Dr. Nadir Ali - 'Insulin resistance and ApoE4 - A Perfect Storm'

Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.
Dr. Ali has championed many aspects of the science and practice of a low-carb lifestyle in the local Clear Lake area since 2013. He organises a monthly nutritional seminar in the Searcy Auditorium of the Clear Lake Hospital that receives more than 100 visitors every month from the local community. Dr Ali’s focus is on managing heart disease, obesity, metabolic syndrome and diabetes.
Please consider supporting Low Carb Down Under via Patreon. A small monthly contribution will assist in the costs of filming and editing these presentations and will allow us to keep producing high quality content free from advertising. For further information visit; / lowcarbdownunder

[@alphacause]

Dr. Nadir Ali is a credit to his specialty. Most cardiologists are very conservative in their approach to nutrition and the overwhelming majority of them still promote the low fat paradigm for cardiac health. Cardiologists like Dr. Ali, Dr. Christian Assad, Dr. Bret Sher, Dr. Aseem Malhotra, etc, should be lauded for thinking like true scientists, who critically evaluate what was taught to them, instead of uncritically dispensing out dated ways of thinking. Health outcomes will only change when our medical professionals think more like scientists and less like religious clerics who just evangelize received "wisdom" as if it is the infallible word from the All Mighty.

[@spin564]

Very interesting, and always good to see someone admit that they have learned new things and are able to change their view.

[@nancyprobst6311]

Wow! I am so grateful for people like this who are figuring out how we function, to help us get healthy.

[@misssusansrockacademy7872]

Thank you so much for pasting this! I feel so lucky to get to hear information at this level. *goes back to watch it seventeen more times since I barely understood any of it*

[@hektor6766]

I gravitate to the videos that are strong on the biochem, and those from Dr. Nadir require 2-3 views to properly digest.And they bring information and detail you don't anywhere else.

[@deckchaironthetitanic]

So when did you graduate medical school, when you were 10? You look like a 30-something, Dr. Nadir. Your work is much appreciated.

[@craig2493]

The government or philanthropists should provide the funds for Dr. Ali and others like him for their exceptional life-saving research.

[@eugeniebreida1583]

Absolutely. But, are they owned by Pfizer? Pfizer? I guess it’s up to the philanthropist to decide… I sure hope there are some honest brokers out there. Dr. Ali deserves all the funds he needs

[@margaretgibbs1007]

Fascinating talk thanks. But quite hard going to understand, for non-medical person like me. I would really love to hear an un-rushed version of this talk, maybe lasting an hour!

[@alphacause]

Dr. Ali has two channels: 1. Eat Mostly Fats: kzbin.info/door/eHgajYvGU-jHgf1QCa1lbg 2. Nadir Mir Ali: kzbin.info/door/OrA1o69tbRny3GaVfTVdMA On both channels he has presentations that run the gamut from ones tailored for laymen to ones that are a bit more esoteric and are meant for medical professionals. I hope that helps.

[@eugeniebreida1583]

@@alphacause Thanks much!

[@user-so1rq7uu3y]

Amazing.Doctor,I can hear your voice.u,We will live better life,because of people like you.Respect.

[@michaeltranchina6358]

Excellent talk by Dr Nadir...Very helpful. Loved your final question to the LC community regarding cycling insulin receptors. I am a lean, muscular, LC, 57 year old who has intuitively figured out that cycling is necessary. Sign me up for that research project!

[@SportCampTirol]

What is your experience Michael? How often and how do you "cycle"?

[@annav7538]

Same here. I add additional (40-50 grams) carbs in the evening usually on the weekend.

[@lorettadillon-ham1574]

FASCINATING 💝 thank you ... Dr Nadir, we are honoured. 🙏🏼

[@YouNolf]

Incredibly interesting. I also came to the conclusion that maybe cycling insulin stimulation once in a while should be productive, as it would mimick our diet in the wild (where we occasionally scored the honey, fruits or tubers, and fasted when we didn't catch any fat animals). Also, our bodies deal better with sunlight with carbs (IIRC it's something to do with vitamin D helping it cope with sugars), and it's only natural that when spring comes we get more sunlight and eat more fruit. I guess the more we get specific and technical with research, the more the big picture indicates that we should simply get back to our ancestral ways of living, of course in an intelligent way and using technology smartly.

[@SierraNovemberKilo]

What a fabulous presentation. There's lots to take in. I am glad there are people out there asking the questions that gets us to here.

[@Rose_Ou]

Excellent talk and great sense of humour. Thank you Dr. Nadir :)

[@marlak4253]

Dr. Nadir Ali is magnificent and personifies his health and medical beliefs. He takes his own medicine and looks very well.

[@gavinr5576]

Seriously fascinating. He poses an interesting question that I would love to see answered: Should we be intermittently stimulating these insulin responses in order to optimize the expression and function of the insulin receptors rather than the traditional "steady state, continuous low-carb" approach that has been prevalent in the LCHF/Keto sphere so far? If so, what is the appropriate timeline for administering these stimulus and what are the ideal macronutrient distributions for this application? My money is on occaisional ingestion of High Glycemic Index foods used intermittently to create larger hormonal responses but there is still so much we are yet to learn, which is very exciting.

[@BaiMengLing]

Get a garden, plant fruit trees and berry bushes. Gorge on them when they are truly ripe. I have experienced that in my permaculture practice, when a tree or a bush has ripe fruits, you have to be quick at picking before birds, and eating all because without pesticides, nor sugar (jam) fresh fruits and berries waste very quickly, so feasting is the optimal solution ;)

[@davidherr6793]

Hopefully two beers a day and I'm the happiest camper

[@charlieanstey9998]

And so I learn a little bit more. Thank you, Dr. Ali

[@alexi2460]

I love Dr Jason and so glad I found Dr Ali.

[@areurdytoparty]

The thing with CICO is that it's concept is so basic (as it should be for the average person to understand), that so many of the intricacies involved in weight loss like hormone regulation or dysfunction is completely missed, and that part of CICO could be overwhelming for some to try and process the information and what it means to them and their weight loss journey. Dr. Ali makes it very easy to understand if you have a background in medicine or science. Bravo!

[@joannekerr8839]

Quite a frightening talk for someone like me - over 60, obese w big belly, newly diagnosed extreme T2 diabetic w very high blood pressure - but thank you, it was great.

[@teresarodriguez3701]

Excellent presentation!

[@livehealthyfinishstrong]

Great information! Thank you!

[@marcial2347]

Dr. Nadir Ali - I am excited about and interested in your ongoing research and discovery presentations, however, I am not a doctor or medical person. It would be nice if every once in a while after a technical explanation that you would summarize in more simple layperson terms. From this presentation I gleaned that we might consider Carb Cycling if on a Keto or Carnivore diet, and especially if APOe4(?), but I'm not sure WHY we might want to do this? Because what might happen if we don't do Carb Cycling? And would the Carb Cycling be mostly beneficial to those with APOe4 or are there the same benefits to those not APOe4? You may have explained all this but I just didn't get it. The diagrams are way over my head and I can't easily follow them. Keep up the good work though - I know you are on to something! Thanks for all you do.

[@rajeshtanwar2445]

Thanks for sharing this insightful and valuable video...

[@alphacause]

If ApoE4 seems so central to the likelihood of developing insulin resistance and the downstream affect of dementia and cardiovascular disease, testing for that genetic marker should be part of our standard of care. My questions is, if I want to test whether I am ApoE4, where would I go about getting tested for it? Has anyone watching this presentation had it done?

[@gretchen5074]

I did 23 and me and it told me that I have one apoe4 genetic variant.

[@alphacause]

@@gretchen5074 Thank you for the information.

[@zephyrzen1]

My cardiologist ordered the test for me. I recently did it and my APOE expression is 3/4

[@AngelTyraelGM]

Wow i didnt think about glucagon(stored sugar) and new consumed sugar as beeing diffrent, and having such diffrent reactions to insulin/insulin resistance.

[@birther1968]

Thank you for the talk. It wll take me several viewings to understand some. I am a victim with normal sugar levels 95 - 102 and normal A1c levels. Hint high Triglycerides and low HDL. in 10 years checking levels. First time insulin test showed 44. Down to 30 on 8 weeks metformin in and intermetant fasting. One criticism, I think Biden is closer to dementia than Trump.

[@michelesteward5170]

Agree😉

[@lisareiter5368]

Really, a photo of Biden would have been perfect.

[@eugeniebreida1583]

It’s a coin toss. Dr Ali for Pres!!

[@mdazizulhaque6722]

Dear Dr Ali, most of the neurons of brain uses Glut 3 and Glut 1 receptors to transport glucose, which is insulin-independent. Insulin mediated glucose transport occurs in hippocampus via Glut 4 receptors. So, insulin resistance can have impact only on hippocampus, not the whole brain. Is that right?

[@sumaridesfree]

The overflow paradigm applies to the liver not every other organ or tissue. And we can guess if the liver becomes insulin resistant due to over flow signals are sent through the body to deregulate insulin receptors

[@naomiklahn9065]

Favourite part - "APOE4 people are pretty smart"

[@VonM.]

My grandma, Dad, uncles, myself all have apoe4. All have genius IQ and Alzheimer’s. I’m 65 and showing symptoms. Flax oil and cottage cheese kept my Dad lucid

[@iss8504]

He needs to update his slide and sub in Grandpa Joe, whose cognitive acuity really is in question

[@TheMinot60]

Climb back to your basket, btw, trump lost and he’s going to jail.

[@kratos_hu]

Oh boy. I had the questions in my head and he finished the presentation with the same questions opened. :D I hardly can wait for the results to come in, but I think if we are not designed to consume refined sugar, than we are designed for seasonal operation within the body. Of course that will change by the climate you live in, but going carb heavier in the summer and live like a hunter gatherer in the winter might be the answer?

[@yaztalli3578]

Hello doc I havnt done nmr test but I have ran all tests Liver function Fasted insulin Fasted blood sugar CBC Crp Homocysteine Metabolic panel Tsh Prostrate Bp 112/72 All are perfect Except lipid panel Hdl three points low Ldl 240 Lipoprotein a 45 Cholesterol 299 Triglycerides 10 points below My primary care blowing up my phone to go in I do low carb , no sugar no rice no pasta no bread no hfcs very very light fruits twice a week Intermittent fast at least 20 hours daily Just got off dry fast protocol 22 hours daily for thirty days then went and got my tests Iam athletic Body fat 10% Feed back appreciated or I can even do virtual consult Thanks

[@Bungifun]

He doesn't explain on the mechanism that pulls out the insulin receptor. This could be the effect of low insulin. I'd like to see this point better supported. A lot of research has now pointed out to PKC buildup in cells due to DAG accumulation, takes out the insulin receptor. Thus fat buildup in the cell causes this.

[@brucemoose926]

Talk about Trump hatred. Biden would have been a better example of APO4 and insulin resistance -> dementia.

[@ronpreece3429]

The joke was funny but it was the wrong President !

[@anwarsaeed3731]

Your a prophet my brother

[@stuartgoldstein1856]

Should one use a statin AFTER stent implantation?

[@blink99v]

So is cpeptide still best

[@grego4835]

I eat unrefined carbs and all my health markers and general feeling of health is better than low carb

[@theancientwonder5586]

I would love to hear your take on drinking alkaline water in terms of stomach acid

[@jeffrey4577]

Will 23and me reveal my ApoE type?

[@BobbyJobling]

Only if you have apoE4

[@kdeutschler]

if you have your raw data (which you can download from 23andme, you can upload to promethease for under $30 and get a full report of all important variants.

[@spaceoyster3761]

Should have been making fun of Biden not Trump!!!!

[@alphacause]

Actually both men have signs of mental impairment. So in reality Dr. Ali should have shown both men, not only because both men show some noticeable cognitive decline, but it would be a bipartisan joke, thus avoiding some unnecessary controversy. I surmise the reason why this video got a few thumbs down, despite the excellent presentation and Dr. Ali's cogently argued case regarding Apoe4 and insulin resistance, is because it offended half the viewer's political sensitivities.

[@kdeutschler]

@@alphacause as of right now, this video only has a 4% thumbs down....so...most folks have a sense of humor.

[@lanael7278]

My 50 g of carbs a day give me Charlie Horses every morning, even though I drink sodium, potassium and magnesium daily amounts every day. Is there an option for a painless low carbing?

[@meagenalexander1466]

I periodically get painful leg and foot cramps too. I've found that taking some salt in a glass of water dissipates it. I've been taking Mg for ages and I'm sure I'm not short of that. I sometimes have low sodium salt for the potassium. I try to drink around 2 litres of water a day but don't always make it. Or, maybe I do if coffee and tea count. I think hydration helps but I haven't nailed it down as to why I'm free of the cramps for a good while and then they come back. I'd be very interested in hearing from anyone about something else we could do as well.

[@minoozola8353]

It helps to take a calcium-magnesium supplement.

[@dustinsorenson21]

23and me can tell you which one you are - www.mygenefood.com/blog/23andme-and-apoe4-reporting-how-to-interpret-your-results/

[@jenlaird1gmail]

Correction: President Trump does not have dementia. Interesting that he chose that. I hate when people inject politics. It lowers their credibility.

[@1qtaz]

Have you heard of how he eats? He's a stroke waiting to happen

[@eugeniebreida1583]

You truly think that it lowers Dr. Alice medical credibility? Admit that the joke partisan, and that was probably a poor choice. Personally I would laugh whether it’s Biden or Trump, I think both of them are losing it. And have been for some While. Very sad.

[@GMAAndy333]

Sorry stopped video when I read you got political at the end. Don’t need to be reminded in a medical presentation how divided our country is.

[@eugeniebreida1583]

OR you could laugh, as it was a joke. Maybe he will include Biden and Trump in the conclusive photos next time. I thought it was pretty funny…

[@christinehutchins2446]

Why do you make fun of my President? He does not have dementia, yet.

[@eugeniebreida1583]

That’s debatable.

[@beau5296]

He could use some carbs.

[@TheShumoby]

He's Indian... If he gets a little fat, he gets diabetes.

[@alphacause]

If you are referring to how lean he is, keep in mind that Dr. Ali is an avid cyclist. Hence, his very slender frame, at the age of 60, is perfect for the type of activity he enjoys.

[@suesimmons926]

He Cycles 30 min to work in the morning but does not break his overnight fast until lunch time. On really busy days he ends up skipping lunch and does not break his fast until after his return ride home ... definitely fat adapted, but not much fat to spare!

[@Bshervais]

You lost me at the end. Showed your true idiocy. Unsubscribed.

[@eugeniebreida1583]

I’m pretty sure that used to be called melting like a snowflake… We will miss you

[@Lambsear565]

Change that picture with Biden trumps thriving lol

[@eugeniebreida1583]

trump$ thriving - ye$$iree!