Endocrinology | Pancreas: Glucagon Function

[@kmkim37]

Regarding the relationship between low blood glucose and glucagon release... it looks confusing. But I guess the explanation by Ninja Nerd is the best at present moment. The link between low concentrations of glucose and depolarization of the cell membrane is still under debate. According to one of the hypotheses, they think ATP-dependent K+ channels (KATP) plays important roles as in beta cells but the downstream link seems to be not clear yet. At moderate inhibition of KATP (low glucose concentration), membrane is moderately depolarized to open Na+ channels, resulting in the opening of voltage-dependent calcium channels. At high glucose concentration, KATP is strongly inhibited and the membrane potential is strong enough to inactivate Na+ channels, and calcium channels cannot be activated. This is just one of the current hypothesis, and it is not still clear why this does not apply in the regulation of insulin secretion in beta cells.

[@vidhivora3578]

this part was bugging in whole video... thanks you so much

[@saurabhranakoti7621]

@@vidhivora3578 even I came to comment section just to clear that part

[@Easypeasy007]

@@saurabhranakoti7621 can u plz explain m not able to understand

[@Easypeasy007]

@@vidhivora3578 can u explain

[@vidhivora3578]

@@Easypeasy007 there's video on insulin just before watch that first and then this ..you will know why I got confused and the above explaination ..then I guess you might get answer to your doubt ..if not then I'll explain you ..

[@abraxadabra4224]

For anyone perplexed about the Ca Channels, I think the answer is : Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA).

[@damlakacmaz8743]

Oh now it makes sense! Alpha cells, ones secrete glucagon has LVA Ca channels and beta cells has HVA Ca channels.

[@unkown-uz4lp]

Exectly

[@fretelianadedeus7951]

Thank you! I was so confused in the beginning

[@questioneverymatter5851]

Now I got it right. For Alpha cell the membrane is embedded by LVA calcium channel and for Beta cell it's HVA calcium channel. It's just a matter of cell type.

[@-BhadoriyaMohitSinghN]

You all people....Thank you so much for being involved and to initiate this kind of discussion on calcium channel...❤ Its really really very helpful...

[@Sk1pperCS]

'I think Ill mention it for those students who want to learn a little more' This means so much to me to hear. Thank you dearly.

[@mohammadhossain8730]

He is a gifted teacher!

[@shreyadixit8908]

You are a god's gift to medical students. Thank you so much for sharing your knowledge with us. Really very grateful!

[@wardakashif2469]

i had my endocrine exam today and it went absoleutuly great, actually i aced it, thank u sooo much for all of these videos. this whole endocrine palylist was soo detailed yet so easy to understand.

[@mahmadchorahi]

Which program you are studying

[@miriamcampillo7459]

Hey ! I am studying Biotechnology and have some exams in a few weeks. I just wanted to tell you that your videos are incredibly well explained. I could just watch them for fun. Congratulations for all the work and effort and thank you very much :)

[@rabiamaham473]

You get all the concepts together and make them understandable in a very easy manner. Great work and thank u so much for all these videos

[@richardwellens8932]

Thanks!

[@supernovachampions]

I love how you added glucagons effect on the myocardium... useful in beta blocker and CCB overdose. Great review!

[@schuggy4408]

I am now a fan. You are becoming my favorite KZbin channel. I am so glad you exist as a person and you do what you do. Keep making these videos and I'll keep watching them. Look for a patreon donation coming your way.

[@vatsalshah4582]

Comprehensive information provided here. You make life really easy in just 25 minutes. And after this, reading through text book becomes a breeze. Keep up the work and would love to see more topics covered.

[@samanthasurjana2892]

Thanks

[@valterbarros100]

Hi, Zach! I don't know if you'll read this, but I just want to say thank you for your free lectures here on YT... they help me on my med school tremendously! Having these lectures are truly making me learn some not so clear concepts on metabolism. You're awesome, dude! Keep transforming the student's lives through education!

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I appreciate the way you're enthusiastic about the things you explain - it makes the difference!! :D

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You're an angel. I'll marathon your videos as prep for my licensure exam!!

[@ElectricKoolaid904]

how did only 9.6k people like this video out of 337k views?! Zach is the best instructor on YT hands down

[@safaaamehdar579]

I hope you reach 10 million subscribers Very well explained, You are amazing teacher ! Lucky to have you Ninja nerd ❤️

[@loloonthelow]

the best teacher... i wish i could pay my med school tuition to this king

[@vinalkumar7041]

yes !! i did enjoy the video !! and thank you for keeping these for free us students to learn and always come back to!! Much appreciation from a fellow med student.

[@marshallbasumatary]

This helped me so much in connecting the important key points and describing an overall picture of the process. So helpful .🙏🏻

[@2YKSS2N]

thank you for sticking through the whole process of making this video

[@CarnivoreAnesthetist]

Who are the 20 people that didn’t like this video? Good job! Loved the refresher!

[@shahbaz9231]

hello Dr. WE need more videos of yours. start a new series of videos on any system. please keep em coming. we really love and appreciate your work.

[@WANaval-zl5vb]

Dude best class on glucagon on have seen so far.

[@MrBalko]

Thanks a lot for your great way of teaching.. I never thought I'd understand Biochemistry the way I start to understand it now..

[@mamalhjn9258]

You are one of the best teacher in the world 👍

[@ClinicalMedicinewithDrT]

the best teacher on youtube.THank you for the effort

[@reabitansky2769]

My exams are all oral and your videos are precious for explaining and connecting dotes

[@jonqn07]

AMAZING EXPLANATION! Wow, CLEAR explanation to the details! I'm a visual learner so your video really provides a complete picture for my understanding. Thank you very much! SUBSCRIBED!

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surprisingly during my bodybuilding prep, your content has massively helped keep me productive & focused. I've learnt so much information from your videos which will significantly help me deliver a better service to my clients as a online nutritionist coach. Thank you

[@yachiapatel]

This man👨‍💼 is so firm, confident and understandable in the era where people opt for confusion related data. 🙌 Just so in love❤ with you, your teaching skills and your management skills 🙌✌🌟 Kindly keep doing what you do 😍💕🌠

[@shreyaray5500]

Secretin inhibits Glucagon secretion , while CCK stimulates it. So you were partly correct originally. Love your work, Zach just can’t thank you enough for your amazing videos ❤️

[@abhisheksingh-qo1mw]

One thing for you is, you are my Super hero for biology, You gave me inspiration, and yeah man I am getting addicted to it. Thanks a lot for these lectures, and I gonna meet you one day Mr biologist

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I'm so addicted to all your vidss/ Love t them, start making shorts they actually help me even more

[@patriciavarga4084]

Laymen here. Interesting and mind challenging. Thank you

[@SivaS-qb2xj]

Thank you! This summer I aim to review all my physiology following your videos!! Thank you!!

[@melieaperakis4438]

My favorite teaching on this subject. I am definitely subscribing. I am a visual learner. Thank you so much.

[@vinayakkapatral4246]

Fantastic.... man I am running out of words to comment. Still feel like having notes or prints! Zachcellent!

[@himanshuambilkar4160]

Pancreas- Hetrocrine Accini Islets of langerhans. Alpha cells glucagon hypoglycemia Beta cells insulin hyperglycemia. In alpha cells GLUT1.less ATP. Less membrane depolarization. Ca++ chhanel. NE CCK SECRETIN. GLUCAGON. IN blood. Liver fasting state- Glyogenolysis. Glucogenesis. Adipocytes- Hormone sensitive lipase. LIPOLYSIS. Heart- Ca++ uptake. Thank you sir

[@SC-lj5sy]

Beautifully explained. Awesome teacher

[@MaKa-dm7kh]

U are a Hero without a cape! Greets from Germany.

[@nisargshah8550]

at the end can you leave a picture of the board so it can be printed off?

[@odysseyoddworld572]

Yes please, that would be very helpful. Thank you ninja nerd science.

[@danielachavez8346]

Pleaseee

[@frayedendsofsanity1733]

Omg yesssss

[@Pieguts123]

@@frayedendsofsanity1733 I go over the video, bit at a time, draw the diagrams and make notes of the explanations. I use coloured, erasable pens and this allows me to correct mistakes. Doing this means that I am re-listening to the lecture plus writing it down and then reviewing it whenever I want. This means a lot of revision of the topic: re-listening, note-taking, drawing, re-reading. I think this might help to truly learn rather than looking at a print-out?? I don't know; we all learn differently.

[@drholiday4147]

Pieguts123 same here ; )

[@fitrianib6563]

this is awesome... its helped me to more understand about glucagon.. thank you

[@freemigo]

Saved me. Amazing work. Love Ninja Science nerd.

[@Dexx837]

Thank you. Clear and right to the point

[@melissa5030]

Absolutely amazing thank you so much professor i have never understood more, such an amazing explanation really simple and clear bravo ✅❤️

[@snickerstoasted2212]

Packed with information and the drawings really help for someone like me that is a visual learner. Im actually a IT guy thus well done cruizin through the medical sections

[@injamamulhoque2013]

Sir, you are great teacher, I am your big fan from India ❤️

[@shansha7364]

brilliant explanation

[@linamaaref8373]

god give u health and wealth professor ur incredible from algeria

[@yazsam930]

Thank you man . Amazing as usual . Keep going my friend .

[@nirvanasharleen6994]

In a short time presenting a lot of things ! If the time of lectures in this video would be one hour it would be so good to present all the information more simply & easily what you wanted to present that goes to be more understandable ! Lastly thanks a lot to present all these mechanisms deeply !!

[@premedy1917]

Awesome thank you very much. You're the gift to community and our blessing.

[@garystone1252]

incredible lecture. Well done!!!

[@tsachie4822]

you make biochemistry so simple to understand

[@abdelraheemsalahin8537]

Good doctor ever

[@genevieved6743]

Professor Zach! You are awesome! Thank you so much!!!

[@fengcheng3507]

Excellent talk!

[@kannannatrajan6036]

well defined and great lecture

[@migueldelgadillo1835]

According to Costanzo CCK is a factor that stimulates glucagon secretion, so you were originally correct.

[@thomassmearcheck2819]

I love your videos , you have a teaching gift .

[@aparnakaranjkar1227]

Awesome explaination 👍

[@whatev3857]

Thank you for making learning so enjoyable 💓💓💓

[@alfia.55]

Ur videos are really helpful...uh did a great job...thanx for making these very informative videos 🌺✨

[@bilalclasher4722]

Thank you for the vedio. Really appreciate it❤

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Just amazing, good job man!

[@shahabuddin6149]

Love you sir,,sault to your effort,,you make very easy every topic for us,,a bundle of thanks sir...keep it up,,I am only depending on your sweet lecture...

[@wombat2379]

Great job, thank you!

[@komalrasheed2713]

Great concepts bro😘😘stay blessed

[@mohammadsulemansakhi7480]

Good explanation amazing sir

[@Fil-AmRN]

You are a heaven sent... Thank you soo much!!!!!! now I am feeling kinda Nerdy :D Great videos! very clear ! love it all, I don't even notice the time whenever I binge watch your videos..... Hope for some printed materials to guide medical students like me as well, practice quizzes and what not :)

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THANK YOU FOR THIS VIDEOS YOUR AMAZING FOR DOING THIS

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Every single time I feel like I had an epiphany watching your videos :D

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Cool presentation

[@elizabethcharles6973]

Thank you so much, this is awesome! You're absolutely mind blowing in your teaching skills.

[@NinjaNerdOfficial]

+Elizabeth Charles wow thank You so much for your kind comment!! I am so glad we were able to help!

[@myleeyenn]

I am not a bio student but I can understand, thanks for ur video

[@rippularora6366]

Amazing work 👍👍. Thankyou so much🤗♥️♥️

[@rosamariathol9546]

Lovel 💕💕💕💕 your lessons you are great explaining.

[@vinayakkapatral4246]

Zachcellent!

[@ahmedramadan8926]

what an amazing explain

[@ninjaman302]

Thank you my brother for the great info.😁🙏🏾🌈

[@amnakarim2k2]

Hello I hope you are doing well. Your video are really informative and enjoyable ❤ I actually have a confusion regarding the calcium channel. In this video you are saying that when there is increased glucose level, there is production of ATP which binds to the potassium channels causing their closure, in response to accumulation of K+, the calcium channel closes (6:35). while in the other video on insulin function, you mention it as that there is opening of calcium channels for its influx and release of insulin(11:15). It is creating a little confusing.😟

[@Mengjoanne]

Can you do a video on fasting, glucagon and lipolysis? Key to fat loss?

[@LHost-sx2kk]

Hey man I got a question, in the video on Insulin you actually said that those Calcium channels open, to stimulate the insulin release to the blood, now you say when there is too much depolarization they close, I'm quiet confused with what you mean, if you could help me get this right, thank you in advance!

[@laithenani671]

second that, please elaborate. Thank you

[@LHost-sx2kk]

6:00 , but maybe it has do do with the different threshold levels for that Calcium channels in alpha and beta cell's? I understood what he said but not why it doesn't happen in the beta cell as well

[@teekay5166]

Yes same. Confused at this point

[@NouziMora]

Same! If ATP channels close and K+ accumulates, there should be a membrane depolarization which causes Ca++ channels open. Don't understand why would positive charge close the channels?

[@LHost-sx2kk]

Okay,clearification for you guys since this guy refuses either to admit he is wrong about this topic or he either too cool to answer to us, forget what he said, when B cells release insulin caused by hyperglycemia it also secretes glutamate, that will have effect on alfa cells Cl- receptor channels, increasing uptake of cloride by cell and hyperpolarizing it. When the stimulus is low glucose levels this action of Cl- channels is inhubited because less glutamate is comming form b-cells and the alfa cell will depolarize, giving the threshold for Ca++ release into the cell

[@Oktofalldown]

Thnkk uu sir uu teach really really well

[@blessingadima4597]

@Ninja nerd please can you give diagrammatic explanation of the secretion and physiological action of glicentin.. please

[@hafsaislam6773]

Great sir . Thank Uh 💙💙

[@LadieBjj]

I wish I could talk about this as you do!

[@freddiespinoza]

Excellent!

[@mohammedal-shrouf8238]

Thank you 😊

[@jocoso1234]

Hi, some concept is wrong in this video. The opening of voltage-dependent N and T type -Ca channel and Na-channel is because of Katp channel. (opens with a low ATP/ADP level). when K flows out the membrane, locally, the membrane will depolarize and opens the Ca and Na channels. your video is still awesome for learning.

[@a_key411]

Sir I have one question Actually a confusion....in previous lec. You talked directly about increase k+ ions and it stimulates opening of ca2+ channels and here you said that increased positive polarization inhibits the opening of ca+ ion channels..... please can you help me in clearing this confusion?!! Thank you !

[@LuchiaNan165]

Hi, Voltage-activated Ca channels can be divided into 2 subgroups based on their activation threshold: Low voltage activated LVA (Alpha) cells And High voltage activated HVA (Beta) cells.. Hope that makes sense!!

[@فاطمهالهاديابراهيمعثمان]

thanks ninja ❤❤❤❤❤

[@kmkim37]

The α-cells and β-cells have opposite Ca+ signaling patterns in response to glucose. At low glucose concentration, the cytosolic ATP/ADP ratio is low; KATP channels demonstrate a moderate activity, which situates the α-cells to a membrane potential that allows the opening of voltage-dependent T- and N-type Ca2 + channels. The resulting increased intracellular calcium concentrations, in turn, stimulate exocytosis and glucagon secretion. On the contrary, high glucose blocks KATP channels, which depolarizes the α-cells to a membrane potential range that suppresses the voltage-dependent Ca2 + channels. Consequently, Ca2 + signaling and glucagon release are blocked. (Adapted from Anatomy, Histology, and Function of the Pancreas. C. Shi, E. Liu, in Pathobiology of Human Disease, 2014)

[@tibayounis9977]

In 6:24 minute is there any wrong ??calicium channel will open when theris too much membrane potential not close please if ther is any one told me I really confuse

[@rasilarg8055]

On the source i got. It seems that in Apha cells low ATP closes k+ channels. Which causes depolirasation, and as a results voltage sensitive ca++ channels will open. Whereas in Beta cells high ATP due to high glucose closes th k+ channels causing depolirasation also. And ca++ channels will open. U must be able to differentiate activities happening on beta and alpha cells

[@Creb4100]

Good job

[@nidashams2185]

Adipose tissue contain both insulin and glucagon receptor which produces protein kinase A that stimulates different functions. How does the protein kinase A know which function to perform.

[@sushantchauhan2148]

i have seen his all biochem videos and at 1.7x speed and its damn good at that speed idk may be its only me who did that. but he is slow for normal but god mod at that speed .

[@turkersoykan5695]

Eyvallah Ninja kardeş! 🙏🏽❤️