Exciting Developments in the Treatment of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt

[@RichardWagenknecht]

Thanks so much for having these fine gentleman on. They’ve been quietly working on this for many years and they need some exposure to secure their next funding.

[@rickcinway2312]

I have Type 2 diabetes. And had two severe bouts of neuropathy on my left leg and feet. So severe that the pain caused me to stop walking and I had to take painkillers to be able to sleep. I was taking Rosuvastatin drug or other statin drugs on and off for about four years. So, I heard that statin drugs can cause or make worse neuropathy. So, I stopped taking the Rosuvastatin pill and the agonizing neuropathy pain on my left leg subsided after about 13 days. And I was able to walk unhindered by pain. Although, I still have residual numbness on my left foot and a tiny amount of numbness on my right foot. Now, I am able to go for long walks and climb stairs at the park which has 85 steps.

[@wendybrooks6202]

My oncologist had me ice my hands and feet during chemo infusion. It was uncomfortable, but I did sooo much better than anyone I know who had same chemo. I do have some neuropathy but very little comparatively. I was so grateful!

[@eugeniebreida1583]

Wow, what a brilliant and practical solution to preventing the chemo from entering the finer capillaries (feeding the fine nerves) of your precious fingers and toes…

[@Suzitao]

I think I will stick to natural methods of improving mitochondrial function. (My partner and I both have peripheral neuropathy since getting covid..neither is diabetic). Fasting exercise lower carb diet acv sunshine heat and cold therapy lymph drainage omega 3 rich small fish. Supplementation such as turmeric magnesium NAC ALA etc. In my experience side effects seem to usually outweigh the benefits of prescription drugs. Interesting talk though. Thank you all.

[@patriciabanks9651]

It's from inflammation-CoV is a Viral infection resulting in inflammatory issues

[@davidconner5441]

How are you doing? Seeing any improvements in your neuropathy? What kind of symptoms did you have with your neuropathy

[@PattiHill-g9t]

Covid left me with neuropathy in my hand. I still can't believe it's not discussed more! Soooo many people like myself. I hold onto hope for healing, but it's been 4 years. We need more funding and research, and we desperately need something to come out in the next five years or so. I really hope they are able to push something through.

[@katiequ2058]

If I get windfall will send chunk of change your way! Thanks Dr P for not interrupting the guests w/ constant requests for further explanation for lay persons. We have google and makes interview flow

[@davidnorman5488]

Blood flow, nitric oxide, increasing VO2 Max seems like all would help, beyond the blood sugar issues.

[@davidnorman5488]

You gentlemen are doing great, inquisitive work. I am hearing several clear examples of the FDA steering what they care about..... symptom treatment with pain drugs and away from root cause analysis altogether. They do this by only asking or allowing certain questions to be asked and explored. I think it is obvious that non-pharma medicine is simply not allowed a seat at the table.

[@elkegreiser1799]

I have exactly the same impression!

[@patriciabanks9651]

It's all a balancing act, however those who live with injuries and pain issues such as I've done since 12/85, learn that they must investigate all avenues available!

[@pacificislandgirl]

My neuropathy is caused by spinal stenosis at L4/L5. My diabetes is considered under control / normal at an A1C of 5.6 and achieving this has not affected my neuropathy - it is still the same with dropfoot. The neuropathy started after a very serious bout of pneumonia and coughing which aggravated my stenosis that my doc did not take seriously and that caused a month in the hospital. Uric Acid is 391 umol/L.

[@patriciabanks9651]

I have stenosis c2-3 c3-4 c4-5 L4-5 L5-S1 it's managed by anti-inflammatory food and regular tolerable exercise. Pneumonia would initiate or aggravate conditions, just keep following your body's signals to manage it all by pacing yourself! :-)

[@BillEarl]

Fascinating discussion. The takeaway for me is....stay healthy, look after your diet and avoid diabetes ect. as one illness leads to another.

[@geegev.1239]

Loved the talk, very scientific but understandable. I do not have diabetes, but a recent diagnosis of PAD. A little more about what causes foot pain in the absence of diabetes would have been helpful. I do have autoimmune thyroid and a build up of heat in my back L4-L5 which might be flaring up the neuropathy in feet? It's all a science project. Thank you

[@adorableadornments1101]

My sister has idiopathic neuropathy. She was told by her doctor that it was caused by her taking vitamin b6 over many years. So far after getting off the B6, she is not getting better. She also has essential tremor, but tested for adrenal tumors, none found. She is 79 and lives in Assisted Living, and her pain and imbalance makes her reliant on a walker. She doesn't have type two diabetes.

[@AdrianaJSC11]

Has she been tested for mold/mycotoxins?

[@silvieb2024]

Research the TTFD and benfotiamine versions of vit b1. EONUTRITION has good info on yt. It works for many. Best wishes to your sister.❤

[@Debbie3360]

Get her on carnivore

[@lovechildaz6613]

Also it has to be the methylated version of b6 and b1.to avoid toxicity.

[@Sean-h4l]

​@@lovechildaz6613correctamundo!

[@Kathleenschweiker]

Peripheral neuropathy, is often experienced in patients with autoimmune illnesses, - Sjogrens, Mast Cell activation, autoimmune dysautonomia POTS, Lyme disease.

[@il3mendo]

It started with my when celiac disease/thyroid issues started. I know know that with my polymorphism on the mthfr gene, my vitamin b 2, folate, B12 were in a severe deficit.

[@eugeniebreida1583]

Definitely. The damage to our blood vessels prevents O2, NO and other nutrients from reaching smaller capillaries/feeding those smaller nerve fibers, beginning w/furthest peripherals. It’s a problem for me - psoriatic arthritis… I do my best w/movement (through pain), daily niacin, aspirin, omega 3’s etc etc

[@Sean-h4l]

​@@il3mendoMy peripheral neuropathy has improved dramatically in the course of about 10 days; all since taking a combination of Wiley's Cod Liver oil; 3 tablespoons once daily, and Topically applying Iodine 'oil'; 4 drops on my wrist, and sometimes also 3 drops on each of my calf muscles. It has to be in an oil form for Topical application, as water soluble iodine primarily evaporates, as the skin is 'waterproof' - but it's not 'oilproof', i.e. oil based iodine gets absorbed into the Bloodstream, whereas water based iodine does not for the most part! I was already (and still am) taking methylated B vitamins which included the Benfotiamine form of B1, plus occasionally some Brewers Yeast. Best wishes!

[@aslamw9770]

Ask the public for funding, GoFundMe or anything similar. The world will donate like never before.

[@wisdomrules8474]

I looked up the negative side affects of muscarinic antagonists and they seem concerning, particularly in the elderly.

[@Jack-ru9sr]

While diabetic, I never had issues of leg neuropathy until I had an adverse reaction to Leviquin in 2016. My reaction was bad enough that despite walking 4 miles per day prior, within two days, I had to crawl down our stairs. The leg cramps that I never had before were intense and still plague me to some extent, even with taking 600mg of magnesium malate. Still have tingling on occasion, often leg cramps during the night. If you don't want to get medical help, tell a doctor that you had a reaction to Leviquin.

[@dwdwone]

Try horse chestnut with French maritime pine for the cramps.

[@swamiman]

This sounds like an exciting prospect and they can make this treatment available to others in 2026-27.

[@lindalembeck7286]

Really interesting. I wonder if this drug could work for shingles or traumatic injury to nerves from say a car accident.

[@patriciabanks9651]

Both issues are inflammation-shingles is a virus, injuries are painful inflammation

[@tonihager202]

My daughter & I have Charcot-Marie-Tooth (CMT2) a poly perpherial neuropathy.

[@WeBeGood06]

Interesting, so Pirenzepine could be delivered to the bladder via catheter to improve bladder control? OK, where do I get Pirenzepine Cream? Found it interesting the discussion on Mitochondrial Damage in nerves, would be interesting to see a NAC study wrt nerve function.

[@lynnewilson269]

N acetyl cysteine? I've been taking this for many years 600 mg a day. I still have neuropathy and the doctors just ignore any kind of treatment for it, but they know I won't take drugs. They encourage P/T. Maybe I'd be worse without NAC.

[@Sean-h4l]

​@@lynnewilson269I also take NAC but at a higher dose of 1,500 mg daily - but only for around 3 or 4 months at a time, then give it a break. Apparently it's best not to take it (at least in my dose) for extended periods. One of the reasons it's so effective is that it increases Glutathione; and not just in the LIVER, but also the lungs; and is hence a decent 'mucolytic'! Alternatives include Milk Thistle tincture, Dandelion Root and various other 'Liver' detox herbs; but again only for a few months at a time, with a gap of at least a month or so.

[@johnschlesinger2009]

Re diabetic neuropathy: if tight glycaemic control is put into place early, neuropathy shouldn't occur. And, with normoglycaemia, neuropathy is reversible. And access to things like insulin pumps is a nonsense. I have had type one diabetes for 59 years, and have no complications. My HbA1c is 4.5%.

[@eugeniebreida1583]

Shouldn’t occur as a result of hyperglycemia . . . which they seem to focus on in their research/discussion here. To the detriment of bringing to light the many other contributing pathologies.

[@WeBeGood06]

Type 1 with a1c of 4.5% is 82 blood sugar, how do you do it? Are insulin pumps that good?

[@RichardWagenknecht]

Many people don’t have access to proper health care.

[@Sean-h4l]

​@@eugeniebreida1583As John said, it's done with 'tight glycaemic control'; so presumably some form of Keto and non/low oxalate salad items - but (in my opinion) which involves adjusting one's diet with the seasons. Granted it's not for the 'faint hearted'. And to paraphrase Sean Croxton; 'you gotta JERF (Just Eat Real Food)'!

[@Sean-h4l]

​@@eugeniebreida1583Hyperglycaemia produce excess Free Radicals and Oxidative Stress which directly damages nerve tissue, and produces excess inflammation, which if unchecked creates an inflammatory 'cascade', which produces both pressure on the nerves and more damage! Also EXCESS Glucose 'drains' vitamin C (and the bioflavonoids); not good as these are needed as Anti-oxidants to neutralise Free Radicals, and are Antiinflammatories - plus are needed for nerve repair. Best wishes!

[@jedadruled984]

Fat is bad. The political correct food advice to reduce eating fats has been a disaster for health.

[@Sean-h4l]

So true; but only the truly good fats, such as Butter, Ghee, raw organic Coconut oil, and Eve Beef lard, and extra virgin olive oil. In other words, the good fats (lipids ) are those that haven't been processed to death - so definitely Avoid the highly pro inflammatory Margarine and 'spreads' and most Mayo's - especially all fats / oils in plastic bottles (which are lipid soluble)!

[@Sean-h4l]

What about HYPERBARIC OXYGEN Treatments to Stimulate Nerve Growth; this has been shown to stimulate Stem Cell growth including in the Nervous System which include with Strokes, TBI's etc etc!

[@Sean-h4l]

PS Additionally Hyperbaric Oxygen Treatment also moves Mitochondrial Function to more primarily Aerobic activity, rather than more of an Anaerobic state (the latter being typical in Peripheral Neuropathy). Likewise early morning Infrared light positively upregulates Mitochondrial Function!

[@karenf9137]

I wonder if the tests at Siphox Health could help. 🤔idk. Just a thought.

[@mikebreler9724]

Topical Dihexa?

[@bellelacroix5938]

Typos!

[@markmarston]

benfotiamine

[@silvieb2024]

And TTFD, together.

[@rddtdx444444ex]

I heard alcohol is like the second highest leading cause which can attack any part of the body. I have it on my penis the glans and foreskin - my right upper thigh and now foot and as well my right arm…. I am in my 20’s and alcohol neuropathy I heard it’s similar but should not be ignored a lot of people drink alcohol.

[@rddtdx444444ex]

Mine is painful which focuses on a burning feeling.

[@vietnameseamericansocialpoliti]

🥰💘🤝🙏✍