Coagulation cascade | Human anatomy and physiology | Health & Medicine | Khan Academy

[@MuhammadZubair-mp6cm]

I studied Robbin's pathology, I studied guyton and believe me, these 14 minutes have stood more valuable for me than those 20 pages of textbooks

[@kerrybiery6360]

Exactly! Those who really know how complicated this whole coagulation thing is have great respect for this presentation. Of course, this presentation is targeted towards an entry-level allied health students: nurses, paramedics, respiratory therapists, etc. I am a nurse (now retired, thank God) with an extensive background teaching allied health students, and many years of experience in ICU, PACU, ER, and Med-Surg. and I’ve forwarded these coag. videos to colleagues who’ve enjoyed them as I have.

[@rishavmadhukalya2]

World needs more teachers like you...

[@HampsteadO]

10 years out of college and I tried to learn it in multiple occasions from so many different textbooks and you did it in 14 minutes. Thanks 🤣😍

[@christinelouis7493]

Studying this cascade from the pov of different subjects at college and never been able to carack it doen like today

[@daisymay8488]

Nicely broken down and very easy to follow! I swear, I spend an hour just trying to read about this stuff, but watching a 15 minute video and I completely grasp the concept now! Thanks a lot!

[@abiazizahmed2808]

A living legend...man u dont know how much u help...i can only say God bless u

[@markblaze4746]

I felt less dumb after watching this video, my lecturer talked like a machine gun

[@jamesalipio1631]

our lecturers always have

[@wellman15able]

"lets say you weren't very good at counting" omg that entire part brought my sides into orbit

[@hannahfuller6088]

"Assuming you have those friends" LOL

[@mylynnwoods1565]

Lol. I can relate

[@tatner7146]

It's just wonderful how you organize notes so that it can be easily remembered! Love your videos!

[@seafoam7095]

Been studying this sh*t for ages and you taught me the easiest way to remember it! I like how you said about the numbers (factors) ultimately leading to the 'goal.' And yes it worked for me because I'm bad at counting lmao

[@robynneRN]

This was fascinating. I am learning about anti-coagulants in nursing school, and this really helped me with the foundation as to WHY we bother with PTT, PT/INR lab values. Thank you!

[@enoente1888]

I tried to learn this a couple of years ago for my exams and I must confess, I could not answer the question. Listening to this video and watching you create such a complex concept so simply is so good, thank you

[@joshuaharris5605]

Almost a decade later and still the best video on the net to learn clotting factors

[@Schatten2712]

honestly, after the complement system this is like a walk in the park

[@gh-ps5es]

It's the opposite for me? But this was still pretty easy to understand. Guess it depends on who u r learning from as well

[@kkomber6888]

@@gh-ps5es how is it easy for you I am dying trying to learn them 😂💔

[@yksci2740]

I’m about to cry this video helped me more than I could imagine

[@jedidiahmanna3863]

Omg …. This video is so good. I had to pause it halfway to give a thumbs up and comment. I am phlebotomist, and I have been wondering how anti Xa works. With all the video I have gone through online. This video, I believe is the best. The cascade is well explained with tricks to help me remember. I will love to explain to some of my patients this amazing biological process in our human body. Thank you for this amazing 🤩 video 🙏

[@jcvn8915]

No way i can describe how much of a great helpful and intelligent human being you are

[@kthekactus]

This was amazing! I was struggling to fully understand my uni lecture on coagulation but this video made it so much easier by going thru the steps diagrammatically and vvv simply! v relevant + to the point too, no waffle!!

[@admoh8835]

This video deserves noble prize in education

[@AJohnson0325]

thanks! I have to study 140 pages of notes on anticoagulant, anti-platelet, and fibrinolytic drugs. This is going to help me a bunch.

[@lobarita]

You have helped me understand this thru the past several months. It took a while, but it's all coming together. Thank you.

[@Sali_Levi]

Extremely clear explanation!! amazing

[@SethMundall]

"...while evolution was designing us". Wow! Such an intelligent designer evolution is. How people can believe this masterpiece just came together with no design is beyond human comprehension or reason.

[@samphonnetgamgee5625]

They're stubborn

[@francesca95]

I thought the same thing! Such a betrayal of their own beliefs to personify a seemingly meaningless and random process!

[@pippaharris-patel6490]

"Wouldn't it be easier if you called 5 friends and then those friends each called 5 friends?" I clearly don't have friends, I am watching this video on a Saturday night with a hard seltzer.

[@BeautiFAHT]

This is the absolute BEST video I've watched on intrinsic/extrinsic pathways! Such a clear understanding now! THANK YOU!

[@toddfennimore6625]

Wow! Amazing explanation - I have heard or read over a dozen lectures or articles on the clotting cascade, and I feel as though I finally understand it and can retain it.

[@dr.h.a.bpediatrics8999]

Thank you very much sir .. Thats how medicine should be explained to doctors .. 👍

[@merhanessam]

this video helped me alot ....i really spent days to try to understand this part :( .....but now everything is clear for me....thank u so much

[@Andrew-kh7rz]

i really spent 2 to three fcking days to get used to insertions and origins of the muscles as well as the lumpy bits

[@cat5220]

thank god for this channel... about to singlehandedly save my degree!!

[@mc_dibia]

this was beautifully done. it made so much sense. if my lecturer only showed this video instead of talking for an hour

[@raspberry765]

"you'd become one large walking clot" HAHAHAHAH

[@jessc7952]

you just explained in 15 minutes what my lecturer failed to do in 3 hours

[@riyaroka]

Fell in love with the explanation, its saving the life out of me. Thank you sm❤️❤️❤️

[@CollinScottTibbitts]

One of the best coagulation videos out there!

[@gazamax3]

then is one of the best videos ive ever watch in my whole medical school. THANX ALOT

[@habib080]

Which medical school do you go too?

[@gazamax3]

Ha080 it is in Turkiye, Ankara, yildirim beyazit university

[@hadjerswift4519]

This is very helpful and easy to understand ,also loved the tricks to memorize it better

[@nadaramadan5709]

amazing... i am an egyptian vet and i love your videos so much 💙💙💙

[@mandaparker21]

Videos like this make me love KZbin. Great job! I loved the visuals.

[@shalomsiansangu9179]

Best best vedio on coagulation cascade I've come across

[@FishoeShoe_da_great]

this literally just rewired my whole brain

[@hana-bt7rf]

best video? no best video EVER!!!

[@sbbperson]

I clicked on your video by accident. But your video and explanation skills were so good, I subscribed. Thank you for the information, this is great!

[@nontobekomdluli]

this is amazing...you are God's sent. my teacher makes it look so complicated...

[@PonzooonTheGreat]

Wow, thanks! My lecturers are shit! You explained in 15 minutes what my lecturer could not in an hour. What's heparin? I hear that comes into play when breaking down a clot or something.

[@doktorone1666]

Heparin is basically a natural anti coagulant protein . Natural because is made in your body. You can use it before performing a cannulation , you put some heparin on the tip of the needle to prevent blood clots from forming and eventually close the tip of that needle, which would make injecting drugs into the vein harder.. :P

[@lukask.9870]

Heparin promotes Antithrombin 3 (a serine protease). Antithrombin 3 inactivates Factors 2 and 10.

[@nalapisa]

Doktor One True, only heparin is NOT a protein but a GAG (glicoseaminoglican) polymer.

[@palshah2463]

PonzooonTheGreat it's an anticoagulant made by liver which keeps the blood in liquid form when the blood capillaries are not hurt

[@Gossypol]

Does Prekallekrein and HMW Kininogen also includes in the intrinsic pathway? Please explain anyone. Thankyou.

[@befriendGPT]

wow this video is super good! im gonna leave a comment here! ...and then i saw who published it; OH! KHAN! i knew it. thanks khan academy ;)

[@primeascendant797]

Zymogen forms are one of the most amazing things in the body, in my view. Your body is locked and loaded to do so many things, it's very efficient. Especially in this case, when something soluble is turning into something insoluble.

[@Vermazeren]

"Wonderfully explained! You have such a great voice to listen to. Have you ever thought of telling the whole story, starting with the vasoconstriction and platelet aggregation phase? And what about the tPA phase for reversing coagulation? Right now, you only discuss AT and a bit of plasmin, but since platelets play a crucial role in delivering thrombin, it would be great to include details on the role of TXA2 (vasoconstriction and platelet attraction) and how fibrin strands connect to platelets through GP2b/3a."

[@Vermazeren]

Another great point is how the TF-VIIa complex also activates IX, allowing it to activate X independently of VIII-albeit very slowly. Ultimately, IX needs VIII to speed things up, since VIII alone can’t activate X without IX. Just an coagulation lover here :))

[@girldetective18]

God bless you!! You explain this so well and oh my gosh I needed this!

[@jl981015]

Clotting factor 2 is actually Prothrombin, not thrombin. Thrombin is 2a. Great Video!

[@tiffanyann9936]

Thank you. This was much easier to follow than the first two I watched.

[@МилорадЈеремић21]

omg, you are my hero, god bless you, im gona smash this knowledge right to my profesor face, thank you so much!!!

[@ohheyitsadrian4412]

Just Khan Academy saving the day again. thanks!

[@mutelarsorhougbe4606]

This was so so very well explained! And I love the little things to help us remember it!

[@JuanCarlosMedinaAgredo]

Great video, greetings from Colombia Armenia U. Humboldt

[@dareenashgar1965]

Easiest way to remember it, thank you so much!

[@kamyarsharifi4064]

Im a dental school student and I've had this explained to me many a times, but never this well

[@MasterThil29]

It's not easy getting your head around this but you did a great job of explaining all the pathways. Thanks.

[@thinoronha]

Great explanation!

[@nooranoor6221]

I alway look for videos from Khan academy .. always useful .. many thanks ❤️

[@dolphindiva99]

how people think the body works: 'blood clot needed! time to produce some proteins to do the thing' how the body actually works: ‘blood clot needed! time to produce some proteins that do the thing AND proteins that stop the thing from happening and then watch them fight it out in a complex battle of upregulation vs. downregulation until the balance tips and the thing maybe, possibly happens’ no wonder we’re tired all the time when our body spends energy doing stuff like this lol

[@kmirandakondo]

This video is an A for brilliant explanation

[@asha2393]

Great summary, really useful; but you said the first step would be the platelets aggregating to the site of injury, but wouldn't the first step be vasoconstriction? This would significantly slow down the blood flow

[@bhavnatrehan7664]

I think it is because he is talking only about the clotting cascade with platelets and such, even though that would be the first part.

[@user-rj8wm8oj1c]

obviously...

[@kastle5433]

@@user-rj8wm8oj1c If it was obvious then why bring it up? A little bit of a contradiction here lol.

[@tennies9002]

Three years too late.. but vasoconstriction will be the first thing to occur in PRIMARY hemostasis. The coagulation cascade occurs in SECONDARY hemostasis. He shouldnt have worded it that way, but for this portion of hemostasis it makes sense.

[@aishwarya_ganapathy]

i just love the way you teach along side how to remember it. i wish my teachers were like this! :/ thanks

[@shannonhogan5859]

Wow - great little story to remember the factors :) thanks!!

[@douniasaleh8211]

Thank you so much, I always come in this channel for help and you guys never disappoint me

[@Esmeralda505]

You made this sound so easy and it made so simple to understand. Thank you so much!!!

[@JohnCitizenCitizen]

such a good teacher. thanks for making this!

[@Its.me.2234]

Very simple to understand it by these little cute drawings . Thanks a lot .

[@andreacalabrese6193]

Thank you so much for your great videos! I got a better grade on my midterm from watching your videos!

[@cathg.956]

im so happy i found your page!

[@ForYourConsideration]

Thank you for the excellent lesson. The amplification sequence explanation (07:16) was very helpful in understanding the significance of the activation process.

[@jhessiecdj1211]

thank you Patrick for the very informative lecture :)

[@gangabahadurlimbu1239]

Brilliant Lecture.

[@Jongui_]

Seriously, this video is amazing.

[@DC-qk7hx]

Brilliant delivery. Thank you!

[@jazzlikesyoochoob]

this video is gold

[@ivo3185]

I- I finally understand. Thank you so much! Incredible video. You made the topic really easy to memorize!

[@Abdulelah_]

The best explanation I ever had in coagulation cascade I wish you where our lecturer 🥹

[@LauraHernandez-dt9bb]

Wow! You really helped me learn this material. I was so confused by my professor. Thank you !!

[@sudharshan6257]

this guy is just awesome..

[@katelingates-gonzales7086]

What a great video. Thank you :) I would love to see a video like this and include how heparin, Coumadin, aspirin, etc works on this pathway. :)

[@swas2907]

yup

[@mitchellornelas8348]

+Katelin Gates Subscribe to my channel, I will be posting the cntent in a matter of moments

[@crvargasa]

That would make this video pretty lengthy and kind of long shot. Aspirin inhibits formation of TXA2 (thromboxane2) which is part of the primary hemostasis process. Coumadin inhibits epoxide reductase which activates Vitamin K. Vitamin K is necessary for gamma carboxylation of factors II, VII, IX, X and proteins C and S. And heparin inactivates thrombin (IIa) and Xa through another mechanism known as antithrombin dependent mechanism.. Maybe in a different video it would be helpful

[@sania1593]

Katelin Gates ]b

[@1412Z]

Thank you so much for your efforts in doing this video!! God bless you

[@swinxfee]

"assuming you had those friends". Bold of you to assume that

[@janineschwegman7920]

Most beautifully explained - thank you!

[@zahraaammer8700]

You did such a magnificent work over here Well done

[@memoboy4141]

Thanks for existing

[@ManpreetSingh-gc6bo]

it's just awesome! you simplified it like a boss

[@preciousbankole6350]

Wow this explanation was amazing

[@Raxorium]

Very helpful video, a small thing is maybe you could explain when the thrombin activates its negative feedback. Is it when there is too much thrombin in the blood?

[@nicolle6620]

Great job! The visual illustration makes the lecture 1000% more understandable

[@safayyy269]

ASSUMING YOU HAD MORE FRIENDS 😭😭😭

[@anthonychoyo9203]

This is exactly what I wanted.

[@randa2113]

you have just saved me !!! thank you so much for the video

[@cathelaine_ong]

CRAMMING RN FOR A TEST LMAOOOO

[@denirn8725]

Cramming to TEACH clotting & endothelial damage during CoVid Cytokine Storm! Who knew nurses SHOULD learn & consider what’s happening with patients sinking from not too sick into REALLY, REALLY SICK due to clotting abnormalities?

[@sbbperson]

Did you pass?

[@cathelaine_ong]

@@sbbperson I did!

[@sbbperson]

@@cathelaine_ong SALAMAT PO ATE

[@Unarine.Ratombo]

thank you so much for this video, so easy to follow

[@TheRosagirly]

such a clear simple explanation thank u!!

[@enterpriserjohn]

This guy is good

[@LitaMonroe1913]

This is exactly what I'm looking for! This is very helpful!

[@dopechick457]

U made it so easy

[@mohammedal-hammadi5085]

This video is pretty good, thank you so much really