Wnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations

Lesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway.
NOTE: In the video, I misspoke and said that Beta catenin enters the "mitochondria" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :)
Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway.
If you found this video helpful, please like and subscribe for more videos :)
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.

[@jjmedicine]

Hey everyone! At 4:12 in the video, I misspoke and said that beta catenin "translocates into the mitochondria". I'm not sure why I said that, but I meant to say "translocates into the NUCLEUS". Sorry for the confusion. I hope you all found this video helpful though! :)

[@crazybaboon1749]

Great video, May I ask this Q: in invasive lobular carcinoma we lack E-cadherin and as Beta-catenin binds to E-cadherin is pathogenesis has to do smt with WNT pathway or just cell-cell adhesion?

[@vishalkhandelwal01]

That’s okay jj you can make it better next time but you are my saviour.

[@gideonobeng9143]

well, the mitochondria has its own set of genes so it might be possible. You never know...

[@Valeriaarianna]

i spent 2 hrs trying to understand this from my med school lectures, and you just explained it clearly in a few min🤯🤯

[@stevensmith3976]

great video, incredibly clear, if only some of my lectures were like this

[@maryellenelizabethhart7370]

Exactly what I hoped for. Thank you for your excellent explanation.

[@jjmedicine]

Glad you found it helpful :)

[@gabrielyan2972]

I’ve got a expo of this tomorrow with drawings by hand, you just saved me.

[@GSouf1105]

This was very helpful background information for my research on podoplanin. Thank you for the clear explanation.

[@viniciomonge3960]

HEY! THANKS A LOT. I'm an electrical engineering student in a struggle to undestand this pathway, and your video was awesome. Because, it was SHORT, and COMPLETE. Thanks really. Some advice tho, please share your references and books for further reading. And please keep doing this kind of videos, specially for people who are not studying health related majors :3

[@hafsajabeen5303]

why would u need this

[@vanessamorales5810]

Thank you so much for Uploading this tutorial thia is very helpful and it makes my reading easier to understand!

[@jjmedicine]

Glad it was helpful!

[@ru-jengteng6312]

Concise and clear information in such a short time for layperson like me.

[@leanswagger5822]

wow, great vid! thanks so much man, have an assignment just about this! Made it very clear, and gave me a ground level understanding of it!

[@lifeonthesweeterside]

SO HELPFUL, wish had found these videos before

[@sapientnz]

Your videos are amazing, thanks so much for sharing your knowledge in such a clear way. :)

[@peter_3435]

This video is very good as a description of the canonical Wnt pathway and how Wnt binding at Fz leads to increased transcription of certain genes. However, there are some issues with the description of Wnt family and the depiction of the destruction complex disassembly is shown incorrectly.

[@prisce7642]

wow, this was soooo good, thank you, you've got a gift for teaching!

[@ritzee13]

Thankyou so much! I'm making a presentation on APC and this was so helpful.

[@betulceylaner]

This video is really helpful and easy to understand. Thanks for helping us :)

[@vicket4]

Thanks for sharing your knowledge. Helped me a lot.

[@danielnguyen7587]

Fantastic, crystal-clear explanation. Extremely helpful.

[@rockstarmoosegod]

Good content. Just be sure to note this as being the canonical pathway!

[@Flaschenente]

Thank you for this very good explanation.

[@laurenhardin2651]

How does this pathway play a role in cancer or neurodegenerative diseases?

[@vinniesharon477]

Made so simple and easy! Thanks!!

[@visnuc]

Nice one! Thanks!

[@AG_UofT]

AMAZING VIDEO THANK YOU!

[@imadmo2910]

very well explained.

[@mahasaber424]

Excellent video. Thank you

[@vipshorts9949]

kindly make a video on VHL in cancer induction

[@crazybaboon1749]

Great video, May I ask this Q: in invasive lobular carcinoma we lack E-cadherin and as Beta-catenin binds to E-cadherin is pathogenesis has to do smt with WNT pathway or just cell-cell adhesion?

[@awesomemia13]

Nucleus** not the mitochondria

[@nathangonsalves2711]

AMAZING DUDE !

[@anleyteferra7846]

Thank you so much!

[@alexanderdiederichs7332]

So interesting!

[@stephanieceolin021]

you are amazing! thank you so much!

[@sakshitewari5315]

so clear!

[@angelicagallespen7742]

So helpful! Ty!

[@tristan8172]

you are amazing bless you

[@getfreelisting29]

Is it possible to inhibit β-Catenin?

[@kyngoftops7851]

What an amazing video

[@박시언-k1l]

와... 우리 교수님들께서 설명 이렇게 해주셨으면 ㄹㅇ..

[@CaraxYT]

Hey JJ, loving the Bio videos, definitely re-piquing my interest in Biology! I just wanted to ask, do you ever plan on returning to your piano videos again? I always loved those videos and they're what got me playing piano again after 5 years, been through almost all of them :)

[@jjmedicine]

Hey! Thanks for the comment. Yes, I plan on uploading more videos to that channel, just not sure when - hopefully in the beginning of the new year :)

[@CaraxYT]

JJ Medicine ahhh this has me so hyped you have no idea!!

[@mrsdiggory3211]

Thank you, really helpful tysm!

[@abidmahmood8094]

v v good lecture

[@emmanuelpapadopoulos9838]

excellent

[@sopanshinde5860]

nice one

[@sudhakarreddy1453]

What is the expansion of *wnt* genes ?

[@hamadimadhi7648]

translocates to the nucleus! not to the mitochondria.

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Whats the fullform of CKI ?

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CKI - Cdk inhibitor proteins, inactivate cyclin-cdk complexes.

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What the hell is "dabliuenntee"? its pronounced "Weent". The basics!!

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You are pronouncing beta catenin and WNT wrong. Hard to take what you are saying seriously.

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so show your answers

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