CRISPR-Cas9 and the age of gene-edited humans

What is CRISPR-Cas9? CRISPR-Cas9 is a tool in molecular biology that can be used to edit the genomes of a wide variety of organisms, including people. Find our full video library only on Osmosis: osms.it/more.
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[@ruijiezhang8184]

A really good illustrative animated video! Thank you very much!

[@thomaslapsley8145]

This was recently released in the news. Most of the media these days in New York City has been doing a terrible job. Osmosis excellent work. The immediate response from Osmosis shows hat osmosis is worth the subscription. In school I have been taught that science is advanced through the free flow of information for the betterment of mankind on an international community. Secrecy is frowned upon. It is encouraged to publish etc...Time will determine if this scientist is hero or villain. Tom TL

[@trihardFTW]

Amazing quality as always! This breaks down the topic to make it much easier to understand. Thank you!

[@doooooooommm]

Regarding the 3:40 part, He already confirmed that one of the twins is heterozygous, and will therefore not be resistant. The other twin is homozygous, and will (as far as I know) always be mosaic when using this technique. But note that this mozaic can also appear within the population of immune cells, meaning that some immune cells are resistant and others are not. So if she does get infected with HIV, I expect there to be some kind of natural selection within her immune-cells, which will result in her being fully immune.

[@jeherulislam6903]

nat selection don't work that way, its more acceptable in a population rather in a given individual. i think the individual wil likely develop AIDS coz , considering half her TH CELL RESISTANT, the other half getting destroyed by HIV wont be enough to provide her adequate healthy TH cell. ok,by your premise if those healthy cells want to cope up with the lost TH cell, it may be life threatening to her long before her healthy TH cell make enough of resistant varities. natural selection works better and more pronounced in a population rather than an individual.

[@gm_9567]

Good explanation for CRISPR technology

[@237antonio6]

excellent video.well explained for even a toddler to understand.

[@lisagonzalez2902]

Another great video. Thanks so much for illustrating us on this new technology. I wanted to point out a mistake: since U is replacing T, in RNA, the correct sequence is CCG𝗨T𝗨. That way, Uracil is replacing the two Thymidines, contrary to the video where Uracil is replacing Adenine.

[@wongsimone4938]

I believe you have been mistaken. For starters, nitrogenous bases (A, T, C, G) do not ‘replace’ one another. They form complementary base-pairings, in which hydrogen bonds are the ‘glue’ holding them together. Adenine always pairs with Thymine or Uracil (in RNA). Why? Because A and T are complementary to each other. Each base can only bond with a specific base partner. Just as Cytosine always pairs with Guanine. The reason behind this lies in the bases’ structural components. If you’d like, I could touch more on this. In the context of this video, the sequence indeed is CCGAUA. Thymine in DNA (4th & 6th base of the sequence) has to pair with the Adenine in RNA. We both know RNAs use Uracil instead of Thymine. Uracil has a similar structure to Thymine, thus U has to pair with A in DNA (5th base).

[@laniduong8930]

There's no mistake. The RNA sequence in the video is correct.

[@halaab5098]

Great explanation thanks alot

[@doctorkyrgyz]

Thank you sir

[@bok..]

Can you do a video on the exact mechanisms of the Cas9 enzyme?

[@StevenTohme]

why does this only have 30k views

[@christinekocher2585]

There is an amazing series on Netflix called Human Nature where they discuss the crispr cas 9 discovery and uses.

[@durgavedwal1203]

I also made a project on it......it is really Awesome....wanna go in research ahead...

[@JuliaHelen777]

What you & they say... I have a problem with the expression: "improved symptoms" -> how so? 😟 Symptoms should decrease not improve (in your context), right? What am I missing, except 'some' NLP? 😉

[@magnanimus9692]

Technically you can say either "the symptoms improved" or "the symptoms decreased [implying they decreased in severity]", both mean the same thing (that the patient's symptoms are not as bad as before). The opposite is also true; if you want to indicate that the patient's condition is getting worse, you could say "his symptoms have increased [in severity]" or "his symptoms have worsened". However, most use the terms "improved/worsened" to describe symptom progression rather than "increased or decreased". The terms "increased/decreased" are typically reserved for things you can measure, like vital signs and quantitative lab values.

[@mitsukislife]

Ummmm, was Jiankui gonna secretly infect them with HIV to check if his experiment worked?? 😳

[@krecikowi]

What about consent of the genome edited individual?

[@joepeeer4830]

What happens when AI figures out crisper cas 9 tech. in what fashion will IT program us to benefit IT ?

[@mariusthered5843]

all to *improve symptoms* ....so much for a cure

[@rahulpaul2976]

Is it possible to change skin color by using crispr cas9 system??

[@kazomazo6646]

You can change skin, hair, eye color and most of the physical look.

[@hoche27]

@Joseph Field people spend hours and hours sunbathing exposing themselves to risk of cancer. Im sure theres a big market for it.

[@giahoangphu5211]

I'm here because of 2020 Nobel prize :))

[@mahendrakrisnamurti9599]

My wild guess of what the future would become The rich are getting smarter, stronger, with longer lifespan, etc since the genetical engineering costs a lot of money. The poor could only do so much they could only work as a grunt at best. They wouldn't be able to compete with the rich. With this, the gap between poor and the rich is getting wider and wider. A giant step towards dystopian future folks. Let's enjoy the ride

[@albertchen2020]

What do you mean by "future"? It already is the reality now, is it not?

[@Talktopics2000]

@@albertchen2020 so what is solution?

[@albertchen2020]

@@Talktopics2000 Better public education, universal health care system, and social security? Just kidding, the more realistic solution is to move up the social class ladder and simply don't let you or your children become "them". Step 1. Work harder in school.

[@Talktopics2000]

@@albertchen2020 what if I don’t care for western economic system and simply want to leave usa or Western Europe altogether Point is I don’t like individual values or communism I prefer naturalism

[@albertchen2020]

@@Talktopics2000 Ok buddy, you do you 👍 migration is one of the options.

[@thematrixredpill]

Or make bioweapons

[@BlackbodyEconomics]

Whoa, whoa, whoa - wait just a second ... He did NOT act in secrecy. There was a large number of people and institutions that knew what he was up to.

[@andrewkerns2081]

Gene Editing is the first Step to obtaining Superpowers, Combine it With Nanotechnology,, you'd get Superpowers

[@bobleclair5665]

don’t forget AI

[@Ksis123]

I thought this method isnt being used though because it's not as safe..? So confused.

[@hope3761]

MRNA delivery system

[@5h4d0wBG]

Is this a sponsored video?

[@mateuszbieniek4791]

Scientists "have moved quicker than the ethicists" - The whole point of the outrage which you have mentioned was that He worked alone and against scientists. So that is not fair to attribute this to the "Scientists" as a whole.

[@JuliaHelen777]

Seemingly, it needs less ethics when "scientists" design illness thAn when it helps to be prevented, as usual... 😔 Who talks about bio-war-fare? Nobody! Is "classified information", right? 😔😖

[@mateuszbieniek4791]

​@@JuliaHelen777 Hey, I am not sure what you are trying to say. Unfortunately anything related to the military is most likely kept secret, but not always. Occasionally research on delicate topics is published and made public.

[@JuliaHelen777]

@@mateuszbieniek4791 Long story trying to make you understand "what am I trying to say". To make it easier on NOT getting even more complicated, I suggest an-opendminded-dig in "The Venus Project"'s ideas. But: be aware! It needs you to be in a certain "zone" of understanding. Therefore, is imperative to take the reactions in the comments section with precaution and not let you be influenced by it. Just saying...

[@blackguard5883]

It appears you have missed the point of being human Julia. Our nature must not be suppressed. This "Venus Project" will _not_ create humans. It will produce a societal abomination that is a hollow simulacrum of humanity. The human mind must remain sacrosanct, while the flesh is enhanced to conform to the will. The mind must remain unaltered. Any "restructuring" or "sublimation of primal tendencies" is tantamount to defiling the very fabric of humanity. A true abomination. Have you given _this_ aspect any thought?

[@JuliaHelen777]

@@blackguard5883 Ofcourse I did &/do! Is wat keeps me going... Each day. & Each day I struggle for an fit-answer. Some suggest, actualy hard emphesize, that there isN't a way to stop evolution (whatever "evolution" means, then...) At the other side of "reality": Current situation painfully sucks & isn't of less atrocious & vacuous conglomerated economic-biology, either. So, what's real YouR choice?

[@srijandey87]

Best lucid video on CRISPR cas9

[@osmosis]

Thanks! 🥰❤️🙏🏼

[@srijandey87]

@@osmosis most welcome ❤❤❤

[@magnanimus9692]

Lol so now He Jiankui is like the Bad-luck Brian of science. > Thinks he will be revered and formally recognized for his contributions to genetic engineering > Provoked widespread condemnation and is considered the Josef Mengele of our time

[@adalam1686]

The whole human DNA engineering thing is ILLEGAL in China either. This guy and his team ended up being sent into jail for 3years and penalised with more than 420 thousands.

[@sonsoffunk4437]

Relax its far and done

[@DSesignD]

Like gunpowder, the printing press, and the internet... the Pandora's Box is open...

[@amicusentropia332]

Pls. Pls. Try CRISPR ON COVID-19 Despirate PATIENTS???!!!!! They Need it, CRISPR NEEDS IT TOO, RIGHT..???

[@amicusentropia332]

I will be your Despirate PATIENT, PLS HELP !!!!

[@ThanosDestroyeryearsago]

Amicus Entropia it could be dangerous.

[@amicusentropia332]

I still do.not understand, THANK YOU SO.MUCH FOR REPLY, but even for Despirate patients about to die ?

[@ThanosDestroyeryearsago]

Amicus Entropia well, if you test it on a patient about to die it could either save them or kill them quicker, it is non-perfect technology, it is new and dangerous, as Gene editing techniques become better THEN they will be able to test on patients with terrible diseases. As of right now, Covid-19 patients can not be helped with gene editing(It is possible to try and maybe work, but since everyone is different, on patient may have a different reaction than a different one, and for some it won’t even work).

[@amicusentropia332]

Thanos, thanks ja, I understand. I wished somehow they could put more funding & seriousness to the technology'. As now I hear that WHO could have immediately halted this Pandemic instantly, had they done their job right 😳, take care, thx!

[@-SUM1-]

Germline editing will happen very soon, and it will be for the better. The ethicists and their overblown "outcry" will never stop the determination to beat genetic diseases at their root cause.

[@PeteS_1994]

SUM1 There will be side effects though. The twins spoken about on this video may have a shorter lifespan as a result of the gene editing. You can google this. I imagine there would be the same result for other gene edits, not a shorter life but increased suspect ability to some other diseases if one is treated to be immune to a specific disease. It will take a long time for this science to be perfected.

[@mid7699]

@@PeteS_1994 If we gene edit their lifespan?

[@amicusentropia332]

Why this not used for COViD-19 ????!!!!

[@mid7699]

Yes

[@christinekocher2585]

IT IS! The vaccine is an MRNA gene therapy. It's experimental. Good luck with that.

[@cloutdasaucegod6871]

quicker we expierment on humans the quicker we learn plz let people valunteer

[@dribnsaja]

Among first

[@shawncaskey9186]

Kudos to the Chinese!

[@lem09able]

Why? The technology is still in its infancy and they already risked trying it on a human being. Without the consent of the scientific and ethical community at that. Imagine the repercussions to those children had this experiment gone awry.

[@shawncaskey9186]

Lem Manalo the technology is ready for the Secondary Oocyte. I have plasmids that work in both Secondary Oocyte and Hematopoietic Stem Cella.

[@crafter2u]

edit me

[@thesuvdaa]

Second 💕

[@Monoblue303]

Was this how they made corona?

[@yaqubaismail6116]

Yes

[@samvrit]

FIRST!

[@robinwarren6924]

Shut up nigga

[@albertchen2020]

"Wait for us, we are not there yet." "Hey, that evil scientist cross the line and is ahead of us, sent him to prison!"

[@TS-00]

Expect all covid researchers and their humanitatian funding 💰 parties will be the VERY FIRST to trial an mRNA vaccine ahead of would be sheep 🐑💉☣️💰⚕️

[@durgavedwal1203]

Designer babies...

[@artaxias]

This is dangerous because while you may have Gucci and Prada babies, there are going to be counterfeit babies and us not being able to tell if they're real or not without proper lab equipment

[@EliteprosoldierMW3]

@@artaxias that's dystopic, not only you have to avoid STDs now you have to test if you boyfriend or girlfriend is a genetically modified human.

[@thomasrowe3179]

Hurry the hell up ethicists

[@superstandard]

People who oppose new things are so annoying and detrimental to our society

[@superstandard]

Ethics my ass

[@maitreyabd]

All new things is not good... It can be bullshit or dangerous...!! 😎