Pharmacology of Cephalosporins - Classification , spectrum of activity and clinical use : Part 1

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Cephalosporins
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Beta-lactam antibiotics are among the most commonly prescribed drugs, grouped together based upon a shared structural feature, the beta-lactam ring. Cephalosporins cover a broad range of organisms, are generally well-tolerated, and are easy to administer; thus, these agents are frequently used beta-lactam drugs.
CLASSIFICATION OF CEPHALOSPORINS
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Most of the available cephalosporins are semi-synthetic derivatives of cephalosporin C, a compound with antibacterial activity produced by the fungus Cephalosporium. The closely related cephamycin compounds (derived from Streptomyces spp) are regarded as members of the cephalosporin class. In clinical practice, these antibiotics are grouped into five "generations" based upon their spectrum of activity against aerobic and facultative gram-negative bacilli and gram-positive bacteria :
●First generation (eg, cefazolin)
●Second generation
A. Subgroup with activity against Haemophilus influenzae (eg, cefuroxime)
B. Cephamycin subgroup with activity against Bacteroides spp (eg, cefoxitin and cefotetan)
●Third generation
A. Subgroup with broad gram-negative activity but poor activity against Pseudomonas aeruginosa (eg, cefotaxime and ceftriaxone)
B. Subgroup with broad gram-negative activity including good activity against Pseudomonas aeruginosa (eg, ceftazidime)
●Fourth generation (eg, cefepime)
●Fifth generation (eg, ceftaroline)
#cephalosporins #cephalosporin #pharmacologyofcephalosporins #pharmacologycephalosporins

[@Nomadicsumit]

Sir....I'm students of b.pharm no one is like you(after gobind rai garg sir) in pharmacology .... Your lectures are informative and doubtless.....

[@arnabdas3156]

Have you subscribed garg lectures?

[@Nomadicsumit]

@@arnabdas3156 yes

[@arnabdas3156]

@@Nomadicsumit is it beneficial for GPAT?

[@shrutipandey5244]

hii

[@Manasvi_pray_tobe_dasanudas]

​@@Nomadicsumit where i can subscribe dr garg lecture pls tell

[@DrAdnan]

It’s difficult to remember all the characteristics of different classes. Nice video!

[@ajaysrivastava5963]

You are amazing and your art of teaching is priceless 🎉🎉 Sir make video on our Hindi language sir please ❤

[@doctorbhanuprakash]

Sure I will

[@aao_kabhi_hamri_rasoiyan_me]

best video for revision

[@waqasyousef3868]

Sir penicillin ka apka lecture mena bhout search kea mela he nh mugha still

[@falaq277]

there is any app?

[@rajivdas8185]

Good

[@tapansamanta1060]

Very very nice vedio

[@doctorbhanuprakash]

Thanks a lot

[@HamidAli-Rph]

Best Book for Pharmacology sir?

[@sameer0tnwr]

Very good explanation sir .. great

[@doctorbhanuprakash]

Heloo

[@ShivrajSingh-os7vp]

Conceptual lectures

[@gurleenkaur5808]

Sir ceftraxone iv kitnna time ma paitrent ko rection kr jatta ha ?

[@deepakkumar-cq4so]

Thank you sir

[@farhathashmi2574]

But cefuroxime Axetil which is second generation has a very good coverage against gram positive pathogen as s aureus

[@flaminmongrel6955]

as the generations increase the the spectrum they act against becomes more negative

[@annamallasanthosha5228]

Plz upload chemotherapy classes sir

[@herbalwaysherbalremedies1249]

You have not added even single word from my Review Book... atleast add few lines Some memonics... on this I shall release soon

[@thankyoudearscholars9505]

sir plz upload pencillin lecture it is not here

[@maaelakhan7710]

Where did you discuss Penicillin sir? I cant find that video

[@ibadsamejo7568]

sameee... did you get it?

[@hrishikesheshwar9375]

Thank you sir!!!

[@jaanu19082]

Nice explanation sir.but I want complete explantation pharmacology

[@doctorbhanuprakash]

As soon as possible

[@nileshgosawi5202]

Please upload penicillin video.its not been swen

[@premarawat5905]

Typing glt q ho rhi kuch bhi post krna hota h

[@ajaysrivastava5963]

🎉🎉🎉

[@arikadivya6099]

Tq sir

[@venkybly]

Tq

[@muazmohammed686]

Not dowload sometime

[@athiram2572]

😍😍

[@samilikee7154]

👍💓

[@bhuvankuswah5355]

Thank you sir..

[@samilikee7154]

Thank you sir