What is CRISPR?

[@youngkim6755]

It took our teacher 45 minutes to explain this in class and countless hours for students to understand it. This guy did it in just 7 minutes. I would be a biology major if he was my teacher.

[@nicolasdelaeter4124]

Same here bro!

[@sristyhalder6551]

Same here..

[@mikeb5030]

That's is why I think schools are scams.

[@the__man1]

It your creative minds

[@the__man1]

You can still do it all by your self and some help from the internet

[@kelso_abe]

8 years later your videos continue saving lives and degrees. Incredible explanations! Please, for the love of god and the hope of future generations, never take down your posts!!

[@iammrbeat]

I didn't truly understand what CRISPR was until I watched this. Great job breaking it down.

[@rollerbladinggeek5507]

not really. his explanation is terrible & unnecessarily hard to follow

[@lamaripiazza5226]

@@rollerbladinggeek5507 Explain

[@adrianrodriguezareal4324]

Quite the same feeling from me too; Conpletely agree.

[@kxx139]

whattttttt! Can't believe I see you here after your john brown video

[@100nirosta]

Hello. 1.Why is the kas heading to the place where the guide rnc has settled? And why does the guide RNA attach itself to a specific nucleotide sequence, how does it find them? 2. How does a bacterium understand that macrophage dna has been launched into it? And how does it start to produce those RNAs with the same nucleotide sequence that are contained in the DNA of macrophages? 3. I cannot understand. Does the Cas 9 protein break hydrogen bonds between nucleotides, or does it completely rip the gene out of the DNA molecule? 4. Will the required template be inserted into the DNA molecule by itself, you just need to inject it into the blood plasma, and it will itself get into the part that was removed by the cas-9 protein? 5. Please show the video footage that was filmed in the laboratories. What exactly happens in the nuclei of cells, how does this protein cas-9 carry out its task. Ato with this computer graphics absolutely nothing is clear.

[@dontcallmelil8619]

I love this guy, he feels like he's MY teacher, I've never met him, but it feels like I've taken his classes for years, even though I've only watched a handful of his videos, he just feels like such a great teacher!

[@EqualToBen]

what a fantastic balance between information and understandability

[@c3ncor3dplaylists74]

Rev 9:6

[@alyssaalcantara6739]

Bless these science videos on youtube that make complicated topics more simplified!! Honestly, so grateful to be living in this era of highly-developed technology which serves as a helpful learning resource :)

[@NstaOrgNSTA]

Hey Paul--you knocked it out of the ball park again! This is a hot topic, and we love how you break it down in terms everyone can understand.

[@Bozemanscience1]

+National Science Teachers Association Thanks so much!

[@TotoLakay]

I would like to know Where i can learn to do just that...Because my want to make (let's say a purple banana) and i want to know the steps that would lead me there from buying a book to how to use that "machine " to sequence dna, etc. Or a simple video of a potato being engineered from start to finish. since i am a "hands-on" and visual learner.I ll pay good money for that.

[@antdx316]

+Bozeman Science, Only a matter of time because some people super mutate into things that eat itself alive like people who were subjected to directly radiation after a nuclear event. The pain levels could be beyond anything that has ever existed in life before. Some scientist and other people could get docs that create a new form of disease that could never ever be fixed or people would discover new ways to fix the "beach" but this is after people become collateral damage in the process. It would seem only people who want to be familiar with such new technology will be the potential victims. Better than chemo maybe but could be a lot worse. It will be a lot interesting to watch on the news from an observation point of view but being within the circle of testers, it could spread into skin like ebola then probably would be a secret quaranteen to probably an MH370 quiet style execution where no one in the world must know or else mass pandemonium for the common good like when they jacked the the software from China having it. They probably jacked the engineers and killed everyone else. They prob have the highest top level top secret people who know the word could never get out and why. I feel as the the technology was so good that if the tech was sold to rogue nations like NK we would all be fucked so action had to be taken to ensure it's kept in the right hands.

[@SMThecla2]

Is Anthony Abelardo a messed up conspiracy theorist? (Old just insane?) 😬🍥 😯

[@mid1chosen]

After lots of crap videos finally a good one.u r one of the best teacher .

[@coffeelatte7760]

I watched this for my school activity and I have to rewatch it over and over to understand since I'm very slow. But it is TOTALLY HELPFUL, with all the illustrations and the explanations. Thank you!

[@Ferrist1]

🤣🤣🤣🤣 same!

[@lamichael19]

I'm an Undergraduate student in Biochemistry, taking a graduate biotech class, and this is honestly more helpful and time efficient than going through the book or notes. Thanks again, I've been watching your videos since high school Bio about 4 years ago.

[@chrisbacot8584]

Have been away from molecular biology for several decades. Now in retirement, I am adjuncting at a local college. This was quite helpful in understanding a major advance in a mechanism for treatment of genetic based disease. Many thanks!

[@DK-zn8cq]

Thank you for the amazing video! What is funny is that I have been watching your videos for help ever since my first undergraduate bio class. I'm now in my senior year and am taking molecular biology. When my professor came across this topic in class she said " here's a great video that sums everything up" and sure enough, it was your video! Just goes to show you are not only helping students, you are helping professors clarify the material. Keep up the stupendous work and thanks again!

[@AnaPereira-iz7py]

Thank god I found this. After fighting for 1h with CRISPR terms that I could not understand, THIS WAS ALL I NEEDED AND EVERYTHING MAKES SENSE NOW, THANK YOU!

[@MrDymb]

I have watched you for years. After watching multiple videos, specifically with Crispr, yours is truly the perfect balance between complex and simplified. Thank you for your work!

[@Digma2008]

My teacher adviced my entire class to watch this video for a better understanding, and now I can see why. You just saved my essay man, thank you!

[@smartereveryday]

Man... this is legit.

[@jillmarshall4941]

omg hi Destin ily

[@c3ncor3dplaylists74]

Rev 9:6

[@BlackbodyEconomics]

​@@c3ncor3dplaylists74 6:9 veR ... huh - nope, not palindromic

[@codyellsworth7927]

RADAR

[@ceenadrifts6610]

big fan

[@katherinehemsley5576]

This is the best explanation of CRISPR-Cas9 on the internet! Like he said all the others have either been too simple or too complex. And I have been researching this to write an essay on it for over a month. Thankyou!

[@alakhdar100]

Here after the announcement of 2020 Nobel Prize in Chemistry.

[@timothycampbell3439]

3:45. He called it 4 years ago.

[@하이하이-t2o]

@@timothycampbell3439 lmao

[@fabianperson]

@@timothycampbell3439 It was kinda just a matter of time though^^

[@organizedchaos4559]

What happen at there?

[@alakhdar100]

@@organizedchaos4559 this technique won the 2020 Nobel prize in chemistry.

[@sauravpanicker9446]

I bet you this is one of the best explanations I have heard in CRISPR CAS9 SYSTEM...

[@lorandnagy6442]

I wish I could thank this man personally because he helped me through a 15 minute presentation and an essay to go along with it. Thank you!

[@leafmiee9024]

I am a 15 years old student in Taiwan. And I have watched more than 10 videos about CRISPR. Your video is the best to understand and not be too simple! Thank you♥

[@soonhyo0113]

This vid is planned out so well without any cuts between footage And an amazing job in explaining Jeez Your one wonderful human being.

[@azoto3671]

Your videos have helped me in every major step in my academic career. I am a 1st year medical student and still come back to your videos for help. Thank you so much for all that you do!

[@jillianeastman5681]

I am an AP Biology teacher and am always recommending your videos to explain topics. I recently came across CRSPR in the news and was discussing it with some of my more seasoned bio students. When I got the NSTA digest and YOUR video was in there....I was ecstatic! It was like two worlds meeting. Anyhow, great job. Thanks for keeping up with everything.

[@HermitKing731]

do you think crispr could potentially change someones sexual orientation some day? i am asexual and am hoping it can be changed some day.

[@acampinglamp]

I had a genetics professor point to this video as a great explanation for CRISPR and boy was she right. Strikes a great balance between the simple and advanced

[@JLee12927]

I've been struggling to understand this for months since I covered it in one of my final year modules, but this explained it incredibly well, thanks very much!

[@meitalbar3]

Have looked at so many other videos about CRISPR, but only yours made a difference and helped me understand it in a very memorable way! Once again- Thank you!!

[@Archer267]

You did a great job with this video, so much so that a layperson could grasp it. Thank you. Please do one on Oligodendroglioma brain tumors!

[@vyangoel2886]

I have been looking for good CRISPR explanation vids but could NOT find it until I watched this vid. It was very helpful in explaining to me what CRISPR is and what it does. Thank you and keep up the extremely good work

[@Pretty_Boy6]

This was a great breakdown, I'm in College for microbiology and specifically for crispr. Videos like this help me learn more and more, and make me excited to learn.

[@lubnaahmad8831]

this is the best explanation anywhere. i went and visited my lecturer twice asking her to explain this but she couldn't. hands down best channel ever!

[@jessical6944]

Amazing! I've been reading articles about how it works. It has been confusing to wrap my head around but your video was much help!

[@oliviajanusz8671]

I'm a Science teacher and we watch your videos all the time. They're a great combo of info and visuals- thanks!

[@Rice8003]

Had to watch this like 3 times and only took notes the third time for most of it to sink in. God help me this is just the beginning

[@dreamer1923]

Yes this is the vaccine for the world coronavirus .

[@bev78229]

This is what I have puzzled over - trying to understand CRSPR and getting further and further in the weeds. You accomplished breaking something so brilliant down to where an ordinary mortal can begin to understand - which takes another special type of brilliance. Thank you for recognizing the need. You made my day

[@SattarJayed]

3:42 Her name ends with dna !!

[@herryhermawan5278]

coincidence ?

[@guyjanssen5250]

@@herryhermawan5278 I THINK NOT

[@kentuckyblugrass]

@@herryhermawan5278 Highly unlikely

[@wavewavewave640]

Coincidence? I don't think so. Hotel? Trivago.

[@Tiotsa]

I always come back to this video when I need a refresher on CRISPR. This video has it all. Thank you!

[@akawumpus]

Thanks! I'm doing an independent studies class and wanted to focus on this for my topic, and needed a general understanding to jump off from this really helped!

[@seriousblakk]

Dude thank you. The other videos were seriously vague

[@TheDutySpot]

I'm currently working on graduate research at an infectious disease institute, specifically focusing on knockout techniques with mycobacteria abscessus. This is the best explanation of CRISPR I have ever seen.

[@nomunomu1014]

Preparing for my med-sku interview tomorrow, I hope they'll ask me something about this so I could show off as a 17 year old. Lord bless me.

[@johannes7578]

Thank you very much. Just the right length and complexity between a Wikipedia entry and a local news story trying to explain CRISPR. Just what I needed

[@Mdmathemovie2016]

So I've just watched half a dozen videos on CRISPR, including this one, and none of them explain how the system can enter every singe cell in a living organism. All the videos (including this one) only explain it once you get the CRISPR/CAS9 into a single cell. How do you get it into a single cell to begin with? And how do you get it into EVERY SINGLE CELL inside a living organism? Can someone explain this? Thanks.

[@juliettedaze]

well, i'm a student that just worked on gene editing using crispr and basically, we added plasmid that contained Cas9 and CRISPR to the cells we worked with. We then centrifuged it to break cell walls to allow the plasmid to actually reach the cell's DNA. I hope this kind of helped.

[@Mdmathemovie2016]

Thanks for your response. I'm even more confused now, though. If you have to centrifuge the cells and break the cell walls, how do you get CRISPR into living, multi-celled organisms, like a human being. Supposedly there are human studies underway. I don't understand how the system can get into all the cells in a living, human body.

[@JPSIBZ]

No one knows for sure yet. There have been varying degrees of success with several different methods. Most notably is the direct injection of a viral vector carrying the crispr/cas 9 genetic code and after transduction, allowing the host cell machinery to assemble the proteins/enzymes themselves. www.sciencedirect.com/science/article/pii/S1931524415003321

[@Mdmathemovie2016]

Thanks! That's what I wanted to know. :)

[@Cyclases]

There are various ways on how to insert exogenous materials into cells. One of which is microinjection, which is mechanical. Another way is through modified viruses, where the genes for these CRISPR and Cas are also included in that viral genome.

[@ohheycrystalhey]

Heyyy, I used to watch your channel for AP bio in high school 4 years ago, and here I am in senior year of college and you’re still helping me out. Thanks for such good explanations over these four years 😊

[@sdpy15]

Fantastic! I just wanted to point out a mistake: when CAS1 inserts a spacer into the host DNA it is added UPSTREAM (ie: closer to the CAS gene), not downstream. This is due to a "polar" acquisition leading to a sequential "hierarchy". Otherwise great video, you continue to be my fall-back resource for exam preps. :)

[@carinamasferrerferragutcas4443]

I absolutely love you. You have saved me from a huge fail in my final exam in a few hours.

[@tessagee]

i have a final in a few hours and this helped tremendously thanks!

[@filipematias2239]

Same

[@antdx316]

So he basically explained your entire schooling in a 7 minute video? Why even go to school?

[@subwayvesubscriber]

Anthony Abelardo You make the education system sound so simple. Sure, there's a well-made 7 minute video about CRISPR on KZbin, but will you find everything that is taught in school from grade 1 up until graduation? I highly doubt it. Most students need teachers to clarify and explain things they perhaps didn't understand the first or even the second time. They need feedback, criticism, an environment where they can learn to compete and work together. And there are all the social aspects that going to school incorporates. I frankly think many of these things are incredibly valuable and not replaceable by a few succinct videos. And for me personally, videos like this have only served to refresh my memory on topics I have already learned to just get back into it again if I haven't looked at them a while, not completely teach me everything from zero.

[@antdx316]

+subwayvesubscriber, They should just show some of these videos in high school so people can decide if they want to learn further rather than have a lot of people waste time and money in a program they won't even get a career they went to college for but then there would be too many people who would be good at what they do and the really best people would have a hard time shining as bright as w/ the way the system is engineered now.

[@lcl1129]

still in 2019, i have searched many videos to understand well this guru mechanism, finally I got here from BOZEMAN. Not words of mine will be enough to compliment you. Thank u for all your works to spread science.

[@dmflyboy2]

MINOR quibbles: 1) usually new spacer-repeats are added at the proximal, not distal, end of the CRISPR locus; 2) This is NOT "exactly" how mammalian immune systems work ("just on a larger scale") as you've stated; 3) HOST DNA, not RNA, is used in gene replacement. Nice graphics!

[@jazmincastro9248]

I never write commentaries here on YT, but this time I need to do it to thank for this, I never understood de CRISP-Cas9 system till now!!! I'M SO HAPPY!!! I know it's kind of ridiculous, but feels great to understand something you couldn't before. Now I can really read the paper and actually understand. THANK YOU THANK YOU THANK YOU

[@thokomalinga942]

Pretty much everything I needed, just would have loved to hear you speak about the PAM targeting mechanism... other than that this is great

[@burntthetoast]

Yeah, Intermediate Bio final coming up and have already been tested on this. Sufficient to say that in the seven minutes it took for you to explain this, I realized how many hours I wasted of my life that i'll never get back trying to understand it. Thank you for your simple and elegant description of CRISPR CAS9

[@tedchirvasiu]

Thank you so much, your lessons are always so clear and interesting!

[@WeezyGR]

This is the best video about CRISPR i've seen so far! Im having a presention in january about casposons and how they were the "ancestors" of the acquired immunity mechanism called CRISPR-Cas and I finally understood the meaning behind the CRISPR-Cas actions so i can finally compare these two things! Big thanks and a happy new year!!!

[@sciencetutor85]

Hello Mr Paul I am Musa a middle school Science teacher in Saudi Arabia.I am very crazy about using technology in my classes and this had made my students to watch several of your videos.Recently I promised to invite you to speak with them about a particular topic they have taken before just for few minutes so that they can have the chance of speaking with you directly and asking you questions.please i will be glad to get your response into my personal email.We really love your videos. hope to read your response soon Sir.Thanks

[@inshithkaur577]

Thankyou. Please keep making videos I don't care if there are videos present of certain topic because the way I explain in small amount of time. It's the best.

[@inshithkaur577]

*you

[@WALLACE9009]

Thanks! This was excellent. I wonder how the class 1 CAS protein can add new pieces of viruses to the library and distinguish harmful RNA from endogenous RNA?

[@danielle4685]

im a bio major at uc berkeley and i've taken 3 biology classes so far that all tried to explain crispr, one of those classes was taught by professor doudna. i never fully understood the mechanism until i watched this video. thank you

[@chrisharrel8837]

Ctrl + A, Ctrl + X, Ctrl + V

[@TimmyMoza]

This one is most succinct.

[@Tottiten]

Ctrl + C*

[@c3ncor3dplaylists74]

Rev 9:6

[@chrisharrel8837]

@@c3ncor3dplaylists74 The bible is the most successful man-made fraud ever crafted. Using technology to proselytize is peak irony. I pray and give thanks to Newton and Leibniz and Darwin and Euler and Pascal and Bernoulli.

[@c3ncor3dplaylists74]

@@chrisharrel8837 the greatest lies of all time is believing that satan doesnt exist.

[@caroline-hp5ni]

this is the first CRISPR video i've watched that actually made sense, thank you

[@georgedwilkinson]

6:30 "As we break the DNA, the host DNA is going to be added" Fascinating. And what is the magic involved in this?

[@vqh]

Double stranded breaks can be repaired by a repair pathway known as Homologous Recombination, and the donor DNA is integrated in this process.

[@blissclasswork8650]

We have learned an immense amount about DNA repair pathways, some through cancer research

[@deimuader]

This is called "Homology Directed Repair (HDR)"

[@AusyJo]

In vitro, can you use other cloning methods like TOPO or Gibson Assembly after you PCR your desired insert?

[@Rana26g]

Does this mean that we can introduce ANY sequence of DNA and the repair system will replace the target DNA (cut by CRISPR) with it? Any criteria to design this sequence?

[@shraddhapathak8350]

Stumbled across it during my breakfast and such a wonderful video it is. The concept is explained very lucidily.

[@willjack5848]

I still don’t understand it

[@hipisss5836]

I know that this is an old comment but which part you have not understood?

[@terikumo]

​@@hipisss5836 hii, i know that i'm not the OP, but i'm a bit confused too. i thought crispr was some sort of tool to edit dna-like a machine that humans use to edit dna. but apparently it's a biological thing that happens in bacteria and organisms? i watched this video and it left me with more questions than answers 😞 i'm sorry if my question sounds dumb. i've gotten into genetic engineering recently and we haven't learned about it in classes yet

[@hipisss5836]

@@terikumo Ok, I'm not expert either becouse I just finished my first year at university but I will try to explain it briefly. Also, I'm sorry for any misspelings or gramatical mistakes but english isn't my primary language. So getting to the point... CRISPR is sort of immunological system inside prokaryotic organisms that is actually preety similiar to our own but instead fighting other cells and microorganisms, it defends the bacteria from "hostile genetic code" (like viruse's DNA). CRISPR's system includes sets of many proteins (all of them are designated as "Cas" proteins) and specific area in bacteria's chromosom. If a bacteria is infected with some kind of hostile DNA, some of Cas proteins will find it and after some procesing, they will insert it into CRISPR area of bacteria's chromosom. DNA stored this way can be then copied and inserted into other type of Cas protein as RNA. Cas protein "armed up" this way, with help of tracerRNA, will start looking for the hostlie DNA segments corresponding to the one it is prepared for. If the protein will find the correct DNA fragment, it will LITTERALY cut it, making it useless and preventing it from cousing any harm to the bacteria. Now to the genetic engeniring part... So like I said, to do all that stuff I mentioned above, bacterias need a whole bunch of different proteins but scientists found one bacteria - S. pyogenes (the one mentioned in video), that can do most of this stuff with just one protein, protein designated as "Cas-9". Researchers found a way to extract that protein and way to "arm it up" with whatever sequence of DNA we want, even with sequences of whole gens that appear in chromosoms of eucariotic organisms. Cas-9 prepared that way can be then injected into ANY cell and it will start "looking for" the fragment of DNA it is equiped with (just like in bacteria). Once it will find the correct sequence, it will cut the fragment of DNA out of the chromosome. So if we "arm up" cas-9 with the sequence of certain gen, it can completly remove it from the cell and it's genom. Of course such cutting out whole gene will make a huge gap in chromosom which is bad, so cell will fill the gap but if the gap too large, it will eventually end up with bunch of non-sense that will not provide any influance. However, if we provide the cell with other gen that we would like to place in gap created after removing other part of DNA and with some specific treatment, we can make the cell fill the gap with the gen we wanted, creating genetically modified cell. I hope that I explained it well enought and wrote it clear enought. If I made any mistake or you still don't understand some part feel free to comment again!

[@Proximacentauri1618]

@@hipisss5836this was very helpful thank you!

[@xiiiaomei]

@@hipisss5836you’re such a real one for spending so much of your time to teach others!! thank you for this

[@diegoh1458]

I typically never leave comments on videos, but you really taught me an entire lecture and lecture video that my teracher assigned. She's not a bad teacher i actually like her, but somehow not everything gets through. I was so shaky on the concept or the crispr system and didn't know what was what. Now i feel as though i have some illegal knowledge that the government will try to take me in for at some point in my life.

[@halilibrahimkocoglu5899]

In short.. After all a zombie apocalypse is not going to be sci fi anymore

[@imrocknreeling]

Oh my god gracious!!! This is the best video for Crispr. Thank you. Love from India.

[@pallingtontheshrike6374]

More people have heard about it now: Kurzegesagt and SciShow have now made vids on it.

[@zakuro8532]

still, this is way more informative

[@kristenswonger4572]

I show Bozeman videos all the time to my students. You do a great job explaining things in a way most anyone can understand. I am going to share this in my biochem class in our malaria / sickle cell anemia discussion since they are looking at doing this to mosquitoes to hopefully get rid of malaria

[@antpaste]

Thats some badass shit

[@isabellamixton-garcia9500]

Honestly, thank you so much. I have a Science Olympiad regional in two days, and they threw this topic on me last minute. I have no background in this field, and watching all these videos with words I didn't know (I basically was looking up every word). Your video gave me the basics to understand the rest of the complicated videos. Thank you again.

[@MrTridac]

This is so awesome - no, it's frightening - Awesome! - Frightening! - Damn, I can't decide. Guess it's both.

[@Bozemanscience1]

+MrTridac Agreed.

[@Shahid2971]

just wondering is learning about CRISPA undergraduate level biology or high school level biology.

[@Shahid2971]

CRISPR

[@MelissaFlaquer]

+MrTridac it is both

[@guitarsean]

It's a tool, so it depends on what we do with it.

[@AnNguyenyds]

Best video explaining CRISPR/Cas9 I have ever seen! Thank you so much!

[@purejuiceful]

Nice.

[@hibatawfeeq7126]

The best video I have watched for explaining CRISPR/Cas9 system

[@knzay]

im already tracrRNA

[@DeadInside-ct6dl]

Ke La God, I saw tracrRNA, and I legit just thought about this meme.

[@meeeesosoup9997]

came down here to see if anyone made that joke

[@jeanah6345]

fuck u im in grad school trying to learn crispr and i literally had to find this video bc every time i hear "tracrRNA" my shit brain immediately blocks everything else out except for that meme. im gonna fail because of a shitty overwatch meme i can't believe it

[@lepjee]

Thanks i hate it

[@hanac5586]

Thanks I hate it

[@lukeparry3373]

that was an amazing description of CRISPR. I liked the history behind it and understanding that its based off of a natural defense mechanism originating from bacterial cells fighting viruses. loved it

[@JohnSmith-nz1vj]

I laughed at the #NobelPrize more than I should've.

[@swimfreestyle18]

+John Smith Hey its history in the making though :)

[@jeanfernandez5397]

This technology can cure all inherited diseases! It should win the nobel!!!!

[@HoangNam-]

And it win the nobel prize =))

[@georgehayden134]

This is such a great video that really helped get an understanding of what CRISPR is as my text book brought in terms that weren't defined. Excellent video so happy with this.

[@gregboffo4985]

The tree of the knowledge of good and evil. Man playing God. Best left alone.

[@entertainmentstuff5616]

I'm not an English speaker and I understood this video. Thank you very much for the explanation. It's very visual and that had helped me a lot. For more teachers like this guy :)

[@halilibrahimkocoglu5899]

Nice Way of mutating humans into zombies

[@rosalbadelriogarcia9598]

Fix the zombie FEED THEM MEAT.. #metabolichealthinitiative #nutritioncoalition #adaptyourlife #carnivorecure #reindeerherdsman

[@xiyuanzhang8501]

literally the best and most clear video of this topic

[@JediWebSurf]

Now explain the mRNA vaccine.

[@Inserent]

I have been searching for CRISPR/CAS9 videos to educate myself out of curiosity. I have been disappointed because they are either too simple or too complex. Your video is an excellent balance of the two for general population (include me). I hope there will be more people learn from your video and know how to make a scientific discovery educational yet understandable for the general public. Science will get a big boost if more people understand what it is all about.

[@kissthesky40]

Playing God? Hello Covid 19-SARS2

[@Viraj_2305]

this is the most beautiful video on CRISPR I have ever watched...Thank you so much, Sir! Great respect from India

[@stanthemann1313]

Most scientifically accurate yet simple explanation of this explosive technique. Well done!

[@izzyl.6389]

This is by far the best explanation of CRISPR Cas9, love the video!

[@williamjayaraj2244]

Thanks for explaining this marvellous CRISPR cas9 invention in a simple way. This is somewhat beyond human imaginative work.

[@steffivarghese3445]

I am just stunned how you were able to explain that in just 7 mins and my professor took like ine hour . Thanks a lot !!!

[@GlidyBun]

I'm studying for my med school entry exam. The book doesn't explain CRISPR very well, but since it's such a revolutionary technology I'm almost certain that this will be on the exam. Thank you.

[@nikkola33]

Maybe after it'ss FDA approved.

[@massiazizi5890]

That was the best clip that i have ever seen about crispr. Thanks a lot.

[@alekseytsoi242]

who would thumbs down this?! excellent and accurate breakdown of something that has been honestly vastly misrepresented in pop media reporting

[@blanfs]

GRACIAS, ni un solo video con el que pudiese entenderlo y ahora me ha quedado clarísimo 🫶🏻

[@orynfolkor4042]

Medical student here. Nicely done Mr. Anderson!

[@jasonabele8053]

I watched your videos in my Biology class sophomore year of high school, and here I am watching for my biology class sophomore year of college.

[@meganevans8006]

Awesome! Spent all week trying to sort this out. Should have looked here first! Thank you!

[@constantinerafikov]

This is exactly what popular science should be. Thank you!

[@akablessed8841]

Thank you! You just saved my assignment. I forgot to add the deletions and insertions part after the DNA is cut- thanks!

[@theoldhip]

As usual - Your teaching is excellent. I have had undergraduate and graduate courses in molecular biology, and you always give understanding that most formal courses simply don't. I thank you for your efforts, they definitely help.

[@anneitandbanana]

Perfect intermediate-level explanation!!! Thanks so much :) Studying for my cancer pharmacology final exam and we did a special topics lecture on CRISPR Cas9 in cancer therapy