Chediak-Higashi vs. Chronic Granulomatous vs. Leukocyte Adhesion vs. Wiskott-Aldrich

[@DirtyMedicine]

Errata: The NBT test is backwards. 15:45 I spelled Peyton wrong. My bad, Peyton!

[@lokeshdevalla2060]

DirtyUSMLE videos on dermatology cases plz

[@eman37alqisi32]

PLEASE ACCEPT MY DEEPEST THANKS ❤❤🙏🙏🙏

[@HairRival]

Thank goodness for the note, trying to figure out the NBT was some serious Stroop-effect shit.

[@abinashshah8875]

​@@HairRivalaa

[@aidenssillycoolvideos6068]

I remember CD18 by thinking you're supposed to move out when you turn 18. There's a deficiency, and the neutrophils can't "move out" into the tissues.

[@emuwarrior13]

Charla King also, you’re no longer a LAD at 18

[@uni1316]

helpful for non foot ball fans like few of us; I watch England foot ball so "No.18 is the referee who don't you out of the foot ball court during the game because no body can give him red card unless a LADA taxi come and give them lift! so number 18, refree BooooM, can afford LADA taxi "

[@ApplyingForResidency]

I like that - parents "cut the cord" when their kid turns 18.

[@Be1smaht]

So good

[@taytayqp]

I like to think you need to be 18 to get a sticker for voting and you need CD18 for leukocytes to STICK

[@jensonmathew8437]

You know for the visualization of Chediak-Higashi it also works if you make him a The White Knight Chediak-Higashi since it also causes partial albinism.

[@DirtyMedicine]

love it

[@vb9490]

Or the O could have been for oculocutaneous albinism, while the P would have been for phagolysosome

[@seen203]

He's fighting White Walkers

[@brahmaputramoskva1215]

A ched who is a white knight

[@eriktatos]

Racial…I love it ☠️

[@bhaumikpatel7771]

I also use the " A and E" in the WATER mnemonic to remember that there is increased IgA and IgE in Wiskott

[@ASAPUSMLE]

As an added bonus, Wiskott *ALL*-DRINK syndrome shows it affects both T and B cell lines (IgG) therefore causing the pt to get all infections (viral, bacterial and fungal). Great video, as always.

[@pragyasingh2297]

I love it! Thank you so much.

[@nenimarie89]

the comments section is ALMOST as good as your videos. Bless your heart Dirty

[@rianblackwood2081]

Thanks for the mnemonics! I have one for LAD that helped me remember - "LADs must be 18 to Integrate" LAD - Leukocyte Adhesion Deficiency Must be 18 - CD18 Integrate - CD18 is an "integrin" that is necessary for migration

[@gianrodriguez1643]

Hey! Took step 1 today i get home and see this. I got 2 questions on CGD, one Bruton's and leukocyte adhesion which was baby who umbilicus doesn't fall off. Quick tip: study PARASITES!!!! who said they were low yield. Btw great videos guys... keep it up

[@veganwilliams8868]

wow congrats.what other HY systems How was GIT?

[@williemuthui432]

Hello

[@ThatsWhy-]

Did you get usmle 1&2 passed?

[@kabirtorres2672]

No joke just finished this video and on a random UWorld block, first question is on CGD. Had to pause the block to laugh for a good 2 minutes. Great video!

[@DrEktaYadav]

"fungus went up your ass? throw some hydrogen peroxide at it" ---I don't think I've ever laughed that hard and not to mention I will never forget the enzyme again. ty ur videos are AMAZING.

[@Trish.786]

Me too! I’m still cracking up 😂

[@rusinoe8364]

Just a regular Tuesday for me...

[@SuperHaind]

Wiskott for wisky ..drinking "Ethyl Alcohol "= increase in IgE and IgA

[@bretw4754]

works in the wAtEr mnemonic too. But water is less fun...

[@sonny4997]

@@bretw4754 nice

[@coralreef896]

Hi, your videos are amazing + life saver!! For future video topics, could you possibly do them on these: 1) antibiotics overview = when to use which + high yield side effects 2) cardiovascular drugs 3) Dermatology stuff (eg papules/macules etc...) = relevant for step 1 4) GI patho

[@christinaalvarez1]

YAY!! I requested this one a little while back. Thank you, thank you, thank you!!

[@lilliereed8433]

A in WATER could also stand for "actin" because the WAS gene mutation leads to leukocytes/platelets being unable to reorganize their actin cytoskeleton --> ineffective APC function. Also thinking of it as Wisxott rather than Wiskott as it is X-linked recessive!

[@jemalgemtamohamed9614]

You are so clever in how to be adhesive with informations you learn.

[@tiam8836]

idk who you are or how you have the time to make these videos but you are my HERO can you make a video about the upper/lower extremity nerve stuff?

[@suomynonaanonymous]

Your videos are way better than sketchy path

[@DrEktaYadav]

sketchy path is ass and it is way too damn long so I agree 100%

[@thanasegaran1]

Correct me if Im wrong, as for the CGD The nitro blue test Positive = patient have super oxide therefore patient is free from the disease Negative = patient has the disease as the nitroblue remains blue! I think you may have confused us on the positive and negative. Patient has CGD if the test is NEGATIVE not as mentioned in ur video. Do check wiki or correct me if I'm wrong

[@ricardoa.pascual9793]

Not quite! NBT is a colorless dye by itself. He clarifies this in the errata (pinned as the top comment). DirtyUSMLE wrote that the NBT is backwards as per the vid! Here's how it should be: Normal (positive) = turns from clear to BLUE (neutrophils can turn the dye blue because NADPH oxidase is present). In Chronic Granulomatous disease, it's Abnormal (Negative) = No color (indicates that there's No NADPH oxidase). No color = No NADPH Oxidase present Hope this helps!

[@rayray9508]

I used "Leukocyte EIGHTEESHIN deficiency". Thanks for the banger as always

[@1wertyuiopasdfghjkl]

I seriously love this channel

[@dr.manalsamater3737]

Actually, in CGD the Nitroblue tetrazolium, if it’s positive meaning it turn blue the patient doesn’t have the disease. In the other hand, if it’s negative don’t turn blue the patient will have the disease. So in exam if they say the test is negative it means they have the disease.

[@kirubakaran09stanley]

Yes , you are correct

[@nooral4315]

correct. Negative NTB test means the person is lacking NADPH oxidase

[@HistoryHive0001]

Yes you are correct.. I hope he makes correction as I observed it immediately.

[@pavitraattanayake10]

CD18 can be remembered as "I ate $hit because I couldn't stop" where "I ate" = 18 and "couldn't stop" refers to adhesion issues

[@marialoukiaanastasiadou7954]

extremely helpful mneumonics! Please make more of these videos for diseases.

[@dmitrybaer5873]

I love you in and out. Thank you so much for your work.

[@B3bita1215]

Amazing explanation!!! My goodness sooooo glad I found you guys 🙏🏽🙌🏼

[@Sia.1111]

This content and your amazing efforts to make everyone understand this ...are grreatttt ....thank you for teaching such helpful and important information

[@Dr.Kaseses_hunk]

Thanks so much doctor,,, ur videos are the videos I needed to make A's... Good bless u abundantly

[@koolkid4650]

Thanks Sir.... Please videos on Musculo nerve injuries & All Formula videos of book & Imp Graphs video Thanks

[@SanahSaysHello]

I've loved your videos for years. Huge fan. Will be sure to donate later today!

[@ricardoa.pascual9793]

he shot the Menke, *WASP*, and G6P... got your XLR song stuck in my head haha

[@angelonicolascaputizuniga1418]

LAD is a disease with no migration, at age 18 you supose yo migrate from house (CD18), so you stay in home like a baby more time that supose (late umbilicak cord separation). Like if thist helps you

[@yosiguevara]

Thanks because I won't remember that football player LOL

[@fbsdeformedvag8925]

My Son died from CGD in 99 at 6 1/2 years old.

[@hmansaria5632]

I just came across your post. My prayers are with you. May The Almighty place him among the highest ranks in Paradise and may you and your family be blessed with the strength to bear this loss and emerge from it stronger.

[@ezzabashir2278]

Thank you for this. So glad i found it

[@learnteach2learn729]

Why did you remove your line weaver plot video? I liked it and it was really helpful

[@aliyahamid7473]

Amazing mnemonics! Great work

[@nermeenkolta135]

thank u so much , ur videos are really helpful , can u consider to make avideo for embryologic derivatives , thanks

[@suomynonaanonymous]

nermeen kolta yessss

[@pfln]

vitamins vitamins vitamins please please please

[@vanshajchandra307]

Never thought Podrick from GOT would teach me immunology

[@anyquezada2990]

i just got 5 question about it in my last NBME thanks

[@gachett2011]

Could NOT have had better timing! *clutch*

[@ericac2355]

Does the hydrogen peroxide come from the infective organism in catalase negative infections? In CGD they can’t make it themselves right? Awesome video thank you!

[@DirtyMedicine]

Yes this is correct. Our immune systems hijack the native Hydrogen Peroxide in the virulent organism

[@rjj151]

Great video as are all your other ones! For the CGD mnemonic, what about naDph oxidase deficiency?

[@praneethamodumudi4391]

A video on inheritance patterns calculations pls

[@Coverworld-t3y]

You may think of bruno fernandes no 18 for Leukocyte Adhesion Deficiency ☺️☺️☺️

[@Dr.ShubhamPatidar]

sir please make a pdf or slides of your video so make easy to revise in last time of exam

[@musicfreakpolina]

If you can't remember Peyton Manning - CD18 because your umbilical cord is so late falling off that you're 18 years old by the time it does

[@nishisatish3539]

You are amazing.

[@shayekhabedin4462]

YOu inspire me! I wanna be like you!!

[@praneethamodumudi4391]

Thanks a ton😄

[@shokhzodbozorov4252]

thank you a lot!!!!!!!

[@habib080]

for step2 i am seeing Dihydrorhodamine Test being asked for CGD!! just wanted to share

[@matthewmann8969]

Electrolytes, nutrition, and vitamins

[@faiqapirzada]

Its helpful. Thanks !

[@roshnichiru]

Thank you so much Sir 🙏

[@1MinuteFlipDoc]

Great tutorial!

[@HomeHome-he2xq]

Love ur work ! But this could have been more detailed and better . Many points are missing out....

[@DirtyMedicine]

What would you have liked to be included that wasn't? Remember that my primary audience is medical students

[@HomeHome-he2xq]

@@DirtyMedicine Thanks a lot for ur reply ! You could include the Cells that are defective ( eg B ,T or Both) , the organisms that cause infections in these , like some have viruses / fungi and other bacteria ! Just more details in an easy way. This is wonderful ,but just found it a bit concise. Thanks a ton & loads of love for ur vids :)

[@abundanceoffavor1353]

Thank you!

[@1412Z]

Thanks!

[@Lil1104]

This is amazing!

[@abrahamkibret6591]

Thank you

[@chiahsuantsauo8375]

I’m finding the pathophysiology of the infection process difficult to understand, like when does Th17 come into effect and how does it lead to Th1 or Th2? I think a lot of text books and stuff teach each part of immunology like T and B cell separate, then antibodies, then complements etc. but nothing tries to explain the whole process as a whole. I’ve gone through First Aid and General Principles Immunology section and I still don’t understand how everything is co-ordinated…

[@akshatsahai3551]

Thank you so much:)

[@myprettygirl91]

thank you! so helpful :)

[@bnfgh123]

OK, so now I know some awesome mnemonics, but if somebody asks me how any of the syndromes works, I still can't explain.

[@kfabrice7479]

Very clear

[@wicterwterr4245]

Very helpful

[@FG-ng1cy]

Hello.do u have a video about step 2 ck preparation?or could u give some advice regarding preparation.thank u.

[@hilmaandriani8314]

Hope that I can pass the exam

[@elsecretopez]

you have both lymphhistioCYTOSIS and panCYTOPENIA? :O

[@lifes2short4aname]

Yaniv Hadi I read on wikipedia that it has “lymphoma-like syndrome, in which defective white blood cells divide uncontrollably and invade many of the body's organs. The accelerated phase is associated with fever, episodes of abnormal bleeding, overwhelming infections, and organ failure” but the histiocytosis part eludes me

[@thepacemaker8165]

Awesome!

[@il3mendo]

Leukocyte adhesion deficiency can be triggered by vaccine or infection disease such Varicella, Ebv or Citomegalovirus? Can, in the case of chronic illness such celiac disease, someone has a normal neutrophil count while having eosinophilia ? ( Cd 56 marker highly oresent in my gut flora with no cd18/19.. Thanks

[@sohaelsayed8253]

Correct me if im wrng, but wasnt the purported dysfunction of microtubules proven as incorrect through further research?

[@PH-xw1ri]

Guys - donate if you can. I donated $25. Let’s all chip in - student loans or not.

[@rachelslack9451]

Vitamins please I beg of you

[@suomynonaanonymous]

Rachel Slack pllesssseeee

[@ibraheemalma]

you are amazing

[@jazzyvidzz4263]

Awsm

[@SumuduUpatissa]

LAD could also cause due to lack of LFA-1 in C3bi receptor.??

[@048mahamuuthafahima8]

Virat Kohli - Indian cricketer also has 18 number

[@talash6]

can you make a video on electrolyte imbalance? please pplease please

[@hema11901]

Nice

[@padmajahawaldar4319]

Hey dirty whr r u mo updates no recent uploads why dear mentor

[@محمدتقينبيلظاهرحميدي]

Geniussss

[@zeshan35]

awsome

[@realblackbetty2204]

"fungus goes up your ass" hahahahahaha

[@yousefibrahim8087]

duro

[@ooooooo4922]

I love you❤

[@suomynonaanonymous]

yessssssss!

[@GhostofAlanGrant]

Hey what happened to your ovarian tumor video? I had that bookmarked to watch FML

[@DirtyMedicine]

still live. not sure what youre talking about my friend

[@hotchocolatebrownie4397]

👍👍👍

[@imatwat]

i love you

[@jawadfarooq1]

love from pakistan

[@UsmanSiddique-up5wk]

boss

[@nuevoamor_encristo]

Ohhh dirty Reall Brilliant (Rb) lol lol thanks

[@briansu6324]

o7