Erk - part 2: Erk substrates

This video presents the effect Erk has on its substrates, including fos, jun, myc, Elk, Rsk, and Bim.

[@markuswelcker3289]

Jun is phosphorylated on S63, not S36. Myc's S58 is actually T58 and definitively not an ERK site, but targeted by GSK3. You may argue that S62 primes for T58. But the model that these ERK sites activate these proteins is simplistic, because TFs also inhibit genes. Perhaps too soon for this audience. And to complicate things: at least for Myc a more correct model would include destruction-mediated gene transcription which is really not understood yet...