DNA Replication Animation - initiation, elongation and termination

DNA Replication Animation - This animation video lecture explains the DNA replication process in details including DNA replication, elongation and termination. Process of bacterial DNA replication involves a number of proteins coming together in a complex machine DNA replication begins at a single defined DNA sequence of 245 base pairs called only see a protein called DNA increases in concentration as a cell grows and gets very cell division this protein as a complex with ATP can force the onset of initiation by binding to specific nine base pairs repeat or EC the binding distorts the DNA leading to the opening of the adjacent 13 base pairs repeats in the DNA of the opening of the DNA allows protein complexes to enter the replication bubble and bind to the single-stranded DNA each complex consist of the DNA humour case also called DNA B and a DNA fever caseload are also called DNA see the DNA fever caseload is open the DNA humour case protein rings in place the wings around the single-stranded DNA promoters are then released the humour cases use energy from ATP hydrolysis to unwind the DNA helix a tribute to replication forks its DNA humour case recruit an enzyme called DNA primates which synthesisers and RNA primer, DNA template and RNA primer is on its and a three prime hydroxyl group which is required as a starting point for DNA polymerase to add DNA nucleotides the replication polymerase in E. coli is called DNA polymerase three DNA polymerase three complexes of the rate of application forts by protein complexes called clear borders) is also clearly of the protein complexes called sliding clamps the clear blue replaces the sliding clamp onto the DNA and places and attached DNA polymerase three complex next to the sliding clamp the sliding clamp holds the DNA polymerase imposition on the three prime to the growing spray and as the polymerase synthesises new DNA nucleotides with complimentary basis to the tablet or one by one in the five prime to 3 prime direction the synthesis of DNA in the direction of the fourth occurs continuously to the end of the tablet piecemeal squared is called the leading sway and in contrast the other blue sky and call the lagging strand is built in fragments called Okazaki fragments a simplified diagram shows the key differences in the leading and lagging span is known to the tablet scram is a type well with a three prime and five prime a.m. is all you need in opposite directions because DNA polymerase can add nucleotides only in the five prime to 3 prime direction leading strand grows continuously in the direction of the replication fork providing spray and can grow only in short segments as the parental DNA molecule unzips many proteins participate in DNA replication including those called single-stranded DNA binding proteins which quickly code exposed single-stranded regions of DNA and protect the single-stranded DNA from attack by nuclease is all those single-stranded DNA binding proteins are present throughout replication for simplicity we will make the in the rest of the process DNA replication continues as the DNA polymerase providing spray and meets the five prime end of the next primer causing the polymerase of the sliding clamp to disengage of the DNA humour case has moved approximately 1000 pieces as second RNA primer is synthesised of the fork the sliding clamp loader adds a new sliding clamp to the primer and then add the DNA polymerase to begin synthesis on a new Okazaki fragment the cycle continues for the wake of the template strands of the lagging strand now consist of Okazaki fragments with the segment of RNA at one and the RNA is cleaved by an enzyme called RNase H another enzyme called DNA polymerase one uses the three prime of age group of the adjacent Okazaki fragment to fill a large gap with the DNA nucleotides finally an enzyme called DNA ligase closes the remaining makes on the DNA leading a continuous DNA molecule in this way in E. coli chromosome is replicated at to replication forks all the way around the circular molecule.
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DNA replication initiation
DNA replication elongation
DNA replication termination
DNA replication in prokaryotes

[@silviatalaveramarcos7055]

Finally a video that shows both forks occupated by the polimerase holoenzime. And it even shows the moment they bind to the replisome. Awesome. Thank you! P.S.: this is actually outdated, since the holoenzime actually has three core polimerases, not two. But this is what I needed to see :)

[@user-fb3jq9dg7g]

Exm, Why does the holoenzyme have 3 cores? Could you give me some information or a web address

[@1994sammahdi]

@@user-fb3jq9dg7g There is still some contention on whether or not the holoenzyme contains 2 or 3 polymerases (i.e. does the clamp loader contain 2 or 3 tau subunits) pubmed.ncbi.nlm.nih.gov/26786318/

[@aduxvemus6534]

@@user-fb3jq9dg7g en.wikipedia.org/wiki/DNA_polymerase_III_holoenzyme

[@zulkarneynification]

Soo, all these machines and their activities happened to happen by random mutations? wow! such a mind job!

[@KenJackson_US]

The coordination of all those complex moving parts really does beg the question of how random mutations played any role at all.

[@michellehlmok]

nice nice nice thanks. first video i came across with the necessary details all mentioned

[@baraskparas9559]

Magnificent presentation . Thanks!

[@lipsohlips97]

Wow this was amazing!! Cleared up a lot of my doubts and confusions for the process! Only problem with this video is that I was taught DNA C binds to DNA A and delivers the helicase which did not occur in this video.

[@geetha9]

Brilliant explanation. Thank you very much for uploading. It will be great if you restote/upload all the empty videos in your channel from remaining topics.

[@marcelo.7423]

Perfect, thank you

[@shomusbiologyacademy874]

You're welcome

[@brendawarecki6684]

Masterpiece. Thanks!

[@ssankar6473]

Best animation video ❤. Thanks a lot for this🙏.

[@shreyatiwari4966]

Studying DNA replication was never so interesting and easy....!!!!

[@meenuhenry7034]

Well explained video❤❤.... Thank you

[@user-fb3jq9dg7g]

Definitely an excellent video. But some books say the lagging-strand template will loop back and the 2 beta-clamps are located at the same side instead of left and right. I feel a little bit confused.

[@mouvementebr3575]

Intelligent design

[@lucyhorikawa7003]

this was very helpful, but I wish they shows three pol III cores instead of two, that is what I was trying to understand how the three pol III cores look like working together

[@curtislumber6938]

What about Tus and Ter?

[@yuhan5983]

explained really well thanks !

[@kittycat1768]

Thank you sooooooo much!

[@yogeshmishra2815]

Good job

[@saibarsha4614]

Thanks sir

[@Themightybeastincarnate007]

VERY GOOD

[@manindersingh7356]

thank you so much!!!

[@akankshagupta3026]

vry nice video sir

[@elinakhatua2811]

Thank u so much

[@samanthagonah8243]

u saved me

[@amruthamavily]

Tus and ter??

[@BreezyBangladesh]

great

[@monikagautam7946]

thankxxx

[@Winsto25]

My dad never loved me

[@northhallbabe13]

lol i needed that laugh thank you

[@sewaomer1422]

Probably we need it

[@negedeskatyusa]

ahw thank you!

[@lailametwaly2040]

Very nice but what is topoisomerase ???

[@lisanation2203]

dont think he mentioned it. its before the replication fork and prevents super-coiling by making nicks in the helix to release tension

[@user-fb3jq9dg7g]

Cuz topoisomerase just functions as an assistant, and it is not part of the replisome.

[@GauravKumar-fc7sr]

Please help me,,,, how to make this type of videos,,,, please suggest me app name if it's possible,,,,,, please 🙏🙏🙏

[@axa.n3319]

👍

[@dustinsmith8341]

Is DNAa topoisomerase?

[@aiswaryas643]

No

[@iven_sky]

4:21 Here is inaccuracy: primer can't be synthesized from the 5' to 3' end of DNA (in a lagging strand).