Canonical Wnt Signaling Pathway

[@joelakin1]

Hello from the Czech Republic! Excellent explanation. Thanks.

[@suhara6045]

This is really helpful and very clear! Came in handy for Developmental Bio! Thank you!

[@neurobiogirl]

Hey thanks for uploading this. This is helping out with Cancer Bio!

[@felipeabreu7998]

He's too cute. I couldn't pay attention hahahahha

[@hawzhinkhalis8335]

THANK YOUUUUUUUUUUUUUU such a great video

[@natassiacorrea7249]

Thanks David, very good class!

[@owenhoare3464]

There is a lot of essential details missing in this pathway, its vague to say the least. Its not a bad overview of the pathway but APC, Axin and ubiquitination were not mentioned to name a few. There are other videos on KZbin which provide a more detailed explanation and I would recommend these first especially if your planning on using this information for an assignment

[@debertz12]

I understand, Owen. I merely presented the parts of the Wnt pathway that were relevant to the basic cell development and biology as a whole. For the most part, you only need to know these bare details. And i do mean for the most part, for I'm sure theres many times that you need to talk about APC, Axin, and UB, such as in regulated apoptosis, or tumor regulators. The main interest of the Wnt pathway for these videos was for basic cell development. I am sorry I didn't do more. Maybe in the future.

[@owenhoare3464]

No Problem David. It was a good summary over all and I do appreciate your input on this video. There is absolutely no need to be sorry it wasn't a bad video and I hope you didn't feel that my comments were unfair. Thanks for your reply and I wish you well.

[@christophernam7395]

Were is Axin, APC, etc... or is GSK3 the main component of the complex

[@debertz12]

Those are for sure included. But you gotta realize, all these pathways have much MUCH more complicated ones. I mean check out the 'real' Wnt pathway (as best as we understand it) www.sabiosciences.com/pathway.php?sn=WNT_Signaling So I am simply presenting a simplified version (as do many teachers/textbooks according to the lesson taught) that is kind of the bare minimum needed for this level of genetics and cell bio. But yeh, you're absolutely correct with APC and Axin, etc. Its just that for developmental cell biology, GSK3 is one of the more popular molecular targets that is discussed.

[@luxanat460]

@@debertz12 I have one doubt.. . which molecule other than 3 (except beta catenine) to get target site to arrest cancer

[@mikecastro4403]

Youre good!

[@PippyPappyPatterson]

I wish you taught me lol

[@tatianawestacott8810]

Helpful for biology of cancer

[@tatianawestacott8810]

Love the wnt

[@sihemfar971]

Thank. You 🤗

[@claudialuna767]

amazing !!!! ;)

[@madinaomasheva3174]

Thanks!

[@asmita51]

thanks

[@MrBloodmountain]

wnt is coming...

[@Irfan-zy9xu]

what the hell is this, you mutilated Wnt signaling pathway....