Digoxin's mechanism of action when used for AFIB

[@ezgisagir5436]

Watched 4 videos before this and didnt understand a thing. Youve really simplified this and given me the facts. Thanks.

[@AliHamza-bz2oo]

Plz explain digoxin toxicity and its management

[@dpedersen808]

I was thinking the same thing Subaaz! Thanks for the post, Andrew! What do you think about a follow-up illustrating the target cells in the atria and ventricles and how dig imposes negative chronotropic and positive inotropic effects? And an inside look at cellular Na+ and Ca2+ [ ]s being altered? I can't wait to see what you can do with that rad MacBook!

[@shikhu95]

thanks a lot/such clear and crisp presentation. i have a few questions. 1.can we use low dose digoxin to avoid toxicity as you mentioned levels do not correlate with the action. 2.would it be better to use inplae of enteresto/betablockers and diuretics which all combined cause hypotension and still need for a lot off diuretics? thank you so much

[@suasivesubaaz3444]

Your explanations are much clear but it would be more catchy if u prepare with some diagrammatic things :)

[@ranvirghosh196]

so digitoxin is used in chf to increase the contractility and decrease heart rate and again it is used in a fib by decreasing contractility and decrease in conduction. how

[@MrVirginator]

Thanks man!

[@Medgeeks]

No problem at all!

[@ashutoshupadhyaya5725]

You said digoxin increases the intracellular calcium & this prolongs Action potential duration which decreases the heart rate.......But when we use calcium channel blockers, isnt it so that we decrease intracellular calcium then how does that decrease heart rate too......i find it very paradoxical.....please explain.

[@ihsantahseen1472]

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