Endocrinology | Prolactin

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture, Professor Zach Murphy will be discussing the hormone prolactin. We describe the function, target organs, and the regulation of this hormone in the body. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #Prolactin #Endocrinology

[@ellubritsh]

I`ll never become tired telling how grateful to you I am! Huuuge thanks for putting so much effort, for being ”very specific”, for collecting all the information possible, while explaining a particular topic. I admire your passion, courage and involvement! You do inspire to learn, to wish to know more! You and your team do a great job for educating people all over the world! Please , continue. Your teaching abilities are worth being heard. We need you!

[@NinjaNerdOfficial]

Thank you so much!!! 😀😀

[@jasonvillarreal5818]

I have subscribed recently and have watched dozens of these videos. Thank you thank you thank you Z, you have helped so many people! Got my t-shirt yesterday. Always looking for the next topic.. not to mention your lectures have helped me cruise through my classes so much. A true teacher is a gem.

[@paulafrengul9761]

You explain very clearly and are very helpful. Thank you so much!

[@kathymurray4915]

I learned more in 6 of your videos than I did in an entire semester with a teacher that read off powerpoints and expected us to understand. Thank you

[@user-fi1bt3uy4w]

I really do appreciate this kin of teaching. Even if the video is long, each part of the video is useful. He's not wasting our time because when he teaches us, he make sure that he imparted us a complete knowledge about the topic. He's not just reading a script, he's really illlustrating through his drawing which is very helpful in our Physiology classes.

[@nans9629]

I have thyroid disorder and just never quit making milk... drs acted like everything was normal and I was just super confused. This video was the best explanation of what I was experiencing not just your fine.

[@hudamohammed1909]

Idk what I will do without ur videos 🖤🖤 keep going u r perfect 🙏🏻

[@cristianpalaciosrn4153]

Oh my gosh. Amazing. Thank you so much bud, especially clarifying estrogen’s effect on Prolactin. You have no idea how confused I was before. Now I see the light!!

[@Krishna-ub6ij]

Sir you are too good! 😍 Much love and success to you in life! I am medical graduate and watching your videos makes me feel damn I should have watched this in UG days. 😆

[@CrazyBoys534]

Great video helped me a lot to understand many things about the prolactin, pls keep uploding more!!!!

[@haneen9445]

Thank u for ur extremely clear explanation ❤️

[@daisynafula6479]

Thank you so much for all this video...I don't know what physiology would be like without all this

[@2YKSS2N]

thank you for sticking through the whole process of making this video

[@drZamanAli-yk2pz]

Best of the best. Completely good . Bunches of thanks for u sir❤️

[@havocchaos0371]

How effortlessly you switch from anatomy to physiology 🙌🙌👏🏽👏🏽

[@VIVEKKUMAR-dk5uv]

His concepts are so damn clear

[@omermohammedomer4017]

as usual you break it into simple ideas and that make us understand. thanks

[@ghadamohammed-uu6qy]

your explanation is very good and very helpful. thank you so much

[@shaizatariq1447]

I can never thank you enough. After watching every video I'm like wow. How can he make it sound so easy and understandable. Thank you so much. Your videos are life savers. ❤️

[@zenoviacioara1510]

Traduce în l. romana

[@zahrashahabinezhad]

Hi, I wish you made the distinction that estrogen and progesterone increase prolactin production, but they inhibit the effect of prolactin on the production of milk during pregnancy. Once the placenta is delivered, a drop in estrogen, progesterone, and dopamine, allow prolactin to stimulate lactation.

[@shubhankarghosh-2046]

Very nice and good elaborated lecture, Excellent 💯🙏

[@DrJohn_Bhatti]

effort AND RESEARCH IS MARVELLOUS SIR

[@kevinsnyder6815]

Greatest information I've received every. Thank you

[@nkamngangsandra926]

I wish I was your daughter😊 . Am very certain you can explain these things for bed time stories. More strength to your elbows and thank you👍

[@lbpswlbgvanessacamon3770]

Very comprehensive. Spot on.👌👌👌

[@PreetiSharma-sk2il]

Thank you..this is very helpful🤗

[@BillionaireBoyRubix]

I just wanted to learn about prolactin in 2min and I ended up watching till the end. You have just earned a subscriber, congrats!

[@abdelwahabmohamed4329]

Good luck, buthe must be thanked about his efforts, also u

[@davesbabe42able]

So helpful, thank you!

[@moriahndhlovu620]

Thank you nerd. Really helpful

[@gunjabiswas8544]

Thank you very much.... It's really very helpful

[@samiraabdi7465]

Iam so glad to find this video thank u so much ninja😍

[@shreyaspattanshetty2560]

Very helpful Sir, thank you!

[@neshkur3459]

Amazing!! Thanks a lot

[@fardadja]

Great video as always, thank you. Around minute 14 you say too much estrogen inhibits the action of prolactin (PRL) during pregnancy, but I believe it is progesterone during pregnancy that inhibits PRL's effects. Keep up the good work - you and your team are truly an inspiration.

[@drtforex]

both progesterone and estrogen block the receptors to prevent PRL from acting on them

[@teemcc5011]

It's both

[@goallgreenpeacelove]

Great video!! Thank you!!!

[@sound13music]

Your explanation was amazing 😱 thanks so much

[@NinjaNerdOfficial]

+Marcia Salum 😊You’re welcome!

[@syedafiya687]

Osm Sir!.. U really teach very nice....

[@muhammadrifqikhairulummam3942]

Awesome Video!! and vary helpful. Thank u so much!!

[@footballshorts191]

Always the best at explaining concepts simply 👌🙌 I have a simple question why didn't you talk about the PRF Prolactin Releasing Factor ?

[@Jordannewman24]

Thank you ninja nerd science because your videos help me understanding this because it helps so thank you

[@ollymounara605]

William Walsh talks about high copper after pregnancy being the cause of post natal depression. I believe it is related to the high estrogen. So maybe addressing the high copper levels might also stimulate lactation? But maybe the copper stays high while the estrogen drops. Zinc is necessary to lower the copper. And I know iodine can change the two bad estrogens into the good to change cystic breast tissue. It works very quickly as I tried it myself in relatively high doses. I also know DIM and broccoli sprout extract work on estrogens. I'm wondering if they help lower the estrogen as well. I just found that iodine can lower estrogen in dominance so it could be low iodine causing problems in starting lactation. I have suspected low dopamine for myself but never knew it could be connected to sleep. So the high prolactin can cause sleeping issues which is new to me. Yet another insight to sleeping disorders. Thank you!

[@madinamutalipova6461]

Thank you for this video. From which book do you suggest learning Endocrinology?

[@doc.3li]

Thank you so much ☺️ 👏🏻👏🏻👏🏻

[@Jimboishuffle]

This was so enlightening

[@mokazmi9004]

Awesome video! I have a question about the relationship among estradiol, prolactin, and dopamine. I understand that estrogen inhibits dopamine, which in turn leads to elevated prolactin. Why, then, is there so much research that shows that estrogen stimulates dopamine release? What is the mechanism of action? If estrogen stimulates dopamine, should it not inhibit prolactin? Yet, we know elevated estradiol leads to elevated prolactin, because estrogen inhibits dopamine. I can't seem to grasp how estradiol has both paradoxical effects: it inhibits dopamine to stimulate prolactin; yet studies show estradiol potentiates dopamine while simultaneously increasing prolactin. Any clarification is appreciated.

[@rockgod2131]

Estrogen has stimulating effects on prolactin secretion, independent of dopamine. In addition, while estrogen can increase dopamine, it also increases serotonin, which in turn lowers dopamine and increases prolactin. It's all rather complex but in practice, prolactin is actually a better marker for someone's estrogen levels than an actual estrogen blood test.

[@pedrorodrigueztube]

Maybe is a matter of estrogen level. Very high = prolactin release. Moderate = Dopamine release. I guess in males some estrogen is needed to release Dopamine because once I heard crashed estrogen makes prolactin spike up

[@sudiptapatra7262]

Thank you sir

[@fatimaibraheem7498]

Thankey so much.all love for you

[@MeraMohameddrd38]

Subhan Allah 🥺♥️♥️ So nice , Thank you 🥰🥰💛

[@kelvinkavithi1344]

When you talked about breastfeeding as being one of the ways that lead to prolactin release you said that it activates paraventricular nucleus to promote TRH production...Is it also ok to say that oxytocin by the paraventricular nucleus is the one that causes Milk Let down reflex?

[@ladyimma9682]

Thank you

[@sudiptodebnath6579]

Really thankful to you

[@RichardsWorld]

It would be interesting to see a video of the production and effects of prolactin in males.

[@jdsnapp]

I second that!

[@LigerZero77]

The most common symptoms of high prolactin levels on men are : Low libido, erectile dysfunction, low dopamine, and not being able to achieve erections without touching yourself. At least that what i felt when i was on high prolactin level due to taking antidepressants for 2 years, had to take cabergoline to be back to normal again.

[@peacegirl4006]

Stunning 😍

[@msthenoify]

Thank u guys so much This is so helpful 👍🏽

[@NinjaNerdOfficial]

+Atheer Mohamad so happy to help!!!

[@primalstrength8167]

Atheer Mohamad c

[@afd5826]

I'm so grateful

[@nastiianastiia5763]

Thank You

[@user-gh9vn4qy4m]

thank you so much

[@shahedhamdan4002]

It is amazing video! 😭♥️

[@kwstaspapapanos6791]

You are the BEST!!!!!!!!!!

[@sarasara-gl3sd]

thank u very much you are amazing may god bless you sir

[@josetrujillo738]

Boom! Roasted! Sweet Deal! Thank You Zach! Ninja Nerd Science!

[@ricksgiggle8852]

Ben askren reference. Hell yeah! 🔴😈👹

[@user-ki1ss8im9f]

Thank you so Much 👍

[@zeinatwathiq3507]

Best ninja for ever

[@shahnozaxayitova4555]

Thank you so much😍

[@simonagnew9414]

Zach, dude, I've been leaving quite a few comments under a lot of your lecture. U don't feel like writing about it in depth at the moment but a 10x legal dosage overdose was deliberately administered to me late September 2007. It nearly killed me. Now I have a wide range of medical conditions-mainly seen in elderly people ( I'm 46) but my blood work done once I'd figured out what had happened to me I called on my uni biochemistry and pharmacology. As well as many other endorphin interference problems they caused were hyperprolactinemia. I was told normal Prolactin level for a male was one said 270, the other said 320 was maximum healthy for males. My level was 898, I was told that's the level of a breastfeeding mother. The alteration in mental state associated with this is to develop and display an unusual maternally protective aggression/ almost psychotic agitation and protectiveness and somewhat aggressive mannerism s. This, of course, is unusual for a male and open to misinterpretation by your average mental health professional. It's just a nasty extrapyramidal side effect, while one of the primary deliberate effects is to amplify all types of norepinephrine production and increasing reception of them while blocking all ~25 of the dopamines and all~15 types of serotonin. I was turned into one of the world's nastiest pasties. 46yo West Australia male Perth

[@Gandalf-DZ]

I'm sorry you had to deal with all of this, i hope that you overcome this, best regards.

[@viperfishsasori]

Coolest KZbin intro ever!!!

[@smartyaba]

Can u please upload vedios on disorders of hormones

[@vanessazz]

thank you

[@mehranhedayati5538]

Amaaaazing!!

[@mahimapearlin7432]

Thank u so much sir❤

[@Semaj.18272]

When u have high progesterone does it lower prolactin ?

[@dr.anti.social]

These playlists are not intimidating than so called web series 😍

[@adityasinghjodha3788]

Great. Topimaster..👍👊

[@ashishpatro3404]

Thanks 😊

[@DharmendraSingh-em9hp]

Sir mera prolaction 36 hai kam kese hoga ege 24 year our sabhi harmine sahi hai

[@nara9793]

great, thank you! :)

[@nicolemartinez929]

Has anyone else requested video on Hyperprolactinemia? Please help me understand this symptom/condition?

[@mounatiti8446]

Thank u so much !

[@marrymetimothee1243]

hi do high prolactin levels in women cause hair loss/excessive body hair? thanks in advance

[@faaa78]

Thanks!

[@salam7905]

thank you so much ^-^

[@afafrashed6354]

Great!!!!

[@khkhmoh4651]

Excellent Excellent Excellent 👏👏👏👏👏👏👏👏 👍👍👍👍👍👍👍👍

[@DocAmikable]

Does prolactin decrease estrogen levels. I want to know specifically how high prolactin level can lead to amenorrhoea

[@sruthisaravanan1342]

Thank you ❤️

[@248yazhinik3]

Effect of online classes: Numbers as prefix instead of initials

[@blackyrocky7438]

In short prolactin makes milk content. Also prolactin can make proteins which are aqua porins, ion channels, may make glut transporter because milk has water, calcium, lactose sugar, electrolytes, antibodies so forth

[@manalemad1589]

u r a legend thankssss a looooottt

[@user-rk1oj9nx7v]

Thanks

[@mixtureofrandomthings7007]

Can I take contraceptives pills for high prolactin level?

[@2YKSS2N]

you are the best

[@sherzadhajijumaa1711]

I heard that it is progesterone during pegnancy which inhibit action of prolactin. On alveolar cell not estrogen.. ??????

[@fardadja]

I believe you are correct. Estrogen increases PRL production, but it is progesterone which inhibits its action during pregnancy.

[@mounaamal6171]

@@fardadja please why does too much estrogen increases PRL production?

[@sarasnead4096]

I thought estrogen decreases milk production which is why they give progestin only birth control to lactating mothers. Please explain.

[@umidotamurodov8]

Amazing

[@savannahcrawford6401]

Is there such a thing as a dopamine deficiency & could it cause elevated levels of prolactin in a non pregnant/ breastfeeding female without triggering thyroid issues??

[@lauras627]

Savannah Crawford Did you find out? I’m doing research for my 20 yr old daughter w/ 20-40 points higher levels than normal w/ no p.g. tumor.

[@tylerb7194]

This question is pretty old, but in case this helps someone, I'll give the sliver of knowledge I have. SSRIs (selective serotonin re-uptake inhibitors) inhibit dopamine, which could result in an over-production of PRL and may then result in lack of menstrual cycle and milk secretion. Might be worth investigating.

[@alexamorales7212]

Savannah Crawford did you ever get this question answered?

[@TheMdub27]

As a bro science thing people on KZbin say that there is. It's not so much of a deficiency I don't think. If you want to lower prolactin don't worry so much about increasing dopamine so much, lower the stress in your life by eating healthy foods and supplements. Stress and estrogen can increase prolactin

[@SRBOMBONICA86]

@@TheMdub27 which supplements would you reccomend?

[@shnyarmukhtar9347]

what about progesterone role in prolactin production?

[@jeffberry5487]

Hello Doc. I was wandering as it pertains to prolactin in males,is it possible to have prolactinomas when the levels are in the normal but very high end of the range? To give a more complete picture of my question, the prolactin would be in the very high end of normal and testosterone would be in the very low end of normal. For example the free testosterone would be 300.00 nanograms per deciliter on a reference range chart of 205.00-781.00 and the prolactin would be 12.00 on a reference range chart of 2.64 -3.13 nanograms per milliliter.. These are roughly actual real numbers I've witnessed.Thanks for any info!

[@petesantana7302]

Can you do a video about level in man ? Prolactin in man

[@jeremybear573]

Yes. My brother has very high Prolactin and it has destroyed his self esteem, high weight gain, loss of desire, and so on. I've found very little information for men but so much for woman. Id love to find a good source for men and what treatment works best

[@andreic738]

What is your bibliografy at Fiziology :D

[@fatemakhanpurwala1473]

Ur video s are super awesome but i wish it was a bit more louder live voice

[@rakanalsahil8934]

I didn’t get the last point, you said estrogen stimulates the production of prolactin, how does it inhibit it’s function in the alveolar cell?

[@yournanstoplip7874]

Awesome stuff abit demeaning I had to put it in 0.75 to kind of understand but awesome stuff