Nucleophiles and Electrophiles: Crash Course Organic Chemistry #12

[@yourstruly4817]

A neutron walks into a bar and asks "how much for a beer?" The bartender says "for you, no charge."

[@improvemento]

lol

[@rohanjuggler1861]

That's from The Big Bang Theory

[@liampb3555]

thats bad but i did laugh

[@Karajorma]

The bartender says "So shall I pour you a beer then?" The neutron says "I'm not positive"

[@ShauryaSingh-ts2oc]

Original jokes are hard to find nowadays :(

[@prioritalpanic629]

This probably won't ever be seen, but I wanted to say thank you so much for all your help. I'm currently doing some last-minute studying for my chem final and I'm finally understanding these concepts after going over them in lecture for weeks. Not only do I better understand them, but you made chemistry fun again! I honestly can't stand lectures that "suck the life" out of incredibly interesting subjects like chemistry and it kills my motivation to learn about them. But this was very enlightening. Thank you! ^_^

[@crashcourse]

Best of luck on your finals!

[@pvtpain66k]

"Girl, I've got a hot spot for your positive regions"

[@nieks9212]

As a chemist, this show has been so entertaining to watch! It is really interesting to see how you explain all the complicated nomenclature, principles and theories and try and combine them to create an allround understanding of the subject. Can't wait to see you explain some of the more complicated topics later on in the series (Are the Diels-Alder or click reaction making an appearance by any chance?).

[@MolecularMemory]

Yep! We'll be doing an episode on pericyclic reactions later in the series!

[@honey3194]

i love you as the teacher to this series! for me, it's usually really hard to watch crash course videos because they go so fast and everything goes over my head (no shade to the other series'), but you help make everything seem so clear :)

[@zayrael]

Catch me owning my entire grade for organic to crash course. Thank you crash course, for such good and free teaching!

[@henryelicker2403]

Bromoethane talking to it's Br group when it sees a nucleophile. - "I don't wanna play with you anymore".

[@colmryan9289]

Why did I read the title as “Necrophiles and Electrophiles”?

[@hugogamboas.5550]

Hmmm... kinky.

[@scptime1188]

SAME

[@greenfilly]

Same

[@thevioletskull8158]

Oh

[@Tentacular]

Just be glad you didn't read it as "Necrophiles and Ephebophiles."

[@taeganmcfarlane]

This CC series is so good! Can't wait for the next episode!

[@saracahn]

At 9:54 is that taunting guy Gary from Pokémon?

[@SuperAndrewlove]

It is!

[@alexbrockwell8158]

I don't know if I'm into BH3. It's kinda borane (ba-dum-tss)

[@newplanet9540]

This episode took so long. Am happy it's finally here 💞

[@vaughnjohnson8767]

0:45 Me: innocently watching* The video: And Neutrophiles, lovers of their positive regions. Also me:🤨......😳

[@vaughnjohnson8767]

@Eutanazol 95% yeah, I know that. I’m just playing off of the chemistry aspect of it

[@leen8175]

Great efforts and amazing way of teaching , you saved my grade!

[@watuphoney1]

This is an amazing course.

[@SciFactsYT118]

Completely random fact: Like fingerprints, everyone's tongue print is different.

[@Soveliss1986]

Or ears

[@randomness2622]

Or probably any print of a similar size skin from any region..

[@ShirinRose]

Also, koala fingerprints are almost indistinguishable from human fingerprints 🐨

[@kashmerykame]

H1 NMR got fingerprint regions that are unique to each compound

[@Noellexafael]

Finally getting to the good stuff, check ur sit belts because u are about to get into a really wild ride haha.

[@nicolepere2056]

PLEASE HURRY AND MAKE THE OTHER VIDEOS! My o chem class has already covered everything you’ve made a video for plus some other stuff and your videos are the only thing getting me through this class right now 💀💀💀

[@feitocomfruta]

Organic chemistry adjacent question (for biology or medicine experts): With the cyanide example, is the neucleophilic attack part of the reason why cyanide is so deadly as a poison? Is it that strong of a neucleophile?

[@ysbi_]

Not quite, but kind of! Its actually more of an inorganic chemistry question! Cyanide binds to iron in a protein called cytochrome c oxidase, and prevents electron transfer needed to synthesise ATP.

[@feitocomfruta]

Arlexa thanks! I guess I ask because it seems like logically, on an atomic level, these kinds of reactions are why poisons and venoms act the way they do.

[@LangThoughts]

@@ysbi_ Would cyanide antidotes then be strong, non-toxic electrophiles that would produce a non-toxic compound if attacked by cyanide?

[@ysbi_]

@@LangThoughts Not really my area of knowledge sorry, but some quick research seems like cyanide antidotes are typically oxidising agents to oxidise iron in blood. This strongly binds the cyanide at hemoglobin (now methemoglobin) instead of at the cytochrome c complex. Too much of this can prevent oxygen transport in the blood though!

[@nihaal7750]

4:30 GARRY OAK!!! ayy

[@Queen1001N]

Cyanide also keeps you alive. It forms part of the structure of vitamin B12.

[@ishikasingh9254]

People plz make more video!!! This is my last life line to get me through my chem classes and my final exams. This is highly requested!!

[@joelw5996]

This is so well explained!

[@EdgarVegaCarrasco]

I really love this series

[@mystrawxd9940]

Wow I am finally early

[@brianodiero7637]

Deboki you a life saver

[@tany3306]

Yes.thank you for this video..helped me cover up the lecture I had missed at school..whoops

[@pauljackson3491]

When the OH- was substituting into the C4H9Cl why does the Cl- just not go back into the Butyl Alcohol and switch again; probably related to electronegativity? Since it is a simple linear molecule could C4H10O just be called Butyl Alcohol instead of Butyl-1-alcohol or even Butyl-1-hydroxide?

[@nieks9212]

Yes, it is related to relative electronegativity; Cl- is much more stable then OH-, and the C-O bond is less polarized then the C-Cl bond.

[@HoshikawaHikari]

I should ask my chemistry teacher to show the class this video before she goes into organic chemistry, and probably the whole playlist once it's done~ XD

[@jamesprince571]

Organophiles 😍😍😍

[@adventurevloggeradnanahmedusa]

This is incredible. Thank you.

[@BeccaMoses]

my chem foundations class is structured really strangely and this is the first year they’re doing this format so there’s just random orgo showing up places - thank u so much for this oml

[@growthmedia97]

We want new series as a review for the MCAT please

[@kaneezezainab3224]

Its way easier than i thought. . 😀😀😀 thanks !

[@sumanmehta7206]

Can u please increase the frequency of these videos, As I need them very much this year😟🙁😔😌

[@crashcourse]

we would love to, but unfortunately, due to the schedules of our content team, this series will continue rolling out on a biweekly basis until the end of the academic year (May 2021) -NS

[@sumanmehta7206]

@@crashcourse Ok then, Waiting for the next video 🥰😊🥰

[@AZ-wg3eg]

oh baby...when you understand what you don't understand you truly realize your limitations of comprehension lol.

[@illinijamie]

Hi crash course- i love you & your vids. Can you make one on antitrust law & the sherman act?

[@hishamkazia4719]

Please do accounting crash course

[@gentrymower3963]

Excellent video, this helped me so much! Thank you!

[@danielm.1441]

Not going to lie... 'Borane' nearly made me giggle.

[@shyamnavarun]

which animation software/app do you use?

[@SuperAndrewlove]

We use a combination of Illustrator for the artwork and After Effects to animate :)

[@Chemistry-Rocks]

crashcourseophile

[@sajayp]

I have heard enough phile for the year lol

[@gennik7966]

I read the thumbnail as "Necrophile" and was confused as to why crash course would be making a video on the subject.

[@mvp_health-n-beauty]

lol, i would be too ☺️

[@taelororbe3375]

Please do a podcast

[@nahfid2003]

I love the host

please more chemical vids!!

[@videoglitter1483]

Please make video about pharmacology lesson

[@lauranight4572]

If she was a molecule then I'd be a nucleophile, because I love her positive regions :')

[@Karasus_drug_dealer]

Please don't be creepy, thanks

[@cara.bella15]

I’m so screwed

[@silverfairy125]

this was such a good refresher for org chem reactions and nucleophilic substitutions

[@gg3675]

Nucleophilic attack, not to be confused with nuclear attacks.

[@diegonayalazo]

Gracias

[@andrewt15]

Dope

[@zuccthecucc9260]

Yeaaaaah i dont think adding philes at the end of something is a good idea

[@kocengineering769]

I can't stop loving you mam u explain very nicely Thanks a lot

[@jaidamuhammad]

How did y’all know this is what I was just going over in Ochem???

[@ThatOneOddGuy]

What would a person who loves explosions be called

[@comradeofthebalance3147]

Unknown ekrixiphile

[@ThatOneOddGuy]

@@comradeofthebalance3147 what typo?

[@comradeofthebalance3147]

Unknown what

[@ThatOneOddGuy]

@@comradeofthebalance3147 exactly

[@comradeofthebalance3147]

Unknown bruh.

[@brahimbelmouhand9888]

Fitst

[@brahimbelmouhand9888]

First*

[@cerealkeepsyougoingeveryda555]

Well done

[@brahimbelmouhand9888]

@@cerealkeepsyougoingeveryda555 thanx

[@mvp_health-n-beauty]

Wow. I didn’t know comments started like this! Pretty cool! I totally like it 😄

[@beastamaki7940]

Hai

[@vahzu]

Cd

[@lovemoreponi3682]

👏

[@trishhart8766]

🙋🏼‍♀️

[@Patrick-ob7ll]

Copaze

[@Mr1995Musicman]

I'm a computer scientist, what am I doing here?

[@karolinamikesova]

Learning something new, heh.

[@milindkundal1518]

Really you look kinda camilla.

[@addyb5645]

CAN YALL HELP ME???? WHY DID THE ANCESTORS OF NATIVE AMERICANS MIGRATE TO AMERICA??? PLS IM DOING A TEST RIGHT NOW

[@abrakadabra1682]

Slow down pls

[@ManEprz]

Hey you guys are wrong in your video Newton’s Laws:Crash course physics #5. The women presenting was wrong on her force of gravity. It’s actually -9.8 not 9.81. It’s negative because it’s going the opposite direction (down) and acting upon the object. Ask your physics teacher if you don’t believe me. I’m trying to help everyone find their actual answer. Unless you live in the South Pole, either your being brain washed or I don’t know. The force of gravity will always be the same where ever you go.

[@nieks9212]

You might be confusing some things; That is the value for the gravitational acceleration (en.wikipedia.org/wiki/Gravitational_acceleration), which differs slightly depending on your location, and is positive by definition.

[@utkarshmishra7416]

That -ve is just a sign convention, Assuming UP to be positive , also gravity isnt same everywhere it changes depending on latitude and even the local rock densities by small amounts.

[@aadityakarnataki9427]

second

[@matthewwilliams602]

She is pretty...