Destiny and DNA: Our Pliable Genome

Our genes strictly dictate our personalities, appearance and diseases. Or do they? Research has revealed that genes can turn on and off; they can be expressed for years and then silenced. Sometimes, they are never activated. And these genetic instructions-how and when DNA is read-can be determined by the experiences of one’s ancestors, even those several generations back. Epigenetics studies these instructions, the biological markers along our DNA that regulate gene expression in response to features like age or environment, and which can influence the traits we pass onto our children. Glimpse into the future with scientists at the forefront of this emerging field as they reveal the role our genetic markers play in steering our biological destiny.
This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.
The World Science Festival gathers great minds in science and the arts to produce live and digital content that allows a broad general audience to engage with scientific discoveries. Our mission is to cultivate a general public informed by science, inspired by its wonder, convinced of its value, and prepared to engage with its implications for the future.
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Original Program Date: June 1, 2013
MODERATOR: Bill Blakemore
PARTICIPANTS: Frances A. Champagne, Randy L. Jirtle, Jean-Pierre Issa
Bill Blakemore's Introduction 00:06
Participant Introductions 1:55
A brief history of Epigenetics. 3:16
What is Epigenetics? 4:30
Can your DNA be effected by the natural world? 6:05
Why do identical twins end up being different people? 9:17
The mechanics of the physical genome. 14:05
Humans wouldn't be here without variation. 18:35
Three breakthrough studies. 21:41
What is cold mother syndrome? 33:30
The measuring of Epigenetics. 41:05
What are the risks to treat neurological disorders with Epigenetics? 47:24
Is there any denial to the insights of Epigenetics? 53:44
Will we sue our genealogical past? 59:30
The eugenics movement today. 1:05:50
Will there be pills that can change our DNA? 1:10:00
Can this therapy revert metastasis process? 1:15:14
Does what extent does bacteria in the body effect metastasis?1:15:55
What is the effect of culture on Epigenetics? 1:18:49

[@WorldScienceFestival]

Hello, KZbinrs. The World Science Festival is looking for enthusiastic translation ambassadors for its KZbin translation project. To get started, all you need is a Google account. Check out Destiny and DNA: Our Pliable Genome to see how the process works: kzbin.info_video?v=lQrzjZO4Cns&ref=share To create your translation, just type along with the video and save when done. Check out the full list of programs that you can contribute to here: kzbin.info_cs_panel?c=UCShHFwKyhcDo3g7hr4f1R8A&tab=2 The World Science Festival strives to cultivate a general public that's informed and awed by science. Thanks to your contributions, we can continue to share the wonder of scientific discoveries with the world.

[@VahidAryadoust]

One of the most exciting conferences I have ever watched on the World Science Festival!

[@CocoaHerBeansness]

a lot of horrible mistakes started with excited scientists.

[@YeominAraluen]

@@CocoaHerBeansness and a lot, lot, lot more marvelous things.

[@Blaiwnez]

Definitely one of the best WSF panels I have seen. Great insights and information to take a long. A must see for everyone (will help the epigenome).

[@paxdriver]

Fantastic! Thanks so much

[@mamunurrashid5652]

One of the best talks in WSF.........

[@RLNDO-]

Bill Blakemore, FTW. idk you, idk your politics but I want to THANK YOU for turning up the heat at 46:49 AND 40:44. I may be erroneous in my conviction but it sounds like the panel was trying to deflect. That was brilliant and a completely reasonable inquiry. Honestly, if their work keeps going in the same trajectory it is then the answer is YES.

[@anthonymannwexford]

great talk.

[@lisabeysiegel3953]

No need to sensationalize..... Just the facts, please!

[@Chaosandcoatimundis]

I also think it is important for governments to consider theses implications especially in terms of foreign policy

[@vscmodus4766]

Would love to see a follow up discussion on this topic on advances in the field over the past 8 years.

[@Whyer105]

Great topic with great points, despite the annoying moderator

[@cum4tea]

I find the comment about the possibility of sexual orientation modification disturbing

[@batuhand1317]

I would like to listen to a lot more about biochemistry of the process but it was greattttt!

[@dejal.3606]

This is why emotion of pregnant mother is so important.

[@Chaosandcoatimundis]

I would love a discussion of how memetic evolution effects epigenetics

[@SeeMeRolling]

Stuff like this is why I really want to study biology

[@n.d8001]

very interesting

[@jonchristian5069]

I just wanted to say thank you for the complete lack of commercial ads in ALL OF YOUR videos. I am really looking forward to watching A LOT more.

[@CarlosAlbertoBasoli]

There comes a time we'll have quality of life described based in the happiness of our mothers in the pregnant. And our longevity determined by our ability to become far from distress in our lives. Epigenetics points that "no pressure is reasonable" in terms of aggression and their immediate implication on healthy lives and over our descendants.

[@sinisamajetic]

Epic

[@darwinlaluna3677]

Careful

[@tgaming8745]

When it comes to genetics, the contribution from both parents are equal, regardless of the vessel by which the embryo is housed and constructed. Just because the "female" is the medium by which the embryo is housed and constructed doesn't mean that the male contribution, genetically, is any less than the female.

[@RobertHouse101]

I believe the "Vessel" has a role in hormone production.

[@annabeatasohalmy9612]

Jozsue! Te vagy a Vergődő Madár a Farkasokkal táncoló című filmből ("tudom hogy Hacker lettél volna" - kösz a bókot, hogy kinezed belőlem, ez feléért egy vallomásal. JOSH! )

[@cleverusername9324]

this is a revolution im so excited

[@elizondorj]

If even some small amount of health (physical and mental) depends on maternal care at early age, consider the damage we have been doing to our descendants by denying maternity leave... Another cost that is externalized by businesses, borne by society instead of borne by the business itself.

[@lisabeysiegel3953]

Ok, so we experience traits both from dna and experiences of the contributing parents.

[@PDPresents]

This explains the personality disorders of a people who were formerly enslaved and are presently oppressed. It also explains the personality disorders of those who would treat people as property. Sufferers and sociopaths.

[@John83118]

I'm amazed by this content. It calls to mind a book I read that was equally life-changing. "A Life Unplugged: Reclaiming Reality in a Digital Age" by Theodore Blaze

[@briannatayla]

great panel, but quite uncomfortable that of the things we could potentially change with a pill sexuality got brought up. There is nothing wrong with having different sexualities, making it unnecessary and slightly offtopic and is hurtful. It also brings our the concern for the extent of using this technology when essentially someone gets on stage at the world science fair and asks if it could be used as conversion therapy. I do appreciate the response quickly addressing it and refocusing on the topic.

[@tommyboy7233]

new world new thoughts

[@truthseeker1505]

Rey Gold Evans Same world, evolving thought structure i.e awareness, conscious

[@tommyboy7233]

nice..

[@Rawssmusic]

What about generations after slavery and stress?

[@patrickboudreau3846]

We are all slaves of a system where if you don’t perform, that system will take away all possible joy in this one life. The good thing about epigenetics is that you can change your thought process and your children will benefit from it. If you manage to perform somehow, in this system, you will escape slavery and make it easier for your children by the same token. I was born a slave and the smarter and harder i work, the better chance i have of liberation. Lets look foreward and all the best to you.

[@jerrygundecker743]

Sue someone for not taking care of something they didn't know existed? Hmmmm.....

[@warmaxxx]

1:08:00

[@tgaming8745]

The joke about the "male" not participating at all is not funny coming from such social influences as the qualifications of the panel representing their fields of study because it has massive social ramifications and is placating a currently incorrect social stigmata of the male not representing any influence on the offspring other than the sexual contribution. The video explained that the genome as well as the epigenome from BOTH contributors effectively contributed to the biological influences as well, obviously, the social influences over time of a certain individual so the joke about the male contributions is just a social regurgitation and a failure of the current males in our society, especially the ones whom know better, to allow such factious insinuations to permeate our intellectual culture. I'm absolutely embarrassed in reference to the minimization of males in our current culture to defend themselves. The female is not to me minimalized, but to be mininalized by the other is to be influenced by negative aspects of our social culture and to ignore completely the scientifically proven contribution of the male species.

[@tomtailor7492]

dna rules

[@JoinGamesLinks]

The Bible says 7 generations inflicted + affected .

[@mayamachine]

and it's proven,, just smile, love,, have a good life,, make good things every day,,that releases all the good drugs you already make, your a chemistry factory you produce all the drugs your made of,,,

[@mayamachine]

native family,,,

[@botjabber9187]

I believe epigenetic is real

[@deeliciousplum]

This talk is bordering on being disconcerting. Research scientists who have and who do offer meaningful arguments against a number of the epigeneticist's claims are not present. Talks like this one-sided talk take away from the much needed discourse. It impedes me as well as viewers who are equally as curious from getting a better handle on what is known and what are speculative pronouncements.

[@annabeatasohalmy9612]

Minek fertőtlenítesz Jozsue? Én n kitakaritottam a netet a Burger Kingben.

[@vandrya1]

Who is the guy that is hosting the experts? His ego ruins the show.

[@paxdriver]

I've seen a lot of these talks and imho he did a phenomenal job of succinctly elaborating concepts

[@DistractingTest]

@@paxdriver He seemed pretty intent on bringing divisiveness and outdated mentalities into modern science that simply does not recognize them. He brushed over when their chuckling at his commentary without realizing how behind his points were. Lawsuits against ancestors? Sexual preference predisposition? In group out group psychology from the 1800's that focuses on physical might and aggression as relevant to group dynamics? I haven't seen anything about that in years.

[@DistractingTest]

He is good at his job, but from a different generation and time that the scientists even of his time and regular folks of this age already know that aggression is not innate, but ineffective to its goals, nor preselected but often a symptom of their situation. Tribal group theory is no longer even possible in a global, interconnected society without painfully backwards thinking that requires writing off the very groups we evolved to work with, not destroy in mutually assured destruction (MAD) especially now that we know that trauma is far too high a cost to continue war, not something to punish (creating additional trauma) but something to prevent permanently and correct where it occurred until we learn ever better ways.

[@DistractingTest]

If anything, it is a testament to how much we have changed so quickly. Back then, violence might have been used in schools and advocation for war was common, so social science would always point to it as important where in a world where we now know physical or psychological punishments cause rebellion and secrecy, not a correction of behavior but if anything resentment and stagnation if not separation. Sexual preference has been around as long as humanity, but perhaps an overly prudish early America believed in tradition and isolationism too much and rejected simple biology in favor of limited heterogamy of the era. We now know better than to limit people and love for no reason, especially considering the harm that caused with no benefits. What will our descendants possibly learn to overturn our beliefs and traditions of today? Will we stop putting people in boxes assuming it fixes them? Will we ensure food, shelter and clothing to all humans so that basic human needs become basic human rights? Yes, and the sooner the better off everyone will be. Perhaps then we can get back to divisiveness and infighting (self sabotage) but I think by then we'd have found some fascinating alternatives. If we must fight then let us fight for a better world, not against each other in pursuit of a smaller one. A house divided cannot stand, and we know better.

[@DistractingTest]

"No good is worth any evil, nor is there any good in the knowledge of good and evil, so cast it aside and see the two as one, then step forward with studied reasons, heartfelt empathy and a universal awareness of each situation on a case by case basis in pursuit of the Greatest Overall Direction for all."

[@annabeatasohalmy9612]

A NASA - t meghackelni......... :) :D.... Ha újból gyerek képű leszek. :) :D

[@basgordijn9722]

What these people are talking about has been figured out by Weston Price some hundred years ago: If the mother eats healthy you get healthy offspring. What this society has forgotten is the idea that women make babies. Women in our society don't make babies they have careers because they are equal to man. But then suddenly "oh uhm I am pregnant....How did that happen?..." How many women have stress and/or don't eat healthy when they are pregnant? Probably most of them.

[@dianarain8659]

The icy helicopter genomically heal because riverbed climatologically burn by a premium tax. stingy, workable example

[@DistractingTest]

I would love to hear a coherent an explanation of this poem.

[@annabeatasohalmy9612]

Ne jatszal rá arra hogy lelkiismeretes vagyok, mert ha ez az igazság nem leszek a barátod. Ne okoz már csalódást direkt.

[@annabeatasohalmy9612]

Ijesztő vagy jozsue, félek tőled. Ne abrandits már ki hogy a barátod legyek.