Urine Concentration and Dilution | Countercurrent Multiplication

#urine #urinetest #drnajeeb #medicines #pharmacology #medicaleducation #drnajeeblectures
Urine Concentration and Dilution | Countercurrent Multiplication
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(0:00-14:46)
Concepts of Hypo- & Hyperosmolarity; understanding the purpose behind urine concentration and dilution by the kidney.
(14:47-28:35)
Mechanisms of concentration and dilution of urine:
1-Medullary Interstitial Hyperosmolarity (MIH) [Cortico-Papillary Osmolar Gradient]; outline of its mechanism of production and maintenance.
2-Role of ADH as the second mechanism of concentration & dilution of urine.
(28:36-54:50)
Mechanisms of concentration and dilution of urine continued:
1-Development of Medullary Interstitial Hyperosmolarity (MIH); Counter Current Multiplication Mechanism.
(54:51-1:03:26)
Development of MIH continued; Urea Recycling in Renal Medulla.
(1:03:27-1:10:47)
Maintenance of Medullary Interstitial Hyperosmolarity (MIH); Vasa Recta's Counter Current Exchange Mechanism/System.
Comparison of Counter Current Multiplier & Counter Current Exchanger System.
(1:10:50-1:28:55)
Mechanisms of concentration & dilution of urine continued:
2-Role of Anti Diuretic Hormone (ADH); enhancing water permeability in last part of nephron.
(1:28:56-1:47:40)
Recapping the concept of concentration & dilution of urine with the help of an example of a person's thirst and water intake in differing environments; emphasis on effects of ADH on the nephron.
(1:47:41-1:57:57)
Explanation of "Ratio of Tubular Fluid Osmolarity (TF) to Plasma Osmolarity (Posm)" at different points along the nephron; emphasis on the role of ADH.
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