Why Enhancing Metabolic Health Could be the Key to Preventing Alzheimer's Disease

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In this video, Dr. David Perlmutter provides an in-depth exploration of a crucial but contentious topic in Alzheimer's research and treatment. For decades, the pharmaceutical industry has heavily invested in targeting beta-amyloid protein, a “hallmark" of Alzheimer's disease, as the primary approach to treatment. However, this strategy has come under significant scrutiny. Critics argue that focusing solely on beta-amyloid reduction is not only flawed but also poses potential risks, and has shown limited effectiveness in combating the actual progression of Alzheimer's. In contrast, a growing body of scientific research advocates for a paradigm shift towards preventing the disease by improving brain metabolism. This video reveals why enhancing metabolic health could be the key to truly combating and even preventing Alzheimer's, offering new hope and strategies for those affected or even at risk for this devastating disease.
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[@amy11228]

As a female whose lost two family members to ALZ and am a carrier of one copy of the APOE E4 allele, this information is music to my ears and is one more motivating factor to continue eating a low carb/ketogenic diet, daily exercise and good sleep! Thank you, Dr. Perlmutter.

[@ingemp1212]

You could also check out BioPhotoModulation (red and near infrared light)!

[@carlenekingery8860]

Same family history and I have 1 APOE 4e allele. Scary potential for development of ALZ but am also low carb and walking 1 hour most days!

[@DCGreenZone]

Look at Palmitoylethanolamide

[@Alan9457]

@@DCGreenZonewhat is that

[@DCGreenZone]

@@Alan9457 search my SS

[@lesleybeckingham2147]

One of the reasons I took up running in 2020 was that both my parents had Alzheimer's and I'd just discovered your research. Thank you again for proving the essential requirement for exercise in the prevention of this awful disease. I'm currently training for my first marathon in April!

[@user-vm3fk6io5h]

I need to get back to exercising. Before I worked as an in home caregiver i had a gym membership and faithfully participated. Well, I’m wiped after my work day but am determined to get moving again. I will start with walking. I used to be a runner myself 😉

[@bellelacroix5938]

My mother walked and took his hills 6 miles every day did crossword puzzles for decades read three books a month worked in a library was very active socially and died of Alzheimer's and I think because her diet was poor and she drank wine every night.

[@user-vm3fk6io5h]

@@bellelacroix5938 I am so sorry for you. I have been on the Keto lifestyle since last May and eating well for years prior but feel I need to add in some exercise. I want to do whatever possible to protect myself. My dad suffered from dementia as well but had Parkinson’s and died from COVID in a care facility in 2020.

[@ligiasommers]

Thank you for explaining that so clearly. It is difficult to believe in the Farma , more and more . Unfortunately, difficult to believe in FDA also 😢😢😢

[@Miraak1868]

Big Pharma, known as Big Crooks.

[@barbaralopez265]

Thank you Dr. Perlmutter. once again you have spoke with honesty. This is what humanity needs right now.

[@nayoungmathiesen829]

The writing has been on the wall for so very long. Why has it taken so long for the mainstream health-related organizations to bring focus on the fact that plaques and tangles may not be the cause of Alzheimer's. The NUN STUDY which followed over 600 nuns for over 20 years and opening up their brain at death proved that the plaques and tangles also existed in people who even lived up to 100 years and had very clear cognitive function. This research result came out almost 20 years ago, but did not receive so much attention - I wonder why?

[@westfield90]

Well said

[@LIFE0530]

Dementia itself is difficult to treat effectively with natural medicine. However, there is evidence that some elderly demented individuals have a subnormal concentration of vitamin B12 in their cerebrospinal fluid despite having normal serum levels of the vitamin.[5] In those patients, intramuscular administration of vitamin B12 improved the dementia, whereas oral vitamin B12 was not beneficial. Oral administration of other B vitamins may also improve dementia in some cases.[6] Magnesium may also be useful, particularly in patients taking magnesium-depleting medications. I saw an 83-year-old woman who had been diagnosed with Alzheimer’s disease, but who turned out to have furosemide-induced magnesium deficiency. Her mental status became essentially normal after she received a series of intravenous magnesium injections. Interestingly, her serum magnesium level was normal, which is not uncommon in patients with magnesium deficiency, since magnesium is primarily an intracellular ion. If you have read this far, you probably have seen a pattern. Some elderly people may be able to substitute some of their CNS-active medications with treatments such as vitamin B12 injections, other B vitamins, magnesium, iron (if deficient), and L-tryptophan. It may also be worthwhile to encourage lifestyle changes and to work on conflict resolution. It should be noted that L-tryptophan can increase the adverse effects of selective serotonin-reuptake inhibitors and some other medications, so it should be used with caution. The treatment of health problems in the elderly can be difficult and complicated, especially when dementia is involved. However, we can probably do a better job by seeking safer alternatives to prescription medications and remembering to include “adverse drug reactions” in our differential diagnoses.dr gaby doctorgaby.com/drugging-our-old-folks/

[@cindylehman6192]

Thank you so much!!! I just lost my brother-in-law to Alzheimer's. He was such an active human being all his life and loved life, hunting, fishing, building, and you name it. He was 83 and healthy as a horse in every other way. All he and his family were told that there was a new drug coming out! Saddened me so much because I follow Dr. Permultter and Dr. Bredeson, and I know better! I will attempt to spread the news if I can. Thank you again!

[@9jmorrison]

May love abound, and a way be found, amen

[@ryanward7608]

Simufalin from cassava sciences

[@joelbalkam290]

Just finished reading Grain Brain, what a great book and so eye-opening. First time watching one of your videos. Thanks so much.

[@wellnesspathforme6236]

Read Cu-re Your Fatigue as well. Alzheimer’s is a result of the brain’s mitochondrial dysfunction that results in more exhaust and relative to Mg-ATP.

[@sherylbeamer7189]

Thank you Dr.Perlmutter, I’ve learned more from you via your online presentations than any other md (including my own)! You are so generous in sharing your lifelong knowledge and experience, thank you. Your book Drop Acid is particularly excellent , THANK YOU!🙏🏻💕

[@Whitgent]

As an APOE4/4 carrier, this video gives me hope. Thank you Doctor.

[@gracie3174]

New research is saying that statins is contributing to Alzheimer’s….it’s eye opening!

[@Lisimachos]

My mother has had Alz but no statins or other medication…..

[@mettejensen8653]

that does not mean though that statins cannot increase the risk..@@Lisimachos

[@dianadeejarvis7074]

​@@LisimachosSo? The OP didn't say statins caused it. They said statins can make it worse.

[@HSLSFirst]

Thank you for this video. My relatives on my father size almost ended up with a form of dementia/alz. I am 61, Working out hard 6 days/wk, doing 1/2 strength, cardio/HIIT. Not only my body feels good but, I don’t see any signs of cognitive issues. My father had to retire at 62 because of cognitive issues.

[@Miraak1868]

I am sorry that the doctor made no mention of sugar, seed oils and hyper processed foods on the human metabolic system.

[@evabelvain2569]

He did indeed mention the role of blood glucose in providing fuel 4 the brain

[@Miraak1868]

@@evabelvain2569 So what? I am a carnivore who eats no carbs and I still have plenty of glucose for my brain from fat conversion in my body. We all make our own glucose.

[@alisonweir1245]

if you look at his other videos you will see that he also talks about sugar and over-processed foods

[@Miraak1868]

@@alisonweir1245 Thanks, I'll check him out.

[@a.h.kfoury6909]

Thank you so much Dr. Perlmutter for this super important presentation. Thank you for the information and for explaining so clearly what we should do and how important exercise is for our brain. Thank you for sharing your knowledge online. Thank you again.

[@enonknives5449]

Plaques in blood vessels are the result of healing damage, not the cause of damage. Plaques in the brain are the result of healing damage, not the cause of damage. While reducing plaque buildup might protect against heart attacks and strokes, is it really better to have brain bleeds and hemorrhages? Blood vessel damage is the result of metabolic disfunction.

[@karenf9137]

I’m curious about what, if any, effect visceral fat has on brain health, especially dementia. I’ve heard/read repeatedly that VF causes cytokines to be released all the time.

[@sebek12345]

🎯 Key Takeaways for quick navigation: 00:13 *🧠 Lifestyle Choices and Alzheimer's Treatment Challenges* - Lifestyle choices significantly impact brain health and Alzheimer's disease progression. - Drug treatments for Alzheimer's, such as LMI (lanamab) and GAN (Rab), show limited efficacy and potential harmful side effects. - Lifestyle modifications, including exercise and dietary changes, show promise in slowing cognitive decline and preventing Alzheimer's disease. 06:46 *🏥 Challenges with Alzheimer's Drug Approval and Efficacy* - Alzheimer's drugs like Aduhelm (aducanumab) face challenges with efficacy and safety, leading to discontinuation of production and trials. - Few Alzheimer's patients qualify for new drugs, highlighting the limited impact of pharmaceutical interventions. - Prevention and lifestyle modifications offer more promising avenues for addressing Alzheimer's disease. 14:07 *🏋️‍♂️ Exercise and Brain Health* - Exercise impacts brain health by activating muscle-derived chemicals (myokines) that enhance brain metabolism. - Proper muscle-to-brain signaling improves insulin sensitivity and promotes brain energy production. - Lifestyle interventions, including regular exercise, play a crucial role in preventing cognitive decline and Alzheimer's disease. 22:36 *🧠 Brain metabolism and exercise* - Exercise enhances brain metabolism and insulin sensitivity. - Functional MRI studies show increased connectivity and improved brain function after exercise. - Higher levels of physical activity correlate with a reduced risk of dementia. 25:14 *💊 Nitric oxide and brain health* - Nitric oxide plays a crucial role in brain metabolism and vascular function. - Increasing nitric oxide levels may reduce the risk of Alzheimer's disease. - Nitric oxide is linked to glucose utilization and improved blood supply in the brain. 28:24 *🥦 Nitrate-rich foods and nitric oxide production* - Nitric oxide production can be enhanced by consuming nitrate-rich foods like beets. - Mouth bacteria play a role in converting nitrate to nitric oxide. - Studies suggest a potential link between mouthwash use, reduced nitric oxide production, and increased risk of diabetes and hypertension. Made with HARPA AI

[@marzymarrz5172]

Been reading an article about the search for a drug for this condition and its not so easy. An approach that avoids the development of the disease is way more interesting to me. Especially if it involves lifestyle and food. I appreciate that you keep this issue in your sights.

[@user-vm3fk6io5h]

This is one of the most informative and well explained videos. I had to subscribe. Thank you !

[@Ms1Mina]

This was so well presented ... like all your videos frankly. My husband will most likely get it as his father did. He won't alter his lifestyle and has had 2 TBI's. It scares me. Thank you for your videos and information!

[@Gotprivacy-noyoudont]

The role of drugs ( Xanax, benzodiazepines all together, statins, and other ‘standard’ treatments for a plethora of ‘diseases’). Standard treatments are accelerating neurological/ cognitive changes producing Alzheimer’s and dementia.

[@lat1419]

These drugs affect mitochondrial metabolism.

[@bellelacroix5938]

Where is the link to the video you reference that went viral I would like to watch it

[@marydo3175]

Talking about nitrate rich foods, why don't we think of bacon, but beets??? Consuming lots of beets and put yourself at high risk of oxalate harms such as inflammation and kidney stones. I chose bacon instead, which provides me not just good things: protein, saturated and mono saturated fats, nitrate, at the same time not exposing myself to oxalate and fructose from beets.

[@vivianrose6805]

I was pondering the same point, being a carnivore. Seeking guidance....

[@man_at_the_end_of_time]

Arugula is better than beets per the oxalate level.

[@bellelacroix5938]

You can increase it by humming for ohming ❤

[@lat1419]

Many nitrate / nitrite high nest products are available as salami, cured meats etc.

[@marilynnishimura6999]

Don’t know about you, but I don’t eat my beets raw….so no issue with oxalates, as with most other properly cooked beans or veggies that contain oxalates.

[@jlind00]

As always, Thank You for relevant / important research findings & fresh insights!

[@dianadeejarvis7074]

The FDA approved Aduhelm despite the fact that not a single doctor on the advisory board voted in favor of it. There were one or two abstentions, and everyone else voted against it. That says a lot about the modern FDA.

[@susanmorgan3251]

Are there studies regarding NO and Raynaud's disease, and whether NO deficiency may relate to that? Or if there are any studies on whether Raynauds vasoconstriction responds to nitrous oxide?

[@clovermark39]

I’ve heard NO being talked about recently by someone else on KZbin. Possibly Dr Malcolm Kendrick as I’ve just read his new book.

[@SS-wz8po]

Thank you very much for your very informative and educational messages, Dr. Perlmutter 🙏♥️

[@GLORIAJEANEZEKIELMDPHDLONG120]

So cool Dr Perlmutter, Thank you! ❤

[@nda4591]

Thanks for the precious content!

[@IntuitiveCoachTheresa]

Thank you for this comprehensive presentation! NO research looks promising, but even more so is learning the natural ways we can increase its production as well as all holistically oriented interventions!

[@ryan6391]

Drugs are not the answer and neither are drug companies. Glad I listened to the whole thing. You touched on the natural side. Funny I was just finishing making my Beet root and green shake, just after my workout.

[@felicefisher9705]

Thank you so much for your valuable information. Your explanations , which are clear and concise, and are greatly appreciated by me.

[@Shwettyapple]

Great info here, thanks!

[@paultraynorbsc627]

Thanks for sharing this important information 🙏

[@Alice-oe4kd]

This is such good info - THX!

[@user-uu3oh8sg9q]

Thanks dr David/ important information

[@nancyte7]

Thank you, you have educated me by clarifying, the studies on Alzheimer’s disease. Blessings.

[@dgaydos]

Thank you, Dr. P!

[@BillEarl]

Terrific and invaluable presentation presentation from the good doctor.

[@katpinter9857]

Thank you for this information. I am motivated to improve my diet. Have been eating a lot of sugar lately due to increased stress. Have increased strength training this year.

[@donlimuti8659]

You nailed it. Yes, I subscribed.

[@annporter7359]

When I saute kale and have it a few times a day with vinegar I feel better. A heart surgeon suggested the greens with vinegar to produce NO

[@annporter7359]

Awesome presentation !

[@biodivers5294]

Great talk!

[@westfield90]

Thank you for this very informative and important video

[@bernob9770]

Good to know, more workout helps.

[@agoudimoun]

Thanks for the wonderful information you give us. I have heard that the formation of β-amyloid plaques is a protective mechanism in a toxic heavy metal environment. If this is correct could some supplements like Alpha Lipoic Acid, Glutathione etc together with a healthy lifestyle work preventively in regards to the onset of Alzheimer's?? What is your opinion;; Thanks.

[@johnburton9772]

Dr. Perlmutter, thank you for this information on the exciting frontiers of Alzheimer’s prevention and early treatment: brain health, metabolism of glucose & ketones; vascular perfusion of the brain; roles of diet, exercise, sleep, and nitric oxide (NO). All of these factors give cause for hope that this degenerative brain disorder will be more effectively prevented and treated in the years ahead! 🙏🏻🙋‍♂️

[@Johnny-dp5mu]

Follow the money!!!!

[@westaylor1693]

What are your thoughts on red light therapy for MCI and AD? Also would you suggest taking NO supplements for the same? Thank you for your great insight

[@9jmorrison]

'The cause' the drug addresses is wrong, scours waste but not the cause.

[@timgomes1112]

That was fantastic! A fundamental rethinking on brain health. Gives hope! What are the pharmaceutical options to increase Nitrates (hence Nitrites, hence Nitro Oxide)?

[@annetteyoutube742]

28:53 "Nitrate-rich foods are converted by bacteria in the mouth to nitrite, which becomes becomes NO." --> Question: would optimal chewing increase this conversion? 🤞

[@accordionbabe]

I’ll consider your information. Nothing is absolute, and more GOOD research is elucidating. Thank you

[@deborahgraeff7374]

would it help people with neuromuscular diseases as well?

[@ddutton4716]

23:52, How do you get a negative .2 seconds?

[@butch843]

Doc. What do you think about nicotine in the form of pouches or gum in treatment ?

[@TedNemeth]

Wow. Super interesting about nitric oxide & mouth wash.

[@pdid118]

So I'm a little confused with the terms nitrates and nitrites. It was my understanding that they cause cancer. So basically, eat beets?? What other foods contain nitric oxide?

[@laurechrisman7169]

I was too but I just found this helpful video of the topic: kzbin.info/www/bejne/q3-XaJ2rm9CjmNksi=IbPvm-P1YB20W-6r

[@michaelsrowland]

Research Google it

[@robertshook3639]

See Dr. Ken Berry’s video on nitrates. He goes over the latest science. Not cancer producing!

[@sany6521]

Dr!! Thank you! Is there any possibility to translate your videos to Spanish? Another question ..have you investigate Essential Tremor? Tnank you so much!!!

[@raykinney9907]

Yes! ED of the brain. The endothelial smooth muscle can't relax, the small vessel lumen gets glycated, RBCs get inhibited supplying O2 to mitochondria in brain neurons, glucose elevated in the blood at toxic levels causes defenses of brain reducing intake pore numbers, but then the neurons need increased fuel and can't get it, and they then ration energy output resulting in 'brain disease'? Can ketone esters enter uninhibited, via a whole different approach than the glucose problem? Does Viagra bring better blood flow to supply the brain with ketones? In men and women? Can this low fueling problem start right in the mouth, by shutting off nitric oxide signaling?

[@TinselDoll]

The FDA is in the business (literally) of supporting Big Farma, which in turn is in the business of "treating" lab results and imaging, just not actual patients. Adverse effects? What adverse effects?

[@mikeward9870]

For more on muscle as endocrine, see Lyon's book Forever Strong.

[@nancieamethyst2541]

The last thing you wanna eat if you’re risky for Alzheimer’s and you’ve got the APoE4 is saturated fat. The study of a load of Nigerians with high Apo4 all ate high starch/veg fruit diet no junk and have very low Alzheimer’s. I’m going with that as I have one copy. I tried lo carb style and my brain came to a grinding halt. Not surprisingly as it has to have glucose to function ( not table sugar!) In a low low fat environment it works beautifully. See Mastering Diabetes. It’s very link to Denton so is hypertension.

[@deirdrewalsh1134]

Check on Professor Seyfried (world expert on cancer) the brain functions best using ketones provided by saturated fat. You will find it very interisting.🌸

[@evabelvain2569]

Clearly, you know nothing about insulin resistance which over a long period leads to pre-diabetes and Type 2 Diabetes. It is not that there is too little glucose in the blood but too much which the body can no longer absorb. It is now being suggested that Alzheimer's is in fact Type 3 diabetes, which is really Type 2 Diabetes when occurring specifically in the brain. In other words, it is not that the brain is being starved of blood glucose. It's just that insulin resistance prevents the brain from absorbing it.

[@georginachristensen7308]

Am i wrong in thinking that the brain fuel was primarily ketones not glucose that fuels the brain?

[@deanawylot6200]

Thank you for this important info. My grandmother, mother and aunt died with symptoms of Alzheimer’s. I wish there was a magic pill to add extra time to my day to work out! This is just more inspiration to change my priorities.

[@lat1419]

"Work out" is just one form of exercise. Walking, cleaning, gardening are all forms of exercise. We allow ourselves to be convinced to not exercise by age, or of convenience, or pills to curse the ills caused by lack of good diet and activity.

[@jeanreynolds1425]

There are at least 4 or 5 reasons for mental problems; therefore one size fits all never works. UGH!

[@lindamcmaster6024]

Wasn’t this just taken off the market for further research?

[@stpello]

How about the Drug in phase 3 trials called Simufilam by Cassava sciences

[@Johnny-dp5mu]

How about a meat diet! And no seed oils grains and processed junk eating

[@mettejensen8653]

Maybe the risk of diabetes goes up with mouth wash because it is sweet. I remember seeing in programs that even just putting something sweet in your mouth and spitting it out, increases blood sugar.....Maybe it is not just the bacteria killing

[@jotibarratt1829]

Thanks - time to add beets to our family diet!

[@Detmold1965]

Why would you take that drug? Might as well let Alzheimer's run it's course.

[@mettejensen8653]

You would never say that if it was a person, you had very dear...

[@timpitts1229]

What is the truth on statins?

[@dianadeejarvis7074]

Statins help very few people. They do far more harm than good.

[@jkgermany2182]

I obviously do not know the perfect answer but it is more complex and different for different people: My mother, who has vascular problems was prescribed 30 mg of a statin but gave it to her husband who had been prescribed 10 mg ( I recommended he take none). Both got a lot worse and better, once my mom took her pills and my dad stopped. So you need to know whats going on and decide accordingly.

[@EXISTENCE1891]

It surprises me that you are even looking at a drug of any description ...... lifestyle lifestyle lifestyle diet diet diet nutrition nutrition nutrition

[@dianadeejarvis7074]

He probably gets asked about various drugs a lot, so he's just updating people.

[@mettejensen8653]

Cordyceps

[@clovermark39]

So bacon is good not just tastes good.

[@sterlgirlceline]

⭐️⭐️⭐️⭐️⭐️⭐️

[@colleenhaithcock216]

❤❤❤❤❤

[@cdfaulk]

Mouthwash. Who knew wow thanks