the difference between PT and PTT? 2:48 What are the Vitamin K dependent clotting factors? 2:55 What causes a prolonged PTT? 3:09 What causes a prolonged PT? 3:30 What causes a prolonged PT and PTT? 4:04 Where in the coagulation cascade do different anticoagulants work? 5:45 What are the antidotes to anticoagulants? USEFUL STUFF FOR MEDICAL STUDENTS: FREE Amazon Prime 6 Months for Students (Including unlimited 2-day shipping on orders of any value) US: amzn.to/3gMqh0p UK: www.amazon.co.uk/gp/student/signup/info?tag=rhesusmedicin-21 Venepuncture Kit: UK: amzn.to/3r7txrW Pocket Cards: Lab Values / References / ECG / History Taking (Cheatsheets for rotations!) US: amzn.to/3c3UybK UK: amzn.to/3rd37W8 Suture Practice Kit (Complete kit with pad) US: amzn.to/3c5ZJrN UK: amzn.to/3vO76fh Fingertip Pulse Oximeter US: amzn.to/3tFDT43 UK: amzn.to/3eZYoo5 (Affiliate links - We get a small percentage of sales, so if you buy anything, thank you!)

[@bakindeakindapo9618]

From the bottom of my heart, Thank you so much. I really really appreciate your explanation.

[@RhesusMedicine]

Pleased it helped you 🙂

[@dumindasamarawickrama3795]

Great work

[@maisaaabuwasel6040]

what an amazing video! great explanation and very helpful memorizing tools!

[@amanuel3342]

Very helpful , especially the tenis mnemonic

[@michellegordon3319]

Informative, thorough and to the point. Thank you 🙏

[@RhesusMedicine]

Glad it helped, thanks for watching 😁

[@alexahmed2581]

simplified and explained very well thank you!

[@RhesusMedicine]

Thanks for watching!

[@wajeehashah7103]

Awesome video thanks dudes

[@OmnipotentO]

Really nice "cheat sheet" style layout. Very useful

[@bivoist]

Thank you so much. This nice explanation helped me alot.

[@jazzygirl160]

thank you this helped me differentiate between all 3

[@rebbekandahuma2173]

Awesome! Thank you❤️

[@RhesusMedicine]

You're welcome!

[@allisonsouter9589]

best video I have seen yet on this topic, thanks so much

[@RhesusMedicine]

Thank you! Very kind

[@ICU_NERDSE]

you are so brilliant ! Thank you for this!!!

[@RhesusMedicine]

You're very kind, thank you!

[@ritikasrivastava4084]

U r best all in one helps 🙏🙏🙏

[@viona8897]

I just want to say a big big big thanks. I especially enjoyed the memory aids- really amazing!

[@RhesusMedicine]

Definitely a topic that needs memory aids!

[@tejasmahajan1557]

Nice explanation

[@alexandradelliou]

This is your first video that I watched. SUBSCRIBING!

[@hanisofiamazlan794]

Love it, thank you so much

[@RhesusMedicine]

You're welcome!

[@timothywiebe4714]

Great one! TY

[@elpedro812]

It's very helpful and very well explained! TY

[@RhesusMedicine]

You're welcome! Glad it helped 😁

[@wiamalbouzidi7778]

Thank you so much !

[@alangoomez]

Thank you ❤

[@jamiuadebiyi6778]

This is the best video on clothing factors so far.Thank you

[@RhesusMedicine]

Thank you for watching! Means a lot 😁

[@rozekafiaz9244]

dont lie

[@rebbekandahuma2173]

Truly

[@shinigglory3689]

Thanks for this informational ❤️❤️

[@RhesusMedicine]

You're welcome!

[@DrPBaptiste]

Not an easy topic to cover but you've done it really well!

[@RhesusMedicine]

Thanks Dr Baptiste, I appreciate that! Hopefully provides an all in one video for people to come to for a refresher

[@DrPBaptiste]

Rhesus Medicine yes it was good for me!

[@marine-se2vl]

great video

[@gabrielehiraoka4853]

Thank you for this video! Studying for hematology for my lab tech exam and this video really helped

[@RhesusMedicine]

Glad it helped, best of luck! 🤞

[@EJTDB]

You are magnificent! I will never forget this!

[@lammeesakc867]

Thankyou for these❤

[@RhesusMedicine]

Glad they're useful 😊

[@anahit6645]

WONDERFUL.

[@user-lc9xp6lo5z]

Thanks am from long holiday this context has really recaped. My mind

[@theanonymouspotato1924]

i'm not being dramatic when i say this video probably saved my life

[@bryanamante7532]

👏 Amazing. Thanks!

[@RhesusMedicine]

Thank you Bryan!

[@nagatsatti8426]

Thank you very much doctor

[@RhesusMedicine]

You're welcome Nagat!

[@reagananesthetist-ss4bh9wr9]

Fantastic

[@ameliamorton1686]

Thank you God bless

[@dr.leelaram]

Great lecture❤

[@RhesusMedicine]

Thank you for watching 🙂

[@nonyeonochie3250]

Perfect!!

[@macsuip2]

Good job

[@user-mu4uy8dv1y]

As an emergency doctor, this is an excellent recap of the clotting pathway and the relevant drugs.

[@RhesusMedicine]

Thank you, appreciate the feedback!

[@jacquelineparadzayi5859]

Amazing 👌simply amazing

[@aamirmuhammad7962]

Wow amazing 🤩

[@RhesusMedicine]

Thanks! 😃

[@ephraimjosephfalcunit5768]

damn, that was good! thank you!

[@RhesusMedicine]

Glad you found it useful 😁

[@ortaekvator]

Harikaa çok teşekkür ederim. Kanalın ilerleyiş biçimini de çok beğendim emoji kullanmanız odaklanmayı kolaylaştırıyor. Arkadaşlarıma önereceğim inşallah❤

[@hk6474]

Good sheet

[@clieolada3601]

Calcium is not Plasma Factor V, but IV. plasma factor V is labile factor/proaccelerin

[@nilsboller4651]

You can remember Via-K-Ant with the year 1972 (10,9,7,2)

[@rahulkumar-wf1dd]

Been through a lot of videos, in search of this topic, it couldnt have been better 🙏 Posting it at 3.45 a.m, my exam is in next 4 hours, Thank you

[@RhesusMedicine]

Thank you Rahul, the feedback means so much! Crush that exam- best of luck! 💪

[@jaymorgan.]

Did you pass? This topic is still confusing to me. Lol

[@dskim24]

That first sentence you open with; yup, hence I'm here.

[@RhesusMedicine]

😂

[@chisangamanjoni2034]

😂yup, me too

[@dskim24]

@@chisangamanjoni2034 Aaaaaaand 8 months later.... AGAIN!

[@rgvn5]

Ninja nerd taught me an easy way to remember: Intrisic pathway = 12 11 9 8, Extrinisic = 7 3, common pathway = 5 2 1 Put 10 in the middle. Intristic pathway you count down except 10 Extrinisic path way 7 + 3 = 10 Common pathway 5 * 2 * 1 = 10 Now you will never forget again

[@ReyShen-tv3xj]

hello, I thought LMWH didn’t really have a reversal agent, which is why heparin is preferred in critical care situations

[@stevebradford3939]

its very easy to forget.

[@sheliceallen68]

Can you give an example of injuries that would release contact activation or cause tissue factor to be released?

[@RhesusMedicine]

Hi Shelice! Generally speaking, we'd mainly be looking at trauma- which is of course a situation where coagulation would be a physiological attempt to reduce blood loss. There are of course others, but there are technical differences. Endothelial dysfunction, for example, may result from many causes including smoking, hypertension, diabetes mellitus, dyslipidemia etc. Endothelial dysfunction has been shown to contribute to the pathogenesis of thrombosis, but this is more of a pathological process rather than a physiological process seen in response to trauma! Hope that helps somewhat. Thanks for watching!

[@stacymethvin3426]

Thank you ! I needed this for my exam tomorrow and yes....I will be back as well, but the calcium Ion is Factor IV, not V. Just so you can make the change.

[@RhesusMedicine]

Hi Stacy! Thank you! (Also for the coffee!! 😁). I'm so glad it helped - as for the Factor V, you are absolutely correct that Factor IV is a calcium ion, in the video I say that Factor V is needed alongside a Calcium Ion, I can see however how it could cause confusion as they're listed together- I should have made it clearer! Thank you again for your support, it really means a lot. All the best with your exam :)

[@kenp2396]

Is platelet factor 3 the same as tissue factor/factor 3?

[@sohanirahman720]

Tissue factor II is inhibited by heparin

[@sabaamjad632]

why i saw this so late ALSO please mention heparin monitoring is done by APTT n why?

[@09ch03]

hey the calcium is factor IV na

[@kenp2396]

My professor says run(one) to(two) the five and ten store.

[@samjones1320]

I love you

[@zux1153]

👏👏👏👏👏

[@gem270]

Thanks. It’s starting to click

[@RhesusMedicine]

Glad to hear!

[@dianneloma9047]

idracizumab or idarucizumab?

[@zahidfit]

Rhesus monkey😎

[@JzQ21]

Thank you so much!

[@RhesusMedicine]

You're welcome! 😎