Pharmacology of Cephalosporins - Classification , spectrum of activity and clinical use : Part 2

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- t.me/bhanuprak...
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- linktr.ee/DrGB...
Cephalosporins
-------------------------
Beta-lactam antibiotics are among the most commonly prescribed drugs, grouped together based upon a shared structural feature, the beta-lactam ring. Cephalosporins cover a broad range of organisms, are generally well-tolerated, and are easy to administer; thus, these agents are frequently used beta-lactam drugs.
CLASSIFICATION OF CEPHALOSPORINS
-----------------------------------------------------------------
Most of the available cephalosporins are semi-synthetic derivatives of cephalosporin C, a compound with antibacterial activity produced by the fungus Cephalosporium. The closely related cephamycin compounds (derived from Streptomyces spp) are regarded as members of the cephalosporin class. In clinical practice, these antibiotics are grouped into five "generations" based upon their spectrum of activity against aerobic and facultative gram-negative bacilli and gram-positive bacteria :
●First generation (eg, cefazolin)
●Second generation
A. Subgroup with activity against Haemophilus influenzae (eg, cefuroxime)
B. Cephamycin subgroup with activity against Bacteroides spp (eg, cefoxitin and cefotetan)
●Third generation
A. Subgroup with broad gram-negative activity but poor activity against Pseudomonas aeruginosa (eg, cefotaxime and ceftriaxone)
B. Subgroup with broad gram-negative activity including good activity against Pseudomonas aeruginosa (eg, ceftazidime)
●Fourth generation (eg, cefepime)
●Fifth generation (eg, ceftaroline)
#cephalosporins #cephalosporin #pharmacologyofcephalosporins #pharmacologycephalosporins