HOW TO USE EFUDIX 5% CREAM (5-FU / Efudex) | 5-fluorouracil - PLUS SIDE EFFECTS

[@tonypapworth4902]

Applied it twice a day to 3 areas on my face for 4 weeks following biopsies confirming basal cell carcinoma and sun damage. It became inflamed and crusty as predicted, but, was completely effective and after stopping the treatment my skin is clear again. Highly recommend.

[@pamelamiller4289]

Living in Florida my entire life, we used to go to the beach all the time, use baby oil and stay out all day. I can’t believe we did that. In 2011, I was recommended to use Efudex. This was my first time and I decided to apply it on my face, neck, and chest. What a mistake! My face started showing redness within 24 hours. After 14 days and having difficulty sleeping, I went to my doctor. He said, STOP. You got a great reaction all over. I still use Efudex for affected areas. This year I decided to do my entire face again since I was getting more cancers. It was nothing like my first. Use in moderation. Next year I will do my neck or chest again.

[@georgejames7552]

Started using it 3 weeks ago. Scant instructions from a nurse. Your detailed video information put me at ease that I was on the right track for treatment of my Sun damaged face. I will continue to apply the cream as directed. Hope to be recovering in the next 4 to 5 weeks.

[@roadwarrior8560]

How are you now? I have been using Efudix for 2 weeks on a small spot on my face, I'm not sure if I should only apply it to the raised spot area or the area around it as well, GP is useless. The spot is dark red looking now and feels a bit sore, I suppose this means the Efudix is working, but when do I stop and let healing begin?

[@ehawolczecki8759]

I used efudix a few years ago and kept putting on lesions until they really looked awful then stopped ,very painful procedure but once healed skin looked great.

[@douglasdault7392]

Very helpful video...Thanks! I'm just ending my second week of a 3-week treatment (+/-). My Dermatologist said my condition was slight and that I was fortunate to address my condition early on. That said, I was amazed to see redness on my skin where I didn't believe I had an issue, which tells me that fluorouracil really does attack both the surface and underlying keratosis. Know that you will see, and feel, various red patches on your face, which appears as if heat blisters from a sunburn have popped. You will be stared at and asked "what happen to your face," which is an opportunity to make up a really cool story, causing the inquiring party to bugger off. On that note, however, using this medicine is 100% worth it. Other than looking like I was beat up by an angry octopus, my skin is on the mend. I'm looking forward to allowing my skin and immune system to do it's thing and repair the blotched areas after treatment. One final thought for anyone who reads this: never fail to use sunscreen. My many years of hiking, kayaking, skiing, sailing, etc., without sunscreen is why I have to come up with cool stories about the way I look during treatment.

[@katanker6098]

‘I was beat up by an angry octopus’ I’m definitely going to use this line when someone asks me what happened!

[@michaelaaron9513]

This cream really kicked my butt on my face and made it really difficult to sleep until it finally started to heal at 5 weeks.

[@raymondrowe160]

I am 89 and had a basal carcinom surgically removed from my forehead about 20 years ago. Several similar lesions appeared recently and have been treated by efudix cream over 4 weeks. There has been some bleeding, irritation and a less than pleasant appearance, but now after about 2 months the skin is clear and normal - a big improvement over the previous treatment.😂.

[@pkstiever]

I used it this year. I was a lifeguard and am blonde with blue eyes and fair skin. I've had several basal cell cancers removed. I used this cream on one shoulder that had an actinic keratosis (precancerous) and used it on a spot over my eyelid and about one forth of my chest area. The chest area definitely flared up, as did the spot on. my shoulder and over my eyelid. It wasn't nearly as bad as shown in the video though and after 6 weeks once a day, I let it heal for two weeks. So I have a very slight scar that's still a little red over my eye. am very glad I did it and will use it on more of my chest area in the fall so it won't look quite as bad when I wear summer tops. I used makeup concealer when I needed to cover the red spots so no big deal. NOTHING like the surgeries!

[@ai00400]

Wanted to share my experience...After having many aks removed by liquid nitrogen by my dermatologist, he suggested this chemotherapy cream to broadrange treat my skin damaged areas: entire face, upper chest, and back of hands; broken up into sections to be completed 1 at a time. I started with my forehead and temples. Boy was I glad I stopped there because it is horrible. The way this cream brings out the damaged skin even hidden underneath layers of skin is incredible but also a painful treatment. I did also have chemo related side effects: hair loss, appetite loss, fatigue. The lesions caused by treatment does cause intense itching at the healing stage. It is recommended to treat all potential areas that have had aks/crusting pre cancerous scabbing. Hope this helps! Thanks for the video, very helpful for those starting out!

[@michaelaaron9513]

I agree

[@LAM-tg5no]

I read your reply and I am hoping you are able to respond to a few questions. I have been using the cream on the backs of my hands for 23 days. I have many areas on my hands that are red, crusty and peeling, and itchy but the entire surface didn't react, only specific areas. I'm curious if this was the experience you had with your hands? How long did the process take on your hands and how did you know when to stop the treatment? Thank you for any insight you can provide 😊

[@PeteHob]

My dermatologist mentioned using this cream, possibly when I go back in six months. Thank God for KZbin videos. I definitely will not be applying it over large areas even if I do to try it it will definitely only be in small localized lesions.

[@ai00400]

@LAM-tg5no hi! Sorry, I only just saw your question. I hope your treatment went well. I have not gotten to my hands yet... but the areas that I did treat on my face were very similar. You will not have a reaction from your entire skin. I have read articles that have said this cream will only respond to sun damaged skin or skin cells that are replicating quickly, meaning precancerous. I have personally treated for a minimum of 3 weeks depending on response. All of my research indicates that if you do not treat long enough, the ak's will return. And who wants to repeat this process...not me! Personally, I treat the entire area 2 times a day until all red reactive areas have erupted into scabbing lesions. I actually had my face get infected and I needed antibiotics and steroids to calm the reaction down. Keep an eye on your skin and the way you feel. If you have any question or are feeling unwell, like me, I would highly recommend to go in to see the doctor. I had yellowish puss seeping out of my scabs and had a general feeling of unwell, like something was wrong. I'm so glad I went in. The relief was a huge turn around in 24 hours. Unfortunately, my insurance took away my dermatologist in the middle of my treatment, so I had to do my own research and determination on my own. Truly unbelievable, but by the grace of God, I made it through. I should say, if the treatment does need to be repeated, I have heard it is much less aggressive. Assuming that we have learned our lessons and been staying out of the sun. Well, as always, I hope this helps any poor soul going through this. Happy to answer any questions. God bless🙏

[@suziechampagne357]

Thank you for sharing this. I've had Mohs surgery to remove basal cell carcinoma in 2012. Been consistent on sunscreen daily since then. Been having aks removed by cryotherapy every two years on my face. I have been prescribed this cream by a new doctor in March. Putting off using it to November when days and sunlight is at it's minimum at that time of year. The more I watch videos on it and reading people's comments makes me more and more reluctant to start treatment. I will maybe try to find a doctor to treat by cryo as I did before.

[@JackJonner]

I was prescribed this cream years ago on the side of my temple. The inflammation was very noticeable but there was no substitute for the treatment. The main thing is that it worked. At present I am awaiting another appointment to see a dermatologist so I might have to go through it again. Such is life.

[@lindab3211]

Thanks for this informative video. It helped me so much!

[@JackJonner]

@@roadwarrior8560 If you are already two weeks in your skin will become increasingly red and changeable. The treatment is working so no need to apply more.

[@RonKinney-rc6nw]

The use description and expectations described in this video were more informative than I received from my Kaiser dermatologist. Thank you...

[@ajoManajoMan]

In USA medicine is first -- and foremost -- a business. Sad but true (the medical staff being victims as well!!!)

[@7792pnaurfr]

To be fair, the doctor at a center doesn't have youtube slides, a prepared script, and days of preparation and editing for instructing a single medication.

[@allyfielding8085]

Clear and concise video, thank you. Have had the prescription sitting on my kitchen bench for over a week as didn’t feel confident with the info given to me by my Dr, but after watching your video I’m ready to start. 🤞 for a good result.

[@DrODonovan]

I’m glad the video was helpful and thanks for messaging

[@juliewightman6305]

Thank you for the clear and concise information. You have said exactly what my Dermatologist told me. I have procrastinated for 1.5 years over using this treatment and have tried every possible natural remedy available to treat my extensive Actinic Keratosis (I've been using sunbeds since 14 and lived in the Middle East for 28 years. I'm 53 now with skin like a leather handbag. I never used sunscreen and sunbathed in over 100 degrees for 8 hours at a time!) I've just applied my first dose on the three most concerning patches on my face. I shall update on my journey. FYI I'm blonde haired, blue eyed, naturally very pale skinned and absolutely covered in freckles. I'm also completely mortified at what I've done to my skin. Hindsight 🙄🙈....

[@DrODonovan]

You’re welcome and glad you found it helpful. Yes I’m always stressing to my friends and patients the importance of sun protection… it’s still worth it now and it’s not too late! Hope this treatment goes well for you.

[@TinaKenworthy-s6e]

Watching this video helped massively as leaving the surgery I felt overwhelmed and needed someone like you to explain so thank you so much 😊

[@DrODonovan]

So glad that this was helpful for you. Wishing you all the best!

[@mikelewis8037]

I have been using efudix on and off for 25 years. My original dermatologist called it a "search and destroy" medication. I use it a couple of times a year on the advise of my current dermatologist. It works so fast on my skin that I rarely can tolerate it for more than 10 days at a time. I am starting to bleed by then. The end result is excellent. I try to use it in the cooler months of the year. I have used it on my scalp, nose, ears, cheeks, and hands. If you don't mind looking like Quasimodo for a few weeks, go for it.

[@pamelamiller4289]

I also use it during the colder months also.

[@suziechampagne357]

I have been prescribed the cream last March. It was out of stock at the pharmacy so I'm putting off the purchase to November when the days are the shortest and sunlight at it's least in Canada. I've had Mohs surgery to have basal cell carcinoma removed in 2012 and since then I'm consistent on the repeated use of sunscreen everyday.

[@marciasloan534]

I swear I NEED THIS. I cannot stand the thought of using it

[@KrisFrazer2222]

You don't need it, I thought it would be a miracle in a cream. I just commented and then saw this. Pray for wisdom.

[@allanbriggs9007]

Ask doctor about use of Daivobet with Efudix. Only use for 4-7 days. Much less side effects.

[@lindastokes1334]

I'm currently using this cream for a mild form of skin cancer. After my first few applications of the cream, I started to feel generally quite unwell, I was quite relieved to find this was a common side effect of using too much cream, so i reduced theamount i used. I was also pleased that my dermatologist warned me, that my skin would look worse before it got better. Because I've currently got a nasty scab on my face, a good sign that the cream is working. My scab also is prone to bleeding, but im determined to persevere in order to clear everything up.

[@jrom8117]

@@jackthehat9558 I am on day 7 and nothing yet. Will continue for two weeks as told. I seem to be using the correct amount. I thought maybe I wasn't putting enough on.

[@soonertwin2]

Are u applying to one small area ? Does it only affect that area?

[@lnewton3677]

I’ve used a one a day application of 5FU and Calcipotriol for 14 days - it became selectively red, only one or two crusty spots. But then the top layer of skin seemed to peal of leaving redness. It seems a bit superficial if I’m honest, and perhaps not that effective.. 🤷‍♂️

[@lifewellloved0204]

You will only see a reaction from unhealthy cells. If you reaction, congrats, you have no cancerous cells in that area.

[@christinecarstens3907]

I have started using efudix for the second time in my life. 7 years ago on the left side of my nose. Now on the right side. This is a good prevetative treatment and im glad ive been recommended it by my doctor as im doing a wider area to see if there are any other problem areas but not my whole face. Skin has started to break so there is a problem area and some more are inflamed but my doctor suggested i keep on applying so i can see if any other problem areas occure. Both me and my mom have this problem mine is minor than hers but efudix does help a lot and im thankful for it

[@DrODonovan]

Thank you so much for sharing your experiences here

[@bonniemcsparren3073]

I have been using Efudex for 4 weeks have 2 more to go and was not told anything except how to use twice a day on my ear. It's terrible. The pain is unbelievable. Thank you this video.

[@Sternoman1]

Over the past 5 years I've have had a succession of BCCs and SCCs, some of which have required excision, mostly from my face, requiring a skin graft in one extreme case. I was prescribed Efudix by my consultant dermatologist and used it to treat smaller areas of skin traumas. I found that it does work at keeping these lesions under control. I am currently taking a 10mg daily capsule of acitretin as part of a program to see if it will do the same job as Efudix. It requires more supervision by way of regular blood tests and there are side effects. Too much exposure to direct sunlight in a childhood spent in the Middle and Far East in th 1950s has obviously caught up with me in my 70s! I keep on at my grandchildren to do as I say, not as I didn't do, use a sunscreen or sunblock cream.

[@philipwroe4676]

This has been the only source of proper information on the use and effects of Efudix I’ve come across as my Dematologists told me the bear minimum. I’d no idea how to use it or in what quantities so thank you for the clarity and reassurance of this video.

[@DrODonovan]

You’re very welcome. The effects can be quite dramatic so I hope this offers some reassurance.

[@lorioneil2494]

My Derm recommended a combination of Fluorouracil and Calcipotriene cream. I applied it twice a day for 7 days and watched it work for 7 days. So after 14 days I look like I have a minor sunburn. Worth considering if you dont want to look bad for a long time but everyone is different.

[@allanbriggs9007]

I do this. My Skin doctor pointed me to the Harvard research which indicated superior results to straight Efudix. And I agree, having done both treatments. BTW do it in wintertime.

[@bmunch86]

Any idea why they recommend the Calcipotriene with it? Did it once for Actinic Chelitis on my lip but only used Fluorouracil alone. Had good results but need to do it again as it was over a year ago and it’s back

[@rattler287]

@@bmunch86 I was told it counteracts the effects of the Fluorouracil.

[@kevinscheuller4429]

Thanks very much. I just watched this after picking up my prescription to prepare myself for what I’m likely to experience.

[@DrODonovan]

Glad it was helpful!

[@deviantmultimedia9497]

I've used this on multiple occasions and would like to share my experience. During my second time using it I stopped the treatment early. I had an event coming up and didn't want a giant scab on my neck. Everything healed as I hoped it would and I thought I was in the clear. Well I stayed in the clear for a couple of months, but the lesion ended up coming back and it grew to the size it was before treatment fast! Needless to say, I had to start the treatment again from the beginning. Take it from me, it's NEVER a good time to start this stuff so don't even look at your calendar. You'll always find a reason to put it off or temptation to stop early. Just start it right away and stick to your doctor's prescribed treatment period until the very end and not a day sooner. It's not worth the risk of having to do it again. Unless of course you enjoy having oozing scabs on your body. That being said, it's excellent technology and very effective when used as prescribed. Remember to wear gloves or wash your hands thoroughly to minimize systematic absorption.

[@DrODonovan]

Amazing testimony

[@LAM-tg5no]

My doctor wrote me a prescription for this in early December. I have been procrastinating and trying to find a "good" time to start treatment. You've inspired me to just do it!

[@Patti-jm4js]

Can you use on your nose?

[@deviantmultimedia9497]

@@Patti-jm4js Use only as prescribed. You don't want to go putting this stuff on your skin without informed consent from your doctor- especially that close to your eyes. Let me remind you this is topical chemotherapy. Systematic absorption and serious eye injury are both very possible. Consult your doctor.

[@davidreid7293]

Used over last 15 to 20 years. At least 4 times on forehead about 3 years apart. Each time all keratoses repaired but some new ones finally appear. Usually treat for about three weeks and re-treat after two months finding a few small areas that have still not cleared. I have had regular surgery over 40 years for BCCs ,two SCCs and one 1b melanoma followed by follow up.

[@beckykirchner5721]

I find it curious that so many comments mention their Dr. not educating patients on what to expect. I wonder why that is prevalent? I was told I would look like I had a bad sunburn for a few weeks and nothing more. Anyway, thank you for the informative video. I really appreciate the tidy explanation, and I now have a much better idea of what to expect. Btw, I'm going for broke and applying to my entire face ~ field treating, I think you said. Thank you again.

[@deviantmultimedia9497]

Maybe to get their patients to start it right away. For a bad sunburn, you're less likely to check your calendar and look for reasons to postpone the treatment. There's never going to be a good time to start so they probably figure it's best to just get you on it right away and deal with the "you lied to me!" phone call later 😆

[@beckykirchner5721]

@deviantmultimedia9497 I'm sure that's the reason!! There must be a section in the dermatology course for pre cancerous cells titled "Sneaky Ways to Trick Your Patients Into Treatment: Playing Dumb, Evading Answering, and Answering Questions with Questions. In the final exam, you will demonstrate training support staff to keeping the ruse. " Haahaa!!

[@susannehouse3857]

@@beckykirchner5721 I absolutely agree.....all I've been told is you may get a slight inflammatory response!! I have a small area to treat on my leg and I'm only on day 2 so nothing's happened yet but I'm planning for the worst and hoping for the best so this video is a lifeline. I personally think DR's should be upfront with their patients. I'd rather have it cut out or frozen off because that's one day of treatment ....this is 1-3 months when you factor in any prolonged healing but there's a 45 week wait in my area for referral. The bit I'm going to struggle with is when to stop....not sure if it's ok to carry on if you get blisters or sores which seem quite common....the lack of support from the NHS is quite worrying tbh.

[@bradaltemeyer4472]

I did the face first/ but had MOHS in a few places before even starting on florocil 5%, while doing MOHS I had looked at where most people were getting theirs cut off/ so I followed up the face after a while with forearms and backs of hands/ now doing a cycle on my neck and shoulders.

[@AlanH220]

Thanks - this was a really excellent and well-organized video. Super informative! I was prescribed fluorouracil 5% (Efudex) for treatment of actinic keratoses all over my scalp. I'm at the end of the third week and my dermatologist has told me to "stop". I've been tolerating it pretty well except the last few days there has been itching and some soreness/sensitivity, like a bad sunburn. My main issue was that my original course of treatment was to be 2 weeks - and the medication really didn't start to "kick in" until day 10. I saw little effect up until then. My doctor then told me, "well, you may have to use it for 3, or 4, or even 6 weeks" which I was pretty unhappy about. So I'm glad that, for me, 3 weeks was sufficient for my head. I didn't have any trouble sleeping, interestingly - I purchased a few cheap cotton knit head caps (for use under cycling helmets - they look a bit like Muslim prayer caps) and put them on after the evening application of Efudex. I slept great, kept the bed linens clean, and the end of the cap came down over my ears and eyes, so it was like ear plugs and a blindfold. Been getting 7-8 hours of undisturbed slumber 🙂 Next step will be 2 weeks of triamcinolone 0.1% ointment to settle down the treated area - and hopefully that will be the end of the story.

[@DrODonovan]

Thank you so much for sharing this here. Wishing you the best

[@Togepimp78]

How does it work, I am going to use on scalp 2 x a day, do you shower?

[@kathysterndahl3134]

My doctor neglected to tell me how bad I would look, so I was not able to prepare by buying extra groceries, etc., and avoid going out while looking so scary. Fortunately, I friend helped out with that.

[@pamelamiller4289]

Same thing happened to me. Very little instructions from the doctor.

[@judy9123]

Try to find a new doctor.

[@bigdave4891]

I am currently taking this medicine to treat top of hands and arms due to pre cancerous spots. I'm starting week 3 of treatments and seeing good results with 2 a day treatments. My main minor issues are itching and being tired. The main spots were treated with liquid nitrogen first and now the cream.

[@chickenspoonful]

I’m currently using this again and into my second week. Rather than using a bare fingertip to apply the cream i snip off the fingers of those latex gloves I accumulated over lockdown. It’s hard work for sure , but well worth going through the discomfort with the knowledge its working well. Good luck to everyone using it.❤

[@lindaclements345]

I do the same..... :)

[@bradaltemeyer4472]

I borrow a strategy from hot peppers and the kitchen instead I lotion up my fingertips with normal skin cream first/ sort of like olive oil on your hands before dicing hot peppers, create a layer barrier.

[@nancymayer4774]

I have to start using it for 1 month! I’ve had 2 Moh’s surgeries on my face- upper lip and forehead- one in 2017 and most recently in August 2023.

[@RollYourRock]

Nancy, how did it go... ??

[@beverleyvonne6568]

@Dr O’Donovan So pleased I found your video! I have just been prescribed Efudix 5% cream for a patch of Bowen’s disease on my lower leg. The dermatologist at my local hospital told me to apply it once a day for 6 weeks, using a cotton bud, to the red centre of the lesion. He stressed not to get the Efudix on the surrounding unaffected skin. After the 6 weeks of treatment have finished, I’ve got to wait a further 6 weeks to see the full results. I was told that a further 6 weeks of treatment could be considered if the Bowen’s lesion hadn’t been fully eradicated. Your video has really highlighted what side effects could be experienced - I now feel more comfortable about starting the self treatment. Thank you! ☺️

[@jenniferdavidson5568]

Fantastic advice - many thanks as I have spent hours trying to find the advice I wanted snd here it was all in one video!!

[@DrODonovan]

Glad it helped!

[@smonshaunneary]

Thanks for a most helpful and informative video. I am currently two weeks into a three week course of Efudix, applied morning and evening to treat Actinic Cheilitis aka 'Sailor's Lip', in my case the upper lip. It is in fact the second course, the first was applied about ten weeks ago, if the second course does not work then I will need some other form of treatment. Anyone reading up on the use of Fluorouracil is likely to be wary when using such a potent ointment on the lips which are anyway so sensitive. I was told to expect a robust reaction and, after about a week my lips have become very sore with lesions which are prone to split and bleed. After the first course of treatment it took at least a week before the lips began to heal. Whilst the treatment is not pleasant I would certainly advise anyone prescribed it for Actinic Cheilitis to go ahead. I have a rather puritan streak in my nature and reflect that the problem is pretty much self inflicted and probably reflects years of rash over exposure to UV without sensible precautions. I will be more sensible in the future, and will encourage others to

[@kaycee625]

If only my dermatologist had spent the time to give me this explanation. I got nothing except “use it 5 days a week for 6 weeks and a corticosteroid every day”. I had low grade fevers in the first 2 weeks also.

[@laurielahr1022]

Hello just came across your video today. I was a sun worshipper, blonde and fair skin and now in my 60's. Have had multiply lesions froze and 2 Moh's procedures to remove lesions over the last 10 yrs. And did not want to do that again so was kind of excited to start the fluorouracil cream, never had this for an option. I started my first 14 day round, twice a day on one side of my face as instructed end of October 2024. MD said do only an area at a time as it is uncomfortable and pretty irritated and I would have a hard time sleeping. (side sleeper). I did have about 6 small red spots and did get crusty. So after the holidays I picked back up and did my entire face, chest and back of hands and for 14 days. Today I have some irritated areas around the crows feet area on both sides of my face and a few other red spots on my on of my cheeks/nose and that's it. Nothing on my hands or chest, yet. I know you said these areas could take longer. May I ask some questions of you, I was only instructed to use for 2 wks., you state up to 4 wks. So either I'm not doing the treatment long enough to have reaction as you show in your video or my lesions are not precancerous, I only had maybe 5 more spots show up not my entire face? What is your opinion on regular md chemical peels could this treatment also help in clearing up precancers? My side effects while on this treatment and unsure if related. Ulcer in mouth and dizziness in the am.

[@CathyRudnick]

Used it twice once on my forehead to treat a particular spot and again on my entire face. It worked great for me although the scabby sores look terrible.

[@tinabeattie774]

Thank you so much for this helpful video. I've just started using Efudix 5% cream on three small spots of sun damage, two on my left cheekbone and one on my nose. It's helpful to know what to expect. My dermatologist did warn me about unsightly crusting.

[@DrODonovan]

Glad it was helpful!

[@adamclarke7646]

I’m starting tonight on my scalp and neck. I wonder if I can continue to shave during this time… My scalp is bald. I coach soccer for a living, I’m going to wear a hat and thank goodness my trainings are in the evenings right now. Wish me luck! Let’s do this!

[@MrXrisd01]

This was perfect! I'm a home health nurse. Have to provide patient education on it today.

[@michaelacampbell6521]

Great video. Just been prescribed today for pre BCC ( grew up in Queensland in 70/80’s, now in Uk) ……. Knew the day would come😢

[@DrODonovan]

I’m sorry to hear of your diagnosis but hope you make a good recovery. Totally understand. I’m fitzpatrick skin type 1 and as hard as I try to take precautions I’m sure I may end up with a similar issue down the line. Keep taking those sun precautions and best wishes to you

[@michaelacampbell6521]

@@DrODonovan I’m catching up with the first 20 years of my life being covered in baby oil by the pool or on the beach….. one by one my school friends are all coming up with something 🙄 we had a happy childhood all the same👍🏻

[@lauraannguy392]

I am in the middle of a five day regiment using 5-Fluorouracil Cream plus Calcipotriene cream and looking for as much information as I can find, so I came across this. I did not get a huge amount of information about (for example) using 1% hydrocortisone ointment and this video was helpful for figuring that out. Found this very useful.

[@DrODonovan]

Really glad you found this helpful.

[@janeandersenbeachsullivan4316]

I am using the same combination for my face. I am just on my second section. I hope it is working as there isn't nearly the reaction I was expecting.

[@dalerorex1416]

I live in Thailand and oncologists are not familiar with Efudix cream. How can I obtain this ointment?

[@allanbriggs9007]

I have just completed this treatment for the second time. Originally I used the straight Efudix. I couldn't do past 17 days and the pain was pretty bad for weeks. The combination treatment only lasts for 4-7 days and the side effects are not as bad. The Harvard study indicated excellent results and far superior to using straight Efudix.

[@joannahare5687]

Thank you for the best advice , information and instructions I have ever had in all my years of using Efudix!

[@christinaannabel]

DIFFERENT RECOMMENDATION: My dermatologist and other scientific/medical sources recommend against applying cream or sunscreen over the skin during treatment. Consequently, I had my treatment done in the middle of the winter and I wear a wide-brimmed hat, face mask and large sunglasses when outdoors.

[@THE_NEEDLE]

Just started my treatment

[@lamppole7896]

I am currently using Fluorouracil Cream, the sun doesn’t like blue eyes and fair skin. Anyway, I am treating a small area on my forehead close to my hairline. I am on day 8 applying it twice a day. I was given a 3 week treatment plan. Absolutely zero problems. I have used this cream before and had no problems. I apply a very small amount, that may be the key to not having a reaction. Wash your hands before and after also. Keep out of reach of children and pets. It’s definitely powerful and will works well.

[@DannaQuintana]

@lamppole7896 When you state "no problem", did you have a reaction at all or was it mild and unassuming?

[@lamppole7896]

@@DannaQuintana Actually my skin reacted as it should because I did have some pre cancerous spots. The spots turned red and were slightly itchy. The part of my forehead with no pre cancer had no reaction. That’s normal too. I feel many people are afraid of this cream (I was at first) and I wanted to alleviate those fears if I could. I completed the 3 weeks, saw my Dr. he said I am done. Then said will treat another small part of my face in a few months. Once you stop the cream, your skin heals fast and looks the same as before. Hope that helps.

[@kathygore6615]

@@lamppole7896 thank you - I am terrified of starting this cream tonight and you have made me less scared

[@douglasreid6160]

Have used for many years. Recently had an angry patch on my ear. Applied twice. Ear bled and crusted and is now fully healed.

[@DrODonovan]

Thanks for sharing your experience Douglas

[@diane2hardy]

thank you for this calm informative video. and also for the links.

[@DrODonovan]

Glad it was helpful! And thanks for watching

[@theresaperez2624]

Just started day 2 of 14, 2x a day. My dr did tell me if I had plans for Easter to hold off. There really isn’t a good time so figured I’d rip the bandaid off and just do it. Treating pre cancerous spots on my nose. I’m a bit nervous what to expect. Thanks for the video.

[@markaidan3020]

Thanks!

[@DrODonovan]

Thank you so much - this is really kind of you.

[@specialized29er86]

I used it for the entire top of my scalp for 3 months and on my nose for a month and side effects was 15kgs lost over 6 months the entire experience was horrible and I did kick the cancer in the arse. That was 2 years ago and I have a spot on my nose and leg and using it again because the next doctor appointment is 4 weeks away.

[@jinxh13]

Thank you for this information. You answered all of my questions here. Thus video was very helpful.

[@janicesmith1956]

Yes it worked on my skin cancer 6 weeks once a day. 8t goes dark red but it works. Saved me having more bits cut out.

[@DrODonovan]

Thanks for sharing

[@thaismesquita4787]

5 ⭐ These details are the most important for a person under treatment. Thanks. From Luanda,Angola

[@beverleyshapiro3915]

I used this on my face under guidance from my Dermatologist. It worked very well and I had a good and clear result. Was very happy with outcome.

[@anthonycollins7092]

Thank you for this. I have sun spot on my cheek and looks like a coffee stain. I urged my GP for cryotherapy but she has been stubborn and given me this cream. This video has given me hope. Here’s hoping!

[@DrODonovan]

Glad it was helpful!

[@judy9123]

See a good dermatologist.

[@Cyberdactyl]

I have used about 90% of a 40g tube for moderate superficial Basal Carsinoma over the last four years. I have chosen to do areas like my face, arms, back of my hands, the triangle on the upper chest at differant times because of the discomforrt. Mostly because of the early-on insane itch during treatment. Anyway, I have found the recommened "pea-size" is massive overkill. Fluorouracil 5% is powerful stuff. Only a VERY thin covering/coating is needed over the treaded area. I often use . . maybe. . . a B-B size amount for around six square inches for 3-5 sessions 12 hours apart to start the insanity.

[@DrODonovan]

Thanks for sharing your experience here

[@sweethomealabama4161]

That is good information to know. Starting treatment today. I wasn’t given enough information at the dr office.

[@Cyberdactyl]

@@sweethomealabama4161 Nor was I. That's why I used WAY too much the first year. Another tip. . . try and not itch an area where you applied it in the last few hours. If you do and touch some other area of your body, it feels like fiberglass in that touched or rubbed area the next day.

[@sweethomealabama4161]

@@Cyberdactyl oh my, I appreciate you taking the time to answer this, it helps a lot.

[@grantrohr4948]

I'm on day 9 of a 14 day treatment period and this video was very helpful. I'm applying fluorouracil (5%) to my forehead and scalp. Last night was my first horrible one, I couldn't sleep at all because of the pain. At six in the morning I took some allergy medication and finally got to sleep for a few hours. My doctor prescribed hydrocortisone 2.5 % cream to be used AFTER finishishing the two weeks of Efudex. I assume that this is because the hydrocortisone might reduce the effectiveness of the Efudex. I notice that some people are applying hydrocortisone cream to help with the itching and pain while using Efudex. Hmmm?

[@paulcoonce2493]

Thank you Dr Odonovan. I have used this for precancerous spots on my face, ears, arms and scalp. Yea, I'm Irish too!. My treatments with this was twice a day for one day a week for 15 weeks. This keeps redness to a minimum (or nothing) but eliminating the spots. Some spots take awhile longer but still effective. My older brother was treated with this same medicine but not so gradual. He used the "all on" attack treatment which turned his head and face into a pizza for a few weeks! But it worked too. I'm younger and would prefer not to go through that. I watched gradual elimination with no inflammation of the spots. Thank you for the video. This medicine is a miracle for us white guys/gals w/ too little melanoma!

[@DrODonovan]

Paul - sincerely thank you for taking the time to write this. Amazing personal insight here.

[@giovanna722]

*melanin

[@Ystadcop]

Thanks. My French dermatologist put me on this stuff and it worked, but I stopped using it before time. Great explanation.

[@DrODonovan]

Great to hear!

[@christianahern5517]

Just starting my 8 week treatment on my left hand

[@brodygoalie]

Why 8 weeks? You applied twice a day for 8 weeks? Results? Cheers

[@tomox100]

Have used it several times to good effect but it was some time since I used it last so it was good to have such a comprehensive reminder of how best to use it

[@pumpkineater23]

The problem I had was tiny blisters on my forehead that I've had for a couple of years that weren't clearing up and have recently been getting worse. I went to my doctor, she took a photo of my forehead and a week later I got a text saying they'd prescribed this. So strangely, I don't know what I've been prescribed it for. I'm guessing it's cancerous or pre-cancerous sun damage? (I have abused the sun during my life). Having just finished the course, once a day for four weeks (I did 25 days), I now have a very red, sore forehead. It got gradually worse over the 25 days. As I understand it (from reading up on the internet) this is expected, shows the cream is working and it's very much worth going through this. I'll update this comment in a month or so.

[@pumpkineater23]

@@roadwarrior8560 It’s much better thanks. The inflammation took two weeks until it started to look/feel better. After three weeks the skin felt smooth and ‘youthful’. 3 months later and still no blisters, so hopefully it has done the trick!

[@johnnyfraley2270]

I've done this to my face three times. It is so important to apply the soothing creme 20 minutes after applying the fluorouracil.

[@debrabullion3766]

What soothing cream did you use. My face is burning! Didn’t think this out doing it during summer.

[@debrabullion3766]

How did your face look after healing?

[@johnnyfraley2270]

@@debrabullion3766 Aquaphor is the best!

[@johnnyfraley2270]

@@debrabullion3766 It looked good!

[@dawnconnor4583]

A very useful video, thank you. I'm going to start with this in the new year. I have a good idea what to expect and plan to hide away for a few weeks!

[@DrODonovan]

Glad it was helpful!

[@davefazekas2344]

I just finished my 2 week course today. It's wasn't really bad until the 9th day. I have trouble opening my mouth all the way, I feel like I have a severe sunburn and the face itches really bad. Some times the pain is so bad that I can feel my face throb. Worse part is applying the cream in the condition. Now I understand the term "rubbing salt in the wound". If I go out i where a mask due to me looking the way I do. I'm sure it will be worth it in the long run, but this is definitely difficult.

[@DrODonovan]

Hi Dave. Many thanks for sharing your experience here. I am sure it will be valuable for others. Best wishes. James

[@michelealkins616]

My experience exactly. But BTW no need to wear a mask when you go out. I’m 52 and found that honestly, nobody cares. Seriously. No one cares what you look like. It is rather obvious that there’s something going on and so no one has looked at me funny. Not in the market, not at the veterinarian, not at restaurants or the coffee shop. Masks are itchy and hot. Just be brave because you’re the only one who cares what you look like. I look like a leper. Like my face is bright red and covered with corn flakes.

[@debrabullion3766]

Was it worth it in the end?

[@visune1178]

Thankyou for your very informative video.. I am in UK and have just been diagnosed with BCCs all over my scalp.. 2 large ones which will be surgically removed and loads of little ones.. i dont know what cream my Dermy is intending me to use but this video has really helped me understand what to expect.. the good and the bad.. Thankyou again for the info :)

[@DrODonovan]

Im sorry to hear you are going through this but really glad the video has left you feeling more informed of what to expect. Wishing you the best moving forward.

[@bend3rbot]

I have trouble with memory so my Dermatologist recommended it only once per week for 6 months. I'm amazed that the intensive reaction isn't necessary.

[@lorrainedonaghey5941]

On day three my spots became inflamed and hot. I applied in the morning and evening with a cotton bud. I also had irregular spots near the top of my lips, which my lips became so sore to touch or eat and throbs 😢

[@bradwelljackson6385]

Very good video. Very informative, helpful and straightforward. Thank you.

[@DrODonovan]

Glad it was helpful!

[@dustydubs8139]

I start tomorrow, thank you for this. I keep hoping I'll find a pic online of someone with some type of colored cream on their face showing exactly where to apply. With spots in my eyebrows and dry spots right under my eye, I'm having a hard time figuring out how close I can get that is safe.

[@capt.haddock5750]

Enjoy this video is an understatement. However I have been using it for two weeks now and thought of giving it up. The itching and the pain are too much. Then yesterday I went to the pharmacy and asked for a painkiller and I was advised to apply an ointment that soothes a very dry and irritated skin. It seems to help a little. Now I'm trying to complete the process. Thank you.

[@johnwatson8192]

What a fantastic video. I'm waiting to see when Efudix will be back in stock at my usual Pharmacy and this has helped put a bit more meat on the bones of the doctor's description. I'm certain that I have used this before and the only side effect was a mild stinging so I did not have to stop using it nor apply the hydrocortisone cream that was prescribed at the same time.

[@DrODonovan]

So glad that you found it helpful

[@doshb.1339]

Thank you so much for explaining the pros and cons of application, I fully appreciate your help…

[@DrODonovan]

Glad it was helpful!

[@KO-pk7df]

Yes, this a good description of my experience. It does look terrible while you are going through this treatment, but I explain to family and co-workers what is going on so nobody gets scared off thinking I have some horrible disease. Because they know me well, they are understanding. But stringers and acquaintances don't understand so I try to keep everything covered up and if they look uncomfortable, I quickly explain and that often helps.

[@victorkolouch1718]

I just started with this treatment 4 days ago, and haven’t seen any effects yet, so this video was reassuring. One thing that hasn’t been talked about: after application, I find that I want to touch my face to scratch itchy areas. Do I have to worry about getting the florouracil on my fingers, transferring it to food, other surfaces etc?

[@michelealkins616]

I bought a box of disposable medical gloves to use for application. After application I keep tissues in my pocket and dab with those instead of using my fingers.

[@ai00400]

I keep a qtip nearby to scratch with to avoid cross contamination

[@mikeappignani4383]

I used this on my scalp it worked 💪 out wonderful for me.

[@DrODonovan]

Thanks for sharing!!

[@randyfrantz7195]

I have been using this stuff for about 5 years or more. The first time was a full face application. That was a success, however, it is intense. The pictures on the internet are accurate and you won't want to go out in public for a couple of weeks. And it is uncomfortable. But it is worth the trouble. Since that full face experience, I am applying only on smaller areas as I see the need. In all cases, it works to clear up my skin so that no further outbreaks occur in the treated areas. Right now my nose is beet red on one side from treatment. But I will end up being able to keep my nose.

[@WINCHANDLE]

Thanks for video. Have been thinking about trying this.

[@DrODonovan]

Hope the video was informative

[@susannehouse3857]

I'm on day 15 for a small Bowens lesion on my lower leg.....nothing's happened yet, no erosion, no redness , no inflammation....nothing. I've been advised to use it twice a day for 4 x weeks.....here's hoping something happens soon although I've discovered it apparently doesn't not work for everyone.

[@jenjen836]

I'm day 8 for Bowans lesion above my ankle. Lesion looks like it getting flatter. Not a lot on inflammation yet

[@juliedurocher1780]

Thank you so much for this informative video. It is appreciated.

[@DrODonovan]

Glad it was helpful!

[@richardmason7840]

Thanks Doc, good stuff, be Blessed !

[@DrODonovan]

Any time!

[@rohanlancaster]

Thanks @DoctorODonovan. Very helpful and clear information. A question. My dermatologist told me to use Efudix on my forehead and temples. But my nose has seen the brunt of major sun damage. Would there be any reason not to use it on my nose, given the sun damage I've collected? I'm a week in and so far, it's pretty red and getting sore. I'm on a two to three week course, so hopefully that will be it.

[@ai00400]

I'm sorry the doc didn't answer your question. I wanted to give you advice from my own situation. Yes, absolutely you will want to treat your nose and other areas that have had excessive sun exposure. After having many aks removed by liquid nitrogen by my dermatologist, he suggested this chemotherapy cream to broadrange treat my skin damaged areas: entire face, upper chest, and back of hands; broken up into sections to be completed 1 at a time. I started with my forehead and temples. Boy was I glad I stopped there because it is horrible. The way this cream brings out the damaged skin even hidden underneath layers of skin is incredible but also a painful treatment. I did also have chemo related side effects: hair loss, appetite loss, fatigue. The lesions caused by treatment does cause intense itching at the healing stage. It is recommended to treat all potential areas that have had aks/crusting pre cancerous scabbing. Hope this helps you! God bless🙏✝️

[@rohanlancaster]

Thanks for your reply. Appreciate your thoughts.

[@coolingwater9802]

I am using this now day 7 my face is staring to get reddish now . .My twin was able to do this treatment during the pandemic was way easier. Im going to have wear a mask to work.

[@sanaakhudhurjameel]

دكتور احتاج الى ترجمة الفيديو باللغة العربية لانني محتاجة لهذا الفيديو الذي يخص علاج AK بدواء ال Efudix cream مع الشكر

[@zozoselmouni3595]

من فضلك هذا دواء راه عندي ومعرفتش لمن يستعمل قلي يلا تعرف

[@wesleysmith2199]

Of the four nucleic acids in RNA (A, C, G, and T), the T, or thymine, is 5-METHYL-uracil. So, fast growing cancer cells readily incorporate the 5-FLUORO-uracil anywhere thymine is supposed to be. But the very electronegative fluorine in the ersatz T causes the new cell’s RNA to become bent out of shape (literally) and non-functional.

[@FludLight]

Using for Bowens disease spots on arms...followed the prescribed 2 weeks on 2 weeks off course for 5 weeks and have had to stop following blistering over a far greater area and a lot of weeping this has now spread to my head neck and face although no cream was applied. I have been unable to sleep due to intense itching and stinging together with continuous weeping. Am going to let it heal up and see what results are and see whats advised at follow up consultation in 3 weeks time. The videos have been really useful as I don,t believe I was sufficiently briefed regarding usage and potential side effects by the NHS dermatologist (Light House Clinic IOW) And now seem to be having an allergic reaction beyond treated area.

[@PatrickChampion]

You need to show examples of how white or translucent the cream should look on the skin after applying. I want to know if I am applying too thin or too thickly. Basically, should the white cream on the skin be opaquely white, show through a little bit of the redness or be so thin as to be a mild whitenening of the skin. Currently I am doing opaquely white or almost opaque and am worried if this is too much or just right.

[@r.mcd2921]

Thank you so much. Excellent, concise information. Unfortunately you did not mention how toxic the medication is for pets, and that they should not be allowed to lick the medicated areas.

[@bigoldgrizzly]

Very useful info packed video - thank you very much. This cream worked well for me on a variety of lesions on my face. My biggest problem was using it in the summer months, getting hot and sweaty, and the inevitable itching this can cause. I found it almost impossible to avoid automatically wiping or rubbing the area and transferring it to my eyes, which was quite unpleasant. I never really cured this reaction but found that once it got into my eyes, it was best to wash the whole face with plain soap, give it a couple of hours to settle down and add another light application. wearing a cotton sweatband also helped. I also learned to avoid using at night as I seemed to spread it everywhere. Probably not a textbook solution but it worked for me. I found that freezing seemed to work much better for me and was far less hassle in the long run, but I guess not all lesions are suitable for this method.

[@tugaroocrab]

I used it on my nose. It wasn't too bad but bumpy and red. Painful but not to bad because it was in a small area.

[@theresaperez2624]

I just started yesterday for my nose. 2x a day for 14 days. I am nervous!!!

[@crochetingaroundnewzealand]

2nd time using it. First time I applied only to the skin cancers on my cheecks and forehead. This time doing my whole face. 2 weeks so far and starting to slightly notice it working. Really hard to avoid the harsh sun down here.

[@dianabunniss2495]

I had two small areas of roughness on my face, to the side of my nose, that just wouldn’t heal and kept causing problems. Eventually went to the doctor and he has prescribed Efudux. I started about 3 weeks ago. First 2 weeks showed little reaction. But now I have very red and slightly sore patches that are not nice to see. I cover with make up but am now going to stay indoors until they heal as I feel very self conscious. It’s not nice treatment ..but hopefully will work. I was told to apply once a day at night. And only on the specific areas NOT on the whole face.

[@davidross6158]

I use 5 FU and Retinoic Acid ( Vit. A) twice daily for one week, then stop. Great reaction, great result. Did it 10, years ago, clear result! Few others, same result. Best only in winter, no sun here to speak of, and cold. About to do one ear and opposite cheek now. November… scabs come off and looks great , seen no scarring even when „over treated „ by accident.

[@darklin333]

Hi David the Retinoic acid was that the prescription one ..retinol/ trentinol, glad you got through it ❣boy did I lean my lesson when I scratched at the crusty bit on the side of my nose 🔥 Lol

[@martinrumsey9639]

Thanks for the video doc, very clear. My skin was so sore and crusty, but I didn't know I could use a skin cream to moisturize it. So a little Aveeno and it feels much better, still stings a bit though.

[@DrODonovan]

You are so welcome!

[@juliecurran9884]

Very helpful info.Thank you

[@DrODonovan]

You’re welcome Julie

[@iainbremner8909]

an excellent video. I've used Efudex in the past but now my doctor wants me to use it on an area on the top of my head. He's made no mention of side effects to my hair, or whether i can shower and was my hair. I'd welcome some comments re using the cream on my scalp. Thanks

[@harrynewton6437]

thank you dr. you cleared up the whole process for me thanks again from cda

[@DrODonovan]

Glad it was helpful!

[@alicegabusha2563]

I’m so glad I found this video! Just one question how do i use it for the lips?

[@Peter_McKenna587]

I don't think you do. Read the label to be sure

[@SallyBaldwin-n9p]

Thank you. Very helpful instruction s

[@geoffshakespeare1534]

...my skin specialist recommended a 50 : 50 mix of Efudix and Daivonex...great results...

[@FilmbuffWSussex]

Thanks,Doctor…I have a severe scalp disorder but would like to know how it developed since I very rarely venture into the sun…Into week 2 with Efudix and my scalp is still a mess but the itching seems to be subsiding, crusts are still there..very useful video.