Inside the Study That Reveals Promise for Treating Multiple Sclerosis with Stem Cells | Dr. Pluchino

[@MrWoodward42]

TL;DW version: Phase 1 trial (eg. test for safety) of 15 MS patients shows no adverse side effect and no new lesions. (Good!) Biomarker analysis found increases in acylcarnitines in the CSF, suggesting a metabolic response in the brain. Early hypothesis is that these stem cells may reprogram immune cells like microglia. Exosomes released from stem cells may also play a role in communication between cells and tissue repair.

[@andanssas]

Thank you Mr. Woodward, please keep doing these comments 👍

[@mujray]

My brother went through a stem cell transplant in Mexico with Dr. Ruiz. They gave him chemo before the transplant, it has been 6 years and he has only gotten rapidly worse after it. I am not sure what they did but he condition had never gotten this bad this fast, he has had MS for 20 years and although on a wheelchair when we went he now cant even move his arms and cant even hold his neck up! He has trouble speaking because of his weakened stomach muscles. Some days are better so he speaks better those days. He has really really gotten worse. It is not for everyone! although it did help him with his heat sensitivity and bladder issues but because he is quadraplegic we still have to have a urine bag on him at all time because he is immobile. Please be careful about the chemo it has really ruined him. they took our life savings and made him worse. I am not sure if this stem cell transplant is any different from the one he got.

[@rajeshkumarcv7146]

Dr. Perlmutter, your podsasts are top class. I follow them regularly from here in India. One suggestion: there is a bit of echo in voice in almost all videos. Kindly look into it.

[@kendapark2795]

No echo on my podcasts might be you

[@yeahright2068]

I has stem cells injected into me and it did not help for multiple sclerosis. It was way too much money too.

[@pattischmitz2680]

Yeahright what type did u have?

[@mujray]

it did not help my brother either, only made him worse in alot of ways to where he is not completely on the bed. took $50k to make him worse. different doctor though not this one

[@StitchingWithLove]

Thank you for sharing this important information. Very much appreciated.

[@leannatimmerman9922]

Good info but takes forever to get to the bottom line. Forever. Did patients feel better? Regain function?

[@andanssas]

28:34 "it was safe, feasible and well tolerated (no adverse effects)... No increase in lesions nor brain atrophy... but caution: this is a phase 1 study, we need a phase 2... There was a dynamic response to the treatment and we want to understand what's going to happen when a group of patients is injected with a placebo (phase 2)"

[@leannatimmerman9922]

@@andanssas yes, I know all that. How hard is it to ask patients or their caregivers whether they feel better? Subjective info has value, too.

[@andanssas]

@@leannatimmerman9922 the _Institute of Neurological Recovery_ has a few videos on exactly that: they inject the solution and sometimes people report immediate results. Subjective info is valuable for people considering the treatment, but for a study it may be viewed as biasing the results. People on placebo often feel better too... That's why phase 2 is needed.

[@Arugula100]

Doesn't heavy AND almost exclusive consumption of animal proteins and ultra processed foods work as a big risk factor for MS.

[@lendalennuk2484]

Thank you, very exciting topic! I am just curious: how can you tell the difference between a exosome and virus?

[@katherine9798]

High dose vitamin d3 alongside neuro physio, thalassotherapy and no more jabs.

[@aaron___6014]

Consuming seawater residue to cure an autoimmune disease?

[@richardbray8004]

How about treating MS with nutrition and I don't mean processed crap.

[@janetbrowning6602]

In the people who have advanced MS they may very damaged brains so who knows if that would help at a late stage, but I take your point. I have a friend who stopped his MS from progressing rapidly by a nutrition approach. For example, he gave up tomatoes completely. One should consider all options because not even person responds to all approaches optimally. Why not encourage everyone who is looking to help reduce suffering and eventually find a cure. This is a metabolic approach as is nutritional therapy.

[@naomi8097]

What do you mean by metabolic approach? I hear that phrase but no one really explains.

[@59skupe]

@@naomi8097 Dr. Terry Wahls speaks about it. She still has MS but is walking again using a Paleo approach. Look her up and see if she has any talks lined up. She did when her news first came out but that was at least 10-15 years ago.

[@59skupe]

@@janetbrowning6602 One problem is the MS Society is so entrenched with Pharma that they won't discuss nutritional approaches. Doctors don't know much nutrition unless they pay extra and above and beyond medical school to learn it.

[@59skupe]

@@naomi8097 I put a comment on for you but it must have been taken down. Just check out Dr. Terry Wahls.

[@user-Rocket-Fest]

Avoid all these medical issues by eating right in the 1st place, very simple stuff.

[@ckellykelly6919]

seriously ignorant comment

[@futurebankroll]

My friend did it to help cure MS. Result was 0.

[@lendalennuk2484]

did what?

[@pattischmitz2680]

Future..What did she do ?