Dr. Joan Mannick - mTOR’s Role in Aging

During this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune system, sharing her research on how low-dose mTOR inhibitors can upregulate antiviral immunity, creating an opportunity for more targeted vaccines for older adults. After extensive research on mTOR across many species, Dr. Mannick shares impressive insight into how mTOR inhibitors like rapamycin can promote longevity. Tune in to learn more about the latest research in the field.
Intro: (00:00-1:20)
Dr. Mannick’s background (1:20-6:52)
What is mTOR → (6:53-10:15)
How Rapamycin acts on mTOR → (10:16-15:17)
When to treat with Rapamycin → (15:17-21:36)
Dr. Mannick’s trials with rapalogs → (21:37-28:42)
The future of Rapamycin → (28:42-31:02)
Cautions of anti-aging therapies → (31:02-41:10)
Top tip for healthspan → (41:10-41:45)
Closing remarks (41:45-end)
To learn more: hubs.li/Q01CQ86r0
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In the Press - www.insidetracker.com/press-p...

[@betzib8021]

Well my question is how do i...an old person...get the stuff? What you guys are doing is improving the lives of old ..very rich...persons....(whose lives are already pretty dmn good).... because they will be the only ones who can get it.

[@hoffinger]

Go to India mart. Kachhela has the best prices.

[@dbpook]

She'll take her scientific caution to the grave. We are all suffering from a terminal illness which ends in certain death - no time to wait decades for endless studies, I'm going to take it.

[@kaceeboxers3580]

There are several doctors in my area who prescribe rapamycin. Have talked to my functional doctor about this and - we are still talking. No doubt he is doing more research, in his wheelhouse, and we will talk again in two weeks.

[@stanleysokolow]

This was a great interview. Thanks.

[@goodphone156]

It is very clear Dr Joan!!

[@robertloye9381]

I am on David Sinclair's protocol. How can I find out the best dosage for rapamycin used for longevity?

[@stanleysokolow]

I hate the term "healthy diet". There are so many different dietary patterns with proponents who claim that their diet is the best for everyone. People should be more specific when they speak of a healthy diet.

[@cidkagenoh9181]

My biggest question is how does this treatments (and future treatments) affect quality of life, what i mean is does this treatments make a 75 y.o person be active again, or does it only make someone "live longer" but still be frail and weak?

[@bobcocampo]

Will taking Rapamycin speed up autophagy when Fasting?

[@MoreLifePlease]

Has anybody told Ray Kurzweil et al. to skip the supplements for the moment because of the dearth of convincing evidence for their efficacy or against their harmfulness? 😁

[@bobcocampo]

What is the effect of Rapamycin with diabetes and weight loss?

[@250txc]

Another fat F question ... QUIT eating so much sugar!

[@scooterboy2284]

It would be nice if you answered your followers .

[@MoreLifePlease]

I assume that rapamycin has as powerful a down-regulating effect on beneficial viruses in our systems as on destructive ones? That it acts on them in a similar way as broad spectrum antibiotics act on bacteria in our bodies? If so, that could be really bad, couldn't it?

[@InsideTracker2]

Dr. Mannick discusses this briefly in the episode -- that rapamycin can be used as an immunosuppressant because it inhibits T cell replication. What she explains is that when rapamycin is given intermittently to older populations in very specific doses, it has shown to also be useful for enhancing immune function. Researchers are still working out exactly how we can leverage mTOR inhibitors like rapamycin to promote healthy aging.

[@abdelilahbenahmed4350]

All what rapamycin do we maybe can do it safely just with fasting.That being said I appreciate respectfully the works, dedication and passion of Dr Mannick.

[@Mikolas649]

ATNA!

[@pakelly99]

Oh, I got this, ::cough::, “Money”, “More money”, “Lots and Lots of money”.

[@michaelmelamed9103]

If you’re an inbred laboratory mouse 🐭 this information is relevant to you 😂😂😂

[@bobcocampo]

Please experiment to prisoners in third world country like the Philippines.

[@stefanallard3084]

So they can live 20 extra year to rape n do crime... Great idea dude

[@leiladasha]

OMG no!!