De Novo Metastatic Breast Cancer: A Comprehensive Guide

[@naththomas9946]

Thank you, Dr. Griggd, for continuous support about breast cancer ( health).

[@yerbba]

You're very welcome! Thank you for watching!

[@v.m.sharma9542]

Very nicely described the content. Question is regarding my daughter. She was diagnosed with de novo metastatic breast in August 21. She was 36 years old at this time. Her PET showed lesions in lungs, which were not confirmed by biopsy. She started on letrozole, zoladox and abemaciclib. Her PET in Sept 2024, showing increase in breast lesion from minimum 8mm to 14mm. She doesn’t have disease any where in her body. Please advise on surgery for breast lesion removal option.

[@salb4982]

You explain everything so well and your effort is much appreciated My wife has been diagnosed with advanced breast cancer last year, trustuzumab was helping with pain but it still had managed to spread to other parts of her body Now for a year almost she’s been on Enhertu Side effects of it are rough on her the first week or so but it stopped tumors from growing and spreading So far so good If anyone reads this please 🙏🏻 pray for her ❤ And others

[@yerbba]

Thank you for your kind words. It's good to hear that Enhertu is helping despite the tough side effects. We will keep your wife and others in our thoughts and prayers.

[@yazosoyo]

Dear doctor, I was just recently diagnosed with MBC, and already started endocrine treatment, I keep seeing patient stories and all of them have quit their jobs. I’m currently enrolled in a very demanding grad program, and even though my doctors say I can continue, I am so confused about the future and if it is even worth it. I have mild pain in my bones that my doctors say it will go away in less than a month. Going back to school means I have to be in another town and away from my family, and that scares me too. I feel completely lost and afraid I may be wasting time pursuing a career path I may not be able to continue.

[@yerbba]

We're so sorry you're going through this, and it’s completely normal to feel lost and uncertain. Balancing a diagnosis like MBC with your education and future goals is incredibly challenging, especially with the added stress of being away from your family. Everyone’s journey is unique. Some people continue with their careers or studies, while others choose to step back. Your doctors believe you can continue with your grad program, which is encouraging, but it’s crucial to listen to your own feelings and needs. Consider speaking with your university advisors about your situation-they may offer flexibility or resources to support you. Setting short-term goals could help you assess how you’re feeling without putting too much pressure on yourself. Being away from your family is a big decision, and your emotional well-being is just as important as your physical health. If staying closer to them provides comfort and support, that’s something to consider. We have a video that discusses navigating career challenges during breast cancer which you can watch here [kzbin.info/www/bejne/iJfIioqnpcdga7s]. While it doesn’t specifically address your situation, it may offer some helpful tips on managing your professional goals alongside your health. Whatever decision you make, be kind to yourself and remember it’s okay to change course if needed.

[@Livelongwforce]

I had DCIS, grade 3 diagnosed last June after two aggressive biopsies and told I had all the time in the world to get surgery. After DMX on Feb 1st, shown IBC in one lymph node, and on March 6th found IBC in liver. All +++, grade 3. No genetic component. So my questions are.. What are the chances of this happening? Not de novo specifically but fighting for the first time. Also, after thorough research, I found out that this happens quite a lot where aggressive biopsy (12 markers placed, and kept trying to reach for something they thought they saw, which was also DCIS) can cause DCIS to mutate. And that I should of had surgery within two months of the biopsy. So my question is what do you think of these biopsies? Could women just have a minimally invasive biopsy instead? Such as taking one sample once, and not put markers in. Is there really a need for markers if you are going to have a mastectomy and they are taking all of it anyway?

[@yerbba]

It's a reasonable question, and there is no evidence that biopsies change the type or behavior of a cancer. In people who are found to have disease in other parts of the body, it is the case that those cells have been there a while. Of course, it's distressing to have a delay and even more distressing to find out that one has advanced disease at the time of diagnosis. We are hoping that the "Force" in your user name helps you as you move forward in the weeks, months, and years to come.

[@07734KAT]

9:25 Hi Doctor. I know someone who was diagnosed with de novo/stage 4 breast cancer two years ago. She has undergone chemotherapy and is now taking Tamoxifen. Her breast is also NOT removed. She took HRT (Hormonal Replacement Therapy) pills 2 or 3 years prior to her diagnosis. She said she took HRT to lessen or stop her menopausal symptoms. HRT pills might have caused her de novo breast cancer, right? Because HRT pills contain estrogen? She doesn't have family history of breast cancer. Thank you Doctor for your reply.

[@yerbba]

Thanks for the question. Longer durations of HRT that contain estrogen and progesterone are associated with a slightly higher risk of breast cancer. It is unlikely that 2 to 3 years of HRT contributed to your friend's breast cancer. It may have, on the other hand, furthered the growth of the cancer. It is very likely that your friend's cancer will respond to anti-estrogen therapy.

[@HL-qv3yd]

Hi Dr Griggs, very grateful for your support, is there any hope for near future for cure or more effective treatment, er pr positive her2 negative metastatic breast cancer? Thank you❤

[@yerbba]

Thanks for the question. There is always hope for a cure. One reason we don't cover newer therapies is because our videos live on our channel indefinitely. This means that anything that is out of date can cause problems for our subscribers. For example, if a drug looks promising in initial studies and then is found to be ineffective or harmful, we could confuse people and give them information that they find harder to trust. In general, the treatments for ER-positive, HER2-negative breast cancer are far ahead of treatment for other types of breast cancer in part because this is the most common type of breast cancer. The data are mature and rich for this type of breast cancer although of course, we're always trying to do better. Please hang onto your hope!

[@HL-qv3yd]

Thank you so much dear doctor Griggs ❤❤❤

[@nazkhan3719]

Biospy never causes mutations

[@yerbba]

That's correct. The disruption of cells that might occur during a biopsy does not cause mutations. Thanks for your comment.