Deciphering Depression: The Role of Serotonin (The Social Brain ep 37)

[@mikalotto1124]

Hi, your conversation was interesting. A lot of ppl 20years ago said depression is caused by your miserable thought pattern and it was hurtful to hear. I was waisting a lot of time for taking counseling session, but around 2005 when Japan started to sell Sertraline and I changed the medicine from Paxil to Zoloft (sertraline) then I realized what I needed wasn’t a therapeutic talking it was just about chemical imbalance. I guess a lot of ppl now know about depression is caused by a chemical imbalance is a good thing (at least for me) but there r many kinds of depression (including ppl depressed by the terrible life event), since we r all diagnosed by the interview instead of using any biomarker, doctors do not know what kind of therapy or meds fix which patients. I hope we can find something better to diagnose mental illnesses while I’m living.

[@NajibGhaziMirsaeid]

What is your idea about comparing cbtbtobpsychodynamic therapy that goes deeply to underline causes that definitely related to your up growing events that made your personality

[@NajibGhaziMirsaeid]

What is your idea about comparing cbtbtobpsychodynamic therapy that goes deeply to underline causes that definitely related to your up growing events that made your personality and what is the statistics about CBT effectiveness in completely treated a depressed person

[@NajibGhaziMirsaeid]

Hello thanks for your new ideas but what explanations do you have about shrinkage of hypocampus, prefrontal lobes, increasing the size of amygdala, and shrinkage of lambic systems, and the study that shows that cortisol level that related to stress will ruined the hypocampal cells and lymbic systems,

[@NajibGhaziMirsaeid]

Hello would you please share the papers about placebo compared to serotonin reuptake inhibitors, and how about dopamine that completely switches you from a zombie person to active person . And what is your suggestions about treatment of depression which is legitimate

[@NajibGhaziMirsaeid]

And is there any legitimate statistics that show how much the psychodelics, are effective in depressed people , and how many of them came out of depression, would you please give me a good statistics that was based on RCS.

[@NajibGhaziMirsaeid]

Can you explain the reason of depression scientifically

[@robandrews4815]

Serotonin loss is not the cause of my depression. What Seratonin drugs do to me is cause me to become like Mr. Spoke. No emotions at all. If that's what suppose to happen then I want no part of that!!

[@senseofmindshow]

That kind of emotional blunting is really common with SSRIs, at least anecdotally.

[@exodi9420]

ssris will help you preserve brain function into older age via upregulating neurogenesis + the emotional blunting is placebo bs and will probably go away

[@austinrine7606]

​@exodi9420 emotional blunting is an official recognized side effect from ssris and has sound basis in why it happens, too much dampening of amygdala. Think goldilocks effect, too little amygdala suppression you get hyperarousal, too much suppression you get blunting. Person prob needs to reduce ssri dose back into goldilocks zone.